7COB
 
 | | Ternary complex of DNA polymerase Mu (Q441A) with 1-nt gapped DNA (T:dGMPNPP) | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*GP*GP*CP*TP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ... | | Authors: | Guo, M, Zhao, Y. | | Deposit date: | 2020-08-04 | | Release date: | 2021-06-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.797 Å) | | Cite: | Mechanism of genome instability mediated by human DNA polymerase mu misincorporation.
Nat Commun, 12, 2021
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7CO6
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7CO9
 | | Ternary complex of DNA polymerase Mu with 1-nt gapped DNA (T:dGMPNPP) and Mg | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*GP*GP*CP*TP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ... | | Authors: | Guo, M, Zhao, Y. | | Deposit date: | 2020-08-04 | | Release date: | 2021-06-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.599 Å) | | Cite: | Mechanism of genome instability mediated by human DNA polymerase mu misincorporation.
Nat Commun, 12, 2021
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7CO8
 | | Ternary complex of DNA polymerase Mu with 2-nt gapped DNA (T:dGMPNPP) | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*GP*GP*CP*TP*TP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ... | | Authors: | Guo, M, Zhao, Y. | | Deposit date: | 2020-08-04 | | Release date: | 2021-06-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.697 Å) | | Cite: | Mechanism of genome instability mediated by human DNA polymerase mu misincorporation.
Nat Commun, 12, 2021
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7COD
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7COA
 | | Ternary complex of DNA polymerase Mu with 1-nt gapped DNA (T:dGMPNPP) and Mn | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*GP*GP*CP*TP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ... | | Authors: | Guo, M, Zhao, Y. | | Deposit date: | 2020-08-04 | | Release date: | 2021-06-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.698 Å) | | Cite: | Mechanism of genome instability mediated by human DNA polymerase mu misincorporation.
Nat Commun, 12, 2021
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5X07
 | | Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site | | Descriptor: | DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Hepatocyte nuclear factor 3-beta | | Authors: | Li, J, Guo, M, Zhou, Z, Jiang, L, Chen, X, Qu, L, Wu, D, Chen, Z, Chen, L, Chen, Y. | | Deposit date: | 2017-01-20 | | Release date: | 2017-08-16 | | Last modified: | 2017-09-27 | | Method: | X-RAY DIFFRACTION (2.796 Å) | | Cite: | Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site
Biochemistry, 56, 2017
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4P3O
 | | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 2 | | Descriptor: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, GLYCEROL, Threonine--tRNA ligase, ... | | Authors: | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | | Deposit date: | 2014-03-09 | | Release date: | 2015-03-11 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.505 Å) | | Cite: | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
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4P3P
 | | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 3 | | Descriptor: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, GLYCEROL, Threonine--tRNA ligase, ... | | Authors: | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | | Deposit date: | 2014-03-09 | | Release date: | 2015-03-11 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
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4P3N
 | | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 1 | | Descriptor: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, Threonine--tRNA ligase, cytoplasmic, ... | | Authors: | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | | Deposit date: | 2014-03-09 | | Release date: | 2015-03-11 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
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3UV9
 | | Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain | | Descriptor: | Tripartite motif-containing protein 5 | | Authors: | Biris, N, Yang, Y, Taylor, A.B, Tomashevskii, A, Guo, M, Hart, P.J, Diaz-Griffero, F, Ivanov, D. | | Deposit date: | 2011-11-29 | | Release date: | 2012-08-08 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.549 Å) | | Cite: | Structure of the rhesus monkey TRIM5alpha PRYSPRY domain, the HIV capsid recognition module.
Proc.Natl.Acad.Sci.USA, 109, 2012
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8Y6V
 | | Near-atomic structure of icosahedrally averaged jumbo bacteriophage PhiKZ capsid | | Descriptor: | gp119, gp120, gp162, ... | | Authors: | Yang, Y, Shao, Q, Guo, M, Han, L, Zhao, X, Wang, A, Li, X, Wang, B, Pan, J, Chen, Z, Fokine, A, Sun, L, Fang, Q. | | Deposit date: | 2024-02-03 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Capsid structure of bacteriophage Phi KZ provides insights into assembly and stabilization of jumbo phages.
Nat Commun, 15, 2024
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1O7T
 | | Metal nanoclusters bound to the Ferric Binding Protein from Neisseria gonorrhoeae. | | Descriptor: | HF OXO CLUSTER HF5, HF-OXO-PHOSPHATE CLUSTER PHF, IRON BINDING PROTEIN, ... | | Authors: | Alexeev, D, Zu, H, Guo, M, Zhong, W, Hunter, D.J.B, Yang, W, Campopiano, D.J, Sadler, P.J. | | Deposit date: | 2002-11-12 | | Release date: | 2003-02-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | A novel protein-mineral interface.
