7RCG
 
 | |
7RCD
 | |
7RCE
 | |
7RCC
 | |
5JSN
 | | Bcl2-inhibitor complex | | 分子名称: | Apoptosis regulator Bcl-2, Bcl2 inhibitor | | 著者 | Shen, B.W, Stoddard, B.L. | | 登録日 | 2016-05-09 | | 公開日 | 2016-11-16 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.
Elife, 5, 2016
|
|
5E63
 | | K262A mutant of I-SmaMI | | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 2-METHOXYETHANOL, DNA (5'-D(P*CP*AP*GP*GP*TP*GP*TP*AP*CP*G)-3'), ... | | 著者 | Shen, B, Stoddard, B. | | 登録日 | 2015-10-09 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease.
J.Mol.Biol., 428, 2016
|
|
4R6G
 | |
6MAF
 | | native BbvCI A2B2 tetramer at low resolution | | 分子名称: | BbvCI endonuclease subunit 1, BbvCI endonuclease subunit 2 | | 著者 | Shen, B.W, Stoddard, B.L. | | 登録日 | 2018-08-27 | | 公開日 | 2018-11-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.79 Å) | | 主引用文献 | Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI.
Nucleic Acids Res., 47, 2019
|
|
4R5D
 | |
4R5C
 | |
4R6F
 | |
7R9F
 | |
7T8K
 | | BrxR from Acinetobacter BREX type I phage restriction system bound to DNA | | 分子名称: | 1,2-ETHANEDIOL, BrxR, CHLORIDE ION, ... | | 著者 | Doyle, L, Kaiser, B, Stoddard, B. | | 登録日 | 2021-12-16 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Identification and characterization of the WYL BrxR protein and its gene as separable regulatory elements of a BREX phage restriction system.
Nucleic Acids Res., 50, 2022
|
|
5THG
 | |
7RKC
 | | Computationally designed tunable C2 symmetric tandem repeat homodimer, D_3_633 | | 分子名称: | ACETATE ION, D_3_633 | | 著者 | Kennedy, M.A, Stoddard, B.L, Hicks, D.R, Bera, A.K. | | 登録日 | 2021-07-22 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | De novo design of protein homodimers containing tunable symmetric protein pockets.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
6OHH
 | | Structure of EF1p2_mFAP2b bound to DFHBI | | 分子名称: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one, CALCIUM ION, EF1p2_mFAP2b | | 著者 | Doyle, L.A, Stoddard, B.L. | | 登録日 | 2019-04-05 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Incorporation of sensing modalities into de novo designed fluorescence-activating proteins
Nat Commun, 12, 2021
|
|
1YSB
 | | Yeast Cytosine Deaminase Triple Mutant | | 分子名称: | CALCIUM ION, Cytosine deaminase, ZINC ION | | 著者 | Korkegian, A, Black, M.E, Baker, D, Stoddard, B.L. | | 登録日 | 2005-02-08 | | 公開日 | 2005-05-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Computational thermostabilization of an enzyme.
Science, 308, 2005
|
|
7T8L
 | | BrxR from Acinetobacter BREX type I phage restriction system | | 分子名称: | 1,2-ETHANEDIOL, BrxR, CHLORIDE ION | | 著者 | Doyle, L, Kaiser, B, Stoddard, B. | | 登録日 | 2021-12-16 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Identification and characterization of the WYL BrxR protein and its gene as separable regulatory elements of a BREX phage restriction system.
Nucleic Acids Res., 50, 2022
|
|
7LO5
 | | cryoEM structure DrdV-DNA complex | | 分子名称: | CALCIUM ION, DNA (27-MER), DNA (28-MER), ... | | 著者 | Shen, B.W, Stoddard, B.L. | | 登録日 | 2021-02-09 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM.
Structure, 29, 2021
|
|
7RDR
 | |
7LVV
 | | cryoEM structure DrdV-DNA complex | | 分子名称: | CALCIUM ION, DNA (27-MER), DNA (28-MER), ... | | 著者 | Shen, B.W, Stoddard, B.L. | | 登録日 | 2021-02-26 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM.
Structure, 29, 2021
|
|
7JTA
 | | Crystal structure of a putative nuclease with anti-Cas9 activity from an uncultured Clostridia bacterium | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, NITRATE ION, NTF2-like nuclease/anti-CRISPR | | 著者 | Werther, R, Forsberg, K.J, Stoddard, B.L. | | 登録日 | 2020-08-17 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | | 主引用文献 | The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity.
Plos Biol., 19, 2021
|
|
6UW0
 | |
7SQ4
 | | Designed trefoil knot protein, variant 2 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Designed trefoil knot protein, variant 2, ... | | 著者 | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | | 登録日 | 2021-11-04 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.493 Å) | | 主引用文献 | De novo design of knotted tandem repeat proteins.
Nat Commun, 14, 2023
|
|
7SQ3
 | | Designed trefoil knot protein, variant 1 | | 分子名称: | CHLORIDE ION, Designed trefoil knot protein, variant 1, ... | | 著者 | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | | 登録日 | 2021-11-04 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.453 Å) | | 主引用文献 | De novo design of knotted tandem repeat proteins.
Nat Commun, 14, 2023
|
|
