3IYZ
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![BU of 3iyz by Molmil](/molmil-images/mine/3iyz) | Structure of Aquaporin-4 S180D mutant at 10.0 A resolution from electron micrograph | 分子名称: | Aquaporin-4 | 著者 | Mitsuma, T, Tani, K, Hiroaki, Y, Kamegawa, A, Suzuki, H, Hibino, H, Kurachi, Y, Fujiyoshi, Y. | 登録日 | 2010-07-24 | 公開日 | 2010-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (10 Å) | 主引用文献 | Influence of the cytoplasmic domains of aquaporin-4 on water conduction and array formation. J.Mol.Biol., 402, 2010
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1JU8
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![BU of 1ju8 by Molmil](/molmil-images/mine/1ju8) | Solution structure of Leginsulin, a plant hormon | 分子名称: | Leginsulin | 著者 | Yamazaki, T, Takaoka, M, Katoh, E, Hanada, K, Sakita, M, Sakata, K, Nishiuchi, Y, Hirano, H. | 登録日 | 2001-08-23 | 公開日 | 2003-06-17 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | A possible physiological function and the tertiary structure of a 4-kDa peptide in legumes EUR.J.BIOCHEM., 270, 2003
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3VYK
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![BU of 3vyk by Molmil](/molmil-images/mine/3vyk) | Crystal structure of C-type lectin domain of murine dendritic cell inhibitory receptor 2 in complex with N-glycan | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)][2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]methyl alpha-D-mannopyranoside, C-type lectin domain family 4, ... | 著者 | Nagae, M, Yamanaka, K, Hanashima, S, Ikeda, A, Satoh, T, Matsumoto, N, Yamamoto, K, Yamaguchi, Y. | 登録日 | 2012-09-26 | 公開日 | 2013-10-02 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Recognition of Bisecting N-Acetylglucosamine: STRUCTURAL BASIS FOR ASYMMETRIC INTERACTION WITH THE MOUSE LECTIN DENDRITIC CELL INHIBITORY RECEPTOR 2 J.Biol.Chem., 288, 2013
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7WCE
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![BU of 7wce by Molmil](/molmil-images/mine/7wce) | Crystal structure of HIV-1 integrase catalytic core domain in complex with (2S)-2-(tert-Butoxy)-2-(10-fluoro-2-(2-hydroxy-4-methylphenyl)-1,4-dimethyl-5-(methylsulfonyl)-5,6-dihydrophenanthridin-3-yl)acetic acid | 分子名称: | (2S)-2-[10-fluoranyl-1,4-dimethyl-2-(4-methyl-2-oxidanyl-phenyl)-5-methylsulfonyl-6H-phenanthridin-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, GLYCEROL, Integrase catalytic, ... | 著者 | Taoda, Y, Sekiguchi, Y. | 登録日 | 2021-12-20 | 公開日 | 2022-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of tricyclic HIV-1 integrase-LEDGF/p75 allosteric inhibitors by intramolecular direct arylation reaction. Bioorg.Med.Chem.Lett., 64, 2022
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7WMC
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![BU of 7wmc by Molmil](/molmil-images/mine/7wmc) | Crystal structure of macrocyclic peptide 1 bound to human Nicotinamide N-methyltransferase | 分子名称: | Nicotinamide N-methyltransferase, Peptide1 | 著者 | Yoshida, S, Uehara, S, Kondo, N, Takahashi, Y, Yamamoto, S, Kameda, A, Kawagoe, S, Inoue, N, Yamada, M, Yoshimura, N, Tachibana, Y. | 登録日 | 2022-01-14 | 公開日 | 2022-08-31 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides. J.Med.Chem., 65, 2022
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7WMT
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![BU of 7wmt by Molmil](/molmil-images/mine/7wmt) | Crystal structure of small molecule 13 bound to human Nicotinamide N-methyltransferase | 分子名称: | Nicotinamide N-methyltransferase, [(2~{R},4~{S})-4-[2-(aminomethyl)imidazol-1-yl]-2-[1-[(4-chlorophenyl)methyl]-5-methyl-indol-2-yl]pyrrolidin-1-yl]-(1~{H}-pyrrolo[2,3-b]pyridin-5-yl)methanone | 著者 | Yoshida, S, Uehara, S, Kondo, N, Takahashi, Y, Yamamoto, S, Kameda, A, Kawagoe, S, Inoue, N, Yamada, M, Yoshimura, N, Tachibana, Y. | 登録日 | 2022-01-17 | 公開日 | 2022-08-31 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides. J.Med.Chem., 65, 2022
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8J83
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![BU of 8j83 by Molmil](/molmil-images/mine/8j83) | Crystal structure of formate dehydrogenase from Methylorubrum extorquens AM1 | 分子名称: | 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, DI(HYDROXYETHYL)ETHER, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Kobayashi, A, Taketa, M, Sowa, K, Kano, K, Higuchi, Y, Ogata, H. | 登録日 | 2023-04-29 | 公開日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure and function relationship of formate dehydrogenases: an overview of recent progress. Iucrj, 10, 2023
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7WCQ
