1RXK
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![BU of 1rxk by Molmil](/molmil-images/mine/1rxk) | crystal structure of streptavidin mutant (M3) a combination of M1+M2 | Descriptor: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Streptavidin | Authors: | Eisenberg-Domovich, Y, Pazy, Y, Nir, O, Raboy, B, Bayer, E.A, Wilchek, M, Livnah, O. | Deposit date: | 2003-12-18 | Release date: | 2004-05-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural elements responsible for conversion of streptavidin to a pseudoenzyme. Proc.Natl.Acad.Sci.USA, 101, 2004
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1RXH
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![BU of 1rxh by Molmil](/molmil-images/mine/1rxh) | Crystal structure of streptavidin mutant L124R (M1) complexed with biotinyl p-nitroanilide (BNI) | Descriptor: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Streptavidin | Authors: | Eisenberg-Domovich, Y, Pazy, Y, Nir, O, Raboy, B, Bayer, E.A, Wilchek, M, Livnah, O. | Deposit date: | 2003-12-18 | Release date: | 2004-05-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural elements responsible for conversion of streptavidin to a pseudoenzyme Proc.Natl.Acad.Sci.USA, 101, 2004
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1RXJ
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![BU of 1rxj by Molmil](/molmil-images/mine/1rxj) | Crystal structure of streptavidin mutant (M2) where the L3,4 loop was replace by that of avidin | Descriptor: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Streptavidin | Authors: | Eisenberg-Domovich, Y, Pazy, Y, Nir, O, Raboy, B, Bayer, E.A, Wilchek, M, Livnah, O. | Deposit date: | 2003-12-18 | Release date: | 2004-05-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Structural elements responsible for conversion of streptavidin to a pseudoenzyme Proc.Natl.Acad.Sci.USA, 101, 2004
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1Y53
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![BU of 1y53 by Molmil](/molmil-images/mine/1y53) | Crystal structure of bacterial expressed avidin related protein 4 (AVR4) C122S | Descriptor: | Avidin-related protein 4/5, FORMIC ACID | Authors: | Eisenberg-Domovich, Y, Hytonen, V.P, Wilchek, M, Bayer, E.A, Kulomaa, M.S, Livnah, O. | Deposit date: | 2004-12-02 | Release date: | 2005-05-24 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | High-resolution crystal structure of an avidin-related protein: insight into high-affinity biotin binding and protein stability. Acta Crystallogr.,Sect.D, 61, 2005
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1Y52
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![BU of 1y52 by Molmil](/molmil-images/mine/1y52) | structure of insect cell (Baculovirus) expressed AVR4 (C122S)-biotin complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Avidin-related protein 4/5, BIOTIN | Authors: | Eisenberg-Domovich, Y, Hytonen, V.P, Wilchek, M, Bayer, E.A, Kulomaa, M.S, Livnah, O. | Deposit date: | 2004-12-02 | Release date: | 2005-05-24 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | High-resolution crystal structure of an avidin-related protein: insight into high-affinity biotin binding and protein stability. Acta Crystallogr.,Sect.D, 61, 2005
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1Y55
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![BU of 1y55 by Molmil](/molmil-images/mine/1y55) | Crystal structure of the C122S mutant of E. Coli expressed avidin related protein 4 (AVR4)-biotin complex | Descriptor: | Avidin-related protein 4/5, BIOTIN, FORMIC ACID | Authors: | Eisenberg-Domovich, Y, Hytonen, V.P, Wilchek, M, Bayer, E.A, Kulomaa, M.S, Livnah, O. | Deposit date: | 2004-12-02 | Release date: | 2005-05-24 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | High-resolution crystal structure of an avidin-related protein: insight into high-affinity biotin binding and protein stability. Acta Crystallogr.,Sect.D, 61, 2005
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3MM0
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![BU of 3mm0 by Molmil](/molmil-images/mine/3mm0) | Crystal structure of chimeric avidin | Descriptor: | Avidin, Avidin-related protein 4/5 | Authors: | Livnah, O, Eisenberg-Domovich, Y, Maatta, J.A.E, Kulomaa, M.S, Hytonen, V.P, Nordlund, H.R. | Deposit date: | 2010-04-19 | Release date: | 2010-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Chimeric avidin shows stability against harsh chemical conditions-biochemical analysis and 3D structure. Biotechnol.Bioeng., 108, 2011
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7P0O
