5ZMD
 
 | | Crystal structure of FTO in complex with m6dA modified ssDNA | | 分子名称: | Alpha-ketoglutarate-dependent dioxygenase FTO, DNA (5'-D(P*TP*CP*TP*(6MA)P*TP*AP*TP*CP*G)-3'), MANGANESE (II) ION, ... | | 著者 | Zhang, X, Wei, L.H, Luo, J, Xiao, Y, Liu, J, Zhang, W, Zhang, L, Jia, G.F. | | 登録日 | 2018-04-02 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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5IL9
 | | Crystal structure of Deg9 | | 分子名称: | GLYCEROL, Protease Do-like 9 | | 著者 | Ouyang, M, Liu, L, Li, X.Y, Zhao, S, Zhang, L.X. | | 登録日 | 2016-03-04 | | 公開日 | 2017-03-08 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The crystal structure of Deg9 reveals a novel octameric-type HtrA protease
Nat Plants, 3, 2017
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7XQ1
 | | Structure of hSLC19A1+2'3'-CDAS | | 分子名称: | (1~{R},3~{S},6~{R},8~{R},9~{R},10~{S},12~{S},15~{R},17~{R},18~{R})-8,17-bis(6-aminopurin-9-yl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecane-9,18-diol, Reduced folate transporter | | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | | 登録日 | 2022-05-06 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
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5HA9
 | | Crystal structure-based design and disovery of a novel PARP1 antiagonist (BL-PA10) that induces apoptosis and inhibits metastasis in triple negative breast cancer | | 分子名称: | Amitriptyline, GLYCEROL, Poly [ADP-ribose] polymerase 1, ... | | 著者 | Fu, L, Peng, H, Zhang, L, Ouyang, L. | | 登録日 | 2015-12-30 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (4.01 Å) | | 主引用文献 | Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer.
Sci Rep, 6, 2016
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7BVH
 | | Crystal structure of arabinosyltransferase EmbC2-AcpM2 complex from Mycobacterium smegmatis complexed with di-arabinose | | 分子名称: | CALCIUM ION, Integral membrane indolylacetylinositol arabinosyltransferase EmbC, Meromycolate extension acyl carrier protein, ... | | 著者 | Zhao, Y, Zhang, L, Wu, L.J, Wang, Q, Li, J, Besra, G.S, Rao, Z.H. | | 登録日 | 2020-04-10 | | 公開日 | 2020-04-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.
Science, 368, 2020
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7D0C
 | | S protein of SARS-CoV-2 in complex bound with P5A-3A1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of P5A-3A1, ... | | 著者 | Yan, R.H, Wang, R.K, Yu, J.F, Zhang, Y.Y, Liu, N, Wang, H.W, Wang, X.Q, Zhang, L.Q, Zhou, Q. | | 登録日 | 2020-09-09 | | 公開日 | 2021-03-10 | | 最終更新日 | 2021-05-19 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies.
Cell Res., 31, 2021
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7D0B
 | | S protein of SARS-CoV-2 in complex bound with P5A-3C12_1B | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of P5A-3C12, ... | | 著者 | Yan, R.H, Wang, R.K, Ju, B, Yu, J.F, Zhang, Y.Y, Liu, N, Wang, H.W, Wang, X.Q, Zhang, L.Q, Zhou, Q. | | 登録日 | 2020-09-09 | | 公開日 | 2021-03-10 | | 最終更新日 | 2021-05-19 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies.
Cell Res., 31, 2021
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5DUT
 | | Influenza A virus H5 hemagglutinin globular head | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | | 著者 | Zuo, T, Sun, J, Wang, G, Zhou, P, Wang, X, Zhang, L. | | 登録日 | 2015-09-20 | | 公開日 | 2015-12-16 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection
Nat Commun, 6, 2015
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7D0D
 | | S protein of SARS-CoV-2 in complex bound with P5A-3C12_2B | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of P5A-3C12, ... | | 著者 | Yan, R.H, Wang, R.K, Ju, B, Yu, J.F, Zhang, Y.Y, Liu, N, Wang, H.W, Wang, X.Q, Zhang, L.Q, Zhou, Q. | | 登録日 | 2020-09-09 | | 公開日 | 2021-03-10 | | 最終更新日 | 2021-05-19 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies.
Cell Res., 31, 2021
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7W5P
 | | Crystal Structure of the dioxygenase CcTet from Coprinopsis cinereain bound to 12bp N6-methyldeoxyadenine (6mA) containing duplex DNA | | 分子名称: | CcTet, DNA, DNA (12-MER), ... | | 著者 | Mu, Y.J, Zhang, L, Zhang, L. | | 登録日 | 2021-11-30 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA.
Nat.Chem.Biol., 18, 2022
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5DUM
 | | Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody 65C6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 65C6 Heavy Chain, 65C6 Light Chain, ... | | 著者 | Sun, J, Zuo, T, Wang, G, Zhou, P, Zhang, L, Wang, X. | | 登録日 | 2015-09-19 | | 公開日 | 2015-12-16 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.003 Å) | | 主引用文献 | Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection
Nat Commun, 6, 2015
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6N7X
 | | S. cerevisiae U1 snRNP | | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, Pre-mRNA-processing factor 39, Protein NAM8, ... | | 著者 | Li, X, Liu, S, Jiang, J, Zhang, L, Espinosa, S, Hill, R.C, Hansen, K.C, Zhou, Z.H, Zhao, R. | | 登録日 | 2018-11-28 | | 公開日 | 2019-07-24 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.
