9FSE
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![BU of 9fse by Molmil](/molmil-images/mine/9fse) | Human ROR2 cysteine-rich domain (CRD) and Kringle domain | Descriptor: | SULFATE ION, Tyrosine-protein kinase transmembrane receptor ROR2 | Authors: | Griffiths, S.C, Tan, J, Wagner, A, Blazer, L.L, Adams, J.J, Srinivasan, S, Moghisaei, S, Sidhu, S.S, Siebold, C, Ho, H.H. | Deposit date: | 2024-06-20 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling. Elife, 13, 2024
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6S5W
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![BU of 6s5w by Molmil](/molmil-images/mine/6s5w) | Structure of Rib domain 'Rib Long' from Lactobacillus acidophilus | Descriptor: | SODIUM ION, SULFATE ION, Surface protein | Authors: | Griffiths, S.C, Cooper, R.E.M, Whelan, F, Whittingham, J.L, Bateman, A, Potts, J.R. | Deposit date: | 2019-07-02 | Release date: | 2019-12-11 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection. Proc.Natl.Acad.Sci.USA, 116, 2019
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7PGM
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![BU of 7pgm by Molmil](/molmil-images/mine/7pgm) | HHIP-C in complex with heparin | Descriptor: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-3)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hedgehog-interacting protein | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGK
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![BU of 7pgk by Molmil](/molmil-images/mine/7pgk) | HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with glycosaminoglycan mimic SOS | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Hedgehog-interacting protein | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2021-12-22 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGL
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![BU of 7pgl by Molmil](/molmil-images/mine/7pgl) | HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), apo-form | Descriptor: | Hedgehog-interacting protein | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGN
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![BU of 7pgn by Molmil](/molmil-images/mine/7pgn) | HHP-C in complex with glycosaminoglycan mimic SOS | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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1JG1
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![BU of 1jg1 by Molmil](/molmil-images/mine/1jg1) | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with S-ADENOSYL-L-HOMOCYSTEINE | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, protein-L-isoaspartate O-methyltransferase | Authors: | Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O. | Deposit date: | 2001-06-22 | Release date: | 2001-11-16 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate. J.Mol.Biol., 313, 2001
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1JG4
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![BU of 1jg4 by Molmil](/molmil-images/mine/1jg4) | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with S-adenosylmethionine | Descriptor: | S-ADENOSYLMETHIONINE, protein-L-isoaspartate O-methyltransferase | Authors: | Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O. | Deposit date: | 2001-06-22 | Release date: | 2001-11-16 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate. J.Mol.Biol., 313, 2001
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1JG3
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![BU of 1jg3 by Molmil](/molmil-images/mine/1jg3) | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine & VYP(ISP)HA substrate | Descriptor: | ADENOSINE, CHLORIDE ION, SODIUM ION, ... | Authors: | Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O. | Deposit date: | 2001-06-22 | Release date: | 2001-11-16 | Last modified: | 2011-07-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate. J.Mol.Biol., 313, 2001
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1JG2
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![BU of 1jg2 by Molmil](/molmil-images/mine/1jg2) | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine | Descriptor: | ADENOSINE, SODIUM ION, protein-L-isoaspartate O-methyltransferase | Authors: | Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O. | Deposit date: | 2001-06-22 | Release date: | 2001-11-16 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate. J.Mol.Biol., 313, 2001
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7NDG
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![BU of 7ndg by Molmil](/molmil-images/mine/7ndg) | Cryo-EM structure of the ternary complex between Netrin-1, Neogenin and Repulsive Guidance Molecule B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neogenin, ... | Authors: | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2021-02-01 | Release date: | 2021-03-31 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (5.98 Å) | Cite: | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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7NE1
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![BU of 7ne1 by Molmil](/molmil-images/mine/7ne1) | Structure of the complex between Netrin-1 and its receptor Neogenin | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2021-02-02 | Release date: | 2021-03-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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7NE0
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![BU of 7ne0 by Molmil](/molmil-images/mine/7ne0) | Structure of the ternary complex between Netrin-1, Repulsive-Guidance Molecule-B (RGMB) and Neogenin | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2021-02-02 | Release date: | 2021-03-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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8PE9
