4WGF
| YcaC from Pseudomonas aeruginosa with hexane-2,5-diol and covalent acrylamide | 分子名称: | (2R,5R)-hexane-2,5-diol, CHLORIDE ION, PROPIONAMIDE, ... | 著者 | Groftehauge, M.K, Truan, D, Vasil, A, Denny, P.W, Vasil, M.L, Pohl, E. | 登録日 | 2014-09-18 | 公開日 | 2015-07-29 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.34020686 Å) | 主引用文献 | Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide Adduct. Int J Mol Sci, 16, 2015
|
|
4WI5
| Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H310A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
|
|
4WK6
| Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (FabG) (G141A) from Vibrio cholerae in complex with NADPH | 分子名称: | 3-oxoacyl-[acyl-carrier protein] reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PENTAETHYLENE GLYCOL | 著者 | Hou, J, Zheng, H, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2014-10-01 | 公開日 | 2014-11-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Dissecting the Structural Elements for the Activation of beta-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae. J.Bacteriol., 198, 2015
|
|
5OG9
| |
5AB3
| S.enterica HisA mutant D7N, D10G, dup13-15, Q24L, G102A | 分子名称: | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, SODIUM ION, [(2R,3S,4R,5R)-5-[4-AMINOCARBONYL-5-[[(Z)-[(3R,4R)-3,4-DIHYDROXY-2-OXO-5-PHOSPHONOOXY-PENTYL]IMINOMETHYL]AMINO]IMIDAZOL-1-YL]-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL DIHYDROGEN PHOSPHATE | 著者 | Guo, X, Soderholm, A, Newton, M, Nasvall, J, Andersson, D, Patrick, W, Selmer, M. | 登録日 | 2015-07-31 | 公開日 | 2016-09-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | 主引用文献 | Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
4WI3
| |
4WI6
| Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation N434A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
|
|
3UW8
| |
6CJX
| Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 2) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Fc fragment of human IgG1 | 著者 | Van, V, Tolbert, W.D, Pazgier, M. | 登録日 | 2018-02-27 | 公開日 | 2019-03-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fc gamma Receptor Binding. Structure, 2020
|
|
6VQX
| Type I-F CRISPR-Csy complex with its inhibitor AcrF6 | 分子名称: | AcrF6, CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, ... | 著者 | Zhang, K, Li, S, Pintilie, G, Zhu, Y, Huang, Z, Chiu, W. | 登録日 | 2020-02-06 | 公開日 | 2020-03-11 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas complex revealed by cryo-EM. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6CLU
| |
6CMS
| Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor | 分子名称: | 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. | 登録日 | 2018-03-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
|
|
4U5M
| Structure of a left-handed DNA G-quadruplex | 分子名称: | DNA (28-MER), MAGNESIUM ION, POTASSIUM ION | 著者 | Schmitt, E, Mechulam, Y, Phan, A.T, Brahim, H, Chung, W.J, Lim, K.W. | 登録日 | 2014-07-25 | 公開日 | 2015-02-25 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure of a left-handed DNA G-quadruplex. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
3UXV
| Crystal Structure of 7-cyano-7-deazaguanine reductase, QueF from Vibrio cholerae complexed with NADP and PreQ | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, GUANINE, ... | 著者 | Kim, Y, Zhou, M, Gu, M, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2011-12-05 | 公開日 | 2011-12-28 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Crystal Structure of 7-cyano-7-deazaguanine reductase, QueF from Vibrio cholerae complexed with NADP and PreQ To be Published, 2012
|
|
3UZO
