9FSE
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![BU of 9fse by Molmil](/molmil-images/mine/9fse) | Human ROR2 cysteine-rich domain (CRD) and Kringle domain | 分子名称: | SULFATE ION, Tyrosine-protein kinase transmembrane receptor ROR2 | 著者 | Griffiths, S.C, Tan, J, Wagner, A, Blazer, L.L, Adams, J.J, Srinivasan, S, Moghisaei, S, Sidhu, S.S, Siebold, C, Ho, H.H. | 登録日 | 2024-06-20 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling. Elife, 13, 2024
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6S5W
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![BU of 6s5w by Molmil](/molmil-images/mine/6s5w) | Structure of Rib domain 'Rib Long' from Lactobacillus acidophilus | 分子名称: | SODIUM ION, SULFATE ION, Surface protein | 著者 | Griffiths, S.C, Cooper, R.E.M, Whelan, F, Whittingham, J.L, Bateman, A, Potts, J.R. | 登録日 | 2019-07-02 | 公開日 | 2019-12-11 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.07 Å) | 主引用文献 | Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection. Proc.Natl.Acad.Sci.USA, 116, 2019
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7PGM
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![BU of 7pgm by Molmil](/molmil-images/mine/7pgm) | HHIP-C in complex with heparin | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-3)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hedgehog-interacting protein | 著者 | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | 登録日 | 2021-08-14 | 公開日 | 2021-12-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGK
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![BU of 7pgk by Molmil](/molmil-images/mine/7pgk) | HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with glycosaminoglycan mimic SOS | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Hedgehog-interacting protein | 著者 | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | 登録日 | 2021-08-14 | 公開日 | 2021-12-15 | 最終更新日 | 2021-12-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGL
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![BU of 7pgl by Molmil](/molmil-images/mine/7pgl) | HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), apo-form | 分子名称: | Hedgehog-interacting protein | 著者 | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | 登録日 | 2021-08-14 | 公開日 | 2021-12-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGN
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![BU of 7pgn by Molmil](/molmil-images/mine/7pgn) | HHP-C in complex with glycosaminoglycan mimic SOS | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | 著者 | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | 登録日 | 2021-08-14 | 公開日 | 2021-12-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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1JG1
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![BU of 1jg1 by Molmil](/molmil-images/mine/1jg1) | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with S-ADENOSYL-L-HOMOCYSTEINE | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, protein-L-isoaspartate O-methyltransferase | 著者 | Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O. | 登録日 | 2001-06-22 | 公開日 | 2001-11-16 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate. J.Mol.Biol., 313, 2001
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1JG4
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![BU of 1jg4 by Molmil](/molmil-images/mine/1jg4) | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with S-adenosylmethionine | 分子名称: | S-ADENOSYLMETHIONINE, protein-L-isoaspartate O-methyltransferase | 著者 | Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O. | 登録日 | 2001-06-22 | 公開日 | 2001-11-16 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate. J.Mol.Biol., 313, 2001
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1JG3
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![BU of 1jg3 by Molmil](/molmil-images/mine/1jg3) | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine & VYP(ISP)HA substrate | 分子名称: | ADENOSINE, CHLORIDE ION, SODIUM ION, ... | 著者 | Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O. | 登録日 | 2001-06-22 | 公開日 | 2001-11-16 | 最終更新日 | 2011-07-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate. J.Mol.Biol., 313, 2001
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1JG2
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![BU of 1jg2 by Molmil](/molmil-images/mine/1jg2) | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine | 分子名称: | ADENOSINE, SODIUM ION, protein-L-isoaspartate O-methyltransferase | 著者 | Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O. | 登録日 | 2001-06-22 | 公開日 | 2001-11-16 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate. J.Mol.Biol., 313, 2001
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7NDG
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![BU of 7ndg by Molmil](/molmil-images/mine/7ndg) | Cryo-EM structure of the ternary complex between Netrin-1, Neogenin and Repulsive Guidance Molecule B | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neogenin, ... | 著者 | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | 登録日 | 2021-02-01 | 公開日 | 2021-03-31 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (5.98 Å) | 主引用文献 | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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7NE1
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![BU of 7ne1 by Molmil](/molmil-images/mine/7ne1) | Structure of the complex between Netrin-1 and its receptor Neogenin | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | 登録日 | 2021-02-02 | 公開日 | 2021-03-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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7NE0
