7BV6
 
 | | Crystal structure of the autophagic STX17/SNAP29/VAMP8 SNARE complex | | Descriptor: | Synaptosomal-associated protein 29, Syntaxin-17, Vesicle-associated membrane protein 8 | | Authors: | Li, Y, Pan, L.F. | | Deposit date: | 2020-04-09 | | Release date: | 2020-09-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5C2O
 | | Crystal structure of Streptococcus mutans Deoxycytidylate Deaminase complexed with dTTP | | Descriptor: | MAGNESIUM ION, Putative deoxycytidylate deaminase, THYMIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Li, Y.H, Gao, Z.Q, Hou, H.F, Dong, Y.H. | | Deposit date: | 2015-06-16 | | Release date: | 2016-07-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Mechanism of the allosteric regulation of Streptococcus mutans 2'-deoxycytidylate deaminase.
Acta Crystallogr D Struct Biol, 72, 2016
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8CX2
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2 | | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | Deposit date: | 2022-05-19 | | Release date: | 2023-02-15 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
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8GPX
 | | YFV_E_YD73Fab_postfusion | | Descriptor: | Envelope protein, YD73Fab_H, YD73Fab_K | | Authors: | Li, Y, Wu, L, Chai, Y, Qi, J, Yan, J, Gao, G.F. | | Deposit date: | 2022-08-27 | | Release date: | 2022-11-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus.
Innovation (N Y), 3, 2022
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8GPU
 | | YFV_E_YD6Fab_prefusion | | Descriptor: | Envelope protein, YD6Fab_H, YD6Fab_L | | Authors: | Li, Y, Wu, L, Qi, J, Yan, J, Gao, G.F. | | Deposit date: | 2022-08-27 | | Release date: | 2022-11-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus.
Innovation (N Y), 3, 2022
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8F2E
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8EFM
 | | Structure of coral STING receptor from Stylophora pistillata in complex with 2',3'-cGAMP | | Descriptor: | SULFATE ION, Stimulator of interferon genes protein, cGAMP | | Authors: | Li, Y, Slavik, K.M, Morehouse, B.R, Mears, K, Kranzusch, P.J. | | Deposit date: | 2022-09-08 | | Release date: | 2023-07-05 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | cGLRs are a diverse family of pattern recognition receptors in innate immunity.
Cell, 186, 2023
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8CX0
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex | | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | Deposit date: | 2022-05-19 | | Release date: | 2023-02-15 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
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8CX1
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1 | | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | Deposit date: | 2022-05-19 | | Release date: | 2023-02-15 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
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3BW3
 | | Crystal structures and site-directed mutagenesis study of nitroalkane oxidase from Streptomyces ansochromogenes | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-nitropropane dioxygenase, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Li, Y.H, Gao, Z.Q, Hou, H.F. | | Deposit date: | 2008-01-08 | | Release date: | 2009-01-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure and site-directed mutagenesis of a nitroalkane oxidase from Streptomyces ansochromogenes
Biochem.Biophys.Res.Commun., 405, 2011
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8GPT
 | | YFV_E_YD6scFv_postfusion | | Descriptor: | Envelope protein, YD6_VH, YD6_VL | | Authors: | Li, Y, Wu, L, Qi, J, Yan, J, Gao, G.F. | | Deposit date: | 2022-08-27 | | Release date: | 2022-11-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.07 Å) | | Cite: | A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus.
Innovation (N Y), 3, 2022
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3BW2
 | | Crystal structures and site-directed mutagenesis study of nitroalkane oxidase from Streptomyces ansochromogenes | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-nitropropane dioxygenase, FLAVIN MONONUCLEOTIDE | | Authors: | Li, Y.H, Gao, Z.Q, Hou, H.F. | | Deposit date: | 2008-01-08 | | Release date: | 2009-01-13 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure and site-directed mutagenesis of a nitroalkane oxidase from Streptomyces ansochromogenes
Biochem.Biophys.Res.Commun., 405, 2011
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6QPQ
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5HJD
 | | AF9 YEATS in complex with histone H3 Crotonylation at K18 | | Descriptor: | COPPER (II) ION, Protein AF-9, SULFATE ION, ... | | Authors: | Li, Y.Y, Zhao, D, Guan, H.P, Li, H.T. | | Deposit date: | 2016-01-13 | | Release date: | 2016-04-20 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.806 Å) | | Cite: | Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain.
Mol.Cell, 62, 2016
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8Y39
 | | cryo-EM structure of Staphylococcus aureus(ATCC 29213) 70S ribosome in complex with MCX-190. | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Li, Y, Lu, G, Li, J, Pei, X, Lin, J. | | Deposit date: | 2024-01-28 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Synthetic macrolides overcoming MLS B K-resistant pathogens.
