4FHK
 
 | | Crystal Structure of PI3K-gamma in Complex with Imidazopyridazine 19e | | Descriptor: | 3-[2-methyl-6-(pyrazin-2-ylamino)pyrimidin-4-yl]-N-(1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | Authors: | Shaffer, P.L, Tang, J, Yakowec, P. | | Deposit date: | 2012-06-06 | | Release date: | 2013-04-10 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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2LBK
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1PV2
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4B2O
 | | Crystal structure of Bacillus subtilis YmdB, a global regulator of late adaptive responses. | | Descriptor: | FE (II) ION, PHOSPHATE ION, YMDB PHOSPHODIESTERASE | | Authors: | Newman, J.A, Diethmaier, C, Kovacs, A.T, Rodrigues, C, Kuipers, O.P, Stulke, J, Lewis, R.J. | | Deposit date: | 2012-07-17 | | Release date: | 2013-07-24 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | The Ymdb Phosphodiesterase is a Global Regulator of Late Adaptive Responses in Bacillus Subtilis.
J.Bacteriol., 196, 2014
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1B8W
 | | DEFENSIN-LIKE PEPTIDE 1 | | Descriptor: | PROTEIN (DEFENSIN-LIKE PEPTIDE 1) | | Authors: | Torres, A.M, Wang, X, Fletcher, J.I, Alewood, D, Alewood, P.F, Smith, R, Simpson, R.J, Nicholson, G.M, Sutherland, S.K, Gallagher, C.H, King, G.F, Kuchel, P.W. | | Deposit date: | 1999-02-02 | | Release date: | 1999-09-15 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a defensin-like peptide from platypus venom.
Biochem.J., 341, 1999
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1BBU
 | | LYSYL-TRNA SYNTHETASE (LYSS) COMPLEXED WITH LYSINE | | Descriptor: | LYSINE, PROTEIN (LYSYL-TRNA SYNTHETASE) | | Authors: | Onesti, S, Desogus, G, Brevet, A, Chen, J, Plateau, P, Blanquet, S, Brick, P. | | Deposit date: | 1998-04-24 | | Release date: | 2000-11-10 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural studies of lysyl-tRNA synthetase: conformational changes induced by substrate binding.
Biochemistry, 39, 2000
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6MGJ
 | | Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, apoenzyme | | Descriptor: | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, CHLORIDE ION, GLYCEROL, ... | | Authors: | Stogios, P.J, Skarina, T, Nocek, B, Arnal, G, Brumer, H, Savchenko, A. | | Deposit date: | 2018-09-14 | | Release date: | 2019-01-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural enzymology reveals the molecular basis of substrate regiospecificity and processivity of an exemplar bacterial glycoside hydrolase family 74endo-xyloglucanase.
Biochem. J., 475, 2018
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3RY1
 | | Wild-type core streptavidin at atomic resolution | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Streptavidin | | Authors: | Stenkamp, R.E, Wang, Z, Le Trong, I, Stayton, P.S, Lybrand, T.P. | | Deposit date: | 2011-05-10 | | Release date: | 2011-08-24 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.03 Å) | | Cite: | Streptavidin and its biotin complex at atomic resolution.
Acta Crystallogr.,Sect.D, 67, 2011
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2LNS
 | | Solution structure of AGR2 residues 41-175 | | Descriptor: | Anterior gradient protein 2 homolog | | Authors: | Patel, P, Clarke, C.J, Barraclough, D.L, Rudland, P.S, Barraclough, R, Lian, L. | | Deposit date: | 2012-01-04 | | Release date: | 2013-01-09 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion.
J.Mol.Biol., 425, 2013
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3OS2
 | | PFV target capture complex (TCC) at 3.32 A resolution | | Descriptor: | DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*CP*CP*CP*GP*AP*GP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*CP*TP*CP*GP*GP*G)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... | | Authors: | Maertens, G.N, Hare, S, Cherepanov, P. | | Deposit date: | 2010-09-08 | | Release date: | 2010-11-17 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.32 Å) | | Cite: | The mechanism of retroviral integration from X-ray structures of its key intermediates
Nature, 468, 2010
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2LBI
 | | N2-dG:N2-dG interstrand cross-link induced by trans-4-hydroxynonenal | | Descriptor: | (4S)-nonane-1,4-diol, DNA (5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*CP*TP*CP*GP*CP*TP*AP*GP*C)-3') | | Authors: | Huang, H, Kozekov, I.D, Wang, H, Kozekova, A, Rizzo, C.J, Stone, M.P. | | Deposit date: | 2011-03-31 | | Release date: | 2012-04-04 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Formation of a N2-dG:N2-dG carbinolamine DNA cross-link by the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N2-dG adduct.
J.Am.Chem.Soc., 133, 2011
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2B8K
 | | 12-subunit RNA Polymerase II | | Descriptor: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 19 kDa polypeptide, ... | | Authors: | Meyer, P.A, Ye, P, Zhang, M, Suh, M.H, Fu, J. | | Deposit date: | 2005-10-07 | | Release date: | 2006-06-20 | | Last modified: | 2012-06-13 | | Method: | X-RAY DIFFRACTION (4.15 Å) | | Cite: | Phasing RNA Polymerase II Using Intrinsically Bound Zn Atoms: An Updated Structural Model.
