6B88
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![BU of 6b88 by Molmil](/molmil-images/mine/6b88) | E. coli LepB in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino-2-(2-(4-(tert-butyl)phenyl)-4-methylpyrimidine-5-carboxamido)-N-methylbutanamido)-16,26-bis(2-aminoethoxy)-N-(2-iminoethyl)-7-methyl-6,9-dioxo-5,8-diaza-1,2(1,3)-dibenzenacyclodecaphane-4-carboxamide) | Descriptor: | (8S,11S,14S)-14-{[(2S)-4-amino-2-{[2-(4-tert-butylphenyl)-4-methylpyrimidine-5-carbonyl]amino}butanoyl](methyl)amino}-3,18-bis(2-aminoethoxy)-N-[(2Z)-2-iminoethyl]-11-methyl-10,13-dioxo-9,12-diazatricyclo[13.3.1.1~2,6~]icosa-1(19),2(20),3,5,15,17-hexaene-8-carboxamide, PENTAETHYLENE GLYCOL, Signal peptidase I | Authors: | Murray, J.M, Rouge, L. | Deposit date: | 2017-10-05 | Release date: | 2018-10-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.407 Å) | Cite: | Optimized arylomycins are a new class of Gram-negative antibiotics. Nature, 561, 2018
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7PFJ
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7PF8
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![BU of 7pf8 by Molmil](/molmil-images/mine/7pf8) | SynFtn Variant E141A | Descriptor: | CHLORIDE ION, Ferritin, SODIUM ION | Authors: | Hemmings, A.M, Bradley, J.M. | Deposit date: | 2021-08-11 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Key carboxylate residues for iron transit through the prokaryotic ferritin Syn Ftn. Microbiology (Reading, Engl.), 167, 2021
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7PFB
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7PFI
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6PK6
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![BU of 6pk6 by Molmil](/molmil-images/mine/6pk6) | Human PRPF4B bound to benzothiophene inhibitor 329 | Descriptor: | 4-(5-{[(2-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide, SULFATE ION, Serine/threonine-protein kinase PRP4 homolog | Authors: | Godoi, P.H.C, Santiago, A.S, Fala, A.M, Ramos, P.Z, Sriranganadane, D, Mascarello, A, Segretti, N, Azevedo, H, Guimaraes, C.R.W, Arruda, P, Elkins, J.M, Counago, R.M, Structural Genomics Consortium (SGC) | Deposit date: | 2019-06-28 | Release date: | 2019-08-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | to be published To Be Published
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7PF7
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![BU of 7pf7 by Molmil](/molmil-images/mine/7pf7) | Apo structure of SynFtn variant D65A | Descriptor: | CHLORIDE ION, Ferritin, SODIUM ION | Authors: | Hemmings, A.M, Bradley, J.M. | Deposit date: | 2021-08-11 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Key carboxylate residues for iron transit through the prokaryotic ferritin Syn Ftn. Microbiology (Reading, Engl.), 167, 2021
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7PFK
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7PFH
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![BU of 7pfh by Molmil](/molmil-images/mine/7pfh) | 2 minute Fe2+ soak structure of SynFtn E141D | Descriptor: | ACETATE ION, CHLORIDE ION, FE (III) ION, ... | Authors: | Hemmings, A.M, Bradley, J.M. | Deposit date: | 2021-08-11 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Key carboxylate residues for iron transit through the prokaryotic ferritin Syn Ftn. Microbiology (Reading, Engl.), 167, 2021
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4XBR
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![BU of 4xbr by Molmil](/molmil-images/mine/4xbr) | In cellulo Crystal Structure of PAK4 in complex with Inka | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein FAM212A,Serine/threonine-protein kinase PAK 4 | Authors: | Baskaran, Y, Ang, K.C, Anekal, P.V, Chan, W.L, Grimes, J.M, Manser, E, Robinson, R.C. | Deposit date: | 2014-12-17 | Release date: | 2015-12-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 Nat Commun, 6, 2015
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7PFG
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7PF9
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![BU of 7pf9 by Molmil](/molmil-images/mine/7pf9) | SynFtn Variant E141D | Descriptor: | CHLORIDE ION, Ferritin, SODIUM ION | Authors: | Hemmings, A.M, Bradley, J.M. | Deposit date: | 2021-08-11 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Key carboxylate residues for iron transit through the prokaryotic ferritin Syn Ftn. Microbiology (Reading, Engl.), 167, 2021
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4XDS
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![BU of 4xds by Molmil](/molmil-images/mine/4xds) | Deoxyguanosinetriphosphate Triphosphohydrolase from Escherichia coli with Nickel | Descriptor: | Deoxyguanosinetriphosphate triphosphohydrolase, NICKEL (II) ION, SULFATE ION | Authors: | Singh, D, Gawel, D, Itsko, M, Krahn, J.M, London, R.E, Schaaper, R.M. | Deposit date: | 2014-12-19 | Release date: | 2015-02-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.354 Å) | Cite: | Structure of Escherichia coli dGTP Triphosphohydrolase: A HEXAMERIC ENZYME WITH DNA EFFECTOR MOLECULES. J.Biol.Chem., 290, 2015
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7PIM
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![BU of 7pim by Molmil](/molmil-images/mine/7pim) | Partial structure of tyrosine hydroxylase lacking the first 35 residues in complex with dopamine. | Descriptor: | FE (III) ION, L-DOPAMINE, Regulatory domain alpha-helix, ... | Authors: | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. | Deposit date: | 2021-08-20 | Release date: | 2021-12-22 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
