7UWS
 
 | | Atomic model of the partial VSV nucleocapsid | | Descriptor: | Matrix protein, Nucleoprotein, RNA | | Authors: | Zhou, K, Si, Z, Ge, P, Tsao, J, Luo, M, Zhou, Z.H. | | Deposit date: | 2022-05-03 | | Release date: | 2022-09-28 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Atomic model of vesicular stomatitis virus and mechanism of assembly.
Nat Commun, 13, 2022
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5K94
 | | Deletion-Insertion Chimera of MBP with the Preprotein Cross-Linking Domain of the SecA ATPase | | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Maltose-binding periplasmic protein,Protein translocase subunit SecA,Maltose-binding periplasmic protein | | Authors: | Shilton, B.H, Hackett, J, Ghonaim, N. | | Deposit date: | 2016-05-31 | | Release date: | 2017-06-07 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Characterization of a polypeptide-binding site in the DEAD Motor of the SecA ATPase.
FEBS Lett., 591, 2017
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8DZE
 | | Cryo-EM structure of bundle-forming pilus extension ATPase from E. coli in the presence of AMP-PNP (class-1) | | Descriptor: | BfpD, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ZINC ION | | Authors: | Nayak, A.R, Zhao, J, Donnenberg, M.S, Samso, M. | | Deposit date: | 2022-08-07 | | Release date: | 2022-10-26 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Cryo-EM Structure of the Type IV Pilus Extension ATPase from Enteropathogenic Escherichia coli.
Mbio, 13, 2022
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8TK3
 | | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) having oxidized catalytic cysteine and complexed with 6-(difluoromethyl)pyrimidin-4-ol at two allosteric sites | | Descriptor: | 6-(difluoromethyl)pyrimidin-4-ol, DIMETHYL SULFOXIDE, Dual specificity protein phosphatase 3 | | Authors: | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | | Deposit date: | 2023-07-25 | | Release date: | 2024-08-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) having oxidized catalytic cysteine and complexed with 6-(difluoromethyl)pyrimidin-4-ol at two allosteric sites
To Be Published
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5K2R
 | | Crystal structure of lysozyme | | Descriptor: | Lysozyme C | | Authors: | Ko, S, Choe, J. | | Deposit date: | 2016-05-19 | | Release date: | 2017-05-31 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of lysozyme with nano particles
To Be Published
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8DZG
 | | Cryo-EM structure of bundle-forming pilus extension ATPase from E.coli in the presence of ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BfpD, MAGNESIUM ION, ... | | Authors: | Nayak, A.R, Zhao, J, Donnenberg, M.S, Samso, M. | | Deposit date: | 2022-08-07 | | Release date: | 2022-10-26 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM Structure of the Type IV Pilus Extension ATPase from Enteropathogenic Escherichia coli.
Mbio, 13, 2022
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8TS1
 | | Cryo-EM structure of human MRS2 with Mg2+ | | Descriptor: | MAGNESIUM ION, Magnesium transporter MRS2 homolog, mitochondrial, ... | | Authors: | He, Z, Mount, J.W, Zhang, J, Yuan, P. | | Deposit date: | 2023-08-10 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Human mitochondrial MRS2 is a Ca2+-regulated nonselective cation channel
To Be Published
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5KBS
 | | Cryo-EM structure of GluA2-0xSTZ at 8.7 Angstrom resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | | Authors: | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | | Deposit date: | 2016-06-03 | | Release date: | 2016-07-13 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (8.7 Å) | | Cite: | Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy.
Science, 353, 2016
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8TSM
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7UAW
 | | Structure of Clostridium botulinum prophage Tad1 in complex with 1''-2' gcADPR | | Descriptor: | (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, ABC transporter ATPase | | Authors: | Lu, A, Leavitt, A, Yirmiya, E, Amitai, G, Garb, J, Morehouse, B.R, Hobbs, S.J, Sorek, R, Kranzusch, P.J. | | Deposit date: | 2022-03-14 | | Release date: | 2022-10-05 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Viruses inhibit TIR gcADPR signalling to overcome bacterial defence.
Nature, 611, 2022
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1LUD
 | | SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES | | Descriptor: | 2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM, DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Polshakov, V.I, Smirnov, E.G, Birdsall, B, Kelly, G, Feeney, J. | | Deposit date: | 2002-05-22 | | Release date: | 2002-12-18 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | NMR-based solution structure of the complex of Lactobacillus casei dihydrofolate reductase with trimethoprim and NADPH
J.Biomol.Nmr, 24, 2002
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7UW6
 | | The co-crystal structure of low molecular weight protein tyrosine phosphatase (LMW-PTP) with a small molecule inhibitor SPAA-2 | | Descriptor: | 2-[(1,3-benzothiazol-2-yl)amino]-2-oxoethane-1-sulfonic acid, Low molecular weight phosphotyrosine protein phosphatase | | Authors: | Wang, J, Zhang, Z.Y. | | Deposit date: | 2022-05-02 | | Release date: | 2022-10-19 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.
