3LGZ
 
 | | Crystal structure of dehydrosqualene synthase Y129A from S. aureus complexed with presqualene pyrophosphate | | Descriptor: | Dehydrosqualene synthase, MAGNESIUM ION, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | | Authors: | Lin, F.-Y, Liu, Y.-L, Liu, C.-I, Wang, A.H.J, Oldfield, E. | | Deposit date: | 2010-01-21 | | Release date: | 2010-12-22 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Mechanism of action and inhibition of dehydrosqualene synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
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1VFQ
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1J4J
 | | Crystal Structure of Tabtoxin Resistance Protein (form II) complexed with an Acyl Coenzyme A | | Descriptor: | ACETYL COENZYME *A, TABTOXIN RESISTANCE PROTEIN | | Authors: | He, H, Ding, Y, Bartlam, M, Zhang, R, Duke, N, Joachimiak, A, Shao, Y, Cao, Z, Tang, H, Liu, Y, Jiang, F, Liu, J, Zhao, N, Rao, Z. | | Deposit date: | 2001-10-02 | | Release date: | 2003-06-03 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation.
J.Mol.Biol., 325, 2003
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6P9V
 | | Crystal Structure of hMAT Mutant K289L | | Descriptor: | ADENOSINE, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Miller, M.D, Xu, W, Huber, T.D, Clinger, J.A, Liu, Y, Thorson, J.S, Phillips Jr, G.N. | | Deposit date: | 2019-06-10 | | Release date: | 2020-04-22 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.051 Å) | | Cite: | Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes.
Acs Chem.Biol., 15, 2020
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4RYP
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4RXD
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4RXE
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4RXC
 | | T. Brucei Farnesyl Diphosphate Synthase Complexed with Homorisedronate BPH-6 | | Descriptor: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, [1-hydroxy-3-(pyridin-3-yl)propane-1,1-diyl]bis(phosphonic acid) | | Authors: | Cao, R, Liu, Y.-L, Oldfield, E. | | Deposit date: | 2014-12-09 | | Release date: | 2015-04-15 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.
ACS Med Chem Lett, 6, 2015
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8TEP
 | | Human cytomegalovirus portal vertex, virion configuration 1 (VC1) | | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Inner tegument protein, ... | | Authors: | Jih, J, Liu, Y.T, Liu, W, Zhou, H. | | Deposit date: | 2023-07-06 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | The incredible bulk: Human cytomegalovirus tegument architectures uncovered by AI-empowered cryo-EM.
Sci Adv, 10, 2024
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8TEW
 | | Human cytomegalovirus penton vertex, CVSC-bound configuration | | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Large structural phosphoprotein, ... | | Authors: | Jih, J, Liu, Y.T, Liu, W, Zhou, H. | | Deposit date: | 2023-07-07 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | The incredible bulk: Human cytomegalovirus tegument architectures uncovered by AI-empowered cryo-EM.
Sci Adv, 10, 2024
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5OFB
 | | Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation S87L | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, MORC family CW-type zinc finger protein 2, ... | | Authors: | Douse, C.H, Liu, Y, Modis, Y. | | Deposit date: | 2017-07-10 | | Release date: | 2018-02-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Nat Commun, 9, 2018
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5OFA
 | | Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation T424R | | Descriptor: | MAGNESIUM ION, MORC family CW-type zinc finger protein 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Douse, C.H, Liu, Y, Modis, Y. | | Deposit date: | 2017-07-10 | | Release date: | 2018-02-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Nat Commun, 9, 2018
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3NGM
 | | Crystal structure of lipase from Gibberella zeae | | Descriptor: | Extracellular lipase | | Authors: | Lou, Z.Y, Li, M, Sun, Y.N, Liu, Y, Liu, Z, Rao, Z.H. | | Deposit date: | 2010-06-12 | | Release date: | 2011-05-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of a secreted lipase from Gibberella zeae reveals a novel "double-lock" mechanism
Protein Cell, 1, 2010
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6GRC
 | | eukaryotic junction-resolving enzyme GEN-1 binding with Sodium | | Descriptor: | DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MAGNESIUM ION, ... | | Authors: | Lilley, D.M.J, Liu, Y, Freeman, D.J. | | Deposit date: | 2018-06-11 | | Release date: | 2018-09-26 | | Last modified: | 2019-02-13 | | Method: | X-RAY DIFFRACTION (2.452 Å) | | Cite: | A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
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6GRD
 | | eukaryotic junction-resolving enzyme GEN-1 binding with Cesium | | Descriptor: | CESIUM ION, DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), ... | | Authors: | Lilley, D.M.J, Liu, Y, Freeman, D.J. | | Deposit date: | 2018-06-11 | | Release date: | 2018-09-26 | | Last modified: | 2018-11-28 | | Method: | X-RAY DIFFRACTION (2.66 Å) | | Cite: | A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
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5LSK
 | | CRYSTAL STRUCTURE OF THE HUMAN KINETOCHORE MIS12-CENP-C COMPLEX | | Descriptor: | Centromere protein C, Kinetochore-associated protein DSN1 homolog, Kinetochore-associated protein NSL1 homolog, ... | | Authors: | Vetter, I.R, Petrovic, A, Keller, J, Liu, Y. | | Deposit date: | 2016-09-02 | | Release date: | 2016-11-16 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (3.502 Å) | | Cite: | Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.
