4I9W
 
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2A0L
 | | Crystal structure of KvAP-33H1 Fv complex | | Descriptor: | 33H1 Fv fragment, POTASSIUM ION, Voltage-gated potassium channel | | Authors: | Lee, S.Y, Lee, A, Chen, J, Mackinnon, R. | | Deposit date: | 2005-06-16 | | Release date: | 2005-11-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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1BFE
 | | THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 | | Descriptor: | PSD-95 | | Authors: | Doyle, D.A, Lee, A, Lewis, J, Kim, E, Sheng, M, Mackinnon, R. | | Deposit date: | 1998-05-20 | | Release date: | 1998-10-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
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1BE9
 | | THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT. | | Descriptor: | CRIPT, PSD-95 | | Authors: | Doyle, D.A, Lee, A, Lewis, J, Kim, E, Sheng, M, Mackinnon, R. | | Deposit date: | 1998-05-20 | | Release date: | 1998-10-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
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1BL8
 | | POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS | | Descriptor: | POTASSIUM ION, PROTEIN (POTASSIUM CHANNEL PROTEIN) | | Authors: | Doyle, D.A, Cabral, J.M, Pfuetzner, R.A, Kuo, A, Gulbis, J.M, Cohen, S.L, Chait, B.T, Mackinnon, R. | | Deposit date: | 1998-07-23 | | Release date: | 1998-07-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | The structure of the potassium channel: molecular basis of K+ conduction and selectivity.
Science, 280, 1998
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1OTS
 | | Structure of the Escherichia coli ClC Chloride channel and Fab Complex | | Descriptor: | CHLORIDE ION, Fab fragment (heavy chain), Fab fragment (light chain), ... | | Authors: | Dutzler, R, Campbell, E.B, MacKinnon, R. | | Deposit date: | 2003-03-22 | | Release date: | 2003-04-15 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
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1OTU
 | | Structure of the Escherichia coli ClC Chloride channel E148Q mutant and Fab Complex | | Descriptor: | CHLORIDE ION, Fab fragment (Heavy chain), Fab fragment (Light chain), ... | | Authors: | Dutzler, R, Campbell, E.B, MacKinnon, R. | | Deposit date: | 2003-03-23 | | Release date: | 2003-04-15 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
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1OTT
 | | Structure of the Escherichia coli ClC Chloride channel E148A mutant and Fab Complex | | Descriptor: | CHLORIDE ION, Fab fragment (Heavy chain), Fab fragment (Light chain), ... | | Authors: | Dutzler, R, Campbell, E.B, MacKinnon, R. | | Deposit date: | 2003-03-23 | | Release date: | 2003-04-15 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
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6PBY
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6PBX
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6B3R
 | | Structure of the mechanosensitive channel Piezo1 | | Descriptor: | Piezo-type mechanosensitive ion channel component 1, unknown fragment | | Authors: | Guo, Y.R, MacKinnon, R. | | Deposit date: | 2017-09-22 | | Release date: | 2017-12-20 | | Last modified: | 2018-05-16 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure-based membrane dome mechanism for Piezo mechanosensitivity.
Elife, 6, 2017
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1ORQ
 | | X-ray structure of a voltage-dependent potassium channel in complex with an Fab | | Descriptor: | 6E1 Fab heavy chain, 6E1 Fab light chain, CADMIUM ION, ... | | Authors: | Jiang, Y, Lee, A, Chen, J, Ruta, V, Cadene, M, Chait, B.T, MacKinnon, R. | | Deposit date: | 2003-03-14 | | Release date: | 2003-05-06 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003
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1EXB
 | | STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS | | Descriptor: | KV BETA2 PROTEIN, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM CHANNEL KV1.1 | | Authors: | Gulbis, J.M, Zhou, M, Mann, S, MacKinnon, R. | | Deposit date: | 2000-05-02 | | Release date: | 2000-07-19 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels.
Science, 289, 2000
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4JTD
 | | Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Lys27Met mutant of Charybdotoxin | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... | | Authors: | Banerjee, A, Lee, A, Campbell, E, MacKinnon, R. | | Deposit date: | 2013-03-23 | | Release date: | 2013-06-12 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
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4JTC
 | | Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin in Cs+ | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Banerjee, A, Lee, A, Campbell, E, MacKinnon, R. | | Deposit date: | 2013-03-23 | | Release date: | 2013-06-12 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
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5U6O
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5U70
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6V35
 | | Cryo-EM structure of Ca2+-free hsSlo1-beta4 channel complex | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | Authors: | Tao, X, MacKinnon, R. | | Deposit date: | 2019-11-25 | | Release date: | 2019-12-25 | | Last modified: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
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6V22
 | | Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Tao, X, MacKinnon, R. | | Deposit date: | 2019-11-22 | | Release date: | 2019-12-25 | | Last modified: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
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6V38
 | | Cryo-EM structure of Ca2+-bound hsSlo1 channel | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ... | | Authors: | Tao, X, MacKinnon, R. | | Deposit date: | 2019-11-25 | | Release date: | 2019-12-25 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
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5TR1
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6XIT
 | | Cryo-EM structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with PIP2 | | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Niu, Y, Tao, X, MacKinnon, R. | | Deposit date: | 2020-06-21 | | Release date: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM analysis of PIP 2 regulation in mammalian GIRK channels.
Elife, 9, 2020
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5U76
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1BYW
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6CNM
 | | Cryo-EM structure of the human SK4/calmodulin channel complex | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calmodulin-1, DODECYL-BETA-D-MALTOSIDE, ... | | Authors: | Lee, C.H, MacKinnon, R. | | Deposit date: | 2018-03-08 | | Release date: | 2018-05-02 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
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