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PDB: 162 件

4JFL
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Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with 6-({(1S,5R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-2-oxo-3,9-diazabicyclo[3.3.1]non-9-yl}sulfonyl)-1,3-benzothiazol-2(3H)-one
分子名称: 6-({(1S,5R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-2-oxo-3,9-diazabicyclo[3.3.1]non-9-yl}sulfonyl)-1,3-benzothiazol-2(3H)-one, Peptidyl-prolyl cis-trans isomerase FKBP5
著者Wang, Y, Kirschner, A, Fabian, A, Gopalakrishnan, R, Kress, C, Hoogeland, B, Koch, U, Kozany, C, Bracher, A, Hausch, F.
登録日2013-02-28
公開日2013-08-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.
J.Med.Chem., 56, 2013
6HB2
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Structure of Hgh1, crystal form I, Selenomethionine derivative
分子名称: CHLORIDE ION, Protein HGH1
著者Moenkemeyer, L, Klaips, C.L, Balchin, D, Koerner, R, Hartl, F.U, Bracher, A.
登録日2018-08-09
公開日2019-02-27
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2.
Mol.Cell, 74, 2019
6HBA
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Crystal Structure of the small subunit-like domain 1 of CcmM from Synechococcus elongatus (strain PCC 7942), thiol-oxidized form
分子名称: Carbon dioxide concentrating mechanism protein CcmM
著者Wang, H, Yan, X, Aigner, H, Bracher, A, Nguyen, N.D, Hee, W.Y, Long, B.M, Price, G.D, Hartl, F.U, Hayer-Hartl, M.
登録日2018-08-10
公開日2018-12-12
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Rubisco condensate formation by CcmM in beta-carboxysome biogenesis.
Nature, 566, 2019
6HAS
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Crystal Structure of the small subunit-like domain of Rubisco activase from Nostoc sp. (strain PCC 7120)
分子名称: NICKEL (II) ION, Ribulose bisphosphate carboxylase/oxygenase activase
著者Popilka, L, Bracher, A.
登録日2018-08-08
公開日2020-01-15
最終更新日2021-01-27
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Dual Functions of a Rubisco Activase in Metabolic Repair and Recruitment to Carboxysomes.
Cell, 183, 2020
6HBC
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Structure of the repeat unit in the network formed by CcmM and Rubisco from Synechococcus elongatus
分子名称: Carbon dioxide concentrating mechanism protein CcmM, Ribulose 1,5-bisphosphate carboxylase small subunit, Ribulose bisphosphate carboxylase large chain
著者Wang, H, Yan, X, Aigner, H, Bracher, A, Nguyen, N.D, Hee, W.Y, Long, B.M, Price, G.D, Hartl, F.U, Hayer-Hartl, M.
登録日2018-08-10
公開日2018-12-12
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (2.78 Å)
主引用文献Rubisco condensate formation by CcmM in beta-carboxysome biogenesis.
Nature, 566, 2019
6HZK
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BU of 6hzk by Molmil
Crystal structure of redox-inhibited phosphoribulokinase from Synechococcus sp. (strain PCC 6301)
分子名称: Phosphoribulokinase
著者Wilson, R.H, Bracher, A, Hartl, F.U, Hayer-Hartl, M.
登録日2018-10-23
公開日2019-03-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of phosphoribulokinase from Synechococcus sp. strain PCC 6301.
Acta Crystallogr.,Sect.F, 75, 2019
6HB3
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Structure of Hgh1, crystal form II
分子名称: Protein HGH1
著者Moenkemeyer, L, Klaips, C.L, Balchin, D, Koerner, R, Hartl, F.U, Bracher, A.
登録日2018-08-09
公開日2019-02-27
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2.
Mol.Cell, 74, 2019
6HBB
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Crystal Structure of the small subunit-like domain 1 of CcmM from Synechococcus elongatus (strain PCC 7942)
分子名称: Carbon dioxide concentrating mechanism protein CcmM, SULFATE ION
著者Wang, H, Yan, X, Aigner, H, Bracher, A, Nguyen, N.D, Hee, W.Y, Long, B.M, Price, G.D, Hartl, F.U, Hayer-Hartl, M.
