6GVF
| Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine | 分子名称: | 5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Ouvry, G, Aurelly, M, Bonnary, L, Borde, E, Bouix-Peter, C, Chantalat, L, Clary, L, Defoin-Platel, C, Deret, S, Forissier, M, Harris, C.S, Isabet, T, Lamy, L, Luzy, A.P, Pascau, J, Soulet, C, Taddei, A, Taquet, N, Tomas, L, Thoreau, E, Varvier, E, Vial, E, Hennequin, L.F. | 登録日 | 2018-06-21 | 公開日 | 2019-10-02 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Acs Med.Chem.Lett., 10, 2019
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4ML4
| Crystal structure of the complex of signaling glycoprotein from buffalo (SPB-40) with tetrahydropyran at 2.5 A resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase-3-like protein 1, TETRAHYDROPYRAN | 著者 | Yamini, S, Chaudhary, A, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | 登録日 | 2013-09-06 | 公開日 | 2013-09-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of the complex of signaling glycoprotein from buffalo (SPB-40) with tetrahydropyran at 2.5 A resolution To be Published
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5M6L
| Small Molecule inhibitors of IAP | 分子名称: | 1-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2~{R},5~{R})-5-methyl-2-[[(3~{R})-3-methylmorpholin-4-yl]methyl]piperazin-4-ium-1-yl]ethanone, E3 ubiquitin-protein ligase XIAP, SODIUM ION, ... | 著者 | Williams, P.A. | 登録日 | 2016-10-25 | 公開日 | 2017-05-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). J. Med. Chem., 60, 2017
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3IGO
| Crystal structure of Cryptosporidium parvum CDPK1, cgd3_920 | 分子名称: | CALCIUM ION, Calmodulin-domain protein kinase 1, GLYCEROL, ... | 著者 | Wernimont, A.K, Artz, J.D, Finnerty, P, Amani, M, Allali-Hassanali, A, Vedadi, M, Tempel, W, MacKenzie, F, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Weigelt, J, Bochkarev, A, Hui, R, Lin, Y.H, Structural Genomics Consortium (SGC) | 登録日 | 2009-07-28 | 公開日 | 2009-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium. Nat.Struct.Mol.Biol., 17, 2010
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2KDT
| PC1/3 DCSG sorting domain structure in DPC | 分子名称: | Neuroendocrine convertase 1 | 著者 | Dikeakos, J.D, Di Lello, P, Lacombe, M.J, Ghirlando, R, Legault, P, Reudelhuber, T.L, Omichinski, J.G. | 登録日 | 2009-01-19 | 公開日 | 2009-04-07 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease. Proc.Natl.Acad.Sci.USA, 106, 2009
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4HI5
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5M6C
| CRYSTAL STRUCTURE OF T71N MUTANT OF HUMAN HIPPOCALCIN | 分子名称: | CALCIUM ION, Neuron-specific calcium-binding protein hippocalcin | 著者 | Helassa, N, Antonyuk, S.V, Lian, L.Y, Haynes, L.P, Burgoyne, R.D. | 登録日 | 2016-10-24 | 公開日 | 2017-04-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. Hum. Mol. Genet., 26, 2017
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5JH5
| Structural Basis for the Hierarchical Assembly of the Core of PRC1.1 | 分子名称: | BCL-6 corepressor-like protein 1, Lysine-specific demethylase 2B, Polycomb group RING finger protein 1, ... | 著者 | Wong, S.J, Taylor, A.B, Hart, P.J, Kim, C.A. | 登録日 | 2016-04-20 | 公開日 | 2016-09-14 | 最終更新日 | 2016-10-19 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1. Structure, 24, 2016
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5M6M
| Small Molecule inhibitors of IAP | 分子名称: | 1-[[(2~{R},5~{R})-1-[2-[3,3-dimethyl-6-(phenylmethyl)-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]-2-oxidanylidene-ethyl]-5-methyl-piperazin-4-ium-2-yl]methyl]pyrrolidin-2-one, E3 ubiquitin-protein ligase XIAP, SODIUM ION, ... | 著者 | Williams, P.A. | 登録日 | 2016-10-25 | 公開日 | 2017-05-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). J. Med. Chem., 60, 2017
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6GG1
| Structure of PROSS-edited human interleukin 24 | 分子名称: | Interleukin-24, NICKEL (II) ION, SULFATE ION | 著者 | Kolenko, P, Zahradnik, J, Kolarova, L, Schneider, B. | 登録日 | 2018-05-02 | 公開日 | 2019-05-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Flexible regions govern promiscuous binding of IL-24 to receptors IL-20R1 and IL-22R1. Febs J., 286, 2019
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3S3X
| Structure of chicken acid-sensing ion channel 1 AT 3.0 A resolution in complex with psalmotoxin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Amiloride-sensitive cation channel 2, neuronal, ... | 著者 | Dawson, R.J.P, Benz, J, Stohler, P, Tetaz, T, Joseph, C, Huber, S, Schmid, G, Huegin, D, Pflimlin, P, Trube, G, Rudolph, M.G, Hennig, M, Ruf, A. | 登録日 | 2011-05-18 | 公開日 | 2012-05-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1. Nat Commun, 3, 2012
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6GY7
| Crystal structure of XaxB from Xenorhabdus nematophil | 分子名称: | XaxB | 著者 | Schubert, E, Raunser, S, Vetter, I.R, Prumbaum, D, Penczek, P.A. | 登録日 | 2018-06-28 | 公開日 | 2018-07-25 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Membrane insertion of alpha-xenorhabdolysin in near-atomic detail. Elife, 7, 2018