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![BU of 7ne0 by Molmil](/molmil-images/mine/7ne0) | Structure of the ternary complex between Netrin-1, Repulsive-Guidance Molecule-B (RGMB) and Neogenin | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | 登録日 | 2021-02-02 | 公開日 | 2021-03-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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8PE9
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![BU of 8pe9 by Molmil](/molmil-images/mine/8pe9) | Complex between DDR1 DS-like domain and PRTH-101 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Liu, J, Chiang, H, Xiong, W, Laurent, V, Griffiths, S.C, Duelfer, J, Deng, H, Sun, X, Yin, Y.W, Li, W, Audoly, L.P, An, Z, Schuerpf, T, Li, R, Zhang, N. | 登録日 | 2023-06-13 | 公開日 | 2023-06-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.152 Å) | 主引用文献 | A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer. J Immunother Cancer, 11, 2023
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3E1S
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![BU of 3e1s by Molmil](/molmil-images/mine/3e1s) | Structure of an N-terminal truncation of Deinococcus radiodurans RecD2 | 分子名称: | Exodeoxyribonuclease V, subunit RecD | 著者 | Saikrishnan, K, Griffiths, S.P, Cook, N, Court, R, Wigley, D.B. | 登録日 | 2008-08-04 | 公開日 | 2008-08-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | DNA binding to RecD: role of the 1B domain in SF1B helicase activity. Embo J., 27, 2008
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4XP7
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![BU of 4xp7 by Molmil](/molmil-images/mine/4xp7) | Crystal structure of Human tRNA dihydrouridine synthase 2 | 分子名称: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like | 著者 | Whelan, F, Jenkins, H.T, Griffiths, S, Byrne, R.T, Dodson, E.J, Antson, A.A. | 登録日 | 2015-01-16 | 公開日 | 2015-01-28 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | From bacterial to human dihydrouridine synthase: automated structure determination. Acta Crystallogr.,Sect.D, 71, 2015
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6S5Z
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![BU of 6s5z by Molmil](/molmil-images/mine/6s5z) | Structure of Rib R28N from Streptococcus pyogenes | 分子名称: | SODIUM ION, Surface protein R28 | 著者 | Whelan, F, Griffiths, S.C, Whittingham, J.L, Bateman, A, Potts, J.R. | 登録日 | 2019-07-02 | 公開日 | 2019-12-11 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection. Proc.Natl.Acad.Sci.USA, 116, 2019
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6S5X
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![BU of 6s5x by Molmil](/molmil-images/mine/6s5x) | Structure of RibR, the most N-terminal Rib domain from Group B Streptococcus species Streptococcus agalactiae | 分子名称: | Group B streptococcal R4 surface protein, SODIUM ION | 著者 | Whelan, F, Turkenburg, J.P, Griffiths, S.C, Bateman, A, Potts, J.R. | 登録日 | 2019-07-02 | 公開日 | 2019-12-11 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection. Proc.Natl.Acad.Sci.USA, 116, 2019
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6S5Y
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![BU of 6s5y by Molmil](/molmil-images/mine/6s5y) | |
6SX1
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![BU of 6sx1 by Molmil](/molmil-images/mine/6sx1) | Structure of Rib Standard, a Rib domain from Lactobacillus acidophilus | 分子名称: | Surface protein | 著者 | Cooper, R.E.M, Griffiths, S.C, Turkenburg, J.P, Bateman, A, Potts, J.R. | 登録日 | 2019-09-24 | 公開日 | 2019-12-18 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection. Proc.Natl.Acad.Sci.USA, 116, 2019
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8BWD
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![BU of 8bwd by Molmil](/molmil-images/mine/8bwd) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1), crystal form 1 | 分子名称: | SULFATE ION, Twisted gastrulation protein homolog 1 | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | 登録日 | 2022-12-06 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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8BWI
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![BU of 8bwi by Molmil](/molmil-images/mine/8bwi) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1), crystal form 2 | 分子名称: | Twisted gastrulation protein homolog 1 | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | 登録日 | 2022-12-06 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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8BWA
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![BU of 8bwa by Molmil](/molmil-images/mine/8bwa) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with platinum | 分子名称: | PLATINUM (II) ION, Twisted gastrulation protein homolog 1 | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | 登録日 | 2022-12-06 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (3.61 Å) | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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8BWL
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![BU of 8bwl by Molmil](/molmil-images/mine/8bwl) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium | 分子名称: | CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1 | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | 登録日 | 2022-12-06 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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8BWM
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![BU of 8bwm by Molmil](/molmil-images/mine/8bwm) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium, long-wavelength X-ray dataset (4042 eV) | 分子名称: | CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1 | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | 登録日 | 2022-12-07 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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