1CYQ
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![BU of 1cyq by Molmil](/molmil-images/mine/1cyq) | INTRON ENCODED HOMING ENDONUCLEASE I-PPOI (H98A)/DNA HOMING SITE COMPLEX | 分子名称: | 5'-D(*TP*TP*GP*AP*CP*TP*CP*TP*CP*TP*TP*AP*AP*GP*AP*GP*AP*GP*TP*CP*A)-3', INTRON-ENCODED HOMING ENDONUCLEASE I-PPOI, MAGNESIUM ION, ... | 著者 | Galburt, E.A, Chevalier, B, Jurica, M.S, Flick, K.E, Stoddard, B.L. | 登録日 | 1999-08-31 | 公開日 | 1999-11-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | A novel endonuclease mechanism directly visualized for I-PpoI. Nat.Struct.Biol., 6, 1999
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3MIS
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![BU of 3mis by Molmil](/molmil-images/mine/3mis) | I-MsoI re-designed for altered DNA cleavage specificity (-8G) | 分子名称: | CALCIUM ION, DNA (5'-D(*CP*GP*GP*AP*GP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*GP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*CP*TP*CP*CP*G)-3'), ... | 著者 | Taylor, G.K, Stoddard, B.L. | 登録日 | 2010-04-12 | 公開日 | 2010-05-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Res., 38, 2010
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4YY5
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1AF5
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![BU of 1af5 by Molmil](/molmil-images/mine/1af5) | GROUP I MOBILE INTRON ENDONUCLEASE | 分子名称: | I-CREI | 著者 | Heath, P.J, Stephens, K.M, Monnat Junior, R.J, Stoddard, B.L. | 登録日 | 1997-03-21 | 公開日 | 1997-07-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The structure of I-Crel, a group I intron-encoded homing endonuclease. Nat.Struct.Biol., 4, 1997
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3I1C
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1IQD
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![BU of 1iqd by Molmil](/molmil-images/mine/1iqd) | Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab. | 分子名称: | HUMAN FACTOR VIII, HUMAN MONOCLONAL BO2C11 FAB HEAVY CHAIN, HUMAN MONOCLONAL BO2C11 FAB LIGHT CHAIN | 著者 | Spiegel Jr, P.C, Jacquemin, M, Saint-Remy, J.M, Stoddard, B.L, Pratt, K.P. | 登録日 | 2001-07-21 | 公開日 | 2001-08-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII. Blood, 98, 2001
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1G9Y
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![BU of 1g9y by Molmil](/molmil-images/mine/1g9y) | HOMING ENDONUCLEASE I-CREI / DNA SUBSTRATE COMPLEX WITH CALCIUM | 分子名称: | 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', CALCIUM ION, ... | 著者 | Chevalier, B, Monnat, R.J, Stoddard, B.L. | 登録日 | 2000-11-28 | 公開日 | 2001-04-02 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites. Nat.Struct.Biol., 8, 2001
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1EVW
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![BU of 1evw by Molmil](/molmil-images/mine/1evw) | L116A MUTANT OF THE HOMING ENDONUCLEASE I-PPOI COMPLEXED TO HOMING SITE DNA. | 分子名称: | DNA (5'-D(*TP*GP*AP*CP*TP*CP*TP*CP*TP*TP*AP*A)-3'), DNA (5'-D(*TP*GP*GP*CP*TP*AP*CP*CP*TP*TP*AP*A)-3'), DNA (5'-D(P*GP*AP*GP*AP*GP*TP*CP*A)-3'), ... | 著者 | Galburt, E.A, Jurica, M.S, Chevalier, B.S, Erho, D, Stoddard, B.L. | 登録日 | 2000-04-20 | 公開日 | 2000-08-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Conformational changes and cleavage by the homing endonuclease I-PpoI: a critical role for a leucine residue in the active site. J.Mol.Biol., 300, 2000
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1G9Z
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![BU of 1g9z by Molmil](/molmil-images/mine/1g9z) | LAGLIDADG HOMING ENDONUCLEASE I-CREI / DNA PRODUCT COMPLEX WITH MAGNESIUM | 分子名称: | 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*A)-3', 5'-D(P*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', ... | 著者 | Chevalier, B, Monnat, R.J, Stoddard, B.L. | 登録日 | 2000-11-28 | 公開日 | 2001-04-02 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites. Nat.Struct.Biol., 8, 2001
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3E54
