6UOD
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6UOH
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8P03
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![BU of 8p03 by Molmil](/molmil-images/mine/8p03) | 48S late-stage initiation complex with m6A mRNA | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | 著者 | Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. | 登録日 | 2023-05-09 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | N 6 -methyladenosine in 5' UTR does not promote translation initiation. Mol.Cell, 84, 2024
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8P09
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![BU of 8p09 by Molmil](/molmil-images/mine/8p09) | 48S late-stage initiation complex with non methylated mRNA | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | 著者 | Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. | 登録日 | 2023-05-09 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | N 6 -methyladenosine in 5' UTR does not promote translation initiation. Mol.Cell, 84, 2024
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5CNY
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6QV2
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![BU of 6qv2 by Molmil](/molmil-images/mine/6qv2) | Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM#2 | 分子名称: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | 著者 | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | 登録日 | 2019-03-01 | 公開日 | 2019-05-29 | 最終更新日 | 2019-06-05 | 実験手法 | X-RAY DIFFRACTION (4.23 Å) | 主引用文献 | The extracellular gate shapes the energy profile of an ABC exporter. Nat Commun, 10, 2019
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6QV1
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![BU of 6qv1 by Molmil](/molmil-images/mine/6qv1) | Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM1 | 分子名称: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | 著者 | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | 登録日 | 2019-03-01 | 公開日 | 2019-05-29 | 最終更新日 | 2019-06-05 | 実験手法 | X-RAY DIFFRACTION (3.48 Å) | 主引用文献 | The extracellular gate shapes the energy profile of an ABC exporter. Nat Commun, 10, 2019
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6QV0
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![BU of 6qv0 by Molmil](/molmil-images/mine/6qv0) | Structure of ATP-bound outward-facing TM287/288 in complex with sybody Sb_TM35 | 分子名称: | ABC transporter, ATP-binding protein, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | 登録日 | 2019-03-01 | 公開日 | 2019-05-29 | 最終更新日 | 2019-06-05 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | The extracellular gate shapes the energy profile of an ABC exporter. Nat Commun, 10, 2019
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6QUZ
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![BU of 6quz by Molmil](/molmil-images/mine/6quz) | Structure of ATPgS-bound outward-facing TM287/288 in complex with sybody Sb_TM35 | 分子名称: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | 著者 | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | 登録日 | 2019-03-01 | 公開日 | 2019-05-29 | 最終更新日 | 2019-06-05 | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | 主引用文献 | The extracellular gate shapes the energy profile of an ABC exporter. Nat Commun, 10, 2019
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3GRB
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![BU of 3grb by Molmil](/molmil-images/mine/3grb) | Crystal structure of the F87M/L110M mutant of human transthyretin at pH 6.5 | 分子名称: | ACETATE ION, GLYCEROL, Transthyretin, ... | 著者 | Palmieri, L.C, Freire, J.B.B, Foguel, D, Lima, L.M.T.R. | 登録日 | 2009-03-25 | 公開日 | 2010-04-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition. J.Biol.Chem., 285, 2010
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3DGD
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![BU of 3dgd by Molmil](/molmil-images/mine/3dgd) | Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6 | 分子名称: | ACETATE ION, GLYCEROL, Transthyretin, ... | 著者 | Palmieri, L.C, Freire, J.B.B, Foguel, D, Lima, L.M.T.R. | 登録日 | 2008-06-13 | 公開日 | 2008-07-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.383 Å) | 主引用文献 | Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition. J.Biol.Chem., 285, 2010
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3GPS
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![BU of 3gps by Molmil](/molmil-images/mine/3gps) | Crystal structure of the F87M/L110M mutant of human transthyretin at pH 5.5 | 分子名称: | ACETATE ION, GLYCEROL, Transthyretin, ... | 著者 | Palmieri, L.C, Freire, J.B.B, Foguel, D, Lima, L.M.T.R. | 登録日 | 2009-03-23 | 公開日 | 2010-04-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition. J.Biol.Chem., 285, 2010
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3GRG
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![BU of 3grg by Molmil](/molmil-images/mine/3grg) | Crystal structure of the F87M/L110M mutant of human transthyretin at pH 7.5 | 分子名称: | ACETATE ION, GLYCEROL, Transthyretin, ... | 著者 | Palmieri, L.C, Freire, J.B.B, Foguel, D, Lima, L.M.T.R. | 登録日 | 2009-03-25 | 公開日 | 2010-04-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition. J.Biol.Chem., 285, 2010
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3DID
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![BU of 3did by Molmil](/molmil-images/mine/3did) | Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6 soaked | 分子名称: | ACETATE ION, GLYCEROL, Transthyretin, ... | 著者 | Palmieri, L.C, Freire, J.B.B, Foguel, D, Lima, L.M.T.R. | 登録日 | 2008-06-20 | 公開日 | 2008-07-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition. J.Biol.Chem., 285, 2010