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3WCB
| The complex structure of TcSQS with ligand, BPH1237 | 分子名称: | Farnesyltransferase, putative, hydrogen [(1R)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-hydroxy-1-phosphonoethyl]phosphonate | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-27 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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5M6E
| Small Molecule inhibitors of IAP | 分子名称: | 1-[3,3-dimethyl-6-(phenylmethyl)-2~{H}-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2~{R},5~{R})-5-methyl-2-[(4-methylpyrazol-1-yl)methyl]piperazin-4-ium-1-yl]ethanone, DIMETHYL SULFOXIDE, E3 ubiquitin-protein ligase XIAP, ... | 著者 | Williams, P.A. | 登録日 | 2016-10-25 | 公開日 | 2017-05-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). J. Med. Chem., 60, 2017
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3WCL
| The complex structure of HsSQS wtih ligand,BPH1344 | 分子名称: | Squalene synthase, hydrogen [(1R)-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-28 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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4HTP
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7C67
| Crystal structure of beta-glycosides-binding protein of ABC transporter in a closed state bound to cellotriose | 分子名称: | 1,2-ETHANEDIOL, CARBONATE ION, CHLORIDE ION, ... | 著者 | Kanaujia, S.P, Chandravanshi, M, Samanta, R. | 登録日 | 2020-05-21 | 公開日 | 2020-10-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Conformational Trapping of a beta-Glucosides-Binding Protein Unveils the Selective Two-Step Ligand-Binding Mechanism of ABC Importers. J.Mol.Biol., 432, 2020
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3IUC
| Crystal structure of the human 70kDa heat shock protein 5 (BiP/GRP78) ATPase domain in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70kDa protein 5 (Glucose-regulated protein, ... | 著者 | Wisniewska, M, Karlberg, T, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotyenova, T, Kotzch, A, Kraulis, P, Markova, N, Moche, M, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A, Schutz, P, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC) | 登録日 | 2009-08-31 | 公開日 | 2009-09-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78 Plos One, 5, 2010
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5M6N
| Small Molecule inhibitors of IAP | 分子名称: | 1-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2~{R},5~{R})-5-methyl-2-[[(3~{R})-3-methylmorpholin-4-yl]methyl]piperazin-4-ium-1-yl]ethanone, Baculoviral IAP repeat-containing protein 2, SULFATE ION, ... | 著者 | Williams, P.A. | 登録日 | 2016-10-25 | 公開日 | 2017-05-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). J. Med. Chem., 60, 2017
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5M9N
| Crystal structure of human TDRD1 extended Tudor domain in complex with a symmetrically dimethylated E2F peptide | 分子名称: | 1,2-ETHANEDIOL, E2F peptide, N3, ... | 著者 | Tallant, C, Savitsky, P, Moehlenbrink, J, Chan, C, Nunez-Alonso, G, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Fedorov, O, La Thangue, N.B, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2016-11-01 | 公開日 | 2016-11-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of human TDRD1 extended Tudor domain in complex with a symmetrically
dimethylated E2F peptide To Be Published
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7C71
| Crystal structure of beta-glycosides-binding protein (E117A) of ABC transporter in an open state | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, SULFITE ION, ... | 著者 | Kanaujia, S.P, Chandravanshi, M, Samanta, R. | 登録日 | 2020-05-22 | 公開日 | 2020-09-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Conformational Trapping of a beta-Glucosides-Binding Protein Unveils the Selective Two-Step Ligand-Binding Mechanism of ABC Importers. J.Mol.Biol., 432, 2020
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4NAF
| PrcB from Geobacillus kaustophilus, apo structure | 分子名称: | Heptaprenylglyceryl phosphate synthase | 著者 | Peterhoff, D, Beer, B, Rajendran, C, Kumpula, E.P, Kapetaniou, E, Guldan, H, Wierenga, R.K, Sterner, R, Babinger, P. | 登録日 | 2013-10-22 | 公開日 | 2014-06-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization. Mol.Microbiol., 92, 2014
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8R5T
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338D
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5MA8
| GFP-binding DARPin 3G124nc | 分子名称: | GA-binding protein subunit beta-1, Green fluorescent protein | 著者 | Hansen, S, Stueber, J, Ernst, P, Koch, A, Bojar, D, Batyuk, A, Plueckthun, A. | 登録日 | 2016-11-03 | 公開日 | 2017-12-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity. Sci Rep, 7, 2017
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