8DH3
| |
4S0K
| Biphenylalanine modified threonyl-tRNA synthetase from Pyrococcus abyssi: 11BIF, 42F, 79V, and 123A mutant | 分子名称: | DI(HYDROXYETHYL)ETHER, Threonine--tRNA ligase | 著者 | Pearson, A.D, Mills, J.H, Song, Y, Nasertorabi, F, Han, G.W, Baker, D, Stevens, R.C, Schultz, P.G. | 登録日 | 2014-12-31 | 公開日 | 2015-03-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Transition states. Trapping a transition state in a computationally designed protein bottle. Science, 347, 2015
|
|
4RVI
| Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with non-peptidic inhibitor, GRL0519 | 分子名称: | (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, HIV-1 protease | 著者 | Yedidi, R.S, Garimella, H, Kaufman, J.D, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | 登録日 | 2014-11-26 | 公開日 | 2016-05-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Enhanced antiviral activity by the P2-tris-tetrahydrofuran moiety of GRL-0519, a novel nonpeptidic HIV-1 protease inhibitor (PI), against multi-PI-resistant and highly darunavir-resistant strains of HIV-1 To be Published
|
|
8D1T
| Crystal structure of human USP30 in complex with a covalent inhibitor 552 and a Fab | 分子名称: | (1R,2R,4S,7E)-7-[amino(sulfanyl)methylidene]-2-{[(1P)-3-chloro-3'-(1-cyanocyclopropyl)[1,1'-biphenyl]-4-carbonyl]amino}-7-azabicyclo[2.2.1]heptan-7-ium, 1,2-ETHANEDIOL, Ubiquitin carboxyl-terminal hydrolase 30, ... | 著者 | Song, X, Butler, J, Li, C, Zhang, K, Zhang, D, Hao, Y. | 登録日 | 2022-05-27 | 公開日 | 2023-02-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | TBD To Be Published
|
|
8DH1
| T7 RNA polymerase elongation complex with unnatural base dDs-PaTP pair | 分子名称: | 1-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-1H-pyrrole-2-carbaldehyde, GLYCEROL, MAGNESIUM ION, ... | 著者 | Oh, J, Wang, D. | 登録日 | 2022-06-24 | 公開日 | 2023-02-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase. Nat Commun, 14, 2023
|
|
8DH0
| |
8DH5
| |
8DH2
| |
1M1P
| P21 crystal structure of the tetraheme cytochrome c3 from Shewanella oneidensis MR1 | 分子名称: | HEME C, SULFATE ION, Small tetraheme cytochrome c | 著者 | Leys, D, Meyer, T.E, Tsapin, A.I, Nealson, K.H, Cusanovich, M.A, Van Beeumen, J.J. | 登録日 | 2002-06-20 | 公開日 | 2002-08-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Crystal structures at atomic resolution reveal the novel concept of 'electron-harvesting' as a role for the small tetraheme cytochrome c J.Biol.Chem., 277, 2002
|
|
1MI1
| Crystal Structure of the PH-BEACH Domain of Human Neurobeachin | 分子名称: | Neurobeachin | 著者 | Jogl, G, Shen, Y, Gebauer, D, Li, J, Wiegmann, K, Kashkar, H, Kroenke, M, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2002-08-21 | 公開日 | 2002-09-27 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain. EMBO J., 21, 2002
|
|
4S02
| Biphenylalanine modified threonyl-tRNA synthetase from Pyrococcus abyssi: I11BIF, F42W, Y79A, and F123Y mutant | 分子名称: | DI(HYDROXYETHYL)ETHER, Threonine--tRNA ligase | 著者 | Pearson, A.D, Mills, J.H, Song, Y, Nasertorabi, F, Han, G.W, Baker, D, Stevens, R.C, Schultz, P.G. | 登録日 | 2014-12-30 | 公開日 | 2015-03-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Transition states. Trapping a transition state in a computationally designed protein bottle. Science, 347, 2015
|
|
4TQ9
| Crystal Structure of a GDP-bound G12V Oncogenic Mutant of Human GTPase KRas | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D. | 登録日 | 2014-06-10 | 公開日 | 2015-06-10 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.491 Å) | 主引用文献 | Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations. Mol Cancer Res., 13, 2015
|
|
7NOW
| |
8DJG
