7FQE
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![BU of 7fqe by Molmil](/molmil-images/mine/7fqe) | DHFR:NADP+:FOL complex (crystal 2, pass 3, 295 K) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPR
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![BU of 7fpr by Molmil](/molmil-images/mine/7fpr) | DHFR:NADP+:FOL complex at 290 K (crystal 1) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-10 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQG
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![BU of 7fqg by Molmil](/molmil-images/mine/7fqg) | DHFR:NADP+:FOL complex (crystal 2, pass 5, 295 K) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPW
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![BU of 7fpw by Molmil](/molmil-images/mine/7fpw) | DHFR:NADP+:FOL complex at 290 K (multi-crystal) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-10 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPU
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![BU of 7fpu by Molmil](/molmil-images/mine/7fpu) | DHFR:NADP+:FOL complex at 290 K (crystal 4) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-10 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPT
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![BU of 7fpt by Molmil](/molmil-images/mine/7fpt) | DHFR:NADP+:FOL complex at 290 K (crystal 3) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-10 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPV
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![BU of 7fpv by Molmil](/molmil-images/mine/7fpv) | DHFR:NADP+:FOL complex at 290 K (crystal 5) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-10 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPX
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![BU of 7fpx by Molmil](/molmil-images/mine/7fpx) | DHFR:NADP+:FOL complex at 300 K (crystal 1) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-10 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ1
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![BU of 7fq1 by Molmil](/molmil-images/mine/7fq1) | DHFR:NADP+:FOL complex at 300 K (crystal 5) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-10 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPY
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![BU of 7fpy by Molmil](/molmil-images/mine/7fpy) | DHFR:NADP+:FOL complex at 300 K (crystal 2) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-10 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ6
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![BU of 7fq6 by Molmil](/molmil-images/mine/7fq6) | DHFR:NADP+:FOL complex at 310 K (multi-crystal) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPZ
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![BU of 7fpz by Molmil](/molmil-images/mine/7fpz) | DHFR:NADP+:FOL complex at 300 K (crystal 3) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-10 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQA
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![BU of 7fqa by Molmil](/molmil-images/mine/7fqa) | DHFR:NADP+:FOL complex (crystal 1, pass 4, 280 K) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ4
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![BU of 7fq4 by Molmil](/molmil-images/mine/7fq4) | DHFR:NADP+:FOL complex at 310 K (crystal 2) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQD
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![BU of 7fqd by Molmil](/molmil-images/mine/7fqd) | DHFR:NADP+:FOL complex (crystal 2, pass 2, 280 K) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ3
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![BU of 7fq3 by Molmil](/molmil-images/mine/7fq3) | DHFR:NADP+:FOL complex at 310 K (crystal 1) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPP
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![BU of 7fpp by Molmil](/molmil-images/mine/7fpp) | DHFR:NADP+:FOL complex at 280 K (crystal 5) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-09 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.03 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ7
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![BU of 7fq7 by Molmil](/molmil-images/mine/7fq7) | DHFR:NADP+:FOL complex (crystal 1, pass 1, 295 K) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ0
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![BU of 7fq0 by Molmil](/molmil-images/mine/7fq0) | DHFR:NADP+:FOL complex at 300 K (crystal 4) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-10 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ9
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![BU of 7fq9 by Molmil](/molmil-images/mine/7fq9) | DHFR:NADP+:FOL complex (crystal 1, pass 3, 295 K) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.11 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPQ
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![BU of 7fpq by Molmil](/molmil-images/mine/7fpq) | DHFR:NADP+:FOL complex at 280 K (multi-crystal) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-09 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.03 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQB
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![BU of 7fqb by Molmil](/molmil-images/mine/7fqb) | DHFR:NADP+:FOL complex (crystal 1, pass 5, 295 K) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPL
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![BU of 7fpl by Molmil](/molmil-images/mine/7fpl) | DHFR:NADP+:FOL complex at 280 K (crystal 1) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-09 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQC
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![BU of 7fqc by Molmil](/molmil-images/mine/7fqc) | DHFR:NADP+:FOL complex (crystal 2, pass 1, 295 K) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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9B7C
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![BU of 9b7c by Molmil](/molmil-images/mine/9b7c) | |