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![BU of 3e54 by Molmil](/molmil-images/mine/3e54) | Archaeal Intron-encoded Homing Endonuclease I-Vdi141I Complexed With DNA | 分子名称: | DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DTP*DCP*DTP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(*DTP*DTP*DGP*DGP*DCP*DTP*DAP*DCP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(P*DGP*DAP*DGP*DAP*DGP*DTP*DCP*DAP*DG)-3'), ... | 著者 | Nomura, N, Nomura, Y, Sussman, D, Stoddard, B.L. | 登録日 | 2008-08-13 | 公開日 | 2008-12-30 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases Nucleic Acids Res., 36, 2008
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3S1S
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![BU of 3s1s by Molmil](/molmil-images/mine/3s1s) | Characterization and crystal structure of the type IIG restriction endonuclease BpuSI | 分子名称: | 1,2-ETHANEDIOL, IODIDE ION, MANGANESE (II) ION, ... | 著者 | Shen, B.W, Xu, D, Chan, S.-H, Zheng, Y, Zhu, Y, Xu, S.-Y, Stoddard, B.L. | 登録日 | 2011-05-16 | 公開日 | 2011-07-13 | 最終更新日 | 2011-10-19 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Characterization and crystal structure of the type IIG restriction endonuclease RM.BpuSI. Nucleic Acids Res., 39, 2011
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1OX7
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3E0L
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![BU of 3e0l by Molmil](/molmil-images/mine/3e0l) | Computationally Designed Ammelide Deaminase | 分子名称: | Guanine deaminase, ZINC ION | 著者 | Murphy, P.M, Bolduc, J.M, Gallaher, J.L, Stoddard, B.L, Baker, D. | 登録日 | 2008-07-31 | 公開日 | 2009-03-03 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Alteration of enzyme specificity by computational loop remodeling and design. Proc.Natl.Acad.Sci.USA, 106, 2009
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1CZ0
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![BU of 1cz0 by Molmil](/molmil-images/mine/1cz0) | INTRON ENCODED HOMING ENDONUCLEASE I-PPOI/DNA COMPLEX LACKING CATALYTIC METAL ION | 分子名称: | DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*TP*CP*TP*TP*AP*AP*GP*AP*GP*AP*GP*TP*CP*A)-3'), INTRON-ENCODED HOMING ENDONUCLEASE I-PPOI, SODIUM ION, ... | 著者 | Galburt, E.A, Chevalier, B, Jurica, M.S, Flick, K.E, Stoddard, B.L. | 登録日 | 1999-08-31 | 公開日 | 1999-11-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A novel endonuclease mechanism directly visualized for I-PpoI. Nat.Struct.Biol., 6, 1999
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1B0A
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![BU of 1b0a by Molmil](/molmil-images/mine/1b0a) | 5,10, METHYLENE-TETRAHYDROPHOLATE DEHYDROGENASE/CYCLOHYDROLASE FROM E COLI. | 分子名称: | PROTEIN (FOLD BIFUNCTIONAL PROTEIN) | 著者 | Shen, B.W, Dyer, D, Huang, J.-Y, D'Ari, L, Rabinowitz, J, Stoddard, B.L. | 登録日 | 1998-11-06 | 公開日 | 1999-06-29 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | The crystal structure of a bacterial, bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase. Protein Sci., 8, 1999
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4IX0
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![BU of 4ix0 by Molmil](/molmil-images/mine/4ix0) | Computational Design of an Unnatural Amino Acid Metalloprotein with Atomic Level Accuracy | 分子名称: | NICKEL (II) ION, SULFATE ION, Unnatural Amino Acid Mediated Metalloprotein | 著者 | Mills, J, Bolduc, J, Khare, S, Stoddard, B, Baker, D. | 登録日 | 2013-01-24 | 公開日 | 2013-08-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Computational design of an unnatural amino Acid dependent metalloprotein with atomic level accuracy. J.Am.Chem.Soc., 135, 2013
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1IPP
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![BU of 1ipp by Molmil](/molmil-images/mine/1ipp) | HOMING ENDONUCLEASE/DNA COMPLEX | 分子名称: | CADMIUM ION, DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*TP*CP*TP*TP*AP*AP*GP*AP*GP*AP*GP*TP*CP*A)-3'), INTRON-ENCODED ENDONUCLEASE I-PPOI, ... | 著者 | Flick, K.E, Jurica, M.S, Monnat Jr, R.J, Stoddard, B.L. | 登録日 | 1998-03-19 | 公開日 | 1998-09-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI. Nature, 394, 1998
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4YXY
