9BKJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9bkj by Molmil](/molmil-images/mine/9bkj) | Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex | Descriptor: | AMINO GROUP, Cholecystokinin receptor type A, Cholecystokinin-8, ... | Authors: | Cary, B.P, Harikumar, K.G, Zhao, P, Desai, A.J, Mobbs, J.M, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J. | Deposit date: | 2024-04-29 | Release date: | 2024-05-22 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. Plos Biol., 22, 2024
|
|
9BEZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9bez by Molmil](/molmil-images/mine/9bez) | MID domain of human Argo2 bound to RNA | Descriptor: | Protein argonaute-2, [(3~{S},4~{R},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-4-oxidanyl-oxolan-3-yl] [oxidanyl(phosphonooxy)phosphoryl] hydrogen phosphate | Authors: | Harp, J.M, Egli, M. | Deposit date: | 2024-04-16 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth. Curr Protoc, 4, 2024
|
|
9BF0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9bf0 by Molmil](/molmil-images/mine/9bf0) | MID domain of human Argo2 bound to UTP | Descriptor: | Protein argonaute-2, URIDINE 5'-TRIPHOSPHATE | Authors: | Harp, J.M, Egli, M. | Deposit date: | 2024-04-16 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth. Curr Protoc, 4, 2024
|
|
9BF2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9bf2 by Molmil](/molmil-images/mine/9bf2) | MID domain of Ago2 bound to UMP | Descriptor: | Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE | Authors: | Harp, J.M, Egli, M. | Deposit date: | 2024-04-16 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth. Curr Protoc, 4, 2024
|
|
5BS8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5bs8 by Molmil](/molmil-images/mine/5bs8) | Crystal structure of a topoisomerase II complex | Descriptor: | 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DNA gyrase subunit A, DNA gyrase subunit B, ... | Authors: | Blower, T.R, Williamson, B.H, Kerns, R.J, Berger, J.M. | Deposit date: | 2015-06-01 | Release date: | 2016-03-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5BTI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5bti by Molmil](/molmil-images/mine/5bti) | Crystal structure of a topoisomerase II complex | Descriptor: | (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, DNA gyrase subunit A, DNA gyrase subunit B, ... | Authors: | Blower, T.R, Williamson, B.H, Kerns, R.J, Berger, J.M. | Deposit date: | 2015-06-03 | Release date: | 2016-03-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
8UCD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ucd by Molmil](/molmil-images/mine/8ucd) | Cryo-EM structure of human STEAP1 in complex with AMG 509 Fab | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, AMG 509 anti-STEAP1 Fab, heavy chain, ... | Authors: | Li, F, Bailis, J.M, Zhang, H. | Deposit date: | 2023-09-26 | Release date: | 2023-11-22 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer. Cancer Discov, 14, 2024
|
|
6XN8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xn8 by Molmil](/molmil-images/mine/6xn8) | Crystal Structure of 2-hydroxyacyl CoA lyase (HACL) from Rhodospirillales bacterium URHD0017 | Descriptor: | 2-hydroxyacyl-CoA lyase 1, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Miller, M.D, Xu, W, Olmos Jr, J.L, Chou, A, Clomburg, J.M, Gonzalez, R, Philips Jr, G.N. | Deposit date: | 2020-07-02 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of 2-hydroxyacyl CoA lyase (HACL) from Rhodospirillales bacterium URHD0017 To Be Published
|
|
8UPT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8upt by Molmil](/molmil-images/mine/8upt) | Candidatus Methanomethylophilus alvus tRNAPyl in A-site of ribosome | Descriptor: | RNA (71-MER) | Authors: | Krahn, N, Zhang, J, Melnikov, S.V, Tharp, J.M, Villa, A, Patel, A, Howard, R.J, Gabir, H, Patel, T.R, Stetefeld, J, Puglisi, J, Soll, D. | Deposit date: | 2023-10-23 | Release date: | 2024-01-10 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | tRNA shape is an identity element for an archaeal pyrrolysyl-tRNA synthetase from the human gut. Nucleic Acids Res., 52, 2024
|
|
6Y41
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y41 by Molmil](/molmil-images/mine/6y41) | Fibrinogen-like globe domain of human ANGPTL2 | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Angiopoietin-related protein 2, ... | Authors: | Coker, J.A, Krojer, T, Mutisya, J.M, Arrowsmith, C.H, Bountra, C, Midwood, K.S, Yue, W.W, Marsden, B.D, Structural Genomics Consortium (SGC) | Deposit date: | 2020-02-19 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Fibrinogen-like globe domain of human ANGPTL2 To Be Published
|
|
6XZR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xzr by Molmil](/molmil-images/mine/6xzr) | Influenza C virus polymerase in complex with chicken ANP32A - Subclass 1 | Descriptor: | LRRcap domain-containing protein, Polymerase acidic protein, Polymerase basic protein 2, ... | Authors: | Carrique, L, Keown, J.R, Fan, H, Grimes, J.M, Fodor, E. | Deposit date: | 2020-02-05 | Release date: | 2020-11-25 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Host ANP32A mediates the assembly of the influenza virus replicase. Nature, 587, 2020
|
|
6YBQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ybq by Molmil](/molmil-images/mine/6ybq) | Engineered glycolyl-CoA carboxylase (quintuple mutant) with bound CoA | Descriptor: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... | Authors: | Schuller, J.M, Schuller, S.K, Zarzycki, J, Scheffen, M, Marchal, D.M, Erb, T.J. | Deposit date: | 2020-03-17 | Release date: | 2020-10-28 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (1.96 Å) | Cite: | A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation Nat Catal, 2021