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![BU of 7p0o by Molmil](/molmil-images/mine/7p0o) | mitoNEET bound to M1 molecule | Descriptor: | 2-benzamido-4-[(2~{R})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid, 2-benzamido-4-[(2~{S})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid, CDGSH iron-sulfur domain-containing protein 1, ... | Authors: | Livnah, O, Eisenberg-Domovich, Y, Marjault, H.B, Nechushtai, R. | Deposit date: | 2021-06-30 | Release date: | 2022-05-25 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters. Commun Biol, 5, 2022
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7P0P
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![BU of 7p0p by Molmil](/molmil-images/mine/7p0p) | NAF-1 bound to M1 molecule | Descriptor: | 2-benzamido-4-[(2~{R})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid, CDGSH iron-sulfur domain-containing protein 2, FE2/S2 (INORGANIC) CLUSTER | Authors: | Livnah, O, Eisenberg-Domovich, Y, Marjault, H.B, Nechushtai, R. | Deposit date: | 2021-06-30 | Release date: | 2022-05-25 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters. Commun Biol, 5, 2022
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1I9H
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![BU of 1i9h by Molmil](/molmil-images/mine/1i9h) | CORE STREPTAVIDIN-BNA COMPLEX | Descriptor: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, STREPTAVIDIN | Authors: | Livnah, O, Huberman, T, Wilchek, M, Bayer, E.A, Eisenberg-Domovich, Y. | Deposit date: | 2001-03-20 | Release date: | 2001-09-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Chicken avidin exhibits pseudo-catalytic properties. Biochemical, structural, and electrostatic consequences. J.Biol.Chem., 276, 2001
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3S2R
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![BU of 3s2r by Molmil](/molmil-images/mine/3s2r) | ATChloroNEET (H87C mutant) | Descriptor: | AT5g51720/MIO24_14, FE2/S2 (INORGANIC) CLUSTER | Authors: | livnah, O, Eisenberg-Domovich, Y, nechushtai, R. | Deposit date: | 2011-05-17 | Release date: | 2012-05-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Arabidopsis thaliana ChloroNEET, a Member of the New NEET Family of Human Proteins, is Involved in Development, Senescence and Iron Metabolism. To be Published
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3S2Q
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![BU of 3s2q by Molmil](/molmil-images/mine/3s2q) | The crystal structure of AT5g51720 (AT-NEET) | Descriptor: | AT5g51720/MIO24_14, FE2/S2 (INORGANIC) CLUSTER, ZINC ION | Authors: | Livnah, O, Eisenberg-Domovich, Y, Nechushtai, R. | Deposit date: | 2011-05-17 | Release date: | 2012-05-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Arabidopsis thaliana ChloroNEET, a Member of the New NEET Family of Human Proteins, is Involved in Development, Senescence and Iron Metabolism. To be Published
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4OOA
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![BU of 4ooa by Molmil](/molmil-images/mine/4ooa) | CRYSTAL STRUCTURE of NAF1 (MINER1): H114C THE REDOX-ACTIVE 2FE-2S PROTEIN | Descriptor: | CDGSH iron-sulfur domain-containing protein 2, FE2/S2 (INORGANIC) CLUSTER | Authors: | Tamir, S, Eisenberg-Domovich, Y, Conlan, A.R, Stofleth, J.T, Lipper, C.H, Paddock, M.L, Mittler, R, Jennings, P.A, Livnah, O, Nechushtai, R. | Deposit date: | 2014-01-31 | Release date: | 2014-07-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties. Acta Crystallogr.,Sect.D, 70, 2014
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4OO7
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![BU of 4oo7 by Molmil](/molmil-images/mine/4oo7) | THE 1.55A CRYSTAL STRUCTURE of NAF1 (MINER1): THE REDOX-ACTIVE 2FE-2S PROTEIN | Descriptor: | CDGSH iron-sulfur domain-containing protein 2, FE2/S2 (INORGANIC) CLUSTER | Authors: | Tamir, S, Eisenberg-Domovich, Y, Colman, A.R, Stofleth, J.T, Lipper, C.H, Paddock, M.L, Jenning, P.A, Livnah, O, Nechushtai, R. | Deposit date: | 2014-01-31 | Release date: | 2014-07-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties. Acta Crystallogr.,Sect.D, 70, 2014
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1NQN
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![BU of 1nqn by Molmil](/molmil-images/mine/1nqn) | Structure of Avm-W110K (W110K mutant of avidin) | Descriptor: | Avidin | Authors: | Pazy, Y, Eisenberg-Domovich, Y, Laitinen, O.H, Kulomaa, M.S, Bayer, E.A, Wilchek, M, Livnah, O. | Deposit date: | 2003-01-22 | Release date: | 2003-07-15 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Dimer-Tetramer Transition between Solution and Crystalline States of Streptavidin and Avidin Mutants. J.Bacteriol., 185, 2003
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1NQM
