5TXV
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![BU of 5txv by Molmil](/molmil-images/mine/5txv) | HslU P21 cell with 4 hexamers | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU | Authors: | Grant, R.A, Chen, J, Glynn, S.E, Sauer, R.T. | Deposit date: | 2016-11-17 | Release date: | 2017-03-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (7.086 Å) | Cite: | Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation. J. Biol. Chem., 292, 2017
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6RLP
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![BU of 6rlp by Molmil](/molmil-images/mine/6rlp) | Cryo-EM reconstruction of TMV coat protein | Descriptor: | Capsid protein, RNA (5'-R(P*GP*AP*A)-3') | Authors: | Kandiah, E, Effantin, G. | Deposit date: | 2019-05-02 | Release date: | 2022-11-23 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | CM01: a facility for cryo-electron microscopy at the European Synchrotron. Acta Crystallogr D Struct Biol, 75, 2019
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4XTS
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![BU of 4xts by Molmil](/molmil-images/mine/4xts) | Salmonella typhimurium AhpC T43A mutant | Descriptor: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION | Authors: | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | Deposit date: | 2015-01-24 | Release date: | 2016-01-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.704 Å) | Cite: | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid.Redox Signal., 28, 2018
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6OJM
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![BU of 6ojm by Molmil](/molmil-images/mine/6ojm) | |
7VRT
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![BU of 7vrt by Molmil](/molmil-images/mine/7vrt) | The unexpanded head structure of phage T4 | Descriptor: | Capsid vertex protein, Major capsid protein | Authors: | Fang, Q, Tang, W, Fokine, A, Mahalingam, M, Shao, Q, Rossmann, M.G, Rao, V.B. | Deposit date: | 2021-10-24 | Release date: | 2022-10-05 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (5.1 Å) | Cite: | Structures of a large prolate virus capsid in unexpanded and expanded states generate insights into the icosahedral virus assembly. Proc.Natl.Acad.Sci.USA, 119, 2022
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6RSG
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![BU of 6rsg by Molmil](/molmil-images/mine/6rsg) | NMR structure of pleurocidin VA in SDS micelles | Descriptor: | Pleurocidin | Authors: | Manzo, G, Mason, A.J. | Deposit date: | 2019-05-21 | Release date: | 2020-12-09 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy. Commun Biol, 3, 2020
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6OM3
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![BU of 6om3 by Molmil](/molmil-images/mine/6om3) | Crystal structure of the Orc1 BAH domain in complex with a nucleosome core particle | Descriptor: | DNA (146-MER), DNA (147-MER), Histone H2A, ... | Authors: | De Ioannes, P.E, Wang, M, Armache, K.-J. | Deposit date: | 2019-04-18 | Release date: | 2019-07-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure and function of the Orc1 BAH-nucleosome complex. Nat Commun, 10, 2019
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6J30
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![BU of 6j30 by Molmil](/molmil-images/mine/6j30) | yeast proteasome in Ub-engaged state (C2) | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, ... | Authors: | Cong, Y. | Deposit date: | 2019-01-03 | Release date: | 2019-03-20 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations. Mol. Cell, 73, 2019
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4XYC
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![BU of 4xyc by Molmil](/molmil-images/mine/4xyc) | NANOMOLAR INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE 1: SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTALLOGRAPHIC STUDIES | Descriptor: | 9-phenyl-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one, Glutamine synthetase 1 | Authors: | Couturier, C, Silve, S, Morales, R, Ppessegue, B, Llopart, S, Nair, A, Bauer, A, Scheiper, B, poeverlein, c, Ganzhorn, A, Lagrange, S, Bacque, E. | Deposit date: | 2015-02-02 | Release date: | 2015-03-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: Synthesis, biological evaluation and X-ray crystallographic studies. Bioorg.Med.Chem.Lett., 25, 2015
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6J2N
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![BU of 6j2n by Molmil](/molmil-images/mine/6j2n) | yeast proteasome in substrate-processing state (C3-b) | Descriptor: | 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... | Authors: | Cong, Y. | Deposit date: | 2019-01-02 | Release date: | 2019-03-20 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (7.5 Å) | Cite: | Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations. Mol. Cell, 73, 2019
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6J6G
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![BU of 6j6g by Molmil](/molmil-images/mine/6j6g) | Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom | Descriptor: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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6J5I
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![BU of 6j5i by Molmil](/molmil-images/mine/6j5i) | Cryo-EM structure of the mammalian DP-state ATP synthase | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase F1 subunit epsilon, ... | Authors: | Gu, J, Zhang, L, Yi, J, Yang, M. | Deposit date: | 2019-01-11 | Release date: | 2019-06-26 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.34 Å) | Cite: | Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1. Science, 364, 2019
