7RCG
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7RCD
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7RCE
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7RCC
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5JSN
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![BU of 5jsn by Molmil](/molmil-images/mine/5jsn) | Bcl2-inhibitor complex | 分子名称: | Apoptosis regulator Bcl-2, Bcl2 inhibitor | 著者 | Shen, B.W, Stoddard, B.L. | 登録日 | 2016-05-09 | 公開日 | 2016-11-16 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Elife, 5, 2016
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5E63
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![BU of 5e63 by Molmil](/molmil-images/mine/5e63) | K262A mutant of I-SmaMI | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 2-METHOXYETHANOL, DNA (5'-D(P*CP*AP*GP*GP*TP*GP*TP*AP*CP*G)-3'), ... | 著者 | Shen, B, Stoddard, B. | 登録日 | 2015-10-09 | 公開日 | 2016-01-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease. J.Mol.Biol., 428, 2016
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4R6G
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6MAF
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![BU of 6maf by Molmil](/molmil-images/mine/6maf) | native BbvCI A2B2 tetramer at low resolution | 分子名称: | BbvCI endonuclease subunit 1, BbvCI endonuclease subunit 2 | 著者 | Shen, B.W, Stoddard, B.L. | 登録日 | 2018-08-27 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.79 Å) | 主引用文献 | Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI. Nucleic Acids Res., 47, 2019
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4R5D
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4R5C
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4R6F
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7R9F
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7T8K
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![BU of 7t8k by Molmil](/molmil-images/mine/7t8k) | BrxR from Acinetobacter BREX type I phage restriction system bound to DNA | 分子名称: | 1,2-ETHANEDIOL, BrxR, CHLORIDE ION, ... | 著者 | Doyle, L, Kaiser, B, Stoddard, B. | 登録日 | 2021-12-16 | 公開日 | 2022-05-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification and characterization of the WYL BrxR protein and its gene as separable regulatory elements of a BREX phage restriction system. Nucleic Acids Res., 50, 2022
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5THG
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7RKC
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![BU of 7rkc by Molmil](/molmil-images/mine/7rkc) | Computationally designed tunable C2 symmetric tandem repeat homodimer, D_3_633 | 分子名称: | ACETATE ION, D_3_633 | 著者 | Kennedy, M.A, Stoddard, B.L, Hicks, D.R, Bera, A.K. | 登録日 | 2021-07-22 | 公開日 | 2022-05-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | De novo design of protein homodimers containing tunable symmetric protein pockets. Proc.Natl.Acad.Sci.USA, 119, 2022
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6OHH
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![BU of 6ohh by Molmil](/molmil-images/mine/6ohh) | Structure of EF1p2_mFAP2b bound to DFHBI | 分子名称: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one, CALCIUM ION, EF1p2_mFAP2b | 著者 | Doyle, L.A, Stoddard, B.L. | 登録日 | 2019-04-05 | 公開日 | 2020-04-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Incorporation of sensing modalities into de novo designed fluorescence-activating proteins Nat Commun, 12, 2021
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1YSB
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![BU of 1ysb by Molmil](/molmil-images/mine/1ysb) | Yeast Cytosine Deaminase Triple Mutant | 分子名称: | CALCIUM ION, Cytosine deaminase, ZINC ION | 著者 | Korkegian, A, Black, M.E, Baker, D, Stoddard, B.L. | 登録日 | 2005-02-08 | 公開日 | 2005-05-17 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Computational thermostabilization of an enzyme. Science, 308, 2005
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7T8L
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![BU of 7t8l by Molmil](/molmil-images/mine/7t8l) | BrxR from Acinetobacter BREX type I phage restriction system | 分子名称: | 1,2-ETHANEDIOL, BrxR, CHLORIDE ION | 著者 | Doyle, L, Kaiser, B, Stoddard, B. | 登録日 | 2021-12-16 | 公開日 | 2022-05-18 | 最終更新日 | 2022-06-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification and characterization of the WYL BrxR protein and its gene as separable regulatory elements of a BREX phage restriction system. Nucleic Acids Res., 50, 2022
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7LO5
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![BU of 7lo5 by Molmil](/molmil-images/mine/7lo5) | cryoEM structure DrdV-DNA complex | 分子名称: | CALCIUM ION, DNA (27-MER), DNA (28-MER), ... | 著者 | Shen, B.W, Stoddard, B.L. | 登録日 | 2021-02-09 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM. Structure, 29, 2021
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7RDR
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7LVV
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![BU of 7lvv by Molmil](/molmil-images/mine/7lvv) | cryoEM structure DrdV-DNA complex | 分子名称: | CALCIUM ION, DNA (27-MER), DNA (28-MER), ... | 著者 | Shen, B.W, Stoddard, B.L. | 登録日 | 2021-02-26 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM. Structure, 29, 2021
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7JTA
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![BU of 7jta by Molmil](/molmil-images/mine/7jta) | Crystal structure of a putative nuclease with anti-Cas9 activity from an uncultured Clostridia bacterium | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, NITRATE ION, NTF2-like nuclease/anti-CRISPR | 著者 | Werther, R, Forsberg, K.J, Stoddard, B.L. | 登録日 | 2020-08-17 | 公開日 | 2021-09-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | 主引用文献 | The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity. Plos Biol., 19, 2021
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6UW0
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7SQ4
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![BU of 7sq4 by Molmil](/molmil-images/mine/7sq4) | Designed trefoil knot protein, variant 2 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Designed trefoil knot protein, variant 2, ... | 著者 | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | 登録日 | 2021-11-04 | 公開日 | 2022-06-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.493 Å) | 主引用文献 | De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
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7SQ3
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![BU of 7sq3 by Molmil](/molmil-images/mine/7sq3) | Designed trefoil knot protein, variant 1 | 分子名称: | CHLORIDE ION, Designed trefoil knot protein, variant 1, ... | 著者 | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | 登録日 | 2021-11-04 | 公開日 | 2022-06-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.453 Å) | 主引用文献 | De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
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