Nat Commun, 8, 2017
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3VPO
 | | Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant | | 分子名称: | FE (III) ION, MAGNESIUM ION, Ribonucleoside-diphosphate reductase subunit M2 | | 著者 | Chen, X, Xu, Z, Liu, H, Zhang, L, Chen, B, Zhu, L, Yang, C, Zhu, W, Shao, J. | | 登録日 | 2012-03-05 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Essential role of E106 in the proton-coupled electron transfer in human
to be published
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5YVF
 | | Crystal structure of BFA1 | | 分子名称: | BFA1 | | 著者 | Pu, H, Zhang, L, Duan, Z.K, Peng, L.W, Liu, L. | | 登録日 | 2017-11-25 | | 公開日 | 2018-08-08 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.804 Å) | | 主引用文献 | Nucleus-Encoded Protein BFA1 Promotes Efficient Assembly of the Chloroplast ATP Synthase Coupling Factor 1.
Plant Cell, 30, 2018
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3EAX
 | | Crystal structure PTP1B complex with small molecule compound LZP-6 | | 分子名称: | 4,4'-piperazine-1,4-diylbis{1-[3-(benzyloxy)phenyl]-4-oxobutane-1,3-dione}, Tyrosine-protein phosphatase non-receptor type 1 | | 著者 | Zhang, Z.-Y, Liu, S, Zhang, L.-F, Yu, X, Xue, T, Gunawan, A.M, Long, Y.-Q. | | 登録日 | 2008-08-26 | | 公開日 | 2009-07-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.
J.Am.Chem.Soc., 130, 2008
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5IDK
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6JFI
 | | The symmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex | | 分子名称: | FabZK2B10 heavy chain, FabZK2B10 light chain, ZIKV structural protein E, ... | | 著者 | Wang, L, Wang, R.K, Wang, L, Ben, H.J, Yu, L, Gao, F, Shi, X.L, Yin, C.B, Zhang, F.C, Xiang, Y, Zhang, L.Q. | | 登録日 | 2019-02-08 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (11 Å) | | 主引用文献 | Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody.
Cell Rep, 26, 2019
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7FJO
 | | Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with three T6 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, T6 heavy chain, ... | | 著者 | Wang, X, Zhang, L, Zhang, S, Liang, Q. | | 登録日 | 2021-08-04 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants.
Iscience, 25, 2022
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6JEP
 | | Structure of a neutralizing antibody bound to the Zika envelope protein domain III | | 分子名称: | Genome polyprotein, heavy chain of Fab ZK2B10, light chain of Fab ZK2B10 | | 著者 | Wang, L, Wang, R.K, Wang, L, Ben, H.J, Yu, L, Gao, F, Shi, X.L, Yin, C.B, Zhang, F.C, Xiang, Y, Zhang, L.Q. | | 登録日 | 2019-02-07 | | 公開日 | 2019-05-15 | | 最終更新日 | 2019-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.316 Å) | | 主引用文献 | Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody.
Cell Rep, 26, 2019
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7FJN
 | | Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, T6 heavy chain, ... | | 著者 | Wang, X, Zhang, L, Zhang, S, Liang, Q. | | 登録日 | 2021-08-04 | | 公開日 | 2022-04-27 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants.
Iscience, 25, 2022
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7QBA
 | | CryoEM structure of the ABC transporter NosDFY complexed with nitrous oxide reductase NosZ | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | | 著者 | Zipfel, S, Mueller, C, Topitsch, A, Lutz, M, Zhang, L, Einsle, O. | | 登録日 | 2021-11-18 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | | 主引用文献 | Molecular interplay of an assembly machinery for nitrous oxide reductase.
Nature, 608, 2022
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7CHS
 | | Crystal structure of SARS-CoV-2 antibody P22A-1D1 with RBD | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody P22A-1D1 heavy chain, ... | | 著者 | Wang, X, Zhang, L, Ge, J, Wang, R, Zhang, Q. | | 登録日 | 2020-07-06 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | | 主引用文献 | Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2.
Nat Commun, 12, 2021
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7CHP
 | | Crystal structure of SARS-CoV-2 antibody P5A-3C8 with RBD | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody P5A-3C8 heavy chain, ... | | 著者 | Wang, X, Zhang, L, Ge, J, Wang, R, Zhang, Q. | | 登録日 | 2020-07-06 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.357 Å) | | 主引用文献 | Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2.
Nat Commun, 12, 2021
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7REF
 | | Structure of MS3494 from Mycobacterium smegmatis | | 分子名称: | BROMIDE ION, MS3494 | | 著者 | Kent, J.E, Aleshin, A.E, Zhang, L, Niederweis, M, Marassi, F.M. | | 登録日 | 2021-07-12 | | 公開日 | 2021-08-18 | | 最終更新日 | 2022-06-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis.
Nat Commun, 13, 2022
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4R29
 | | Crystal structure of bacterial cysteine methyltransferase effector NleE | | 分子名称: | CITRIC ACID, GLYCEROL, S-ADENOSYLMETHIONINE, ... | | 著者 | Yao, Q, Chen, J, Hu, L, Zhang, L, Shao, F. | | 登録日 | 2014-08-11 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway.
Plos Pathog., 10, 2014
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