6MFZ
| Crystal structure of dimodular LgrA in a condensation state | 分子名称: | 4'-PHOSPHOPANTETHEINE, Linear gramicidin synthase subunit A | 著者 | Reimer, J.M, Eivaskhani, M, Harb, I, Schmeing, T.M. | 登録日 | 2018-09-12 | 公開日 | 2019-11-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (6 Å) | 主引用文献 | Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility. Science, 366, 2019
|
|
6MFW
| Crystal structure of a 4-domain construct of LgrA in the substrate donation state | 分子名称: | (2~{R})-~{N}-[3-[2-[[(2~{S})-2-formamido-3-methyl-butanoyl]amino]ethylamino]-3-oxidanylidene-propyl]-3,3-dimethyl-2-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxy-butanamide, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Linear gramicidin synthase subunit A, ... | 著者 | Reimer, J.M, Eivaskhani, M, Schmeing, T.M. | 登録日 | 2018-09-12 | 公開日 | 2019-11-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility. Science, 366, 2019
|
|
2A6E
| Crystal structure of the T. Thermophilus RNA polymerase holoenzyme | 分子名称: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | 著者 | Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-07-02 | 公開日 | 2005-09-20 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell(Cambridge,Mass.), 122, 2005
|
|
2A6H
| Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin | 分子名称: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | 著者 | Temiakov, D, Zenkin, N, Vassylyeva, M.N, Perederina, A, Tahirov, T.H, Savkina, M, Zorov, S, Nikiforov, V, Igarashi, N, Matsugaki, N, Wakatsuki, S, Severinov, K, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-07-02 | 公開日 | 2005-09-20 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis of transcription inhibition by antibiotic streptolydigin. Mol.Cell, 19, 2005
|
|
6MFX
| Crystal structure of a 4-domain construct of a mutant of LgrA in the substrate donation state | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Linear gramicidin synthase subunit A, N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... | 著者 | Reimer, J.M, Eivaskhani, M, Schmeing, T.M. | 登録日 | 2018-09-12 | 公開日 | 2019-11-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility. Science, 366, 2019
|
|
1UC9
| Crystal structure of a lysine biosynthesis enzyme, Lysx, from thermus thermophilus HB8 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, lysine biosynthesis enzyme | 著者 | Sakai, H, Vassylyeva, M.N, Matsuura, T, Sekine, S, Nishiyama, M, Terada, T, Shirouzu, M, Kuramitsu, S, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2003-04-09 | 公開日 | 2003-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Crystal Structure of a Lysine Biosynthesis Enzyme, LysX, from Thermus thermophilus HB8 J.Mol.Biol., 332, 2003
|
|
1UC8
| Crystal structure of a lysine biosynthesis enzyme, Lysx, from thermus thermophilus HB8 | 分子名称: | lysine biosynthesis enzyme | 著者 | Sakai, H, Vassylyeva, M.N, Matsuura, T, Sekine, S, Nishiyama, M, Terada, T, Shirouzu, M, Kuramitsu, S, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2003-04-09 | 公開日 | 2003-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of a Lysine Biosynthesis Enzyme, LysX, from Thermus thermophilus HB8 J.Mol.Biol., 332, 2003
|
|
6F5W
| Photorhabdus asymbiotica lectin (PHL) in complex with propargyl-fucoside | 分子名称: | CHLORIDE ION, DIMETHYL SULFOXIDE, SODIUM ION, ... | 著者 | Houser, J, Jancarikova, G, Wimmerova, M, Csavas, M, Borbas, A, Herczeg, M, Fujdiarova, E, Kover, E.K. | 登録日 | 2017-12-04 | 公開日 | 2018-01-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Synthesis of alpha-l-Fucopyranoside-Presenting Glycoclusters and Investigation of Their Interaction with Photorhabdus asymbiotica Lectin (PHL). Chemistry, 24, 2018
