4CBT
| Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease | 分子名称: | (1R,2R,3R)-2-[4-(5-fluoranylpyrimidin-2-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide, HISTONE DEACETYLASE 4, ZINC ION | 著者 | Burli, R.W, Luckhurst, C.A, Aziz, O, Matthews, K.L, Yates, D, Lyons, K.A, Beconi, M, McAllister, G, Breccia, P, Stott, A.J, Penrose, S.D, Wall, M, Lamers, M, Leonard, P, Mueller, I, Richardson, C.M, Jarvis, R, Stones, L, Hughes, S, Wishart, G, Haughan, A.F, O'Connell, C, Mead, T, McNeil, H, Vann, J, Mangette, J, Maillard, M, Beaumont, V, Munoz-Sanjuan, I, Dominguez, C. | 登録日 | 2013-10-16 | 公開日 | 2013-12-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | 主引用文献 | Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. J. Med. Chem., 56, 2013
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4CAU
| THREE-DIMENSIONAL STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH 2 HMAB 14C10 FAB | 分子名称: | ENVELOPE PROTEIN E, FAB 14C10 | 著者 | Teoh, E.P, Kukkaro, P, Teo, E.W, Lim, A.P, Tan, T.T, Yip, A, Schul, W, Aung, M, Kostyuchenko, V.A, Leo, Y.S, Chan, S.H, Smith, K.G, Chan, A.H, Zou, G, Ooi, E.E, Kemeny, D.M, Tan, G.K, Ng, J.K, Ng, M.L, Alonso, S, Fisher, D, Shi, P.Y, Hanson, B.J, Lok, S.M, Macary, P.A. | 登録日 | 2013-10-09 | 公開日 | 2013-10-16 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | The Structural Basis for Serotype-Specific Neutralization of Dengue Virus by a Human Antibody. Sci.Trans.Med, 4, 2012
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4BS2
| NMR structure of human TDP-43 tandem RRMs in complex with UG-rich RNA | 分子名称: | 5'-R(*GP*UP*GP*UP*GP*AP*AP*UP*GP*AP*AP*UP)-3', TAR DNA-BINDING PROTEIN 43 | 著者 | Lukavsky, P.J, Daujotyte, D, Tollervey, J.R, Ule, J, Stuani, C, Buratti, E, Baralle, F.E, Damberger, F.F, Allain, F.H.T. | 登録日 | 2013-06-06 | 公開日 | 2013-11-13 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular Basis of Ug-Rich RNA Recognition by the Human Splicing Factor Tdp-43 Nat.Struct.Mol.Biol., 20, 2013
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4BLS
| P4 PROTEIN FROM BACTERIOPHAGE PHI12 Q278A MUTANT IN COMPLEX WITH AMPcPP | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, NTPASE P4 | 著者 | El Omari, K, Meier, C, Kainov, D, Sutton, G, Grimes, J.M, Poranen, M.M, Bamford, D.H, Tuma, R, Stuart, D.I, Mancini, E.J. | 登録日 | 2013-05-04 | 公開日 | 2013-08-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Tracking in Atomic Detail the Functional Specializations in Viral Reca Helicases that Occur During Evolution. Nucleic Acids Res., 41, 2013
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4BPD
| Structure determination of an integral membrane kinase | 分子名称: | (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, DIACYLGLYCEROL KINASE, ZINC ION | 著者 | Li, D, Boland, C, Caffrey, M. | 登録日 | 2013-05-24 | 公開日 | 2014-05-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Cell-Free Expression and in Meso Crystallisation of an Integral Membrane Kinase for Structure Determination. Cell.Mol.Life Sci., 71, 2014
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4BX5
| cis-divalent streptavidin | 分子名称: | 1,2-ETHANEDIOL, STREPTAVIDIN, TETRAETHYLENE GLYCOL | 著者 | Fairhead, M, Krndija, D, Lowe, E.D, Howarth, M. | 登録日 | 2013-07-08 | 公開日 | 2013-09-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.431 Å) | 主引用文献 | Plug-and-Play Pairing Via Defined Divalent Streptavidins. J.Mol.Biol., 426, 2014
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4C14
| The crystal strucuture of PpAzoR in complex with reactive black 5 (RB5) | 分子名称: | DODECAETHYLENE GLYCOL, FMN-DEPENDENT NADH-AZOREDUCTASE 1, [5-[3-[2-[[4-[2-[1-azanyl-7-[2-[4-[methyl-bis(oxidanyl)-$l^{4}-sulfanyl]phenyl]hydrazinyl]-8-oxidanyl-3,6-bis[tris(oxidanyl)-$l^{4}-sulfanyl]naphthalen-2-yl]hydrazinyl]phenyl]-bis(oxidanyl)-$l^{4}-sulfanyl]ethoxy]-7,8-dimethyl-2,4-bis(oxidanylidene)benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] dihydrogen phosphate | 著者 | Goncalves, A.M.D, de Sanctis, D, Bento, I. | 登録日 | 2013-08-09 | 公開日 | 2013-10-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The crystal structure of Pseudomonas putida azoreductase - the active site revisited. FEBS J., 280, 2013
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4C1S