| ADGRL3-lectin domain in complex with an activating synthetic antibody fragment | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Isoform 2 of Adhesion G protein-coupled receptor L3, ... | 著者 | Kordon, S.P, Bandekar, S.J, Arac, D. | 登録日 | 2022-06-30 | 公開日 | 2023-02-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder. Nat Commun, 14, 2023
|
|
1M7B
| Crystal structure of Rnd3/RhoE: functional implications | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rnd3/RhoE small GTP-binding protein | 著者 | Fiegen, D, Blumenstein, L, Stege, P, Vetter, I.R, Ahmadian, M.R. | 登録日 | 2002-07-19 | 公開日 | 2002-08-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of Rnd3/RhoE: functional implications FEBS LETT., 525, 2002
|
|
4TTR
| |
5W3Q
| L28F E.coli DHFR in complex with NADPH | 分子名称: | CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Oyen, D, Wright, P.E, Wilson, I.A. | 登録日 | 2017-06-08 | 公開日 | 2017-08-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.401 Å) | 主引用文献 | Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion. J. Am. Chem. Soc., 139, 2017
|
|
1M52
| Crystal Structure of the c-Abl Kinase domain in complex with PD173955 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 | 著者 | Nagar, B, Bornmann, W, Pellicena, P, Schindler, T, Veach, D, Miller, W.T, Clarkson, B, Kuriyan, J. | 登録日 | 2002-07-08 | 公開日 | 2002-09-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571) Cancer Res., 62, 2002
|
|
1M5H
| Formylmethanofuran:tetrahydromethanopterin formyltransferase from Archaeoglobus fulgidus | 分子名称: | Formylmethanofuran--tetrahydromethanopterin formyltransferase, POTASSIUM ION | 著者 | Mamat, B, Roth, A, Grimm, C, Ermler, U, Tziatzios, C, Schubert, D, Thauer, R.K, Shima, S. | 登録日 | 2002-07-09 | 公開日 | 2002-07-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures and enzymatic properties of three formyltransferases from archaea: environmental adaptation and evolutionary relationship. Protein Sci., 11, 2002
|
|
1M9W
| |
5VFO
| Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | 著者 | Zhu, Y, Wang, W.L, Yu, D, Ouyang, Q, Lu, Y, Mao, Y. | 登録日 | 2017-04-08 | 公開日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome. Nat Commun, 9, 2018
|
|
1MBV
| CRYSTAL STRUCTURE ANALYSIS OF ClpSN HETERODIMER TETRAGONAL FORM | 分子名称: | ATP-Dependent clp Protease ATP-Binding Subunit clp A, Protein yljA | 著者 | Guo, F, Esser, L, Singh, S.K, Maurizi, M.R, Xia, D. | 登録日 | 2002-08-03 | 公開日 | 2002-12-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Crystal Structure of the Heterodimeric Complex of the Adaptor, ClpS, with the N-domain of AAA+ Chaperone ClpA J.Biol.Chem., 277, 2002
|
|
5VHM
| Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | 分子名称: | 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... | 著者 | Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | 登録日 | 2017-04-13 | 公開日 | 2017-08-23 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (8.3 Å) | 主引用文献 | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
|
|
8DB3
| Crystal structure of KaiC with truncated C-terminal coiled-coil domain | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Circadian clock protein KaiC | 著者 | Padua, R.A.P, Grant, T, Pitsawong, W, Hoemberger, M.S, Otten, R, Bradshaw, N, Grigorieff, N, Kern, D. | 登録日 | 2022-06-14 | 公開日 | 2023-03-22 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | From primordial clocks to circadian oscillators. Nature, 616, 2023
|
|
1MJD
| Structure of N-terminal domain of human doublecortin | 分子名称: | DOUBLECORTIN | 著者 | Kim, M.H, Cierpicki, T, Derewenda, U, Krowarsch, D, Feng, Y, Devedjiev, Y, Dauter, Z, Walsh, C.A, Otlewski, J, Bushweller, J.H, Derewenda, Z.S. | 登録日 | 2002-08-27 | 公開日 | 2003-04-29 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | The DCX-domain Tandems of Doublecortin and Doublecortin-like Kinase Nat.Struct.Biol., 10, 2003
|
|