登録日2018-08-10
公開日2018-12-12
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Rubisco condensate formation by CcmM in beta-carboxysome biogenesis.
Nature, 566, 2019
6HZL
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BU of 6hzl by Molmil
Crystal structure of redox-inhibited phosphoribulokinase from Synechococcus sp. (strain PCC 6301), osmate derivative
分子名称: OSMIUM ION, Phosphoribulokinase
著者Wilson, R.H, Bracher, A, Hartl, F.U, Hayer-Hartl, M.
登録日2018-10-23
公開日2019-03-27
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Crystal structure of phosphoribulokinase from Synechococcus sp. strain PCC 6301.
Acta Crystallogr.,Sect.F, 75, 2019
6HB1
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Structure of Hgh1, crystal form I
分子名称: CHLORIDE ION, Protein HGH1
著者Moenkemeyer, L, Klaips, C.L, Balchin, D, Koerner, R, Hartl, F.U, Bracher, A.
登録日2018-08-09
公開日2019-02-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2.
Mol.Cell, 74, 2019
4DRO
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BU of 4dro by Molmil
EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH (1R)-3-(3,4-dimethoxyphenyl)-1-phenylpropyl (2S)-1-{[(1R,2S)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidine-2-carboxylate
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-{[(1R,2S)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid
著者Gopalakrishnan, R, Kozany, C, Gaali, S, Kress, C, Hoogeland, B, Bracher, A, Hausch, F.
登録日2012-02-17
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Evaluation of Synthetic FK506 Analogues as Ligands for the FK506-Binding Proteins 51 and 52.
J.Med.Chem., 55, 2012
4DRH
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BU of 4drh by Molmil
Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low pH
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, SULFATE ION, ...
著者Maerz, A.M, Bracher, A, Hausch, F.
登録日2012-02-17
公開日2013-02-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
Mol.Cell.Biol., 33, 2013
4DRK
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BU of 4drk by Molmil
EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid
著者Gopalakrishnan, R, Kozany, C, Gaali, S, Kress, C, Hoogeland, B, Bracher, A, Hausch, F.
登録日2012-02-17
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Evaluation of Synthetic FK506 Analogues as Ligands for the FK506-Binding Proteins 51 and 52.
J.Med.Chem., 55, 2012
4DRM
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BU of 4drm by Molmil
EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-{[(1S,2R)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-{[(1S,2R)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid
著者Gopalakrishnan, R, Kozany, C, Gaali, S, Kress, C, Hoogeland, B, Bracher, A, Hausch, F.
登録日2012-02-17
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Evaluation of Synthetic FK506 Analogues as Ligands for the FK506-Binding Proteins 51 and 52.
J.Med.Chem., 55, 2012
4DRJ
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BU of 4drj by Molmil
o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP4, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, SULFATE ION, ...
著者Maerz, A.M, Bracher, A, Hausch, F.
登録日2012-02-17
公開日2013-02-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
Mol.Cell.Biol., 33, 2013
4DRQ
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BU of 4drq by Molmil
Exploration of Pipecolate Sulfonamides as Binders of the FK506-Binding Proteins 51 and 52: Complex of FKBP51 with 2-(3-((R)-1-((S)-1-(3,5-dichlorophenylsulfonyl)piperidine-2-carbonyloxy)-3-(3,4-dimethoxy -phenyl)propyl)phenoxy)acetic acid
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, {3-[(1S)-1-[({(2S)-1-[(3,5-dichlorophenyl)sulfonyl]piperidin-2-yl}carbonyl)oxy]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetic acid
著者Gopalakrishnan, R, Kozany, C, Wang, Y, Hoogeland, B, Bracher, A, Hausch, F, Schneider, S.
登録日2012-02-17
公開日2012-04-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Exploration of Pipecolate Sulfonamides as Binders of the FK506-Binding Proteins 51 and 52.
