3K44
| Crystal Structure of Drosophila melanogaster Pur-alpha | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Purine-rich binding protein-alpha, ... | 著者 | Graebsch, A, Roche, S, Niessing, D. | 登録日 | 2009-10-05 | 公開日 | 2009-10-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | X-ray structure of Pur-alpha reveals a Whirly-like fold and an unusual nucleic-acid binding surface Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
6HY1
| Plasmodium falciparum spermidine synthase in complex with 5'-methylthioadenosine and N,N'-Bis(3-aminopropyl)-1,4-cyclohexanediamine after catalysis in crystal | 分子名称: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, ... | 著者 | Sprenger, J, Coertzen, D, Persson, L, Carey, J, Birkholtz, L.M, Louw, B.I. | 登録日 | 2018-10-19 | 公開日 | 2019-10-30 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Plasmodium falciparum spermidine synthase in complex with 5'-methylthioadenosine and N,N'-Bis(3-aminopropyl)-1,4-cyclohexanediamine after catalysis in crystal To Be Published
|
|
3JSS
| |
2NY0
| HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, T257S, V275C, S334A, S375W, A433M) Complexed with CD4 and Antibody 17b | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ... | 著者 | Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D. | 登録日 | 2006-11-20 | 公開日 | 2007-02-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature, 445, 2007
|
|
2O2N
| Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand | 分子名称: | 4-[4-(BIPHENYL-2-YLMETHYL)PIPERAZIN-1-YL]-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE, Apoptosis regulator Bcl-X | 著者 | Bruncko, M, Oost, T.K, Belli, B.A, Ding, H, Joseph, M.K, Kunzer, A, Martineau, D, McClellan, W.J, Mitten, M, Ng, S.C, Nimmer, P.M, Oltersdorf, T, Park, C.M, Petros, A.M, Shoemaker, A.R, Song, X, Wang, X, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H, Elmore, S.W. | 登録日 | 2006-11-30 | 公開日 | 2007-02-27 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL. J.Med.Chem., 50, 2007
|
|
1P92
| |
5N63
| Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9c | 分子名称: | Mitogen-activated protein kinase 14, ~{N}4-[(4-fluorophenyl)methyl]-2-phenyl-quinazoline-4,7-diamine | 著者 | Buehrmann, M, Mueller, M.P, Rauh, D. | 登録日 | 2017-02-14 | 公開日 | 2017-09-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38 alpha MAPK. PLoS ONE, 12, 2017
|
|
6I01
| Structure of human D-glucuronyl C5 epimerase in complex with substrate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Debarnot, C, Monneau, Y.R, Roig-Zamboni, V, Le Narvor, C, Goulet, A, Fadel, F, Vives, R.R, Bonnaffe, D, Lortat-Jacob, H, Bourne, Y. | 登録日 | 2018-10-24 | 公開日 | 2019-04-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6HRA
| Cryo-EM structure of the KdpFABC complex in an E1 outward-facing state (state 1) | 分子名称: | POTASSIUM ION, Potassium-transporting ATPase ATP-binding subunit, Potassium-transporting ATPase KdpC subunit, ... | 著者 | Stock, C, Hielkema, L, Tascon, I, Wunnicke, D, Oostergetel, G.T, Azkargorta, M, Paulino, C, Haenelt, I. | 登録日 | 2018-09-26 | 公開日 | 2018-12-05 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structures of KdpFABC suggest a K+transport mechanism via two inter-subunit half-channels. Nat Commun, 9, 2018
|
|
2O03
| |
2O7P
| The crystal structure of RibD from Escherichia coli in complex with the oxidised NADP+ cofactor in the active site of the reductase domain | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Riboflavin biosynthesis protein ribD | 著者 | Moche, M, Stenmark, P, Gurmu, D, Nordlund, P, Structural Proteomics in Europe (SPINE) | 登録日 | 2006-12-11 | 公開日 | 2007-02-13 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The crystal structure of the bifunctional deaminase/reductase RibD of the riboflavin biosynthetic pathway in Escherichia coli: implications for the reductive mechanism. J.Mol.Biol., 373, 2007
|
|
5NHT
| human 199.54-16 TCR in complex with Melan-A/MART-1 (26-35) peptide and HLA-A2 | 分子名称: | Beta-2-microglobulin, CHLORIDE ION, HLA class I histocompatibility antigen, ... | 著者 | Exertier, C, Reiser, J.-B, Lantez, V, Chouquet, A, Bonneville, M, Saulquin, X, Housset, D. | 登録日 | 2017-03-22 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | human 199.54-16 TCR in complex with Melan-A/MART-1 (26-35) peptide and HLA-A2 To Be Published
|
|
6H9S
| |
8S6J
| NavMs in complex with riluzole | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, CHLORIDE ION, ... | 著者 | Hollingworth, D, Sula, A, Mykhaylyk, V, Wallace, B.A. | 登録日 | 2024-02-27 | 公開日 | 2024-09-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural basis for the rescue of hyperexcitable cells by the Amyotrophic Lateral Sclerosis drug Riluzole To Be Published, 2024
|
|