|
|
6V3W
| Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment with four point mutations in complex with RBN-2397 | 分子名称: | 5-{[(2S)-1-(3-oxo-3-{4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl}propoxy)propan-2-yl]amino}-4-(trifluoromethyl)pyridazin-3(2H)-one, CHLORIDE ION, Protein mono-ADP-ribosyltransferase PARP12 | 著者 | Swinger, K.K, Gozgit, J.M, Vasbinder, M.M, Wigle, T.J, Kuntz, K.W. | 登録日 | 2019-11-26 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity. Cancer Cell, 39, 2021
|
|
2EUL
| Structure of the transcription factor Gfh1. | 分子名称: | ZINC ION, anti-cleavage anti-GreA transcription factor Gfh1 | 著者 | Symersky, J, Perederina, A, Vassylyeva, M.N, Svetlov, V, Artsimovitch, I, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-10-28 | 公開日 | 2005-11-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Regulation through the RNA Polymerase Secondary Channel: STRUCTURAL AND FUNCTIONAL VARIABILITY OF THE COILED-COIL TRANSCRIPTION FACTORS. J.Biol.Chem., 281, 2006
|
|
3QAC
| Structure of amaranth 11S proglobulin seed storage protein from Amaranthus hypochondriacus L. | 分子名称: | 11S globulin seed storage protein | 著者 | Tandang-Silvas, M.R, Carrazco-Pena, L, Barba de la Rosa, A.P, Osuna-Castro, J.A, Utsumi, S, Mikami, B, Maruyama, N. | 登録日 | 2011-01-10 | 公開日 | 2012-01-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.275 Å) | 主引用文献 | Structure of amaranth 11S proglobulin, a major seed storage protein from Amaranthus hypochondriacus L. To be Published
|
|
8D3B
| |
1SMY
| Structural basis for transcription regulation by alarmone ppGpp | 分子名称: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | 著者 | Artsimovitch, I, Patlan, V, Sekine, S, Vassylyeva, M.N, Hosaka, T, Ochi, K, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2004-03-10 | 公開日 | 2004-05-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for transcription regulation by alarmone ppGpp Cell(Cambridge,Mass.), 117, 2004
|
|
1B2W
| COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY | 分子名称: | PROTEIN (ANTIBODY (HEAVY CHAIN)), PROTEIN (ANTIBODY (LIGHT CHAIN)) | 著者 | Fan, Z, Shan, L, Goldsteen, B.Z, Guddat, L.W, Thakur, A, Landolfi, N.F, Co, M.S, Vasquez, M, Queen, C, Ramsland, P.A, Edmundson, A.B. | 登録日 | 1998-12-01 | 公開日 | 1999-05-06 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-gamma-interferon antibody. J.Mol.Recog., 12, 1999
|
|
2O5J
| |
6YUG
| Crystal structure of C. parvum GNA1 in complex with acetyl-CoA and glucose 6P. | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, ACETYL COENZYME *A, Diamine acetyltransferase | 著者 | Chi, J, Cova, M, de las Rivas, M, Medina, A, Borges, R, Leivar, P, Planas, A, Uson, I, Hurtado-Guerrero, R, Izquierdo, L. | 登録日 | 2020-04-27 | 公開日 | 2020-09-30 | 最終更新日 | 2020-11-04 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Plasmodium falciparum Apicomplexan-Specific Glucosamine-6-Phosphate N -Acetyltransferase Is Key for Amino Sugar Metabolism and Asexual Blood Stage Development. Mbio, 11, 2020
|
|
2BE5
| Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin | 分子名称: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | 著者 | Vassylyev, D.G, Svetlov, V, Vassylyeva, M.N, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Artsimovitch, I, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-10-22 | 公開日 | 2005-11-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for transcription inhibition by tagetitoxin Nat.Struct.Mol.Biol., 12, 2005
|
|
7L9Y
