6YHJ
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![BU of 6yhj by Molmil](/molmil-images/mine/6yhj) | Thrombin in complex with D-Phe-Pro-2-chlorothiophen derivative (16e) | Descriptor: | (2~{S})-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]-~{N}-[(5-chloranylthiophen-2-yl)methyl]pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sandner, A, Heine, A, Klebe, G, Collins, C. | Deposit date: | 2020-03-30 | Release date: | 2021-04-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Thrombin in complex with D-Phe-Pro-2-chlorothiophen derivative (16e) To be published
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6FNW
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![BU of 6fnw by Molmil](/molmil-images/mine/6fnw) | Structure of a volume-regulated anion channel of the LRRC8 family | Descriptor: | 1,2-ETHANEDIOL, Volume-regulated anion channel subunit LRRC8A | Authors: | Deneka, D, Sawicka, M, Lam, A.K.M, Paulino, C, Dutzler, R. | Deposit date: | 2018-02-05 | Release date: | 2018-05-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of a volume-regulated anion channel of the LRRC8 family. Nature, 558, 2018
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6G9L
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![BU of 6g9l by Molmil](/molmil-images/mine/6g9l) | Structure of homomeric mLRRC8A volume-regulated anion channel at 5.01 A resolution | Descriptor: | Volume-regulated anion channel subunit LRRC8A | Authors: | Sawicka, M, Deneka, D, Lam, A.K.M, Paulino, C, Dutzler, R. | Deposit date: | 2018-04-11 | Release date: | 2018-05-16 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (5.01 Å) | Cite: | Structure of a volume-regulated anion channel of the LRRC8 family. Nature, 558, 2018
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6RVX
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![BU of 6rvx by Molmil](/molmil-images/mine/6rvx) | |
5OGB
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![BU of 5ogb by Molmil](/molmil-images/mine/5ogb) | Human Cellular Retinoic Acid Binding Protein II (CRABPII) with bound synthetic retinoid DC360. | Descriptor: | 4-[2-(4,4-dimethyl-1-propan-2-yl-quinolin-6-yl)ethynyl]benzoic acid, Cellular retinoic acid-binding protein 2 | Authors: | Chisholm, D, Tomlinson, C, Whiting, A, Pohl, E. | Deposit date: | 2017-07-12 | Release date: | 2018-10-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Fluorescent Retinoic Acid Analogues as Probes for Biochemical and Intracellular Characterization of Retinoid Signaling Pathways. Acs Chem.Biol., 14, 2019
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6G8Z
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![BU of 6g8z by Molmil](/molmil-images/mine/6g8z) | Structure of the pore domain of homomeric mLRRC8A volume-regulated anion channel at 3.66 A resolution | Descriptor: | Volume-regulated anion channel subunit LRRC8A | Authors: | Sawicka, M, Deneka, D, Lam, A.K.M, Paulino, C, Dutzler, R. | Deposit date: | 2018-04-10 | Release date: | 2018-05-16 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Structure of a volume-regulated anion channel of the LRRC8 family. Nature, 558, 2018
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6G9O
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![BU of 6g9o by Molmil](/molmil-images/mine/6g9o) | Structure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolution | Descriptor: | Volume-regulated anion channel subunit LRRC8A | Authors: | Sawicka, M, Deneka, D, Lam, A.K.M, Paulino, C, Dutzler, R. | Deposit date: | 2018-04-11 | Release date: | 2018-05-16 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4.25 Å) | Cite: | Structure of a volume-regulated anion channel of the LRRC8 family. Nature, 558, 2018
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8T0Z
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![BU of 8t0z by Molmil](/molmil-images/mine/8t0z) | Human liver-type glutaminase (K253A) with L-Gln, filamentous form | Descriptor: | GLUTAMINE, Glutaminase liver isoform, mitochondrial | Authors: | Feng, S, Aplin, C, Nguyen, T.-T.T, Milano, S.K, Cerione, R.A. | Deposit date: | 2023-06-01 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Filament formation drives catalysis by glutaminase enzymes important in cancer progression. Nat Commun, 15, 2024
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8SZL
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![BU of 8szl by Molmil](/molmil-images/mine/8szl) | Human liver-type glutaminase (Apo form) | Descriptor: | Glutaminase liver isoform, mitochondrial | Authors: | Feng, S, Aplin, C, Nguyen, T.-T.T, Milano, S.K, Cerione, R.A. | Deposit date: | 2023-05-30 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Filament formation drives catalysis by glutaminase enzymes important in cancer progression. Nat Commun, 15, 2024
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8SZJ
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![BU of 8szj by Molmil](/molmil-images/mine/8szj) | Human glutaminase C (Y466W) with L-Gln and Pi, filamentous form | Descriptor: | GLUTAMINE, Glutaminase kidney isoform, mitochondrial, ... | Authors: | Feng, S, Aplin, C, Nguyen, T.-T.T, Milano, S.K, Cerione, R.A. | Deposit date: | 2023-05-29 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Filament formation drives catalysis by glutaminase enzymes important in cancer progression. Nat Commun, 15, 2024
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8PDE
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![BU of 8pde by Molmil](/molmil-images/mine/8pde) | Crystal Structure of the MADS-box/MEF2 Domain of MEF2D bound to dsDNA and HDAC4 deacetylase binding motif | Descriptor: | DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(P*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), HDAC4 (histone deacetylase 4) binding motif peptide:GSGEVKMKLQEFVLNKK, ... | Authors: | Chinellato, M, Carli, A, Perin, S, Mazzocato, Y, Biondi, B, Di Giorgio, E, Brancolini, C, Angelini, A, Cendron, L. | Deposit date: | 2023-06-12 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA. J.Mol.Biol., 436, 2024
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7BCQ
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![BU of 7bcq by Molmil](/molmil-images/mine/7bcq) | ASCT2 in the presence of the inhibitor Lc-BPE (position "up") in the outward-open conformation. | Descriptor: | 4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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7BCT