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![BU of 7wcq by Molmil](/molmil-images/mine/7wcq) | Crystal structure of HIV-1 protease in complex with lactam derivative 1 | 分子名称: | (3R,4R)-3-[(4-fluorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-3-(4-methylsulfonylphenyl)-4-oxidanyl-pyrrolidin-2-one, Protease | 著者 | Kojima, E, Iimuro, A, Nakajima, M, Kinuta, H, Asada, N, Sako, Y, Nakata, Z, Uemura, K, Arita, S, Miki, S, Wakasa-Morimoto, C, Tachibana, Y, Fumoto, M. | 登録日 | 2021-12-20 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | 主引用文献 | Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket as a Template. J.Med.Chem., 65, 2022
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7WBS
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![BU of 7wbs by Molmil](/molmil-images/mine/7wbs) | Crystal structure of HIV-1 protease in complex with lactam derivative 2 | 分子名称: | (3~{R},4~{R})-1-[(4-methoxyphenyl)methyl]-3-(3-methylbutyl)-3-[4-methylsulfonyl-2-[(2~{S})-1-oxidanylpropan-2-yl]oxy-phenyl]-4-oxidanyl-pyrrolidin-2-one, GLYCEROL, Protease | 著者 | Kojima, E, Iimuro, A, Nakajima, M, Kinuta, H, Asada, N, Sako, Y, Nakata, Z, Uemura, K, Arita, S, Miki, S, Wakabayashi-Morimoto, C, Tachibana, Y, Fumoto, M. | 登録日 | 2021-12-17 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket as a Template. J.Med.Chem., 65, 2022
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1WLK
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1WYC
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![BU of 1wyc by Molmil](/molmil-images/mine/1wyc) | Structure of 6-aminohexanoate-dimer hydrolase, DN mutant | 分子名称: | 6-aminohexanoate-dimer hydrolase | 著者 | Negoro, S, Ohki, T, Shibata, N, Mizuno, N, Wakitani, Y, Tsurukame, J, Matsumoto, K, Kawamoto, I, Takeo, M, Higuchi, Y. | 登録日 | 2005-02-09 | 公開日 | 2006-02-21 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Nylon-oligomer degrading enzyme/substrate complex: catalytic mechanism of 6-aminohexanoate-dimer hydrolase J.Mol.Biol., 370, 2007
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1WQV
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![BU of 1wqv by Molmil](/molmil-images/mine/1wqv) | Human Factor Viia-Tissue Factor Complexed with propylsulfonamide-D-Thr-Met-p-aminobenzamidine | 分子名称: | CALCIUM ION, Coagulation factor VII, N-[DIHYDROXY(PROPYL)-LAMBDA~4~-SULFANYL]THREONYL-N~1~-{4-[AMINO(IMINO)METHYL]BENZYL}METHIONINAMIDE, ... | 著者 | Kadono, S, Sakamoto, A, Kikuchi, Y, Oh-eda, M, Yabuta, N, Koga, T, Hattori, K, Shiraishi, T, Haramura, M, Kodama, H. | 登録日 | 2004-10-02 | 公開日 | 2005-10-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of human factor VIIa/tissue factor in complex with peptide mimetic inhibitor Biochem.Biophys.Res.Commun., 324, 2004
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1WLI
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2RQY
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![BU of 2rqy by Molmil](/molmil-images/mine/2rqy) | Solution structure and dynamics of mouse ARMET | 分子名称: | Putative uncharacterized protein | 著者 | Hoseki, J, Sasakawa, H, Yamaguchi, Y, Maeda, M, Kubota, H, Kato, K, Nagata, K. | 登録日 | 2010-01-26 | 公開日 | 2010-04-21 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and dynamics of mouse ARMET. Febs Lett., 584, 2010
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3VQU
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![BU of 3vqu by Molmil](/molmil-images/mine/3vqu) | CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-amino-5-cyano-6-ethoxypyridin-2- yl)amino]benzamide | 分子名称: | 4-[(4-amino-5-cyano-6-ethoxypyridin-2-yl)amino]benzamide, Dual specificity protein kinase TTK, IODIDE ION | 著者 | Kusakabe, K, Ide, N, Daigo, Y, Itoh, T, Higashino, K, Okano, Y, Tadano, G, Tachibana, Y, Sato, Y, Inoue, M, Wada, T, Iguchi, M, Kanazawa, T, Ishioka, Y, Dohi, K, Tagashira, S, Kido, Y, Sakamoto, S, Yasuo, K, Maeda, M, Yamamoto, T, Higaki, M, Endoh, T, Ueda, K, Shiota, T, Murai, H, Nakamura, Y. | 登録日 | 2012-03-30 | 公開日 | 2012-06-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. Acs Med.Chem.Lett., 3, 2012
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2RRN
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![BU of 2rrn by Molmil](/molmil-images/mine/2rrn) | Solution structure of SecDF periplasmic domain P4 | 分子名称: | Probable SecDF protein-export membrane protein | 著者 | Tanaka, T, Tsukazaki, T, Echizen, Y, Nureki, O, Kohno, T. | 登録日 | 2011-01-30 | 公開日 | 2011-05-18 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and function of a membrane component SecDF that enhances protein export Nature, 474, 2011
