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6KRI	Crystal Structure of Acyl-CoA Dehydrogenase FadE5 from Mycobacteria smegmatis with product released Descriptor: Acyl-CoA dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION Authors: Liu, X, Chen, X.B. Deposit date: 2019-08-21 Release date: 2020-07-01 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.604 Å) Cite: Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria. Proc.Natl.Acad.Sci.USA, 117, 2020
6KS9	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis Descriptor: Acyl-CoA dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION Authors: Liu, X, Chen, X.B. Deposit date: 2019-08-23 Release date: 2020-07-01 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria. Proc.Natl.Acad.Sci.USA, 117, 2020
8YD8	Structure of FADD/Caspase-8/cFLIP death effector domain assembly Descriptor: CASP8 and FADD-like apoptosis regulator subunit p43, Caspase-8, FAS-associated death domain protein Authors: Lin, S.-C, Yang, C.-Y. Deposit date: 2024-02-19 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (3.11 Å) Cite: Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis. Nat Commun, 15, 2024
8YBX	Structure of the FADD/Caspase-8/cFLIP death effector domain assembly Descriptor: CASP8 and FADD-like apoptosis regulator subunit p43, Caspase-8 subunit p10, FAS-associated death domain protein Authors: Lin, S.-C, Yang, C.-Y. Deposit date: 2024-02-16 Release date: 2024-05-15 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis. Nat Commun, 15, 2024
8YD7	Structure of FADD/Caspase-8/cFLIP death effector domain assembly Descriptor: CASP8 and FADD-like apoptosis regulator subunit p12, Caspase-8, FAS-associated death domain protein, ... Authors: Lin, S.-C, Yang, C.-Y. Deposit date: 2024-02-19 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (3.32 Å) Cite: Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis. Nat Commun, 15, 2024
4UBT	Structure of the C93S variant of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis in complex with a steroid and CoA. Descriptor: (2S)-2-[(8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoic acid (non-preferred name), Acetyl-CoA acetyltransferase FadA5, CHLORIDE ION, ... Authors: Schaefer, C.M, Kisker, C. Deposit date: 2014-08-13 Release date: 2014-12-17 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis. Structure, 23, 2015
4UBU	Structure of a modified C93S variant of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis in complex with CoA Descriptor: Acetyl-CoA acetyltransferase FadA5, COENZYME A, GLYCEROL Authors: Schaefer, C.M, Kisker, C. Deposit date: 2014-08-13 Release date: 2014-12-17 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3 Å) Cite: FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis. Structure, 23, 2015
4UBW	Apo structure of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis Descriptor: Acetyl-CoA acetyltransferase FadA5, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Schaefer, C.M, Kisker, C. Deposit date: 2014-08-13 Release date: 2014-12-17 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis. Structure, 23, 2015
4UBV	Structure of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis with an partially acetylated cysteine in complex with acetyl-CoA and CoA Descriptor: 1,4-DIETHYLENE DIOXIDE, ACETYL COENZYME *A, Acetyl-CoA acetyltransferase FadA5, ... Authors: Schaefer, C.M, Kisker, C. Deposit date: 2014-08-13 Release date: 2014-12-17 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis. Structure, 23, 2015
1HW2	FADR-DNA COMPLEX: TRANSCRIPTIONAL CONTROL OF FATTY ACID METABOLISM IN ECHERICHIA COLI Descriptor: 5'-D(*CP*GP*AP*TP*CP*TP*GP*GP*TP*CP*CP*GP*AP*CP*CP*AP*GP*AP*TP*GP*CP*T)-3', 5'-D(*G*CP*AP*TP*CP*TP*GP*GP*TP*CP*GP*GP*AP*CP*CP*AP*GP*AP*TP*CP*GP*A)-3', FATTY ACID METABOLISM REGULATOR PROTEIN, ... Authors: Xu, Y, Heath, R.J, Li, Z, Rock, C.O, White, S.W. Deposit date: 2001-01-09 Release date: 2001-01-22 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (3.25 Å) Cite: The FadR.DNA complex. Transcriptional control of fatty acid metabolism in Escherichia coli. J.Biol.Chem., 276, 2001
7Q86	Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, FAD-bound-form Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Isoform 2 of Peroxisomal acyl-coenzyme A oxidase 1 Authors: Sonani, R.R, Blat, A, Dubin, G. Deposit date: 2021-11-10 Release date: 2022-03-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Crystal structures of apo- and FAD-bound human peroxisomal acyl-CoA oxidase provide mechanistic basis explaining clinical observations. Int.J.Biol.Macromol., 205, 2022
6SLS	Flavin-dependent tryptophan 6-halogenase Thal in complex with FAD Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, PHOSPHATE ION, ... Authors: Moritzer, A, Niemann, H.H. Deposit date: 2019-08-20 Release date: 2019-10-16 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Binding of FAD and tryptophan to the tryptophan 6-halogenase Thal is negatively coupled. Protein Sci., 28, 2019
6UI5	Tmn9 in complex with cofactor FAD Descriptor: 2-polyprenyl-6-methoxyphenol hydroxylase-like FAD-dependent oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE Authors: Paiva, F.C.R, Little, R, Leadlay, P, Dias, M.V.B. Deposit date: 2019-09-30 Release date: 2020-10-07 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Tmn9 in complex with cofactor FAD To Be Published