Cell, 167, 2016
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5LSI
 | | CRYSTAL STRUCTURE OF THE KINETOCHORE MIS12 COMPLEX HEAD2 SUBDOMAIN CONTAINING DSN1 AND NSL1 FRAGMENTS | | Descriptor: | Kinetochore-associated protein DSN1 homolog, Kinetochore-associated protein NSL1 homolog, SULFATE ION | | Authors: | Vetter, I.R, Petrovic, A, Keller, J, Liu, Y. | | Deposit date: | 2016-09-02 | | Release date: | 2016-11-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.002 Å) | | Cite: | Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.
Cell, 167, 2016
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8TES
 | | Human cytomegalovirus portal vertex, virion configuration 2 (VC2) | | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Large structural phosphoprotein, ... | | Authors: | Jih, J, Liu, Y.T, Liu, W, Zhou, H. | | Deposit date: | 2023-07-06 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | The incredible bulk: Human cytomegalovirus tegument architectures uncovered by AI-empowered cryo-EM.
Sci Adv, 10, 2024
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6GRB
 | | eukaryotic junction-resolving enzyme GEN-1 binding with Potassium | | Descriptor: | DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MAGNESIUM ION, ... | | Authors: | Lilley, D.M.J, Liu, Y, Freeman, D.J. | | Deposit date: | 2018-06-11 | | Release date: | 2018-09-26 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
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8TET
 | | Human cytomegalovirus portal vertex, non-infectious enveloped particle (NIEP) configuration 1 (NC1) | | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Large structural phosphoprotein, ... | | Authors: | Jih, J, Liu, Y.T, Liu, W, Zhou, H. | | Deposit date: | 2023-07-07 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.26 Å) | | Cite: | The incredible bulk: Human cytomegalovirus tegument architectures uncovered by AI-empowered cryo-EM.
Sci Adv, 10, 2024
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8TEU
 | | Human cytomegalovirus portal vertex, non-infectious enveloped particle (NIEP) configuration 2 - inverted (NC2-inv) | | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Large structural phosphoprotein, ... | | Authors: | Jih, J, Liu, Y.T, Liu, W, Zhou, H. | | Deposit date: | 2023-07-07 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.01 Å) | | Cite: | The incredible bulk: Human cytomegalovirus tegument architectures uncovered by AI-empowered cryo-EM.
Sci Adv, 10, 2024
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1JDY
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4QSG
 | | Crystal structure of gas vesicle protein GvpF from Microcystis aeruginosa | | Descriptor: | Gas vesicle protein | | Authors: | Xu, B.Y, Dai, Y.N, Zhou, K, Ren, Y.M, Liu, Y.T, Chen, Y, Zhou, C.Z. | | Deposit date: | 2014-07-03 | | Release date: | 2014-11-12 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of the gas vesicle protein GvpF from the cyanobacterium Microcystis aeruginosa.
Acta Crystallogr.,Sect.D, 70, 2014
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7JVQ
 | | Cryo-EM structure of apomorphine-bound dopamine receptor 1 in complex with Gs protein | | Descriptor: | (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | | Authors: | Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. | | Deposit date: | 2020-08-22 | | Release date: | 2021-02-24 | | Last modified: | 2021-03-03 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Cell, 184, 2021
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7JVP
 | | Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein | | Descriptor: | (1R)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | | Authors: | Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. | | Deposit date: | 2020-08-22 | | Release date: | 2021-02-24 | | Last modified: | 2021-03-03 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Cell, 184, 2021
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