2B9E
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![BU of 2b9e by Molmil](/molmil-images/mine/2b9e) | Human NSUN5 protein | Descriptor: | NOL1/NOP2/Sun domain family, member 5 isoform 2, S-ADENOSYLMETHIONINE | Authors: | Min, J.R, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2005-10-11 | Release date: | 2005-10-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The Crystal Structure of Human NSUN5 protein in complex with
S-adenosyl-L-methionine To be Published
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2AVD
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![BU of 2avd by Molmil](/molmil-images/mine/2avd) | Crystal Structure of Human Catechol-O-methyltransferase domain containing 1 | Descriptor: | Catechol-O-methyltransferase, S-ADENOSYLMETHIONINE | Authors: | Min, J.R, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2005-08-29 | Release date: | 2005-09-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Crystal Structure of Human Catechol-O-methyltransferase
domain containing 1 in complex with S-adenosyl-L-methionine To be Published
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3C10
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![BU of 3c10 by Molmil](/molmil-images/mine/3c10) | Crystal structure of catalytic domain of human histone deacetylase HDAC7 in complex with Trichostatin A (TSA) | Descriptor: | Histone deacetylase 7a, POTASSIUM ION, TRICHOSTATIN A, ... | Authors: | Min, J, Schuetz, A, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2008-01-21 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J.Biol.Chem., 283, 2008
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3C6M
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![BU of 3c6m by Molmil](/molmil-images/mine/3c6m) | Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, SPERMINE, Spermine synthase | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Pegg, A.E, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2008-02-04 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J.Biol.Chem., 283, 2008
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3C6K
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![BU of 3c6k by Molmil](/molmil-images/mine/3c6k) | Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, SPERMIDINE, Spermine synthase | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Pegg, A.E, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2008-02-04 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J.Biol.Chem., 283, 2008
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3C0Y
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![BU of 3c0y by Molmil](/molmil-images/mine/3c0y) | Crystal structure of catalytic domain of human histone deacetylase HDAC7 | Descriptor: | Histone deacetylase 7a, POTASSIUM ION, ZINC ION | Authors: | Min, J.R, Schuetz, A, Allali-Hassani, A, Loppnau, P, Kwiatkowski, N.P, Mazitschek, R, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Vedadi, M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2008-01-21 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J.Biol.Chem., 283, 2008
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3C0Z
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![BU of 3c0z by Molmil](/molmil-images/mine/3c0z) | Crystal structure of catalytic domain of human histone deacetylase HDAC7 in complex with SAHA | Descriptor: | Histone deacetylase 7a, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, POTASSIUM ION, ... | Authors: | Min, J, Schuetz, A, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2008-01-21 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J.Biol.Chem., 283, 2008
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3C6G
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![BU of 3c6g by Molmil](/molmil-images/mine/3c6g) | Crystal structure of CYP2R1 in complex with vitamin D3 | Descriptor: | (1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Cytochrome P450 2R1, ... | Authors: | Strushkevich, N.V, Min, J, Loppnau, P, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Plotnikov, A.N, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-02-04 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural analysis of CYP2R1 in complex with vitamin D3. J.Mol.Biol., 380, 2008
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3CKK
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![BU of 3ckk by Molmil](/molmil-images/mine/3ckk) | Crystal structure of human methyltransferase-like protein 1 | Descriptor: | GLYCEROL, S-ADENOSYLMETHIONINE, tRNA (guanine-N(7)-)-methyltransferase | Authors: | Dong, A, Zeng, H, Dobrovetsky, E, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Plotnikov, A.N, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-03-16 | Release date: | 2008-04-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structure of human methyltransferase-like protein 1. To be Published
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3B7P
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![BU of 3b7p by Molmil](/molmil-images/mine/3b7p) | Crystal structure of spermidine synthase from Plasmodium falciparum in complex with spermine | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, SPERMINE, Spermidine synthase | Authors: | Qiu, W, Dong, A, Ren, H, Wu, H, Zhao, Y, Schapira, M, Wasney, G, Vedadi, M, Lew, J, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Plotnikov, A.N, Bochkarev, A, Hui, R, Structural Genomics Consortium (SGC) | Deposit date: | 2007-10-31 | Release date: | 2007-11-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of spermidine synthase from Plasmodium falciparum in complex with spermine. To be Published
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3BFX
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![BU of 3bfx by Molmil](/molmil-images/mine/3bfx) | Crystal structure of human sulfotransferase SULT1C1 in complex with PAP | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase 1C2 | Authors: | Dong, A, Dombrovski, L, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-11-23 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Human Sulfotransferases Sult1B1 and Sult1C1 Complexed with the Cofactor Product Adenosine-3'-5'-Diphosphate (Pap). Proteins, 64, 2006
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2O06
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![BU of 2o06 by Molmil](/molmil-images/mine/2o06) | Human spermidine synthase | Descriptor: | 1,4-DIAMINOBUTANE, 5'-DEOXY-5'-METHYLTHIOADENOSINE, MAGNESIUM ION, ... | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-27 | Release date: | 2006-12-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and mechanism of spermidine synthases. Biochemistry, 46, 2007
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2O8J