| Human PARP14 (ARTD8), catalytic fragment in complex with RBN012042 | 分子名称: | 1,2-ETHANEDIOL, 7-(cyclopentylamino)-5-fluoro-2-{[(piperidin-4-yl)sulfanyl]methyl}quinazolin-4(3H)-one, CHLORIDE ION, ... | 著者 | Dorsey, B.W, Swinger, K.K, Schenkel, L.B, Church, W.D, Perl, N.R, Vasbinder, M.M, Wigle, T.J, Kuntz, K.W. | 登録日 | 2021-01-05 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule. Chembiochem, 22, 2021
|
|
7LUN
| Human PARP14 (ARTD8), catalytic fragment in complex with RBN011980 | 分子名称: | 7-(cyclopentylamino)-5-fluoro-2-{[(trans-4-hydroxycyclohexyl)sulfanyl]methyl}quinazolin-4(3H)-one, CHLORIDE ION, GLYCEROL, ... | 著者 | Dorsey, B.W, Swinger, K.K, Schenkel, L.B, Church, W.D, Perl, N.R, Vasbinder, M.M, Wigle, T.J, Kuntz, K.W. | 登録日 | 2021-02-22 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule. Chembiochem, 22, 2021
|
|
1B4J
| COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY | 分子名称: | ANTIBODY | 著者 | Fan, Z, Shan, L, Goldsteen, B.Z, Guddat, L.W, Thakur, A, Landolfi, N.F, Co, M.S, Vasques, M, Queen, C, Ramsland, P.A, Edmundson, A.B. | 登録日 | 1998-12-22 | 公開日 | 1999-06-15 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-gamma-interferon antibody. J.Mol.Recog., 12, 1999
|
|
1TJL
| Crystal structure of transcription factor DksA from E. coli | 分子名称: | DnaK suppressor protein, ZINC ION | 著者 | Perederina, A, Svetlov, V, Vassylyeva, M.N, Artsimovitch, I, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2004-06-06 | 公開日 | 2004-09-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Regulation through the secondary channel--structural framework for ppGpp-DksA synergism during transcription Cell(Cambridge,Mass.), 118, 2004
|
|
5NQA
| Crystal structure of GalNAc-T4 in complex with the monoglycopeptide 3 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-galactopyranose, GLYCEROL, ... | 著者 | de las Rivas, M, Lira-Navarrete, E, Daniel, E.J.P, Companon, I, Coelho, H, Diniz, A, Jimenez-Barbero, J, Peregrina, J.M, Clausen, H, Corzana, F, Marcelo, F, Jimenez-Oses, G, Gerken, T.A, Hurtado-Guerrero, R. | 登録日 | 2017-04-19 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. Nat Commun, 8, 2017
|
|
2O5I
| Crystal structure of the T. thermophilus RNA polymerase elongation complex | 分子名称: | 5'-D(*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*AP*GP*GP*G)-3', 5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*CP*G)-3', 5'-R(P*GP*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP*G)-3', ... | 著者 | Vassylyev, D.G, Tahirov, T.H, Vassylyeva, M.N. | 登録日 | 2006-12-06 | 公開日 | 2007-07-03 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for transcription elongation by bacterial RNA polymerase. Nature, 448, 2007
|
|
5EK0
| Human Nav1.7-VSD4-NavAb in complex with GX-936. | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide, Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha | 著者 | Ahuja, S, Mukund, S, Starovasnik, M.A, Koth, C.M, Payandeh, J. | 登録日 | 2015-11-03 | 公開日 | 2015-12-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.53 Å) | 主引用文献 | Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science, 350, 2015
|
|
6XAI
| Crystal structure of NzeB in complex with cyclo-(L-Trp-L-Pro) | 分子名称: | (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, 1,2-ETHANEDIOL, NzeB, ... | 著者 | Shende, V.V, Khatri, Y, Newmister, S.A, Sanders, J.N, Lindovska, P, Yu, F, Doyon, T.J, Kim, J, Movassaghi, M, Houk, K.N, Sherman, D.H. | 登録日 | 2020-06-04 | 公開日 | 2021-06-09 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.489 Å) | 主引用文献 | Structure and Function of NzeB, a Versatile C-C and C-N Bond-Forming Diketopiperazine Dimerase. J.Am.Chem.Soc., 142, 2020
|
|