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![BU of 7bct by Molmil](/molmil-images/mine/7bct) | ASCT2 in the presence of the inhibitor ERA-21 in the outward-open conformation. | Descriptor: | Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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7BCS
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![BU of 7bcs by Molmil](/molmil-images/mine/7bcs) | ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation. | Descriptor: | (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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6QPB
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![BU of 6qpb by Molmil](/molmil-images/mine/6qpb) | Cryo-EM structure of calcium-free mTMEM16F lipid scramblase in digitonin | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6 | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-13 | Release date: | 2019-03-06 | Last modified: | 2019-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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6QP6
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![BU of 6qp6 by Molmil](/molmil-images/mine/6qp6) | Cryo-EM structure of calcium-bound mTMEM16F lipid scramblase in digitonin | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6, CALCIUM ION | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-13 | Release date: | 2019-03-06 | Last modified: | 2019-04-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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6QXP
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![BU of 6qxp by Molmil](/molmil-images/mine/6qxp) | Protein peptide complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat extensin-like protein 2, ... | Authors: | Moussu, S, Caroline, C, Santos-Fernandez, G, Wehrle, S, Grossniklaus, U, Santiago, J. | Deposit date: | 2019-03-07 | Release date: | 2020-03-25 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.201 Å) | Cite: | Structural basis for recognition of RALF peptides by LRX proteins during pollen tube growth. Proc.Natl.Acad.Sci.USA, 117, 2020
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6QPI
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![BU of 6qpi by Molmil](/molmil-images/mine/6qpi) | Cryo-EM structure of calcium-free mTMEM16F lipid scramblase in nanodisc | Descriptor: | Anoctamin-6 | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-14 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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6QPC
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![BU of 6qpc by Molmil](/molmil-images/mine/6qpc) | Cryo-EM structure of calcium-bound mTMEM16F lipid scramblase in nanodisc | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6, CALCIUM ION | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-13 | Release date: | 2019-03-06 | Last modified: | 2019-04-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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6QWN
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![BU of 6qwn by Molmil](/molmil-images/mine/6qwn) | Protein peptide complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Moussu, S, Caroline, C, Santos-Fernandez, G, Wehrle, S, Grossniklaus, U, Santiago, J. | Deposit date: | 2019-03-05 | Release date: | 2020-03-18 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.892 Å) | Cite: | Structural basis for recognition of RALF peptides by LRX proteins during pollen tube growth. Proc.Natl.Acad.Sci.USA, 117, 2020
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5JCZ
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![BU of 5jcz by Molmil](/molmil-images/mine/5jcz) | Rab11 bound to MyoVa-GTD | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Pylypenko, O, Attanda, W, Gauquelin, C, Malherbes, G, Houdusse, A. | Deposit date: | 2016-04-15 | Release date: | 2016-09-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.056 Å) | Cite: | Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes. Elife, 5, 2016
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1A45
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![BU of 1a45 by Molmil](/molmil-images/mine/1a45) | GAMMAF CRYSTALLIN FROM BOVINE LENS | Descriptor: | GAMMAF CRYSTALLIN | Authors: | Norledge, B.V, Hay, R, Bateman, O.A, Slingsby, C, White, H.E, Moss, D.S, Lindley, P.F, Driessen, H.P.C. | Deposit date: | 1998-02-10 | Release date: | 1998-06-17 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Towards a molecular understanding of phase separation in the lens: a comparison of the X-ray structures of two high Tc gamma-crystallins, gammaE and gammaF, with two low Tc gamma-crystallins, gammaB and gammaD. Exp.Eye Res., 65, 1997
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6HRA
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![BU of 6hra by Molmil](/molmil-images/mine/6hra) | Cryo-EM structure of the KdpFABC complex in an E1 outward-facing state (state 1) | Descriptor: | POTASSIUM ION, Potassium-transporting ATPase ATP-binding subunit, Potassium-transporting ATPase KdpC subunit, ... | Authors: | Stock, C, Hielkema, L, Tascon, I, Wunnicke, D, Oostergetel, G.T, Azkargorta, M, Paulino, C, Haenelt, I. | Deposit date: | 2018-09-26 | Release date: | 2018-12-05 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structures of KdpFABC suggest a K+transport mechanism via two inter-subunit half-channels. Nat Commun, 9, 2018
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6QMB
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![BU of 6qmb by Molmil](/molmil-images/mine/6qmb) | Cryo-EM structure of calcium-bound nhTMEM16 lipid scramblase in nanodisc (closed state) | Descriptor: | CALCIUM ION, Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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8B8G
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![BU of 8b8g by Molmil](/molmil-images/mine/8b8g) | Cryo-EM structure of Ca2+-free mTMEM16F F518H mutant in Digitonin | Descriptor: | Anoctamin-6 | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-04 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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