6N7Q
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3Q43
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3Q44
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3T8W
| A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases | 分子名称: | CARBONATE ION, M17 leucyl aminopeptidase, N-((2R,3S,6S,18S,21S)-2-amino-18-(4-benzoylbenzyl)-21-carbamoyl-3-hydroxy-6-(naphthalen-2-ylmethyl)-4,7,16,19-tetraoxo-1-phenyl-11,14-dioxa-5,8,17,20-tetraazapentacosan-25-yl)hex-5-ynamide, ... | 著者 | McGowan, S, Klemba, M, Greebaum, D.C. | 登録日 | 2011-08-01 | 公開日 | 2011-09-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases Proc.Natl.Acad.Sci.USA, 108, 2011
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3T8V
| A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases | 分子名称: | M1 family aminopeptidase, MAGNESIUM ION, N-[(2-{2-[(N-{(2S,3R)-3-amino-4-[4-(benzyloxy)phenyl]-2-hydroxybutanoyl}-L-alanyl)amino]ethoxy}ethoxy)acetyl]-4-benzoyl-L-phenylalanyl-N~6~-hex-5-ynoyllysinamide, ... | 著者 | McGowan, S, Klemba, M, Greebaum, D.C. | 登録日 | 2011-08-01 | 公開日 | 2011-09-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases Proc.Natl.Acad.Sci.USA, 108, 2011
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5TZB
| Burkholderia sp. beta-aminopeptidase | 分子名称: | CALCIUM ION, D-aminopeptidase | 著者 | McGowan, S, Drinkwater, N, John, M, Dumsday, G. | 登録日 | 2016-11-21 | 公開日 | 2017-07-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.977 Å) | 主引用文献 | Crystal structure of a beta-aminopeptidase from an Australian Burkholderia sp. Acta Crystallogr F Struct Biol Commun, 73, 2017
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8SVL
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8SW9
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8SVM
| Plasmodium falciparum M17 aminopeptidase bound to MMV1557817 | 分子名称: | CARBONATE ION, Leucine aminopeptidase, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-3,3-dimethylbutanamide, ... | 著者 | McGowan, S, Drinkwater, N. | 登録日 | 2023-05-17 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Characterisation of a novel antimalarial agent targeting haemaglobin digestion that shows cross-species reactivity and excellent in vivo properties. Mbio, 2024
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6N87
| Plasmodium falciparum FVO apical membrane antigen 1 (AMA1) bound to MTSL spin-labelled cyclised RON2 peptide | 分子名称: | Apical membrane antigen-1, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, backbone-cyclised peptide bcRON2hp | 著者 | McGowan, S, Drinkwater, N. | 登録日 | 2018-11-28 | 公開日 | 2019-01-30 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.588 Å) | 主引用文献 | Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe. ChemMedChem, 14, 2019
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6OIU
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4EME
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4F88
| X-ray Crystal Structure of PlyC | 分子名称: | PlyCA, PlyCB | 著者 | McGowan, S, Buckle, A.M, Fischetti, V.A, Nelson, D.C, Whisstock, J.C. | 登録日 | 2012-05-17 | 公開日 | 2012-07-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | X-ray crystal structure of the streptococcal specific phage lysin PlyC. Proc.Natl.Acad.Sci.USA, 109, 2012
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4F87
| X-ray Crystal Structure of PlyCB | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, PlyCB | 著者 | McGowan, S, Buckle, A.M, Fischetti, V.A, Nelson, D.C, Whisstock, J.C. | 登録日 | 2012-05-17 | 公開日 | 2012-07-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | X-ray crystal structure of the streptococcal specific phage lysin PlyC. Proc.Natl.Acad.Sci.USA, 109, 2012
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3KQZ
| Structure of a protease 2 | 分子名称: | CARBONATE ION, M17 leucyl aminopeptidase, NONAETHYLENE GLYCOL, ... | 著者 | McGowan, S, Whisstock, J.C. | 登録日 | 2009-11-17 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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3KQX
| Structure of a protease 1 | 分子名称: | CARBONATE ION, M17 leucyl aminopeptidase, NONAETHYLENE GLYCOL, ... | 著者 | McGowan, S, Whisstock, J.C. | 登録日 | 2009-11-17 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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3KR4
| Structure of a protease 3 | 分子名称: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, CARBONATE ION, M17 leucyl aminopeptidase, ... | 著者 | McGowan, S, Whisstock, J.C. | 登録日 | 2009-11-17 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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3KR5
| Structure of a protease 4 | 分子名称: | (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, CARBONATE ION, M17 leucyl aminopeptidase, ... | 著者 | McGowan, S, Whisstock, J.C. | 登録日 | 2009-11-17 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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3EBG
| Structure of the M1 Alanylaminopeptidase from malaria | 分子名称: | GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... | 著者 | McGowan, S, Porter, C.J, Buckle, A.M, Whisstock, J.C. | 登録日 | 2008-08-27 | 公開日 | 2009-01-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase Proc.Natl.Acad.Sci.USA, 106, 2009
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4K5N
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3EBI
| Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog | 分子名称: | (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, GLYCEROL, M1 family aminopeptidase, ... | 著者 | McGowan, S, Porter, C.J, Buckle, A.M, Whisstock, J.C. | 登録日 | 2008-08-27 | 公開日 | 2009-01-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase Proc.Natl.Acad.Sci.USA, 106, 2009
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4K5P
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4K5M
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4K5L
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4K5O
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