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3WX2
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![BU of 3wx2 by Molmil](/molmil-images/mine/3wx2) | Mouse Cereblon thalidomide binding domain, native | 分子名称: | Protein cereblon, SULFATE ION, ZINC ION | 著者 | Mori, T, Ito, T, Hirano, Y, Yamaguchi, Y, Handa, H, Hakoshima, T. | 登録日 | 2014-07-10 | 公開日 | 2014-08-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs Nat.Struct.Mol.Biol., 21, 2014
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3WX1
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![BU of 3wx1 by Molmil](/molmil-images/mine/3wx1) | Mouse Cereblon thalidomide binding domain, selenomethionine derivative | 分子名称: | Protein cereblon, SULFATE ION, ZINC ION | 著者 | Mori, T, Ito, T, Hirano, Y, Yamaguchi, Y, Handa, H, Hakoshima, T. | 登録日 | 2014-07-10 | 公開日 | 2014-08-06 | 最終更新日 | 2014-09-17 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs Nat.Struct.Mol.Biol., 21, 2014
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6LTM
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![BU of 6ltm by Molmil](/molmil-images/mine/6ltm) | The dimeric structure of G80A/H81A/H82A myoglobin | 分子名称: | Myoglobin, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Nagao, S, Suda, A, Kobayashi, H, Shibata, N, Higuchi, Y, Hirota, S. | 登録日 | 2020-01-22 | 公開日 | 2020-05-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Thermodynamic Control of Domain Swapping by Modulating the Helical Propensity in the Hinge Region of Myoglobin. Chem Asian J, 15, 2020
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3AVE
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![BU of 3ave by Molmil](/molmil-images/mine/3ave) | Crystal Structure of the Fucosylated Fc Fragment from Human Immunoglobulin G1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, ZINC ION | 著者 | Matsumiya, S, Yamaguchi, Y, Saito, J, Nagano, M, Sasakawa, H, Otaki, S, Satoh, M, Shitara, K, Kato, K. | 登録日 | 2011-03-04 | 公開日 | 2011-04-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Corrigendum to "Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1" [J. Mol. Biol. 386/3 (2007) 767-779] J.Mol.Biol., 408, 2011
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6LTL
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![BU of 6ltl by Molmil](/molmil-images/mine/6ltl) | The dimeric structure of G80A myoglobin | 分子名称: | Myoglobin, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Nagao, S, Suda, A, Kobayashi, H, Shibata, N, Higuchi, Y, Hirota, S. | 登録日 | 2020-01-22 | 公開日 | 2020-05-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Thermodynamic Control of Domain Swapping by Modulating the Helical Propensity in the Hinge Region of Myoglobin. Chem Asian J, 15, 2020
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7V5P
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![BU of 7v5p by Molmil](/molmil-images/mine/7v5p) | The dimeric structure of G80A/H81A myoglobin | 分子名称: | Myoglobin, OXYGEN ATOM, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Xie, C, Nagao, S, Shibata, N, Higuchi, Y, Hirota, S. | 登録日 | 2021-08-17 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | 主引用文献 | Experimental and theoretical study on converting myoglobin into a stable domain-swapped dimer by utilizing a tight hydrogen bond network at the hinge region. Rsc Adv, 11, 2021
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3L3F
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1WQ2
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![BU of 1wq2 by Molmil](/molmil-images/mine/1wq2) | Neutron Crystal Structure Of Dissimilatory Sulfite Reductase D (DsrD) | 分子名称: | Protein dsvD, SULFATE ION | 著者 | Chatake, T, Mizuno, N, Voordouw, G, Higuchi, Y, Arai, S, Tanaka, I, Niimura, N. | 登録日 | 2004-09-19 | 公開日 | 2005-09-19 | 最終更新日 | 2023-10-25 | 実験手法 | NEUTRON DIFFRACTION (2.4 Å) | 主引用文献 | Crystallization and preliminary neutron analysis of the dissimilatory sulfite reductase D (DsrD) protein from the sulfate-reducing bacterium Desulfovibrio vulgaris. Acta Crystallogr.,Sect.D, 59, 2003
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1QGI
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![BU of 1qgi by Molmil](/molmil-images/mine/1qgi) | CHITOSANASE FROM BACILLUS CIRCULANS | 分子名称: | 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (CHITOSANASE), SULFATE ION | 著者 | Saito, J, Kita, A, Higuchi, Y, Nagata, Y, Ando, A, Miki, K. | 登録日 | 1999-04-28 | 公開日 | 1999-10-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of chitosanase from Bacillus circulans MH-K1 at 1.6-A resolution and its substrate recognition mechanism. J.Biol.Chem., 274, 1999
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