2AVO
| Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S | Descriptor: | ACETIC ACID, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Liu, F, Boross, P.I, Wang, Y.F, Tozser, J, Louis, J.M, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-30 | Release date: | 2006-01-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J.Mol.Biol., 354, 2005
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2AWN
| Crystal structure of the ADP-Mg-bound E. Coli MALK (Crystallized with ATP-Mg) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Maltose/maltodextrin import ATP-binding protein malK | Authors: | Lu, G, Westbrooks, J.M, Davidson, A.L, Chen, J. | Deposit date: | 2005-09-01 | Release date: | 2005-12-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | ATP hydrolysis is required to reset the ATP-binding cassette dimer into the resting-state conformation. Proc.Natl.Acad.Sci.Usa, 102, 2005
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3UJD
| Phosphoethanolamine methyltransferase mutant (Y19F) from Plasmodium falciparum in complex with phosphocholine | Descriptor: | PHOSPHOCHOLINE, Phosphoethanolamine N-methyltransferase | Authors: | Lee, S.G, Kim, Y, Alpert, T.D, Nagata, A, Jez, J.M. | Deposit date: | 2011-11-07 | Release date: | 2011-11-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target. J.Biol.Chem., 287, 2012
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3UJ6
| SeMet Phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with SAM and PO4 | Descriptor: | PHOSPHATE ION, Phosphoethanolamine N-methyltransferase, S-ADENOSYLMETHIONINE | Authors: | Lee, S.G, Kim, Y, Alpert, T.D, Nagata, A, Jez, J.M. | Deposit date: | 2011-11-07 | Release date: | 2011-11-30 | Last modified: | 2012-03-21 | Method: | X-RAY DIFFRACTION (1.974 Å) | Cite: | Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target. J.Biol.Chem., 287, 2012
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3UK3
| Crystal structure of ZNF217 bound to DNA | Descriptor: | 5'-D(*AP*AP*TP*GP*CP*AP*GP*AP*AP*TP*CP*GP*AP*TP*TP*CP*TP*GP*CP*A)-3', 5'-D(*TP*TP*TP*GP*CP*AP*GP*AP*AP*TP*CP*GP*AP*TP*TP*CP*TP*GP*CP*A)-3', CHLORIDE ION, ... | Authors: | Vandevenne, M.S, Jacques, D.A, Guss, J.M, Mackay, J.P. | Deposit date: | 2011-11-08 | Release date: | 2012-12-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Rediscovering DNA recognition by classical Zinc Fingers. To be Published
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1IGA
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2AVQ
| Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ... | Authors: | Liu, F, Boross, P.I, Wang, Y.F, Tozser, J, Louis, J.M, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-30 | Release date: | 2006-01-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J.Mol.Biol., 354, 2005
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3UJ8
| Phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with sinefungin and PO4 | Descriptor: | PHOSPHATE ION, Phosphoethanolamine N-methyltransferase, SINEFUNGIN | Authors: | Lee, S.G, Kim, Y, Alpert, T.D, Nagata, A, Jez, J.M. | Deposit date: | 2011-11-07 | Release date: | 2011-11-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.351 Å) | Cite: | Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target. J.Biol.Chem., 287, 2012
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2V8O
| Structure of the Murray Valley encephalitis virus RNA helicase to 1. 9A resolution | Descriptor: | FLAVIVIRIN PROTEASE NS3 | Authors: | Mancini, E.J, Assenberg, R, Verma, A, Walter, T.S, Tuma, R, Grimes, J.M, Owens, R.J, Stuart, D.I. | Deposit date: | 2007-08-09 | Release date: | 2007-08-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the Murray Valley Encephalitis Virus RNA Helicase at 1.9 A Resolution. Protein Sci., 16, 2007
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3UED
| Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3 (C2 space group). | Descriptor: | Baculoviral IAP repeat-containing protein 5, N-terminal fragment of histone H3, ZINC ION | Authors: | Niedzialkowska, E, Porebski, P.J, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. | Deposit date: | 2011-10-30 | Release date: | 2012-03-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol.Biol.Cell, 23, 2012
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4J9Z
| Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and NS309 | Descriptor: | (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin, ... | Authors: | Zhang, M, Pascal, J.M, Zhang, J.-F. | Deposit date: | 2013-02-17 | Release date: | 2013-03-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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1JDG
| Solution Structure of a Trans-Opened (10S)-dA Adduct of (+)-(7S,8R,9S,10R)-7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a fully Complementary DNA Duplex | Descriptor: | 5'-D(*CP*CP*TP*CP*GP*TP*GP*AP*CP*CP*G)-3', 5'-D(*CP*GP*GP*TP*CP*(BPA)AP*CP*GP*AP*GP*G)-3', 7S,8R,9R-TRIHYDROXY-7,8,9,10-TETRAHYDRO BENZO[A]PYRENE | Authors: | Pradhan, P, Tirumala, S, Liu, X, Sayer, J.M, Jerina, D.M, Yeh, H.J.C. | Deposit date: | 2001-06-13 | Release date: | 2001-07-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a trans-opened (10S)-dA adduct of (+)-(7S,8R,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a fully complementary DNA duplex: evidence for a major syn conformation. Biochemistry, 40, 2001
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2C2S