Nat. Struct. Biol., 10, 2003
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1W24
 | | Crystal Structure Of human Vps29 | | Descriptor: | VACUOLAR PROTEIN SORTING PROTEIN 29 | | Authors: | Wang, D, Guo, M, Teng, M, Niu, L. | | Deposit date: | 2004-06-26 | | Release date: | 2005-03-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of Human Vacuolar Protein Sorting Protein 29 Reveals a Phosphodiesterase/Nuclease-Like Fold and Two Protein-Protein Interaction Sites.
J.Biol.Chem., 280, 2005
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4ZW1
 | | Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer | | Descriptor: | 1,2-ETHANEDIOL, 2-(4-hydroxy-3,5-dimethylphenyl)-7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one, Bromodomain-containing protein 4 | | Authors: | Liu, B, Zhang, S, Guo, M, Tian, M. | | Deposit date: | 2015-05-19 | | Release date: | 2016-06-22 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer
To Be Published
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2LM3
 | | Structure of the rhesus monkey TRIM5alpha PRYSPRY domain | | Descriptor: | Tripartite motif-containing protein 5 | | Authors: | Biris, N, Yang, Y, Taylor, A.B, Tomashevski, A, Guo, M, Hart, P.J, Diaz-Griffero, F, Ivanov, D.N. | | Deposit date: | 2011-11-21 | | Release date: | 2012-08-08 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structure of the rhesus monkey TRIM5alpha PRYSPRY domain, the HIV capsid recognition module.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1XX5
 | | Crystal Structure of Natrin from Naja atra snake venom | | Descriptor: | ETHANOL, Natrin 1 | | Authors: | Wang, J, Shen, B, Lou, X.H, Guo, M, Teng, M.K, Niu, L.W. | | Deposit date: | 2004-11-04 | | Release date: | 2005-06-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from Naja atra venom that targets the BKCa channel
Biochemistry, 44, 2005
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5ED6
 | | crystal structure of human Hint1 H114A mutant complexing with ATP | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1 | | Authors: | Wang, J, Fang, P, Guo, M. | | Deposit date: | 2015-10-20 | | Release date: | 2017-01-25 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells.
Nat Commun, 10, 2019
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1ZVF
 | | The crystal structure of 3-hydroxyanthranilate 3,4-dioxygenase from Saccharomyces cerevisiae | | Descriptor: | 3-hydroxyanthranilate 3,4-dioxygenase, NICKEL (II) ION | | Authors: | Li, X, Guo, M, Teng, M, Niu, L. | | Deposit date: | 2005-06-02 | | Release date: | 2006-06-02 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | The crystal structure of 3-hydroxyanthranilate 3,4-dioxygenase from Saccharomyces cerevisiae
To be published
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2EXU
 | | Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ETHANOL, Transcription initiation protein SPT4/SPT5, ... | | Authors: | Xu, F, Guo, M, Fang, P, Teng, M, Niu, L. | | Deposit date: | 2005-11-08 | | Release date: | 2006-11-08 | | Last modified: | 2017-08-23 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain
To be published
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4YCV
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4YCW
 | | Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant | | Descriptor: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, Lysine--tRNA ligase, ... | | Authors: | Fang, P, Wang, J, Guo, M. | | Deposit date: | 2015-02-20 | | Release date: | 2015-06-10 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Basis for Specific Inhibition of tRNA Synthetase by ATP Competitive Inhibitor
Chem.Biol., 22, 2015
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4YCU
 | | Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase | | Descriptor: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, GLYCEROL, LYSINE, ... | | Authors: | Fang, P, Wang, J, Guo, M. | | Deposit date: | 2015-02-20 | | Release date: | 2015-06-10 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.
Chem. Biol., 22, 2015
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4DPG
 | | Crystal Structure of Human LysRS: P38/AIMP2 Complex I | | Descriptor: | ALANINE, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | | Authors: | Fang, P, Wang, J, Bennett, S.P, Guo, M. | | Deposit date: | 2012-02-13 | | Release date: | 2013-02-13 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.844 Å) | | Cite: | Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription.
Mol.Cell, 49, 2013
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4DKT
 | | Crystal structure of human peptidylarginine deiminase 4 in complex with N-acetyl-L-threonyl-L-alpha-aspartyl-N5-[(1E)-2-fluoroethanimidoyl]-L-ornithinamide | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Protein-arginine deiminase type-4, ... | | Authors: | Jones, J.E, Slack, J.L, Fang, P, Zhang, X, Subramanian, V, Causey, C.P, Coonrod, S.A, Guo, M, Thompson, P.R. | | Deposit date: | 2012-02-04 | | Release date: | 2012-02-29 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Synthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective Inhibitors.
Acs Chem.Biol., 7, 2012
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