8BHO
 
 | | GABA-A receptor a5 homomer - a5V3 - L655708 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, ethyl (7~{S})-15-methoxy-12-oxidanylidene-2,4,11-triazatetracyclo[11.4.0.0^{2,6}.0^{7,11}]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate | | Authors: | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y. | | Deposit date: | 2022-10-31 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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5O5O
 | | X-ray crystal structure of RapZ from Escherichia coli (P32 space group) | | Descriptor: | RNase adapter protein RapZ, SULFATE ION | | Authors: | Gonzalez, G.M, Durica-Mitic, S, Hardwick, S.W, Moncrieffe, M, Resch, M, Neumann, P, Ficner, R, Gorke, B, Luisi, B.F. | | Deposit date: | 2017-06-02 | | Release date: | 2017-08-30 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (3.404 Å) | | Cite: | Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism.
Nucleic Acids Res., 45, 2017
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5O5Q
 | | X-ray crystal structure of RapZ from Escherichia coli (P3221 space group) | | Descriptor: | RNase adapter protein RapZ, SULFATE ION | | Authors: | Gonzalez, G.M, Durica-Mitic, S, Hardwick, S.W, Moncrieffe, M, Resch, M, Neumann, P, Ficner, R, Gorke, B, Luisi, B.F. | | Deposit date: | 2017-06-02 | | Release date: | 2017-08-30 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism.
Nucleic Acids Res., 45, 2017
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5NBB
 | | Structure of the C-terminal domain of the Escherichia Coli ProQ RNA binding protein | | Descriptor: | RNA chaperone ProQ | | Authors: | Gonzales, G, Hardwick, S, Maslen, S, Skehel, M, Holmqvist, E, Vogel, J, Bateman, A, Luisi, B, Broadhurst, R. | | Deposit date: | 2017-03-01 | | Release date: | 2017-05-03 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Structure of the Escherichia coli ProQ RNA-binding protein.
RNA, 23, 2017
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5O5S
 | | X-ray crystal structure of the RapZ C-terminal domain from Escherichia coli | | Descriptor: | MALONATE ION, RNase adapter protein RapZ | | Authors: | Gonzalez, G.M, Durica-Mitic, S, Hardwick, S.W, Moncrieffe, M, Resch, M, Neumann, P, Ficner, R, Gorke, B, Luisi, B.F. | | Deposit date: | 2017-06-02 | | Release date: | 2017-08-30 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.17 Å) | | Cite: | Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism.
Nucleic Acids Res., 45, 2017
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8BHB
 | | GABA-A receptor a5 homomer - a5V3 - RO154513 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, ethyl 8-[(azanylidene-$l^{4}-azanylidene)amino]-5-methyl-6-oxidanylidene-4~{H}-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate | | Authors: | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y, Wahid, A.A. | | Deposit date: | 2022-10-30 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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8BHI
 | | GABA-A receptor a5 homomer - a5V3 - RO5211223 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, [1,1-bis(oxidanylidene)-1,4-thiazinan-4-yl]-[6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone | | Authors: | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y. | | Deposit date: | 2022-10-31 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.67 Å) | | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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8BHA
 | | GABA-A receptor a5 homomer - a5V3 - Basmisanil - HR | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Basmisanil, Gamma-aminobutyric acid receptor subunit alpha-5 | | Authors: | Malinauskas, T.M, Wahid, A.A, Hardwick, S.W, Chirgadze, D.Y, Miller, P.S. | | Deposit date: | 2022-10-30 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.67 Å) | | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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3J25
 | | Structural basis for TetM-mediated tetracycline resistance | | Descriptor: | PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Tetracycline resistance protein tetM | | Authors: | Doenhoefer, A, Franckenberg, S, Wickles, S, Berninghausen, O, Beckmann, R, Wilson, D.N. | | Deposit date: | 2012-08-22 | | Release date: | 2012-10-17 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (7.2 Å) | | Cite: | Structural basis for TetM-mediated tetracycline resistance.