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3I9I
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![BU of 3i9i by Molmil](/molmil-images/mine/3i9i) | Crystal structure of human transthyretin variant A25T - #2 | 分子名称: | TRIETHYLENE GLYCOL, Transthyretin | 著者 | Palmieri, L.C, Freire, J.B.B, Palhano, F.L, Azevedo, E.P.C, Foguel, D, Lima, L.M.T.R. | 登録日 | 2009-07-11 | 公開日 | 2011-02-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of human transthyretin variant A25T - #2 To be Published
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3I9A
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![BU of 3i9a by Molmil](/molmil-images/mine/3i9a) | Crystal structure of human transthyretin variant A25T - #1 | 分子名称: | TRIETHYLENE GLYCOL, Transthyretin | 著者 | Palmieri, L.C, Freire, J.B.B, Palhano, F.L, Azevedo, E.P.C, Foguel, D, Lima, L.M.T.R. | 登録日 | 2009-07-10 | 公開日 | 2010-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal structure of human transthyretin variant A25T - #1 To be Published
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3RTP
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![BU of 3rtp by Molmil](/molmil-images/mine/3rtp) | Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration | 分子名称: | Mitogen-activated protein kinase 10, N-[4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | 著者 | Bowers, S, Truong, A.P, Neitz, R.J, Hom, R.K, Sealy, J.M, Probst, G.D, Quincy, Q, Peterson, B, Chan, W, Galemmo Jr, R.A, Konradi, A.W, Sham, H.L, Pan, H, Lin, M, Yao, N, Artis, D.R, Zhang, H, Chen, L, Dryer, M, Samant, B, Zmolek, W, Wong, K, Lorentzen, C, Goldbach, E, Tonn, G, Quinn, K.P, Sauer, J, Wright, S, Powell, K, Ruslim, L, Ren, Z, Bard, F, Yednock, T.A, Griswold-Prenne, I. | 登録日 | 2011-05-03 | 公開日 | 2013-05-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration. Bioorg.Med.Chem.Lett., 21, 2011
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4I5M
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![BU of 4i5m by Molmil](/molmil-images/mine/4i5m) | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain | 分子名称: | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Serine/threonine-protein kinase PLK2 | 著者 | Aubele, D.L, Hom, R.K, Adler, M, Galemmo Jr, R.A, Bowers, S, Truong, A.P, Pan, H, Beroza, P, Neitz, R.J, Yao, N, Lin, M, Tonn, G, Zhang, H, Bova, M.P, Ren, Z, Tam, D, Ruslim, L, Baker, J, Diep, L, Fitzgerald, K, Hoffman, J, Motter, R, Fauss, D, Tanaka, P, Dappen, M, Jagodzinski, J, Chan, W, Konradi, A.W, Latimer, L, Zhu, Y.L, Artis, D.R, Sham, H.L, Anderson, J.P, Bergeron, M. | 登録日 | 2012-11-28 | 公開日 | 2013-12-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain. Chemmedchem, 8, 2013
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3PTG
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![BU of 3ptg by Molmil](/molmil-images/mine/3ptg) | Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor | 分子名称: | C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 10, N-[4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | 著者 | Bowers, S, Truong, A.P, Neitz, J, Neitzel, M, Probst, G.D, Hom, R.K, Konradi, A.W, Sham, H.L, Toth, G, Pan, H, Yao, N, Artis, D.R, Brigham, E.F, Quinn, K.P, Sauer, J, Powell, K, Ruslim, L, Bard, F, Yednock, T.A, Griswold-Prenner, I. | 登録日 | 2010-12-02 | 公開日 | 2011-03-02 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor. Bioorg.Med.Chem.Lett., 21, 2011
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4EWW
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![BU of 4eww by Molmil](/molmil-images/mine/4eww) | Human Insulin | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | 登録日 | 2012-04-28 | 公開日 | 2013-05-01 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
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4EX0
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![BU of 4ex0 by Molmil](/molmil-images/mine/4ex0) | Human Insulin | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | 登録日 | 2012-04-29 | 公開日 | 2013-05-01 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
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4EYN
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![BU of 4eyn by Molmil](/molmil-images/mine/4eyn) | Human Insulin | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | 登録日 | 2012-05-01 | 公開日 | 2013-05-01 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.532 Å) | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
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4F0O
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![BU of 4f0o by Molmil](/molmil-images/mine/4f0o) | Human Insulin | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | 登録日 | 2012-05-04 | 公開日 | 2013-05-08 | 最終更新日 | 2013-12-18 | 実験手法 | X-RAY DIFFRACTION (1.672 Å) | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
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4F0N
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![BU of 4f0n by Molmil](/molmil-images/mine/4f0n) | Human Insulin | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | 登録日 | 2012-05-04 | 公開日 | 2013-05-08 | 最終更新日 | 2013-12-18 | 実験手法 | X-RAY DIFFRACTION (1.679 Å) | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
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4F4T
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![BU of 4f4t by Molmil](/molmil-images/mine/4f4t) | Human Insulin | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | 登録日 | 2012-05-11 | 公開日 | 2013-05-15 | 最終更新日 | 2013-12-18 | 実験手法 | X-RAY DIFFRACTION (1.637 Å) | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
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