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![BU of 2o8j by Molmil](/molmil-images/mine/2o8j) | Human euchromatic histone methyltransferase 2 | Descriptor: | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Min, J, Wu, H, Antoshenko, T, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-12-12 | Release date: | 2007-01-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural biology of human H3K9 methyltransferases Plos One, 5, 2010
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2NYU
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![BU of 2nyu by Molmil](/molmil-images/mine/2nyu) | Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionine | Descriptor: | Putative ribosomal RNA methyltransferase 2, S-ADENOSYLMETHIONINE | Authors: | Dong, A, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-21 | Release date: | 2006-12-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | The Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with AdoMet To be Published
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2O28
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![BU of 2o28 by Molmil](/molmil-images/mine/2o28) | Crystal Structure of GNPNAT1 | Descriptor: | 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, COENZYME A, Glucosamine 6-phosphate N-acetyltransferase | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-29 | Release date: | 2006-12-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of Glucosamine-Phosphate N-Acetyltransferase 1 To be Published
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2O07
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![BU of 2o07 by Molmil](/molmil-images/mine/2o07) | Human spermidine synthase | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, SPERMIDINE, Spermidine synthase | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-27 | Release date: | 2006-12-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structure and mechanism of spermidine synthases. Biochemistry, 46, 2007
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2O05
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![BU of 2o05 by Molmil](/molmil-images/mine/2o05) | Human spermidine synthase | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, Spermidine synthase | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-27 | Release date: | 2006-12-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and mechanism of spermidine synthases. Biochemistry, 46, 2007
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3BO5
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![BU of 3bo5 by Molmil](/molmil-images/mine/3bo5) | Crystal structure of methyltransferase domain of human Histone-lysine N-methyltransferase SETMAR | Descriptor: | GLYCEROL, Histone-lysine N-methyltransferase SETMAR, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Lunin, V.V, Wu, H, Ren, H, Dobrovetsky, E, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-12-17 | Release date: | 2008-01-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | The Crystal Structure of Methyltransferase Domain of Human Histone-lysine N-methyltransferase SETMAR in Complex With AdoHcy. To be Published
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2NYR
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![BU of 2nyr by Molmil](/molmil-images/mine/2nyr) | Crystal Structure of Human Sirtuin Homolog 5 in Complex with Suramin | Descriptor: | 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, NAD-dependent deacetylase sirtuin-5, ZINC ION | Authors: | Min, J.R, Antoshenko, T, Allali-Hassani, A, Dong, A, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-21 | Release date: | 2006-12-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin. Structure, 15, 2007
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2O0L
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![BU of 2o0l by Molmil](/molmil-images/mine/2o0l) | Human spermidine synthase | Descriptor: | 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, Spermidine synthase | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-27 | Release date: | 2006-12-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structure and mechanism of spermidine synthases. Biochemistry, 46, 2007
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2O9K
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![BU of 2o9k by Molmil](/molmil-images/mine/2o9k) | WDR5 in Complex with Dimethylated H3K4 Peptide | Descriptor: | H3 HISTONE, WD repeat protein 5 | Authors: | Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-12-13 | Release date: | 2006-12-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis for Molecular Recognition and Presentation of Histone H3 by Wdr5. Embo J., 25, 2006
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2OB0
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![BU of 2ob0 by Molmil](/molmil-images/mine/2ob0) | Human MAK3 homolog in complex with Acetyl-CoA | Descriptor: | ACETYL COENZYME *A, Human MAK3 homolog | Authors: | Walker, J.R, Schuetz, S, Antoshenko, T, Wu, H, Bernstein, G, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-12-18 | Release date: | 2006-12-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of Human MAK3 homolog To be Published
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2KWO
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![BU of 2kwo by Molmil](/molmil-images/mine/2kwo) | Solution structure of the double PHD (plant homeodomain) fingers of human transcriptional protein DPF3b bound to a histone H4 peptide containing N-terminal acetylation at Serine 1 | Descriptor: | Histone peptide, ZINC ION, Zinc finger protein DPF3 | Authors: | Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M. | Deposit date: | 2010-04-14 | Release date: | 2010-07-14 | Last modified: | 2013-06-19 | Method: | SOLUTION NMR | Cite: | Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature, 466, 2010
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2KWN
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![BU of 2kwn by Molmil](/molmil-images/mine/2kwn) | Solution structure of the double PHD (plant homeodomain) fingers of human transcriptional protein DPF3b bound to a histone H4 peptide containing acetylation at Lysine 16 | Descriptor: | Histone peptide, ZINC ION, Zinc finger protein DPF3 | Authors: | Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M. | Deposit date: | 2010-04-13 | Release date: | 2010-07-14 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature, 466, 2010
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2KWK
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![BU of 2kwk by Molmil](/molmil-images/mine/2kwk) | Solution structures of the double PHD fingers of human transcriptional protein DPF3b bound to a H3 peptide wild type | Descriptor: | Histone peptide, ZINC ION, Zinc finger protein DPF3 | Authors: | Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M. | Deposit date: | 2010-04-12 | Release date: | 2010-07-14 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature, 466, 2010
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