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6AY5
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![BU of 6ay5 by Molmil](/molmil-images/mine/6ay5) | CREBBP bromodomain in complex with Cpd17 (5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-3-methylbenzo[d]thiazol-2(3H)-one) | Descriptor: | 5-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-3-methyl-1,3-benzothiazol-2(3H)-one, CREB-binding protein, DIMETHYL SULFOXIDE, ... | Authors: | Murray, J.M. | Deposit date: | 2017-09-07 | Release date: | 2018-02-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors. J. Med. Chem., 60, 2017
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7JY2
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![BU of 7jy2 by Molmil](/molmil-images/mine/7jy2) | Z-DNA joint X-ray/Neutron | Descriptor: | Chains: A,B | Authors: | Harp, J.M, Coates, L, Egli, M. | Deposit date: | 2020-08-28 | Release date: | 2021-04-28 | Last modified: | 2024-04-03 | Method: | NEUTRON DIFFRACTION (1.5 Å), X-RAY DIFFRACTION | Cite: | Water structure around a left-handed Z-DNA fragment analyzed by cryo neutron crystallography. Nucleic Acids Res., 49, 2021
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6PR4
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![BU of 6pr4 by Molmil](/molmil-images/mine/6pr4) | D262N/S128A S. typhimurium siroheme synthase | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, Siroheme synthase | Authors: | Pennington, J.M, Stroupe, M.E. | Deposit date: | 2019-07-10 | Release date: | 2020-02-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site. Nat Commun, 11, 2020
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5KBW
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4XY3
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![BU of 4xy3 by Molmil](/molmil-images/mine/4xy3) | Structure of ESX-1 secreted protein EspB | Descriptor: | ESX-1 secretion-associated protein EspB | Authors: | Wagner, J.M, Korotkov, K.V. | Deposit date: | 2015-02-01 | Release date: | 2015-02-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.04 Å) | Cite: | Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis. J.Struct.Biol., 191, 2015
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7PRG
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![BU of 7prg by Molmil](/molmil-images/mine/7prg) | Joint X-ray/neutron room temperature structure of perdeuterated LecB lectin in complex with perdeuterated fucose | Descriptor: | CALCIUM ION, Fucose-binding lectin, SULFATE ION, ... | Authors: | Gajdos, L, Blakeley, M.P, Haertlein, M, Forsyth, T.V, Devos, J.M, Imberty, A. | Deposit date: | 2021-09-21 | Release date: | 2022-01-12 | Last modified: | 2024-05-01 | Method: | NEUTRON DIFFRACTION (1.85 Å), X-RAY DIFFRACTION | Cite: | Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding. Nat Commun, 13, 2022
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7PSY
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![BU of 7psy by Molmil](/molmil-images/mine/7psy) | X-ray crystal structure of perdeuterated LecB lectin in complex with perdeuterated fucose | Descriptor: | CALCIUM ION, Fucose-binding lectin, SULFATE ION, ... | Authors: | Gajdos, L, Blakeley, M.P, Haertlein, M, Forsyth, T.V, Devos, J.M, Imberty, A. | Deposit date: | 2021-09-24 | Release date: | 2022-01-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding. Nat Commun, 13, 2022
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4XTD
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![BU of 4xtd by Molmil](/molmil-images/mine/4xtd) | Structure of the covalent intermediate E-XMP* of the IMP dehydrogenase of Ashbya gossypii | Descriptor: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase | Authors: | Buey, R.M, Ledesma-Amaro, R, Balsera, M, de Pereda, J.M, Revuelta, J.L. | Deposit date: | 2015-01-23 | Release date: | 2015-07-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Increased riboflavin production by manipulation of inosine 5'-monophosphate dehydrogenase in Ashbya gossypii. Appl.Microbiol.Biotechnol., 99, 2015
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6P7C
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![BU of 6p7c by Molmil](/molmil-images/mine/6p7c) | D104A/S128A S. typhimurium siroheme synthase | Descriptor: | CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE, Siroheme synthase | Authors: | Pennington, J.M, Stroupe, M.E. | Deposit date: | 2019-06-05 | Release date: | 2020-02-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site. Nat Commun, 11, 2020
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7K44
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7EKB
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![BU of 7ekb by Molmil](/molmil-images/mine/7ekb) | Crystal structure of 4E10 modified with pyrene acetamide | Descriptor: | ACETATE ION, Fab region of the heavy chain of broadly neutralizing antibody anti-HIV-1 4E10, Fab region of the light chain of the broadly neutralizing anti-HIV-1 antibody 4E10, ... | Authors: | Caaveiro, J.M.M, Rujas, E, Nieva, J.L. | Deposit date: | 2021-04-05 | Release date: | 2021-08-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile. Iscience, 24, 2021
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