Structure, 14, 2006
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2L21
 | | chicken IGF2R domain 11 | | Descriptor: | Cation-independent mannose-6-phosphate receptor | | Authors: | Williams, C, Hoppe, H, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Rezgui, D.Z, Crump, M.P, Hassan, A.B. | | Deposit date: | 2010-08-10 | | Release date: | 2012-02-15 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | CD loop dependency of the IGF2: M6P/IGF2 receptor binding interaction predates imprinting
To be Published
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1M6E
 | | CRYSTAL STRUCTURE OF SALICYLIC ACID CARBOXYL METHYLTRANSFERASE (SAMT) | | Descriptor: | 2-HYDROXYBENZOIC ACID, LUTETIUM (III) ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Zubieta, C, Ross, J.R, Koscheski, P, Yang, Y, Pichersky, E, Noel, J.P. | | Deposit date: | 2002-07-16 | | Release date: | 2003-09-09 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Basis for Substrate Recognition in The Salicylic Acid Carboxyl Methyltransferase Family
Plant Cell, 15, 2003
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4D1D
 | | STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER with the inhibitor 5-(2-naphthylmethyl)-L-hydantoin. | | Descriptor: | 5-(2-NAPHTHYLMETHYL)-D-HYDANTOIN, 5-(2-NAPHTHYLMETHYL)-L-HYDANTOIN, HYDANTOIN TRANSPORT PROTEIN, ... | | Authors: | Weyand, S, Brueckner, F, Geng, T, Drew, D, Iwata, S, Henderson, P.J.F, Cameron, A.D. | | Deposit date: | 2014-05-01 | | Release date: | 2014-07-02 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1.
Embo J., 33, 2014
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3OIX
 | | Crystal structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans | | Descriptor: | FLAVIN MONONUCLEOTIDE, GLYCEROL, Putative dihydroorotate dehydrogenase; dihydroorotate oxidase | | Authors: | Liu, Y, Gao, Z.Q, Liu, C.P, Dong, Y.H. | | Deposit date: | 2010-08-20 | | Release date: | 2010-09-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.399 Å) | | Cite: | Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans
Acta Crystallogr.,Sect.F, 67, 2011
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4CY7
 | | Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form II | | Descriptor: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | | Authors: | Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. | | Deposit date: | 2014-04-10 | | Release date: | 2014-05-28 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.
Biochemistry, 53, 2014
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4D1S
 | | Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors | | Descriptor: | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1H-pyrrole-3-carboxamide, TYROSINE-PROTEIN KINASE JAK2 | | Authors: | Bertrand, J, Canevari, G, Fasolini, M, Brasca, M.G, Nesi, M, Avanzi, N, Ballinari, D, Bandiera, T, Bindi, S, Carenzi, D, Casero, D, Ceriani, L, Ciomei, M, Cirla, A, Colombo, M, Cribioli, S, Cristiani, C, Della Vedova, F, Fachin, G, Felder, E.R, Galvani, A, Isacchi, A, Mirizzi, D, Motto, I, Panzeri, A, Pesenti, E, Vianello, P, Gnocchi, P, Donati, D. | | Deposit date: | 2014-05-05 | | Release date: | 2014-07-23 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Pyrrole-3-Carboxamides as Potent and Selective Jak2 Inhibitors.
Bioorg.Med.Chem., 22, 2014
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1Q4V
 | | CRYSTAL STRUCTURE OF ALLO-ILEA2-INSULIN, AN INACTIVE CHIRAL ANALOGUE: IMPLICATIONS FOR THE MECHANISM OF RECEPTOR | | Descriptor: | Insulin, PHENOL, ZINC ION | | Authors: | Wan, Z.L, Xu, B, Chu, Y.C, Katsoyannis, P.G, Weiss, M.A. | | Deposit date: | 2003-08-04 | | Release date: | 2003-08-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the
mechanism of receptor binding.
Biochemistry, 42, 2003
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2L29
 | | Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II | | Descriptor: | Insulin-like growth factor 2 receptor variant, Insulin-like growth factor II | | Authors: | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | | Deposit date: | 2010-08-13 | | Release date: | 2012-02-15 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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1MPP
 | | X-RAY ANALYSES OF ASPARTIC PROTEINASES. V. STRUCTURE AND REFINEMENT AT 2.0 ANGSTROMS RESOLUTION OF THE ASPARTIC PROTEINASE FROM MUCOR PUSILLUS | | Descriptor: | PEPSIN, SULFATE ION | | Authors: | Newman, M, Watson, F, Roychowdhury, P, Jones, H, Badasso, M, Cleasby, A, Wood, S.P, Tickle, I.J, Blundell, T.L. | | Deposit date: | 1992-02-19 | | Release date: | 1993-10-31 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0 A resolution of the aspartic proteinase from Mucor pusillus.
J.Mol.Biol., 230, 1993
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1S4H
 | | NMR structure of cross-reactive peptides from L. braziliensis | | Descriptor: | 60S acidic ribosomal protein P2 | | Authors: | Soares, M.R, Bisch, P.M, Campos de Carvalho, A.C, Valente, A.P, Almeida, F.C.L. | | Deposit date: | 2004-01-16 | | Release date: | 2004-03-16 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis
Febs Lett., 560, 2004
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1DOE
 | | THE MOBIL FLAVIN OF 4-OH BENZOATE HYDROXYLASE: MOTION OF A PROSTHETIC GROUP REGULATES CATALYSIS | | Descriptor: | 2,4-DIHYDROXYBENZOIC ACID, BROMIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Gatti, D.L, Palfey, B.A, Lah, M.S, Entsch, B, Massey, V, Ballou, D.P, Ludwig, M.L. | | Deposit date: | 1994-09-06 | | Release date: | 1994-11-30 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The mobile flavin of 4-OH benzoate hydroxylase.
Science, 266, 1994
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6MEI
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4D65
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