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![BU of 8pe9 by Molmil](/molmil-images/mine/8pe9) | Complex between DDR1 DS-like domain and PRTH-101 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Liu, J, Chiang, H, Xiong, W, Laurent, V, Griffiths, S.C, Duelfer, J, Deng, H, Sun, X, Yin, Y.W, Li, W, Audoly, L.P, An, Z, Schuerpf, T, Li, R, Zhang, N. | Deposit date: | 2023-06-13 | Release date: | 2023-06-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.152 Å) | Cite: | A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer. J Immunother Cancer, 11, 2023
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3E1S
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![BU of 3e1s by Molmil](/molmil-images/mine/3e1s) | Structure of an N-terminal truncation of Deinococcus radiodurans RecD2 | Descriptor: | Exodeoxyribonuclease V, subunit RecD | Authors: | Saikrishnan, K, Griffiths, S.P, Cook, N, Court, R, Wigley, D.B. | Deposit date: | 2008-08-04 | Release date: | 2008-08-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | DNA binding to RecD: role of the 1B domain in SF1B helicase activity. Embo J., 27, 2008
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4XP7
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![BU of 4xp7 by Molmil](/molmil-images/mine/4xp7) | Crystal structure of Human tRNA dihydrouridine synthase 2 | Descriptor: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like | Authors: | Whelan, F, Jenkins, H.T, Griffiths, S, Byrne, R.T, Dodson, E.J, Antson, A.A. | Deposit date: | 2015-01-16 | Release date: | 2015-01-28 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | From bacterial to human dihydrouridine synthase: automated structure determination. Acta Crystallogr.,Sect.D, 71, 2015
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6S5Z
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![BU of 6s5z by Molmil](/molmil-images/mine/6s5z) | Structure of Rib R28N from Streptococcus pyogenes | Descriptor: | SODIUM ION, Surface protein R28 | Authors: | Whelan, F, Griffiths, S.C, Whittingham, J.L, Bateman, A, Potts, J.R. | Deposit date: | 2019-07-02 | Release date: | 2019-12-11 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection. Proc.Natl.Acad.Sci.USA, 116, 2019
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6S5X
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![BU of 6s5x by Molmil](/molmil-images/mine/6s5x) | Structure of RibR, the most N-terminal Rib domain from Group B Streptococcus species Streptococcus agalactiae | Descriptor: | Group B streptococcal R4 surface protein, SODIUM ION | Authors: | Whelan, F, Turkenburg, J.P, Griffiths, S.C, Bateman, A, Potts, J.R. | Deposit date: | 2019-07-02 | Release date: | 2019-12-11 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection. Proc.Natl.Acad.Sci.USA, 116, 2019
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6S5Y
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![BU of 6s5y by Molmil](/molmil-images/mine/6s5y) | |
6SX1
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![BU of 6sx1 by Molmil](/molmil-images/mine/6sx1) | Structure of Rib Standard, a Rib domain from Lactobacillus acidophilus | Descriptor: | Surface protein | Authors: | Cooper, R.E.M, Griffiths, S.C, Turkenburg, J.P, Bateman, A, Potts, J.R. | Deposit date: | 2019-09-24 | Release date: | 2019-12-18 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection. Proc.Natl.Acad.Sci.USA, 116, 2019
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8BWD
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![BU of 8bwd by Molmil](/molmil-images/mine/8bwd) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1), crystal form 1 | Descriptor: | SULFATE ION, Twisted gastrulation protein homolog 1 | Authors: | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | Deposit date: | 2022-12-06 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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8BWI
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![BU of 8bwi by Molmil](/molmil-images/mine/8bwi) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1), crystal form 2 | Descriptor: | Twisted gastrulation protein homolog 1 | Authors: | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | Deposit date: | 2022-12-06 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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8BWA
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![BU of 8bwa by Molmil](/molmil-images/mine/8bwa) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with platinum | Descriptor: | PLATINUM (II) ION, Twisted gastrulation protein homolog 1 | Authors: | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | Deposit date: | 2022-12-06 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (3.61 Å) | Cite: | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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8BWL
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![BU of 8bwl by Molmil](/molmil-images/mine/8bwl) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium | Descriptor: | CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1 | Authors: | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | Deposit date: | 2022-12-06 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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8BWM
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![BU of 8bwm by Molmil](/molmil-images/mine/8bwm) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium, long-wavelength X-ray dataset (4042 eV) | Descriptor: | CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1 | Authors: | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | Deposit date: | 2022-12-07 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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