J.Med.Chem., 65, 2022
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1LJR
 | | GLUTATHIONE TRANSFERASE (HGST T2-2) FROM HUMAN | | Descriptor: | GLUTATHIONE, GLUTATHIONE S-TRANSFERASE | | Authors: | Rossjohn, J, Mckinstry, W.J, Oakley, A.J, Verger, D, Flanagan, J, Chelvanayagam, G, Tan, K.L, Board, P.G, Parker, M.W. | | Deposit date: | 1998-03-08 | | Release date: | 1999-03-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site.
Structure, 6, 1998
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8JZZ
 | | Structure of human C5a-desArg bound human C5aR1 in complex with Go | | Descriptor: | Antibody fragment ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... | | Authors: | Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. | | Deposit date: | 2023-07-06 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-08 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
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5JQB
 | | Crystal structure of Ebola glycoprotein in complex with ibuprofen | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein 1,Envelope glycoprotein 1,Envelope glycoprotein 1, Envelope glycoprotein 2, ... | | Authors: | Zhao, Y, Ren, J, Stuart, D.I. | | Deposit date: | 2016-05-04 | | Release date: | 2016-06-29 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Toremifene interacts with and destabilizes the Ebola virus glycoprotein.
Nature, 535, 2016
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8TXQ
 | | CryoEM structure of non-neutralizing antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2 | | Descriptor: | CBH-4B Heavy chain, CBH-4B Light chain, envelope glycoprotein E2 | | Authors: | Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A. | | Deposit date: | 2023-08-24 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | CryoEM structure of non-neutralizing antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2
To Be Published
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8TK6
 | | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) in apo form | | Descriptor: | Dual specificity protein phosphatase 3 | | Authors: | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | | Deposit date: | 2023-07-25 | | Release date: | 2024-08-14 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock
To Be Published
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5UNN
 | | Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase SMc02828 (SmGhrA) from Sinorhizobium meliloti in apo form | | Descriptor: | CHLORIDE ION, GLYCEROL, NADPH-dependent glyoxylate/hydroxypyruvate reductase | | Authors: | Shabalin, I.G, LaRowe, C, Kutner, J, Gasiorowska, O.A, Handing, K.B, Bonanno, J, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2017-01-31 | | Release date: | 2017-02-22 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies.
Biochemistry, 57, 2018
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1L8L
 | | Molecular basis for the local confomational rearrangement of human phosphoserine phosphatase | | Descriptor: | D-2-AMINO-3-PHOSPHONO-PROPIONIC ACID, L-3-phosphoserine phosphatase | | Authors: | Kim, H.Y, Heo, Y.S, Kim, J.H, Park, M.H, Moon, J, Park, S.Y, Lee, T.G, Jeon, Y.H, Ro, S, Hwang, K.Y. | | Deposit date: | 2002-03-21 | | Release date: | 2003-04-01 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase.
J.Biol.Chem., 277, 2002
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5JR5
 | | RHCC in Complex with Elemental Sulfur | | Descriptor: | SULFATE ION, Tetrabrachion, octathiocane | | Authors: | McDougall, M, Meier, M, Stetefeld, J. | | Deposit date: | 2016-05-05 | | Release date: | 2017-05-10 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Archaea S-layer nanotube from a "black smoker" in complex with cyclo-octasulfur (S8 ) rings.
Proteins, 85, 2017
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8TK4
 | | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate | | Descriptor: | Dual specificity protein phosphatase 3, PHOSPHATE ION | | Authors: | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | | Deposit date: | 2023-07-25 | | Release date: | 2024-08-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate
To Be Published
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8TON
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8TS3
 | | Cryo-EM structure of human MRS2 with Ca2+ | | Descriptor: | CALCIUM ION, Magnesium transporter MRS2 homolog, mitochondrial, ... | | Authors: | He, Z, Mount, J.W, Zhang, J, Yuan, P. | | Deposit date: | 2023-08-10 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Human mitochondrial MRS2 is a Ca2+-regulated nonselective cation channel
To Be Published
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7V2Y
 | | cryo-EM structure of yeast THO complex with Sub2 | | Descriptor: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2, ... | | Authors: | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | | Deposit date: | 2021-08-10 | | Release date: | 2022-07-27 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex.
Sci Bull (Beijing), 66, 2021
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8TK5
 | | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with HEPES | | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | | Deposit date: | 2023-07-25 | | Release date: | 2024-08-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock
To Be Published
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