3MLI
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![BU of 3mli by Molmil](/molmil-images/mine/3mli) | 2ouf-ds, a disulfide-linked dimer of Helicobacter pylori protein HP0242 | Descriptor: | CALCIUM ION, Putative uncharacterized protein | Authors: | King, N.P, Sawaya, M.R, Jacobitz, A.W, Yeates, T.O. | Deposit date: | 2010-04-16 | Release date: | 2010-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure and folding of a designed knotted protein. Proc.Natl.Acad.Sci.USA, 107, 2010
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3MLG
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![BU of 3mlg by Molmil](/molmil-images/mine/3mlg) | 2ouf-2x, a designed knotted protein | Descriptor: | 2X chimera of Helicobacter pylori protein HP0242 | Authors: | King, N.P, Sawaya, M.R, Jacobitz, A.W, Yeates, T.O. | Deposit date: | 2010-04-16 | Release date: | 2010-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Structure and folding of a designed knotted protein. Proc.Natl.Acad.Sci.USA, 107, 2010
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3EL5
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![BU of 3el5 by Molmil](/molmil-images/mine/3el5) | |
1T7J
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![BU of 1t7j by Molmil](/molmil-images/mine/1t7j) | crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V) | Descriptor: | ACETATE ION, Pol Polyprotein, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | Authors: | King, N.M, Prabu-Jeyabalan, M, Nalivaika, E.A, Wigerinck, P.B.T.P, De Bethune, M.-P, Schiffer, C.A. | Deposit date: | 2004-05-10 | Release date: | 2005-05-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor J.Med.Chem., 48, 2005
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1T7I
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![BU of 1t7i by Molmil](/molmil-images/mine/1t7i) | The structural and thermodynamic basis for the binding of TMC114, a next-generation HIV-1 protease inhibitor. | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ACETATE ION, PHOSPHATE ION, ... | Authors: | King, N.M, Prabu-Jeyabalan, M, Nalivaika, E.A, Wigerinck, P.B.T.P, De Bethune, M.-P, Schiffer, C.A. | Deposit date: | 2004-05-10 | Release date: | 2005-05-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor J.Med.Chem., 48, 2005
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1T3R
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![BU of 1t3r by Molmil](/molmil-images/mine/1t3r) | HIV protease wild-type in complex with TMC114 inhibitor | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, protease RETROPEPSIN | Authors: | King, N.M, Prabu-Jeyabalan, M, Nalivaika, E.A, Wigernick, P.B, de Bethune, M.P, Schiffer, C.A. | Deposit date: | 2004-04-27 | Release date: | 2005-05-03 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor J.Med.Chem., 48, 2005
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8C6D
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![BU of 8c6d by Molmil](/molmil-images/mine/8c6d) | Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate. | Descriptor: | (2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol, Genome polyprotein, Genome polyprotein (Fragment) | Authors: | Kingston, N.J, Snowden, J.S, Stonehouse, N.J, Rowlands, D.J, Hogle, J.M. | Deposit date: | 2023-01-11 | Release date: | 2023-02-22 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate. Biorxiv, 2023
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7ZQ8
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![BU of 7zq8 by Molmil](/molmil-images/mine/7zq8) | VelcroVax tandem HBcAg with SUMO-Affimer inserted at MIR (T=4 VLP) | Descriptor: | VelcroVax tandem HBcAg with SUMO-Affimer inserted at MIR | Authors: | Kingston, N.J, Grehan, K, Snowden, J.S, Alzahrani, J, Ranson, N.A, Rowlands, D.J, Stonehouse, N.J. | Deposit date: | 2022-04-29 | Release date: | 2023-01-18 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | VelcroVax: a "Bolt-On" Vaccine Platform for Glycoprotein Display. Msphere, 8, 2023
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7ZQA
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![BU of 7zqa by Molmil](/molmil-images/mine/7zqa) | VelcroVax tandem HBcAg with SUMO-Affimer inserted at MIR (T=3* VLP) | Descriptor: | VelcroVax tandem HBcAg with SUMO-Affimer inserted at MIR | Authors: | Kingston, N.J, Grehan, K, Snowden, J.S, Alzahrani, J, Ranson, N.A, Rowlands, D.J, Stonehouse, N.J. | Deposit date: | 2022-04-29 | Release date: | 2023-01-18 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | VelcroVax: a "Bolt-On" Vaccine Platform for Glycoprotein Display. Msphere, 8, 2023
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5IM6
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![BU of 5im6 by Molmil](/molmil-images/mine/5im6) | Crystal structure of designed two-component self-assembling icosahedral cage I32-28 | Descriptor: | Designed self-assembling icosahedral cage I32-28 dimeric subunit, Designed self-assembling icosahedral cage I32-28 trimeric subunit | Authors: | Liu, Y.A, Cascio, D, Sawaya, M.R, Bale, J.B, Collazo, M.J, Thomas, C, Sheffler, W, King, N.P, Baker, D, Yeates, T.O. | Deposit date: | 2016-03-05 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (5.588 Å) | Cite: | Accurate design of megadalton-scale two-component icosahedral protein complexes. Science, 353, 2016
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5IM4
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![BU of 5im4 by Molmil](/molmil-images/mine/5im4) | Crystal structure of designed two-component self-assembling icosahedral cage I52-32 | Descriptor: | 6,7-dimethyl-8-ribityllumazine synthase, Phosphotransferase system, mannose/fructose-specific component IIA | Authors: | Liu, Y.A, Cascio, D, Sawaya, M.R, Bale, J.B, Collazo, M.J, Thomas, C, Sheffler, W, King, N.P, Baker, D, Yeates, T.O. | Deposit date: | 2016-03-05 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Accurate design of megadalton-scale two-component icosahedral protein complexes. Science, 353, 2016