J.Med.Chem., 55, 2012
3SYK
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BU of 3syk by Molmil
Crystal structure of the AAA+ protein CbbX, selenomethionine structure
分子名称: Protein CbbX, SULFATE ION
著者Mueller-Cajar, O, Stotz, M, Wendler, P, Hartl, F.U, Bracher, A, Hayer-Hartl, M.
登録日2011-07-18
公開日2011-11-09
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase.
Nature, 479, 2011
3SYL
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BU of 3syl by Molmil
Crystal structure of the AAA+ protein CbbX, native structure
分子名称: Protein CbbX, SULFATE ION
著者Mueller-Cajar, O, Stotz, M, Wendler, P, Hartl, F.U, Bracher, A, Hayer-Hartl, M.
登録日2011-07-18
公開日2011-11-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase.
Nature, 479, 2011
3T15
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BU of 3t15 by Molmil
Structure of green-type Rubisco activase from tobacco
分子名称: Ribulose bisphosphate carboxylase/oxygenase activase 1, chloroplastic
著者Stotz, M, Wendler, P, Mueller-Cajar, O, Hartl, F.U, Bracher, A, Hayer-Hartl, M.
登録日2011-07-21
公開日2011-11-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structure of green-type Rubisco activase from tobacco.
Nat.Struct.Mol.Biol., 18, 2011
5D5W
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BU of 5d5w by Molmil
Crystal structure of Chaetomium thermophilum Skn7 with HSE DNA
分子名称: HSE DNA, Putative transcription factor
著者Neudegger, T, Verghese, J, Hayer-Hartl, M, Hartl, F.U, Bracher, A.
登録日2015-08-11
公開日2015-12-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure of human heat-shock transcription factor 1 in complex with DNA.
Nat.Struct.Mol.Biol., 23, 2016
5D5Z
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Structure of Chaetomium thermophilum Skn7 coiled-coil domain, crystal form II
分子名称: Putative transcription factor
著者Neudegger, T, Verghese, J, Hayer-Hartl, M, Bracher, A, Hartl, F.U.
登録日2015-08-11
公開日2015-12-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of human heat-shock transcription factor 1 in complex with DNA.
Nat.Struct.Mol.Biol., 23, 2016
5D5Y
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BU of 5d5y by Molmil
Structure of Chaetomium thermophilum Skn7 coiled-coil domain, crystal form I
分子名称: Putative transcription factor
著者Neudegger, T, Verghese, J, Hayer-Hartl, M, Hartl, F.U, Bracher, A.
登録日2015-08-11
公開日2015-12-30
最終更新日2016-02-10
実験手法X-RAY DIFFRACTION (1.03 Å)
主引用文献Structure of human heat-shock transcription factor 1 in complex with DNA.
Nat.Struct.Mol.Biol., 23, 2016
5D5U
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BU of 5d5u by Molmil
Crystal structure of human Hsf1 with HSE DNA
分子名称: Heat shock Element DNA, Heat shock factor protein 1
著者Neudegger, T, Verghese, J, Hayer-Hartl, M, Hartl, F.U, Bracher, A.
登録日2015-08-11
公開日2015-12-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Structure of human heat-shock transcription factor 1 in complex with DNA.
Nat.Struct.Mol.Biol., 23, 2016
5D60
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Structure of Chaetomium thermophilum Skn7 coiled-coil domain, crystal form III
分子名称: Putative transcription factor
著者Neudegger, T, Verghese, J, Hayer-Hartl, M, Hartl, F.U, Bracher, A.
登録日2015-08-11
公開日2016-06-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of human heat-shock transcription factor 1 in complex with DNA.
Nat.Struct.Mol.Biol., 23, 2016
5D5V
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BU of 5d5v by Molmil
Crystal structure of human Hsf1 with Satellite III repeat DNA
分子名称: DNA, Heat shock factor protein 1, MAGNESIUM ION
著者Neudegger, T, Verghese, J, Hayer-Hartl, M, Hartl, F.U, Bracher, A.
登録日2015-08-11
公開日2015-12-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of human heat-shock transcription factor 1 in complex with DNA.
Nat.Struct.Mol.Biol., 23, 2016

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