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7VD2
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![BU of 7vd2 by Molmil](/molmil-images/mine/7vd2) | Human TOM complex without cross-linking | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Mitochondrial import receptor subunit TOM22 homolog, Mitochondrial import receptor subunit TOM40 homolog, ... | Authors: | Liu, D.S, Sui, S.F. | Deposit date: | 2021-09-06 | Release date: | 2022-07-13 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors. Proc.Natl.Acad.Sci.USA, 119, 2022
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4XBW
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![BU of 4xbw by Molmil](/molmil-images/mine/4xbw) | |
6S9W
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![BU of 6s9w by Molmil](/molmil-images/mine/6s9w) | |
6S8B
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![BU of 6s8b by Molmil](/molmil-images/mine/6s8b) | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1 | Descriptor: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | Authors: | Sofos, N, Montoya, G, Stella, S. | Deposit date: | 2019-07-09 | Release date: | 2020-07-08 | Last modified: | 2020-09-16 | Method: | ELECTRON MICROSCOPY (2.41 Å) | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas. Mol.Cell, 79, 2020
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6JB1
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![BU of 6jb1 by Molmil](/molmil-images/mine/6jb1) | Structure of pancreatic ATP-sensitive potassium channel bound with repaglinide and ATPgammaS at 3.3A resolution | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ... | Authors: | Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y. | Deposit date: | 2019-01-25 | Release date: | 2019-05-22 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel. Cell Rep, 27, 2019
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6IXJ
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![BU of 6ixj by Molmil](/molmil-images/mine/6ixj) | The crystal structure of sulfoacetaldehyde reductase from Klebsiella oxytoca | Descriptor: | 2-hydroxyethylsulfonic acid, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Sulfoacetaldehyde reductase | Authors: | Zhou, Y, Xu, T, Lin, L, Zhang, Y, Yuchi, Z. | Deposit date: | 2018-12-10 | Release date: | 2019-02-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Biochemical and structural investigation of sulfoacetaldehyde reductase fromKlebsiella oxytoca. Biochem. J., 476, 2019
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5TRG
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![BU of 5trg by Molmil](/molmil-images/mine/5trg) | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide DPLG-2 | Descriptor: | N,N-diethyl-N~2~-[(2E)-3-phenylprop-2-enoyl]-L-asparaginyl-4-fluoro-N-[(naphthalen-1-yl)methyl]-L-phenylalaninamide, Proteasome subunit alpha, Proteasome subunit beta | Authors: | Hsu, H.-C, Fan, H, Singh, R.K, Wang, R, Sukenick, G, Nathan, C, Lin, G, Li, H. | Deposit date: | 2016-10-26 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.804 Å) | Cite: | Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome. Biochemistry, 56, 2017
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6S8A
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![BU of 6s8a by Molmil](/molmil-images/mine/6s8a) | Crystal Structure of EGFR-T790M/C797S in Complex with Covalent Pyrrolopyrimidine 19h | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Epidermal growth factor receptor, ~{N}-[3-[6-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-methylpropoxy)-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]propanamide | Authors: | Niggenaber, J, Mueller, M.P, Rauh, D. | Deposit date: | 2019-07-09 | Release date: | 2019-10-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S. Chem Sci, 10, 2019
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6S91
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![BU of 6s91 by Molmil](/molmil-images/mine/6s91) | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 2 | Descriptor: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | Authors: | Sofos, N, Montoya, G, Stella, S. | Deposit date: | 2019-07-11 | Release date: | 2020-07-08 | Last modified: | 2020-09-16 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas. Mol.Cell, 79, 2020
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4XLZ
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![BU of 4xlz by Molmil](/molmil-images/mine/4xlz) | N,N'-diacetylchitobiose deacetylase (SeMet derivative) from Pyrococcus furiosus in the presence of cadmium | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CADMIUM ION, CHLORIDE ION, ... | Authors: | Nakamura, T, Niiyama, M, Hashimoto, W, Ida, K, Uegaki, K. | Deposit date: | 2015-01-14 | Release date: | 2015-06-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Multiple crystal forms of N,N'-diacetylchitobiose deacetylase from Pyrococcus furiosus. Acta Crystallogr.,Sect.F, 71, 2015
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4XVW
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5UF3
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![BU of 5uf3 by Molmil](/molmil-images/mine/5uf3) | |
6S9X
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![BU of 6s9x by Molmil](/molmil-images/mine/6s9x) | Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 15c | Descriptor: | RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-[(4-hydroxyphenyl)methyl]-6-oxidanylidene-2-phenyl-1~{H}-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide | Authors: | Landel, I, Mueller, M.P, Rauh, D. | Deposit date: | 2019-07-15 | Release date: | 2019-10-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. Angew.Chem.Int.Ed.Engl., 58, 2019
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