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![BU of 1nqm by Molmil](/molmil-images/mine/1nqm) | Structure of Savm-W120K, streptavidin mutant | Descriptor: | BIOTIN, Streptavidin | Authors: | Pazy, Y, Eisenberg-Domovich, Y, Laitinen, O.H, Kulomaa, M.S, Bayer, E.A, Wilchek, M, Livnah, O. | Deposit date: | 2003-01-22 | Release date: | 2003-07-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Dimer-Tetramer Transition between Solution and Crystalline States of Streptavidin and Avidin Mutants. J.Bacteriol., 185, 2003
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3P63
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![BU of 3p63 by Molmil](/molmil-images/mine/3p63) | Structure of M. laminosus Ferredoxin with a shorter L1,2 loop | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, Ferredoxin | Authors: | Livnah, O, Nechushtai, R, Eisenberg-Domovich, Y, Michaeli, D. | Deposit date: | 2010-10-11 | Release date: | 2011-02-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Allostery in the ferredoxin protein motif does not involve a conformational switch. Proc.Natl.Acad.Sci.USA, 108, 2011
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2OF9
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![BU of 2of9 by Molmil](/molmil-images/mine/2of9) | |
2OF8
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![BU of 2of8 by Molmil](/molmil-images/mine/2of8) | Crystal structure of AVR4 (D39A/C122S)-BNA complex | Descriptor: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Avidin-related protein 4/5, FORMIC ACID | Authors: | Livnah, O, Hayouka, R, Eisenberg-Domovich, Y. | Deposit date: | 2007-01-03 | Release date: | 2007-12-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Critical importance of loop conformation to avidin-enhanced hydrolysis of an active biotin ester. Acta Crystallogr.,Sect.D, 64, 2008
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2OFA
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![BU of 2ofa by Molmil](/molmil-images/mine/2ofa) | Crystal structure of apo AVR4 (R112L,C122S) | Descriptor: | Avidin-related protein 4/5, FORMIC ACID | Authors: | Livnah, O, Hayouka, R, Eisenberg-Domovich, Y. | Deposit date: | 2007-01-03 | Release date: | 2007-12-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Critical importance of loop conformation to avidin-enhanced hydrolysis of an active biotin ester. Acta Crystallogr.,Sect.D, 64, 2008
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2OFB
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![BU of 2ofb by Molmil](/molmil-images/mine/2ofb) | Crystal structure of AVR4 (R112L/C122S)-BNA complex | Descriptor: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Avidin-related protein 4/5, FORMIC ACID | Authors: | Livnah, O, Hayouka, R, Eisenberg-Domovich, Y. | Deposit date: | 2007-01-03 | Release date: | 2007-12-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | Critical importance of loop conformation to avidin-enhanced hydrolysis of an active biotin ester. Acta Crystallogr.,Sect.D, 64, 2008
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4E6A
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![BU of 4e6a by Molmil](/molmil-images/mine/4e6a) | p38a-PIA23 complex | Descriptor: | (2S)-2-methoxy-3-(octadecyloxy)propyl (1R,2R,3R,4S,6S)-2,3,4-trihydroxy-6-(2-methylpropoxy)cyclohexyl hydrogen (S)-phosphate, Mitogen-activated protein kinase 14 | Authors: | Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. | Deposit date: | 2012-03-15 | Release date: | 2012-10-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424, 2012
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4E5A
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![BU of 4e5a by Molmil](/molmil-images/mine/4e5a) | |
4E6C
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![BU of 4e6c by Molmil](/molmil-images/mine/4e6c) | p38a-perifosine Complex | Descriptor: | (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl hydrogen phosphate, Mitogen-activated protein kinase 14 | Authors: | Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. | Deposit date: | 2012-03-15 | Release date: | 2012-10-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424, 2012
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4E8A
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![BU of 4e8a by Molmil](/molmil-images/mine/4e8a) | The crystal structure of p38a MAP kinase in complex with PIA24 | Descriptor: | (1R,2S,3R,4S,6S)-6-(cyclohexylmethoxy)-2,3,4-trihydroxycyclohexyl (2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen (S)-phosphate, Mitogen-activated protein kinase 14 | Authors: | Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. | Deposit date: | 2012-03-20 | Release date: | 2012-10-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424, 2012
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