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1D7P
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![BU of 1d7p by Molmil](/molmil-images/mine/1d7p) | Crystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A | 分子名称: | COAGULATION FACTOR VIII PRECURSOR, CYSTEINE, GLYCEROL, ... | 著者 | Pratt, K.P, Shen, B.W, Stoddard, B.L. | 登録日 | 1999-10-19 | 公開日 | 1999-12-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure of the C2 domain of human factor VIII at 1.5 A resolution. Nature, 402, 1999
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3KO2
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![BU of 3ko2 by Molmil](/molmil-images/mine/3ko2) | I-MsoI re-designed for altered DNA cleavage specificity (-7C) | 分子名称: | 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*GP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*CP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... | 著者 | Taylor, G.K, Stoddard, B.L. | 登録日 | 2009-11-13 | 公開日 | 2010-05-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Res., 38, 2010
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3MX4
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![BU of 3mx4 by Molmil](/molmil-images/mine/3mx4) | DNA binding and cleavage by the GIY-YIG endonuclease R.Eco29KI inactive variant E142Q | 分子名称: | DNA (5'-D(P*CP*GP*GP*GP*AP*GP*GP*CP*CP*CP*GP*CP*GP*GP*GP*CP*CP*GP*CP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*GP*CP*GP*GP*CP*CP*CP*GP*CP*GP*GP*GP*CP*CP*TP*CP*CP*CP*G)-3'), Eco29kIR | 著者 | Mak, A.N.S, Lambert, A.R, Stoddard, B.L. | 登録日 | 2010-05-06 | 公開日 | 2010-09-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Folding, DNA Recognition, and Function of GIY-YIG Endonucleases: Crystal Structures of R.Eco29kI. Structure, 18, 2010
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3O6Y
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![BU of 3o6y by Molmil](/molmil-images/mine/3o6y) | Robust computational design, optimization, and structural characterization of retroaldol enzymes | 分子名称: | Retro-Aldolase, SULFATE ION | 著者 | Althoff, E.A, Wang, L, Jiang, L, Moody, J, Bolduc, J, Lassila, J.K, Wang, Z.Z, Smith, M, Hari, S, Herschlag, D, Stoddard, B.L, Baker, D. | 登録日 | 2010-07-29 | 公開日 | 2011-06-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | 主引用文献 | Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J.Mol.Biol., 415, 2012
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3NXF
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![BU of 3nxf by Molmil](/molmil-images/mine/3nxf) | Robust computational design, optimization, and structural characterization of retroaldol enzymes | 分子名称: | Retro-Aldolase, SULFATE ION | 著者 | Althoff, E.A, Jiang, L, Wang, L, Lassila, J.K, Moody, J, Bolduc, J, Wang, Z.Z, Smith, M, Hari, S, Herschlag, D, Stoddard, B.L, Baker, D. | 登録日 | 2010-07-13 | 公開日 | 2011-06-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J.Mol.Biol., 415, 2012
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1QVJ
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![BU of 1qvj by Molmil](/molmil-images/mine/1qvj) | structure of NUDT9 complexed with ribose-5-phosphate | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-O-phosphono-beta-D-ribofuranose, ADP-ribose pyrophosphatase, ... | 著者 | Shen, B.W, Perraud, A.-L, Scharenberg, A.S, Stoddard, B.L. | 登録日 | 2003-08-27 | 公開日 | 2003-09-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | The crystal structure and mutational analysis of human NUDT9 J.Mol.Biol., 332, 2003
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3UD6
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![BU of 3ud6 by Molmil](/molmil-images/mine/3ud6) | Structural analyses of covalent enzyme-substrate analogue complexes reveal strengths and limitations of de novo enzyme design | 分子名称: | 1-(6-METHOXYNAPHTHALEN-2-YL)BUTANE-1,3-DIONE, RETRO-ALDOLASE, SULFATE ION | 著者 | Baker, D, Stoddard, B.L, Althoff, E.A, Wang, L, Jiang, L, Moody, J, Bolduc, J, Lassila, J, Hilvert, D. | 登録日 | 2011-10-27 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | 主引用文献 | Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J.Mol.Biol., 415, 2012
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