| Glycoside hydrolase family 76 (mannosidase) Bt3792 from Bacteroides thetaiotaomicron VPI-5482 | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, GLYCOSIDE HYDROLASE FAMILY 76 MANNOSIDASE | 著者 | Cuskin, F, Lowe, E.C, Zhu, Y, Temple, M, Thompson, A.J, Cartmell, A, Piens, K, Bracke, D, Vervecken, W, Munoz-Munoz, J.L, Suits, M.D.L, Boraston, A.B, Williams, S.J, Davies, G.J, Abbott, W.D, Martens, E.C, Gilbert, H.J. | 登録日 | 2013-08-13 | 公開日 | 2013-11-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Human Gut Bacteroidetes Can Utilize Yeast Mannan Through a Selfish Mechanism. Nature, 517, 2015
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4BTV
| Structure of PhaZ7 PHB depolymerase in complex with 3HB trimer | 分子名称: | (1R)-3-{[(1R)-3-METHOXY-1-METHYL-3-OXOPROPYL]OXY}-1-METHYL-3-OXOPROPYL (3R)-3-HYDROXYBUTANOATE, PHB DEPOLYMERASE PHAZ7 | 著者 | Hermawan, S, Subedi, B, Papageorgiou, A.C, Jendrossek, D. | 登録日 | 2013-06-19 | 公開日 | 2013-09-18 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (1.594 Å) | 主引用文献 | Biochemical Analysis and Structure Determination of Paucimonas Lemoignei Poly(3-Hydroxybutyrate) (Phb) Depolymerase Phaz7 Muteins Reveal the Phb Binding Site and Details of Substrate-Enzyme Interactions. Mol.Microbiol., 90, 2013
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4CC0
| Notch ligand, Jagged-1, contains an N-terminal C2 domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, PROTEIN JAGGED-1, ... | 著者 | Chilakuri, C.R, Sheppard, D, Ilagan, M.X.G, Holt, L.R, Abbott, F, Liang, S, Kopan, R, Handford, P.A, Lea, S.M. | 登録日 | 2013-10-17 | 公開日 | 2013-11-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands Cell Rep., 5, 2013
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4BWZ
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4CF7
| Crystal structure of adenylate kinase from Aquifex aeolicus with MgADP bound | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ADENYLATE KINASE, ... | 著者 | Kerns, S.J, Agafonov, R.V, Cho, Y.-J, Pontiggia, F, Otten, R, Pachov, D.V, Kutter, S, Phung, L.A, Murphy, P.N, Thai, V, Hagan, M.F, Kern, D. | 登録日 | 2013-11-13 | 公開日 | 2014-12-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.594 Å) | 主引用文献 | The Energy Landscape of Adenylate Kinase During Catalysis. Nat.Struct.Mol.Biol., 22, 2015
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4CDX
| Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP12 | 分子名称: | 1-(5-((3'-METHYL-[1,1'-BIPHENYL]-4-YL)OXY)PENTYL)-3-(, SODIUM ION, VP1, ... | 著者 | De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. | 登録日 | 2013-11-07 | 公開日 | 2014-02-12 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules. Nat.Struct.Mol.Biol., 21, 2014
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4CDW
| Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP4 | 分子名称: | 1-[(3S)-5-(4-iodanylphenoxy)-3-methyl-pentyl]-3-pyridin-4-yl-imidazolidin-2-one, SODIUM ION, VP1, ... | 著者 | De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. | 登録日 | 2013-11-06 | 公開日 | 2014-02-12 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules Nat.Struct.Mol.Biol., 21, 2014
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4BTQ
| Coordinates of the bacteriophage phi6 capsid subunits fitted into the cryoEM map EMD-1206 | 分子名称: | MAJOR INNER PROTEIN P1 | 著者 | Nemecek, D, Boura, E, Wu, W, Cheng, N, Plevka, P, Qiao, J, Mindich, L, Heymann, J.B, Hurley, J.H, Steven, A.C. | 登録日 | 2013-06-18 | 公開日 | 2013-12-11 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (7.5 Å) | 主引用文献 | Subunit Folds and Maturation Pathway of a Dsrna Virus Capsid. Structure, 21, 2013
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4BU4
| RIBONUCLEASE T1 COMPLEX WITH 2'GMP | 分子名称: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PROTEIN (RIBONUCLEASE T1) | 著者 | Loris, R, Devos, S, Langhorst, U, Decanniere, K, Bouckaert, J, Maes, D, Transue, T.R, Steyaert, J. | 登録日 | 1998-09-14 | 公開日 | 1998-09-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Conserved water molecules in a large family of microbial ribonucleases. Proteins, 36, 1999
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4CEW
| Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor ALD | 分子名称: | 4-[3-[(3s)-5-[4-[(e)-ethoxyiminomethyl]phenoxy]-3-methyl-pentyl]-2-oxidanylidene-imidazolidin-1-yl]pyridine-2-carboxamide, VP1, VP2, ... | 著者 | De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. | 登録日 | 2013-11-12 | 公開日 | 2014-02-12 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules. Nat.Struct.Mol.Biol., 21, 2014
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4CDA
| Spectroscopically-validated structure of ferric cytochrome c prime from Alcaligenes xylosoxidans | 分子名称: | CYTOCHROME C', HEME C, SULFATE ION | 著者 | Kekilli, D, Dworkowski, F, Antonyuk, S, Hough, M.A. | 登録日 | 2013-10-30 | 公開日 | 2014-05-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Fingerprinting Redox and Ligand States in Haemprotein Crystal Structures Using Resonance Raman Spectroscopy. Acta Crystallogr.,Sect.D, 70, 2014
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4BRX
| Focal Adhesion Kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor | 分子名称: | 2-(4-(2-methoxy-4-morpholinophenylamino)-1,3,5-triazin-2-ylamino)-N-methylbenzamide, FOCAL ADHESION KINASE 1, SULFATE ION | 著者 | Le Coq, J, Lietha, D. | 登録日 | 2013-06-05 | 公開日 | 2013-07-24 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Synthesis of Novel Diarylamino-1,3,5-Triazine Derivatives as Fak Inhibitors with Anti-Angiogenic Activity. Bioorg.Med.Chem.Lett., 23, 2013
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4C28
| Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(4-chlorophenyl)piperazin-1-yl)-2-fluorobenzamide. | 分子名称: | (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(4-chlorophenyl)piperazin-1-yl)-2-fluorobenzamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Vieira, D.F, Calvet, C.M, Choi, J.Y, Cameron, M.D, Gut, J, Kellar, D, Siqueira-Neto, J.L, McKerrow, J.H, Roush, W.R, Podust, L.M. | 登録日 | 2013-08-16 | 公開日 | 2014-09-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Binding Mode and Potency of N-Indolyl-Oxopyridinyl-4-Amino-Propanyl-Based Inhibitors Targeting Trypanosoma Cruzi Cyp51 J.Med.Chem., 57, 2014
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4BPB
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4BOC
| Structure of mitochondrial RNA polymerase elongation complex | 分子名称: | 5'-D(*CP*AP*TP*GP*GP*GP*GP*TP*AP*AP*TP*TP*AP*TP *TP*TP*CP*GP*AP*CP*GP*CP*CP*AP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*TP*GP*GP*CP*GP*TP*GP*CP*GP*CP *GP*CP*CP*GP*CP*TP*AP*CP*CP*CP*CP*AP*TP*G)-3', 5'-R(*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP)-3', ... | 著者 | Schwinghammer, K, Cheung, A, Morozov, Y, Agaronyan, K, Temiakov, D, Cramer, P. | 登録日 | 2013-05-18 | 公開日 | 2013-09-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure of Human Mitochondrial RNA Polymerase Elongation Complex Nat.Struct.Mol.Biol., 20, 2013
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4BYM
| Structure of PhaZ7 PHB depolymerase Y105E mutant | 分子名称: | CHLORIDE ION, PHB DEPOLYMERASE PHAZ7, SODIUM ION | 著者 | Hermawan, S, Subedi, B, Papageorgiou, A.C, Jendrossek, D. | 登録日 | 2013-07-20 | 公開日 | 2013-09-18 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.598 Å) | 主引用文献 | Biochemical Analysis and Structure Determination of Paucimonas Lemoignei Poly(3-Hydroxybutyrate) (Phb) Depolymerase Phaz7 Muteins Reveal the Phb Binding Site and Details of Substrate-Enzyme Interactions. Mol.Microbiol., 90, 2013
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4CE4
| 39S large subunit of the porcine mitochondrial ribosome | 分子名称: | 16S Ribosomal RNA, ICT1, MRPL13, ... | 著者 | Greber, B.J, Boehringer, D, Leitner, A, Bieri, P, Voigts-Hoffmann, F, Erzberger, J.P, Leibundgut, M, Aebersold, R, Ban, N. | 登録日 | 2013-11-08 | 公開日 | 2013-12-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Architecture of the Large Subunit of the Mammalian Mitochondrial Ribosome. Nature, 505, 2014
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4BT5
| acetolactate decarboxylase with a bound (2S,3R)-2,3-Dihydroxy-2- methylbutanoic acid | 分子名称: | (2S,3R)-2,3-dihydroxy-2-methylbutanoic acid, ALPHA-ACETOLACTATE DECARBOXYLASE, ZINC ION | 著者 | A Marlow, V, Rea, D, Najmudin, S, Wills, M, Fulop, V. | 登録日 | 2013-06-12 | 公開日 | 2013-09-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Structure and Mechanism of Acetolactate Decarboxylase. Acs Chem.Biol., 8, 2013
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