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5CY5
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![BU of 5cy5 by Molmil](/molmil-images/mine/5cy5) | Crystal structure of the T33-51H designed self-assembling protein tetrahedron | Descriptor: | T33-51H-A, T33-51H-B | Authors: | Cannon, K.A, Cascio, D, Park, R, Boyken, S, King, N, Yeates, T.O. | Deposit date: | 2015-07-30 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Design and structure of two new protein cages illustrate successes and ongoing challenges in protein engineering. Protein Sci., 29, 2020
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4ZK7
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![BU of 4zk7 by Molmil](/molmil-images/mine/4zk7) | Crystal structure of rescued two-component self-assembling tetrahedral cage T33-31 | Descriptor: | Chorismate mutase, Divalent-cation tolerance protein CutA | Authors: | Liu, Y, Cascio, D, Sawaya, M.R, Bale, J, Collazo, M.J, Park, R, King, N, Baker, D, Yeates, T. | Deposit date: | 2015-04-30 | Release date: | 2015-07-29 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression. Protein Sci., 24, 2015
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8FBO
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![BU of 8fbo by Molmil](/molmil-images/mine/8fbo) | |
8FBI
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![BU of 8fbi by Molmil](/molmil-images/mine/8fbi) | |
8FBK
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![BU of 8fbk by Molmil](/molmil-images/mine/8fbk) | |
8FBJ
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![BU of 8fbj by Molmil](/molmil-images/mine/8fbj) | |
8FBN
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![BU of 8fbn by Molmil](/molmil-images/mine/8fbn) | |
5KP9
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![BU of 5kp9 by Molmil](/molmil-images/mine/5kp9) | Structure of Nanoparticle Released from Enveloped Protein Nanoparticle | Descriptor: | EPN-01* | Authors: | Votteler, J, Ogohara, C, Yi, S, Hsia, Y, Natterman, U, Belnap, D.M, King, N.P, Sundquist, W.I. | Deposit date: | 2016-07-02 | Release date: | 2016-12-07 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Designed proteins induce the formation of nanocage-containing extracellular vesicles. Nature, 540, 2016
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3VCD
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![BU of 3vcd by Molmil](/molmil-images/mine/3vcd) | Computationally Designed Self-assembling Octahedral Cage protein, O333, Crystallized in space group R32 | Descriptor: | CHLORIDE ION, Propanediol utilization polyhedral body protein PduT, SULFATE ION | Authors: | Sawaya, M.R, King, N.P, Sheffler, W, Baker, D, Yeates, T.O. | Deposit date: | 2012-01-03 | Release date: | 2012-06-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science, 336, 2012
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5VL4
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![BU of 5vl4 by Molmil](/molmil-images/mine/5vl4) | Accidental minimum contact crystal lattice formed by a redesigned protein oligomer | Descriptor: | T33-53H-B | Authors: | Cannon, K.A, Cascio, D, Sawaya, M.R, Park, R, Boyken, S, King, N, Yeates, T. | Deposit date: | 2017-04-24 | Release date: | 2018-05-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Design and structure of two new protein cages illustrate successes and ongoing challenges in protein engineering. Protein Sci., 29, 2020
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4DDF
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![BU of 4ddf by Molmil](/molmil-images/mine/4ddf) | Computationally Designed Self-assembling Octahedral Cage protein, O333, Crystallized in space group P4 | Descriptor: | CHLORIDE ION, Propanediol utilization polyhedral body protein PduT, SULFATE ION | Authors: | Sawaya, M.R, King, N.P, Sheffler, W, Baker, D, Yeates, T.O. | Deposit date: | 2012-01-18 | Release date: | 2012-06-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science, 336, 2012
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4NWP
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![BU of 4nwp by Molmil](/molmil-images/mine/4nwp) | Computationally Designed Two-Component Self-Assembling Tetrahedral Cage, T33-21, Crystallized in Space Group R32 | Descriptor: | AMMONIUM ION, Putative uncharacterized protein, SULFATE ION, ... | Authors: | McNamara, D.E, King, N.P, Bale, J.B, Sheffler, W, Baker, D, Yeates, T.O. | Deposit date: | 2013-12-06 | Release date: | 2014-05-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Accurate design of co-assembling multi-component protein nanomaterials. Nature, 510, 2014
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4NWN
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![BU of 4nwn by Molmil](/molmil-images/mine/4nwn) | Computationally Designed Two-Component Self-Assembling Tetrahedral Cage T32-28 | Descriptor: | Propanediol utilization: polyhedral bodies pduT, Uncharacterized protein | Authors: | McNamara, D.E, King, N.P, Bale, J.B, Sheffler, W, Baker, D, Yeates, T.O. | Deposit date: | 2013-12-06 | Release date: | 2014-05-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4.5 Å) | Cite: | Accurate design of co-assembling multi-component protein nanomaterials. Nature, 510, 2014
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4NWR
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![BU of 4nwr by Molmil](/molmil-images/mine/4nwr) | Computationally Designed Two-Component Self-Assembling Tetrahedral Cage T33-28 | Descriptor: | Macrophage migration inhibitory factor-like protein, integron gene cassette protein | Authors: | McNamara, D.E, King, N.P, Bale, J.B, Sheffler, W, Baker, D, Yeates, T.O. | Deposit date: | 2013-12-06 | Release date: | 2014-05-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Accurate design of co-assembling multi-component protein nanomaterials. Nature, 510, 2014
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