| Human Dihydrofolate Reductase Complexed With NADPH and 2,4-Diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, A novel boron containing, nonclassical Antifolate | Descriptor: | 2,4-DIAMINO-5-(1-O-CARBORANYLMETHYL)-6-METHYLPYRIMIDINE, DIHYDROFOLATE REDUCTASE, GLYCEROL, ... | Authors: | Leung, A.K.W, Reynolds, R.C, Riordan, J.M, Borhani, D.W. | Deposit date: | 2005-09-29 | Release date: | 2007-04-10 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation. J.Med.Chem., 50, 2007
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4J9Y
| Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant | Descriptor: | CALCIUM ION, Calmodulin, GLYCEROL, ... | Authors: | Zhang, M, Pascal, J.M, Zhang, J.-F. | Deposit date: | 2013-02-17 | Release date: | 2013-03-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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3V4A
| Structure of ar lbd with activator peptide and sarm inhibitor 2 | Descriptor: | (5R)-3-(3,4-dichlorophenyl)-5-(4-hydroxyphenyl)-1,5-dimethyl-2-thioxoimidazolidin-4-one, Androgen receptor, SULFATE ION | Authors: | Nique, F, Hebbe, S, Peixoto, C, Annoot, D, Lefrancois, J.-M, Duval, E, Michoux, L, Triballeau, N, Lemoullec, J.M, Mollat, P, Thauvin, M, Prange, T, Minet, D, Clement-Lacroix, P, Robin-Jagerschmidt, C, Fleury, D, Guedin, D, Deprez, P. | Deposit date: | 2011-12-14 | Release date: | 2012-09-05 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Discovery of diarylhydantoins as new selective androgen receptor modulators. J.Med.Chem., 55, 2012
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2PX5
| Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAH (Orthorhombic crystal form) | Descriptor: | Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION | Authors: | Assenberg, R, Ren, J, Verma, A, Walter, T.S, Alderton, D, Hurrelbrink, R.J, Fuller, S.D, Owens, R.J, Stuart, D.I, Grimes, J.M, Oxford Protein Production Facility (OPPF) | Deposit date: | 2007-05-14 | Release date: | 2007-05-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. J.Gen.Virol., 88, 2007
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3V6F
| Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound | Descriptor: | Fab e6 Heavy Chain, Fab e6 Light Chain | Authors: | Dimattia, M.A, Watts, N.R, Stahl, S.J, Grimes, J.M, Steven, A.C, Stuart, D.I, Wingfield, P.T. | Deposit date: | 2011-12-19 | Release date: | 2013-02-06 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein. Structure, 21, 2013
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2Q7H
| Pyrrolysyl-tRNA synthetase bound to adenylated pyrrolysine and pyrophosphate | Descriptor: | (2R)-2-AMINO-6-({[(2S,3R)-3-METHYLPYRROLIDIN-2-YL]CARBONYL}AMINO)HEXANOYL [(2S,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL HYDROGEN (R)-PHOSPHATE, 1,2-ETHANEDIOL, PYROPHOSPHATE 2-, ... | Authors: | Kavran, J.M, Steitz, T.A. | Deposit date: | 2007-06-06 | Release date: | 2007-07-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation. Proc.Natl.Acad.Sci.Usa, 104, 2007
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3UJC
| Phosphoethanolamine methyltransferase mutant (H132A) from Plasmodium falciparum in complex with phosphocholine | Descriptor: | PHOSPHOCHOLINE, Phosphoethanolamine N-methyltransferase | Authors: | Lee, S.G, Kim, Y, Alpert, T.D, Nagata, A, Jez, J.M. | Deposit date: | 2011-11-07 | Release date: | 2011-11-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target. J.Biol.Chem., 287, 2012
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1ICA
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1I1J
| STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS | Descriptor: | MELANOMA DERIVED GROWTH REGULATORY PROTEIN | Authors: | Lougheed, J.C, Holton, J.M, Alber, T, Bazan, J.F, Handel, T.M. | Deposit date: | 2001-02-02 | Release date: | 2001-05-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins. Proc.Natl.Acad.Sci.USA, 98, 2001
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2PFJ
| Crystal Structure of T7 Endo I resolvase in complex with a Holliday Junction | Descriptor: | 27-MER, CALCIUM ION, Endodeoxyribonuclease 1 | Authors: | Hadden, J.M, Declais, A.C, Carr, S.B, Lilley, D.M, Phillips, S.E. | Deposit date: | 2007-04-05 | Release date: | 2007-10-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The structural basis of Holliday junction resolution by T7 endonuclease I. Nature, 449, 2007
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3UJ7
| Phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with SAM and PO4 | Descriptor: | PHOSPHATE ION, Phosphoethanolamine N-methyltransferase, S-ADENOSYLMETHIONINE | Authors: | Lee, S.G, Kim, Y, Alpert, T.D, Nagata, A, Jez, J.M. | Deposit date: | 2011-11-07 | Release date: | 2011-11-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.549 Å) | Cite: | Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target. J.Biol.Chem., 287, 2012
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1DIR
| CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER | Descriptor: | DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Varughese, K.I, Su, Y, Skinner, M.M, Matthews, D.A, Whitely, J.M, Xuong, N.H. | Deposit date: | 1994-04-18 | Release date: | 1994-07-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver. Acta Crystallogr.,Sect.D, 50, 1994
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2Q01
| Crystal structure of glucuronate isomerase from Caulobacter crescentus | Descriptor: | POTASSIUM ION, Uronate isomerase | Authors: | Patskovsky, Y, Bonanno, J, Sridhar, V, Sauder, J.M, Freeman, J, Powell, A, Koss, J, Groshong, C, Gheyi, T, Wasserman, S.R, Raushel, F, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-05-18 | Release date: | 2007-05-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Crystal Structure of Glucuronate Isomerase from Caulobacter crescentus. To be Published
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