Proc.Natl.Acad.Sci.USA, 109, 2012
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8BEJ
 | | GABA-A receptor a5 homomer - a5V3 - APO | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5 | | Authors: | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y. | | Deposit date: | 2022-10-21 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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8BHM
 | | GABA-A receptor a5 homomer - a5V3 - DMCM | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate | | Authors: | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y. | | Deposit date: | 2022-10-31 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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8BHQ
 | | GABA-A receptor a5 homomer - a5V3 - RO7172670 | | Descriptor: | 2-[[5-methyl-3-(6-methylpyridazin-3-yl)-1,2-oxazol-4-yl]methyl]-5-(5-oxa-2-azaspiro[3.5]nonan-2-yl)pyridazin-3-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5 | | Authors: | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Kasaragod, V.B. | | Deposit date: | 2022-10-31 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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8BHS
 | | GABA-A receptor a5 homomer - a5V3 - RO4938581 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[bis(fluoranyl)methyl]-15-bromanyl-2,4,8,9,11-pentazatetracyclo[11.4.0.0^{2,6}.0^{8,12}]heptadeca-1(13),3,5,9,11,14,16-heptaene, Gamma-aminobutyric acid receptor subunit alpha-5 | | Authors: | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y. | | Deposit date: | 2022-10-31 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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7B1C
 | | Cryo-EM of Aedes Aegypti Toll5A trimer bound to Spz1C | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AAEL013433-PA, ... | | Authors: | Gangloff, M, Hardwick, S.W, Chirgadze, D.Y. | | Deposit date: | 2020-11-24 | | Release date: | 2022-07-13 | | Last modified: | 2023-01-25 | | Method: | ELECTRON MICROSCOPY (3.74 Å) | | Cite: | Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
Nat Commun, 13, 2022
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7B1B
 | | Cryo-EM of Aedes Aegypti Toll5A dimer bound to Spz1C | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AAEL013433-PA, ... | | Authors: | Gangloff, M, Hardwick, S.W, Chirgadze, D.Y. | | Deposit date: | 2020-11-24 | | Release date: | 2022-07-13 | | Last modified: | 2023-01-25 | | Method: | ELECTRON MICROSCOPY (4.23 Å) | | Cite: | Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
Nat Commun, 13, 2022
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7B1D
 | | Cryo-EM of Aedes Aegypti Toll5A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor | | Authors: | Gangloff, M, Hardwick, S.W, Chirgadze, D.Y. | | Deposit date: | 2020-11-24 | | Release date: | 2022-07-13 | | Last modified: | 2023-01-25 | | Method: | ELECTRON MICROSCOPY (3.41 Å) | | Cite: | Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
Nat Commun, 13, 2022
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1SW6
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5A7U
 | | Single-particle cryo-EM of co-translational folded adr1 domain inside the E. coli ribosome exit tunnel. | | Descriptor: | REGULATORY PROTEIN ADR1, ZINC ION | | Authors: | Nilsson, O.B, Hedman, R, Marino, J, Wickles, S, Bischoff, L, Johansson, M, Muller-Lucks, A, Trovato, F, Puglisi, J.D, O'Brien, E, Beckmann, R, von Heijne, G. | | Deposit date: | 2015-07-10 | | Release date: | 2015-09-16 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Cotranslational Protein Folding Inside the Ribosome Exit Tunnel.
Cell Rep., 12, 2015
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1V0K
 | | Xylanase Xyn10A from Streptomyces lividans in complex with xylobio-deoxynojirimycin at pH 5.8 | | Descriptor: | ENDO-1,4-BETA-XYLANASE A, PIPERIDINE-3,4,5-TRIOL, beta-D-xylopyranose | | Authors: | Gloster, T.M, Williams, S.J, Roberts, S, Tarling, C.A, Wicki S, J, Withers, G, Davies, G.J. | | Deposit date: | 2004-03-31 | | Release date: | 2004-08-16 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.03 Å) | | Cite: | Atomic Resolution Analyses of the Binding of Xylobiose-Derived Deoxynojirimycin and Isofagomine to Xylanase Xyn10A
Chem.Commun.(Camb.), 16, 2004
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5M5H
 | | RIBOSOME-BOUND YIDC INSERTASE | | Descriptor: | Membrane protein insertase YidC | | Authors: | Kedrov, A, Wickles, S, Crevenna, A.H, van der Sluis, E, Buschauer, R, Berninghausen, O, Lamb, D.C, Beckmann, R. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis.
Cell Rep, 17, 2016
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7AU2
 | | Cryo-EM structure of human exostosin-like 3 (EXTL3) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-like 3, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Wilson, L.F.L, Dendooven, T, Hardwick, S.W, Chirgadze, D.Y, Luisi, B.F, Logan, D.T, Mani, K, Dupree, P. | | Deposit date: | 2020-11-02 | | Release date: | 2022-05-18 | | Last modified: | 2022-06-15 | | Method: | ELECTRON MICROSCOPY (2.43 Å) | | Cite: | The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis.
Nat Commun, 13, 2022
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7AUA
 | | Cryo-EM structure of human exostosin-like 3 (EXTL3) in complex with UDP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-like 3, MANGANESE (II) ION, ... | | Authors: | Wilson, L.F.L, Dendooven, T, Hardwick, S.W, Chirgadze, D.Y, Luisi, B.F, Logan, D.T, Mani, K, Dupree, P. | | Deposit date: | 2020-11-02 | | Release date: | 2022-05-18 | | Last modified: | 2022-06-15 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis.
Nat Commun, 13, 2022
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2YJV
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7NZM
 | | Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | Authors: | Yan, Y, Hardwick, S, Ron, D. | | Deposit date: | 2021-03-24 | | Release date: | 2021-09-29 | | Last modified: | 2021-10-20 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Nat.Struct.Mol.Biol., 28, 2021
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6TCI
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