6ZE5	FAD-dependent oxidoreductase from Chaetomium thermophilum in complex with fragment 2-(1H-indol-3-yl)-N-[(1-methyl-1H-pyrrol-2-yl)methyl]ethanamine Descriptor: 2-(1H-indol-3-yl)-N-[(1-methyl-1H-pyrrol-2-yl)methyl]ethanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Svecova, L, Skalova, T, Kolenko, P, Koval, T, Oestergaard, L.H, Dohnalek, J. Deposit date: 2020-06-16 Release date: 2021-05-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum. Acta Crystallogr D Struct Biol, 77, 2021
6ZE6	FAD-dependent oxidoreductase from Chaetomium thermophilum in complex with fragment 4-nitrocatechol Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-NITROCATECHOL, ... Authors: Svecova, L, Skalova, T, Kolenko, P, Koval, T, Oestergaard, L.H, Dohnalek, J. Deposit date: 2020-06-16 Release date: 2021-05-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum. Acta Crystallogr D Struct Biol, 77, 2021
6ZE4	FAD-dependent oxidoreductase from Chaetomium thermophilum in complex with fragment 4-oxo-N-[(1S)-1-(pyridin-3-yl)ethyl]-4-(thiophen-2-yl)butanamide Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-oxo-N-[(1S)-1-(pyridin-3-yl)ethyl]-4-(thiophen-2-yl)butanamide, ... Authors: Svecova, L, Skalova, T, Kolenko, P, Koval, T, Oestergaard, L.H, Dohnalek, J. Deposit date: 2020-06-16 Release date: 2021-05-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum. Acta Crystallogr D Struct Biol, 77, 2021
6ZE3	FAD-dependent oxidoreductase from Chaetomium thermophilum in complex with fragment (4-methoxycarbonylphenyl)methylazanium Descriptor: (4-methoxycarbonylphenyl)methylazanium, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Svecova, L, Skalova, T, Kolenko, P, Koval, T, Oestergaard, L.H, Dohnalek, J. Deposit date: 2020-06-16 Release date: 2021-05-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum. Acta Crystallogr D Struct Biol, 77, 2021
6ZE2	FAD-dependent oxidoreductase from Chaetomium thermophilum Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... Authors: Svecova, L, Skalova, T, Kolenko, P, Koval, T, Oestergaard, L.H, Dohnalek, J. Deposit date: 2020-06-16 Release date: 2021-05-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum. Acta Crystallogr D Struct Biol, 77, 2021
3K88	Crystal structure of NADH:FAD oxidoreductase (TftC) - FAD, NADH complex Descriptor: Chlorophenol-4-monooxygenase component 1, FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Kang, C, Webb, B.N. Deposit date: 2009-10-13 Release date: 2009-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) of Burkholderia cepacia AC1100. J.Biol.Chem., 285, 2010
3K87	Crystal structure of NADH:FAD oxidoreductase (TftC) - FAD complex Descriptor: Chlorophenol-4-monooxygenase component 1, FLAVIN-ADENINE DINUCLEOTIDE Authors: Kang, C.H, Webb, B.N. Deposit date: 2009-10-13 Release date: 2009-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) of Burkholderia cepacia AC1100. J.Biol.Chem., 285, 2010
6L2U	Soluble methane monooxygenase reductase FAD-binding domain from Methylosinus sporium. Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Methane monooxygenase Authors: Park, J.H, Ha, S.C, Rao, Z, Yoo, H, Yoon, C, Kim, S.Y, Kim, D.S, Lee, S.J. Deposit date: 2019-10-07 Release date: 2021-03-03 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Elucidation of the electron transfer environment in the MMOR FAD-binding domain from Methylosinus sporium 5. Dalton Trans, 50, 2021
7DVE	Crystal structure of FAD-dependent C-glycoside oxidase Descriptor: 6'''-hydroxyparomomycin C oxidase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION Authors: Senda, M, Watanabe, S, Kumano, T, Kobayashi, M, Senda, T. Deposit date: 2021-01-13 Release date: 2021-09-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: FAD-dependent C -glycoside-metabolizing enzymes in microorganisms: Screening, characterization, and crystal structure analysis. Proc.Natl.Acad.Sci.USA, 118, 2021
3QJ4	Crystal structure of Human Renalase (isoform 1) Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Renalase, SULFATE ION Authors: Milani, M, Ciriello, F, Baroni, S, Pandini, V, Aliverti, A, Canevari, G, Bolognesi, M. Deposit date: 2011-01-28 Release date: 2011-07-13 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation J.Mol.Biol., 411, 2011
6KSB	Crystal Structure of E447A M130G Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C16CoA Descriptor: Acyl-CoA dehydrogenase, COENZYME A, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Liu, X, Chen, X.B. Deposit date: 2019-08-23 Release date: 2020-07-01 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.973 Å) Cite: Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria. Proc.Natl.Acad.Sci.USA, 117, 2020
6LQ5	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C16CoA Descriptor: Acyl-CoA dehydrogenase, COENZYME A, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Liu, X, Chen, X.B. Deposit date: 2020-01-13 Release date: 2020-07-01 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria. Proc.Natl.Acad.Sci.USA, 117, 2020

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