|
|
5CE3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ce3 by Molmil](/molmil-images/mine/5ce3) | The Yersinia YopO - actin complex with MgADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Lee, W.L, Singaravelu, P, Grimes, J.M, Robinson, R.C. | Deposit date: | 2015-07-06 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | The Yersinia YopO - actin complex with MgADP To Be Published
|
|
6XZQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xzq by Molmil](/molmil-images/mine/6xzq) | Influenza C virus polymerase in complex with human ANP32A - Subclass 1 | Descriptor: | Acidic leucine-rich nuclear phosphoprotein 32 family member A, Polymerase acidic protein, Polymerase basic protein 2, ... | Authors: | Fan, H, Carrique, L, Keown, J.R, Grimes, J.M, Fodor, E. | Deposit date: | 2020-02-05 | Release date: | 2020-11-25 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Host ANP32A mediates the assembly of the influenza virus replicase. Nature, 587, 2020
|
|
6Y43
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y43 by Molmil](/molmil-images/mine/6y43) | Fibrinogen-like globe domain of human ANGPTL6 | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Angiopoietin-related protein 6, ... | Authors: | Coker, J.A, Krojer, T, Mutisya, J.M, Arrowsmith, C.H, Bountra, C, Midwood, K.S, Yue, W.W, Marsden, B.D, Structural Genomics Consortium (SGC) | Deposit date: | 2020-02-19 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fibrinogen-like globe domain of human ANGPTL6 To Be Published
|
|
5CFN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5cfn by Molmil](/molmil-images/mine/5cfn) | Crystal structure of anemone STING (Nematostella vectensis) in complex with 3',3' c-di-AMP, c[A(3',5')pA(3',5')p] | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of Interferon Genes | Authors: | Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E. | Deposit date: | 2015-07-08 | Release date: | 2015-08-26 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol.Cell, 59, 2015
|
|
5BVJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5bvj by Molmil](/molmil-images/mine/5bvj) | |
8V55
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v55 by Molmil](/molmil-images/mine/8v55) | Human mitochondrial DNA polymerase gamma bound to a replication fork in an open conformation | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, M.J, Copeland, W.C. | Deposit date: | 2023-11-30 | Release date: | 2024-07-10 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis. Nucleic Acids Res., 52, 2024
|
|
8V3N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v3n by Molmil](/molmil-images/mine/8v3n) | CCP5 in complex with Glu-P-Glu transition state analog | Descriptor: | (2S)-2-{[(S)-[(3S)-3-acetamido-4-(ethylamino)-4-oxobutyl](hydroxy)phosphoryl]methyl}pentanedioic acid, Cytosolic carboxypeptidase-like protein 5, D-MALATE, ... | Authors: | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | Deposit date: | 2023-11-28 | Release date: | 2024-07-17 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature, 631, 2024
|
|
8V4M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v4m by Molmil](/molmil-images/mine/8v4m) | CCP5 in complex with microtubules class3 | Descriptor: | Cytosolic carboxypeptidase-like protein 5, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | Deposit date: | 2023-11-29 | Release date: | 2024-07-17 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature, 631, 2024
|
|
8V3P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v3p by Molmil](/molmil-images/mine/8v3p) | CCP5 in complex with Glu-P-peptide 2 transition state analog | Descriptor: | Cytosolic carboxypeptidase-like protein 5, Tubulin beta-2A chain, ZINC ION | Authors: | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | Deposit date: | 2023-11-28 | Release date: | 2024-07-17 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature, 631, 2024
|
|
8V4K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v4k by Molmil](/molmil-images/mine/8v4k) | CCP5 in complex with microtubules class1 | Descriptor: | Cytosolic carboxypeptidase-like protein 5, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | Deposit date: | 2023-11-29 | Release date: | 2024-07-17 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature, 631, 2024
|
|
8V3S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v3s by Molmil](/molmil-images/mine/8v3s) | Structure of CCP5 class3 | Descriptor: | Cytosolic carboxypeptidase-like protein 5, GLUTAMIC ACID, ZINC ION, ... | Authors: | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | Deposit date: | 2023-11-28 | Release date: | 2024-07-17 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature, 631, 2024
|
|
8V4L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v4l by Molmil](/molmil-images/mine/8v4l) | CCP5 in complex with microtubules class2 | Descriptor: | Cytosolic carboxypeptidase-like protein 5, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | Deposit date: | 2023-11-29 | Release date: | 2024-07-17 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature, 631, 2024
|
|
6YI9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yi9 by Molmil](/molmil-images/mine/6yi9) | Crystal structure of the rat cytosolic PCK1, acetylated on Lys244 | Descriptor: | 1,2-ETHANEDIOL, Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | Authors: | Latorre-Muro, P, Baeza, J, Hurtado-Guerrero, R, Hicks, T, Delso, I, Hernandez-Ruiz, C, Velazquez-Campoy, A, Lawton, A.J, Angulo, J, Denu, J.M, Carrodeguas, J.A. | Deposit date: | 2020-04-01 | Release date: | 2020-12-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity. J.Biol.Chem., 296, 2021
|
|