Cell Discov, 10, 2024
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8Y37
 | | Cryo-EM structure of Staphylococcus aureus (15B196) 50S ribosome in complex with MCX-190. | | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, 7-[4-[3-[[(1~{S},2~{R},5~{R},6~{S},7~{S},8~{R},9~{R},11~{R},13~{R},14~{R})-8-[(2~{S},3~{R},4~{S},6~{R})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid, ... | | Authors: | Li, Y, Lu, G, Li, J, Pei, X, Lin, J. | | Deposit date: | 2024-01-28 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.53 Å) | | Cite: | Synthetic macrolides overcoming MLS B K-resistant pathogens.
Cell Discov, 10, 2024
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8Y38
 | | Cryo-EM structure of Staphylococcus aureus 70S ribosome (strain 15B196) in complex with MCX-190. | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Li, Y, Lu, G, Li, J, Pei, X, Lin, J. | | Deposit date: | 2024-01-28 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.58 Å) | | Cite: | Synthetic macrolides overcoming MLS B K-resistant pathogens.
Cell Discov, 10, 2024
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6U18
 | | Directed evolution of a biosensor selective for the macrolide antibiotic clarithromycin | | Descriptor: | CITRATE ANION, CLARITHROMYCIN, Erythromycin resistance repressor protein | | Authors: | Li, Y, Reed, M, Wright, H.T, Cropp, T.A, Williams, G. | | Deposit date: | 2019-08-15 | | Release date: | 2020-08-19 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Development of Genetically Encoded Biosensors for Reporting the Methyltransferase-Dependent Biosynthesis of Semisynthetic Macrolide Antibiotics.
Acs Synth Biol, 2021
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8Y36
 | | cryo-EM structure of Staphylococcus aureus(ATCC 29213) 50S ribosome in complex with MCX-190. | | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, 7-[4-[3-[[(1~{S},2~{R},5~{R},6~{S},7~{S},8~{R},9~{R},11~{R},13~{R},14~{R})-8-[(2~{S},3~{R},4~{S},6~{R})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid, ... | | Authors: | Li, Y, Lu, G, Li, J, Pei, X, Lin, J. | | Deposit date: | 2024-01-28 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Synthetic macrolides overcoming MLS B K-resistant pathogens.
Cell Discov, 10, 2024
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2QM4
 | | Crystal structure of human XLF/Cernunnos, a non-homologous end-joining factor | | Descriptor: | Non-homologous end-joining factor 1 | | Authors: | Li, Y, Chirgadze, D.Y, Sibanda, B.L, Bolanos-Garcia, V.M, Davies, O.R, Blundell, T.L. | | Deposit date: | 2007-07-14 | | Release date: | 2007-12-11 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ.
Embo J., 27, 2008
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5HJC
 | | BRD3 second bromodomain in complex with histone H3 acetylation at K18 | | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 3, CHLORIDE ION, ... | | Authors: | Li, Y.Y, Zhao, D, Guan, H.P, Li, H.T. | | Deposit date: | 2016-01-13 | | Release date: | 2016-04-20 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
Mol.Cell, 62, 2016
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8GZ1
 | | Cryo-EM structure of human NaV1.6/beta1/beta2,apo state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Sodium channel protein type 8 subunit alpha, ... | | Authors: | Li, Y, Jiang, D. | | Deposit date: | 2022-09-24 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin.
Nat Commun, 14, 2023
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8GZ2
 | | Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin | | Descriptor: | (1R,2S,3S,4R,5R,9S,11S,12S,14R)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 8 subunit alpha, ... | | Authors: | Li, Y, Jiang, D. | | Deposit date: | 2022-09-24 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin.
Nat Commun, 14, 2023
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5DO2
 | | Complex structure of MERS-RBD bound with 4C2 antibody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4C2 heavy chain, 4C2 light chain, ... | | Authors: | Li, Y, Wan, Y, Liu, P, Zhao, J, Lu, G, Qi, J, Wang, Q, Lu, X, Wu, Y, Liu, W, Yuen, K.Y, Perlman, S, Gao, G.F, Yan, J. | | Deposit date: | 2015-09-10 | | Release date: | 2015-10-14 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.409 Å) | | Cite: | A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.
Cell Res., 25, 2015
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6QNX
 | | Structure of the SA2/SCC1/CTCF complex | | Descriptor: | Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog, Transcriptional repressor CTCF | | Authors: | Li, Y, Muir, K.W, Panne, D. | | Deposit date: | 2019-02-12 | | Release date: | 2020-01-22 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The structural basis for cohesin-CTCF-anchored loops.
Nature, 578, 2020
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