| Crystal Structures of Branched-Chain Aminotransferase from Deinococcus radiodurans Complexes with alpha-Ketoisocaproate and L-Glutamate Suggest Its Radio-Resistance for Catalysis | 分子名称: | Branched-chain-amino-acid aminotransferase, GLUTAMIC ACID, PYRIDOXAL-5'-PHOSPHATE | 著者 | Chen, C.D, Huang, Y.C, Chuankhayan, P, Hsieh, Y.C, Huang, T.F, Lin, C.H, Guan, H.H, Liu, M.Y, Chang, W.C, Chen, C.J. | 登録日 | 2011-12-07 | 公開日 | 2012-12-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structures of Complexes of the Branched-Chain Aminotransferase from Deinococcus radiodurans with alpha-Ketoisocaproate and L-Glutamate Suggest the Radiation Resistance of This Enzyme for Catalysis J.Bacteriol., 194, 2012
|
|
6CMZ
| 2.3 Angstrom Resolution Crystal Structure of Dihydrolipoamide Dehydrogenase from Burkholderia cenocepacia in Complex with FAD and NAD | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, D-MALATE, ... | 著者 | Minasov, G, Shuvalova, L, Dubrovska, I, Kiryukhina, O, Grimshaw, S, Kwon, K, Anderson, W.F, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2018-03-06 | 公開日 | 2018-03-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | 2.3 Angstrom Resolution Crystal Structure of Dihydrolipoamide Dehydrogenase from Burkholderia cenocepacia in Complex with FAD and NAD. To Be Published
|
|
8XN7
| Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 9f | 分子名称: | 5-amino-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-8-(2-(trifluoromethyl)benzyl)pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase kinase kinase kinase 1 | 著者 | Huang, W.X, Liu, R, Ding, K. | 登録日 | 2023-12-29 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur.J.Med.Chem., 269, 2024
|
|
8XOU
| |
6W8S
| Crystal structure of metacaspase 4 from Arabidopsis | 分子名称: | Metacaspase-4, SULFATE ION | 著者 | Zhu, P, Yu, X.H, Wang, C, Zhang, Q, Liu, W, McSweeney, S, Shanklin, J, Lam, E, Liu, Q. | 登録日 | 2020-03-21 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.484 Å) | 主引用文献 | Structural basis for Ca2+-dependent activation of a plant metacaspase. Nat Commun, 11, 2020
|
|
4UFT
| Structure of the helical Measles virus nucleocapsid | 分子名称: | 5'-R(*CP*CP*CP*CP*CP*CP)-3', NUCLEOPROTEIN | 著者 | Gutsche, I, Desfosses, A, Effantin, G, Ling, W.L, Haupt, M, Ruigrok, R.W.H, Sachse, C, Schoehn, G. | 登録日 | 2015-03-19 | 公開日 | 2015-04-29 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Near-Atomic Cryo-Em Structure of the Helical Measles Virus Nucleocapsid. Science, 348, 2015
|
|
4UPB
| Electron cryo-microscopy of the complex formed between the hexameric ATPase RavA and the decameric inducible decarboxylase LdcI | 分子名称: | ATPASE RAVA, LYSINE DECARBOXYLASE, INDUCIBLE | 著者 | Malet, H, Liu, K, El Bakkouri, M, Chan, S.W.S, Effantin, G, Bacia, M, Houry, W.A, Gutsche, I. | 登録日 | 2014-06-15 | 公開日 | 2014-08-20 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (11 Å) | 主引用文献 | Assembly Principles of a Unique Cage Formed by Hexameric and Decameric E. Coli Proteins. Elife, 3, 2014
|
|
6VOC
| icosahedral symmetry reconstruction of brome mosaic virus (RNA 3+4) | 分子名称: | Capsid protein | 著者 | Beren, C, Cui, Y.X, Chakravarty, A, Yang, X, Rao, A.L.N, Knobler, C.M, Zhou, Z.H, Gelbart, W.M. | 登録日 | 2020-01-30 | 公開日 | 2020-05-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Genome organization and interaction with capsid protein in a multipartite RNA virus. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
8YRF
| |
6W5D
| Crystal Structure of Fab RSB1 | 分子名称: | RSB1 Fab Heavy Chain, RSB1 Fab Light Chain | 著者 | Harshbarger, W, Chandramouli, S, Malito, M. | 登録日 | 2020-03-13 | 公開日 | 2020-11-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F. Plos Pathog., 16, 2020
|
|
6W8T
| Crystal structure of metacaspase 4 from Arabidopsis (microcrystals treated with calcium) | 分子名称: | Metacaspase-4, SULFATE ION | 著者 | Zhu, P, Yu, X.H, Wang, C, Zhang, Q, Liu, W, McSweeney, S, Shanklin, J, Lam, E, Liu, Q. | 登録日 | 2020-03-21 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for Ca2+-dependent activation of a plant metacaspase. Nat Commun, 11, 2020
|
|