1OND
| THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TROLEANDOMYCIN MACROLIDE ANTIBIOTIC | 分子名称: | 23S RIBOSOMAL RNA, 50S ribosomal protein L22, 50S ribosomal protein L32, ... | 著者 | Berisio, R, Schluenzen, F, Harms, J, Bashan, A, Auerbach, T, Baram, D, Yonath, A. | 登録日 | 2003-02-27 | 公開日 | 2003-04-15 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural insight into the role of the ribosomal tunnel in cellular regulation Nat.Struct.Biol., 10, 2003
|
|
3JYO
| Quinate dehydrogenase from Corynebacterium glutamicum in complex with NAD | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Quinate/shikimate dehydrogenase | 著者 | Hoeppner, A, Niefind, K, Schomburg, D. | 登録日 | 2009-09-22 | 公開日 | 2010-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Enzyme-substrate complexes of the quinate/shikimate dehydrogenase from Corynebacterium glutamicum enable new insights in substrate and cofactor binding, specificity, and discrimination. Biol.Chem., 394, 2013
|
|
3J68
| Structural mechanism of the dynein powerstroke (pre-powerstroke state) | 分子名称: | Dynein motor domain | 著者 | Lin, J, Okada, K, Raytchev, M, Smith, M.C, Nicastro, D. | 登録日 | 2013-12-23 | 公開日 | 2014-04-23 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (30 Å) | 主引用文献 | Structural mechanism of the dynein power stroke. Nat.Cell Biol., 16, 2014
|
|
2O2D
| Crystal structure of phosphoglucose isomerase from Trypanosoma brucei complexed with citrate | 分子名称: | CITRIC ACID, GLYCEROL, Glucose-6-phosphate isomerase, ... | 著者 | Arsenieva, D, Mazock, G.H, Appavu, B.L, Jeffery, C.J. | 登録日 | 2006-11-29 | 公開日 | 2007-11-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of phosphoglucose isomerase from Trypanosoma brucei complexed with glucose-6-phosphate at 1.6 A resolution Proteins, 74, 2008
|
|
6HU6
| Structure of ARF1 RNA | 分子名称: | AMMONIUM ION, RNA (19-MER), RNA (5'-R(*CP*UP*GP*GP*UP*AP*CP*UP*C)-3'), ... | 著者 | Emmerich, C, Lazzaretti, D, Bandholz-Cajamarca, L, Bono, F. | 登録日 | 2018-10-05 | 公開日 | 2018-11-21 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | 主引用文献 | The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity. Life Sci Alliance, 1, 2018
|
|
2O3V
| Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site complexed with paromamine derivative NB33 | 分子名称: | (2S,3R,4R,5S,6R)-3-AMINO-4-({[(2S,3R,4R,5S,6R)-3-AMINO-2-{[(1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYL]OXY}-5-HYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-4-YL]OXY}METHOXY)-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIOL, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') | 著者 | Kondo, J, Hainrichson, M, Nudelman, I, Shallom-Shezifi, D, Baasov, T, Westhof, E. | 登録日 | 2006-12-02 | 公開日 | 2007-11-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites. Chembiochem, 8, 2007
|
|
1OT8
| Structure of the Ankyrin Domain of the Drosophila Notch Receptor | 分子名称: | MAGNESIUM ION, Neurogenic locus Notch protein | 著者 | Zweifel, M.E, Leahy, D.J, Hughson, F.M, Barrick, D. | 登録日 | 2003-03-21 | 公開日 | 2003-10-28 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure and stability of the ankyrin domain of the Drosophila Notch receptor Protein Sci., 12, 2003
|
|
6HMG
| Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-(1,2-anhydro-carba-glucosamine) | 分子名称: | (1~{S},2~{R},3~{R},4~{R},6~{S})-4-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3-diol, ACETATE ION, Glycosyl hydrolase family 71, ... | 著者 | Sobala, L.F, Lu, D, Zhu, S, Bernardo-Seisdedos, G, Millet, O, Zhang, Y, Sollogoub, M, Jimenez-Barbero, J, Davies, G.J. | 登録日 | 2018-09-12 | 公開日 | 2018-09-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | From 1,4-Disaccharide to 1,3-Glycosyl Carbasugar: Synthesis of a Bespoke Inhibitor of Family GH99 Endo-alpha-mannosidase. Org.Lett., 20, 2018
|
|
2OHF
| |
1OVE
| The structure of p38 alpha in complex with a dihydroquinolinone | 分子名称: | 1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE, GLYCEROL, Mitogen-activated protein kinase 14 | 著者 | Fitzgerald, C.E, Patel, S.B, Becker, J.W, Cameron, P.M, Zaller, D, Pikounis, V.B, O'Keefe, S.J, Scapin, G. | 登録日 | 2003-03-26 | 公開日 | 2003-09-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity Nat.Struct.Biol., 10, 2003
|
|
5NK0
| Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1j | 分子名称: | 2-[[3-[(3-azanyl-2,2-dimethyl-propyl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide, Ephrin type-A receptor 2 | 著者 | Kudlinzki, D, Linhard, V.L, Witt, K, Gande, S.L, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H. | 登録日 | 2017-03-31 | 公開日 | 2017-06-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.597 Å) | 主引用文献 | Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. ChemMedChem, 12, 2017
|
|