5NKK
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![BU of 5nkk by Molmil](/molmil-images/mine/5nkk) | SMG8-SMG9 complex GDP bound | Descriptor: | 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Li, L, Basquin, J, Conti, E. | Deposit date: | 2017-03-31 | Release date: | 2017-04-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins. RNA, 23, 2017
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5NKM
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![BU of 5nkm by Molmil](/molmil-images/mine/5nkm) | SMG8-SMG9 complex | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Li, L, Basquin, J, Conti, E. | Deposit date: | 2017-03-31 | Release date: | 2017-04-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.493 Å) | Cite: | Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins. RNA, 23, 2017
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7ZEG
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![BU of 7zeg by Molmil](/molmil-images/mine/7zeg) | Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7GMP | Descriptor: | 1,2-ETHANEDIOL, 7-methylguanosine phosphate-specific 5'-nucleotidase, MAGNESIUM ION, ... | Authors: | Kubacka, D, Kozarski, M, Baranowski, M.R, Wojcik, R, Jemielity, J, Kowalska, J, Basquin, J. | Deposit date: | 2022-03-31 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism. Pharmaceuticals, 15, 2022
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7ZEE
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![BU of 7zee by Molmil](/molmil-images/mine/7zee) | Human cytosolic 5' nucleotidase IIIB | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7-methylguanosine phosphate-specific 5'-nucleotidase, ... | Authors: | Kubacka, D, Kozarski, M, Baranowski, M.R, Wojcik, R, Jemielity, J, Kowalska, J, Basquin, J. | Deposit date: | 2022-03-31 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism. Pharmaceuticals, 15, 2022
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7ZEH
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![BU of 7zeh by Molmil](/molmil-images/mine/7zeh) | Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7Guanine | Descriptor: | 1,2-ETHANEDIOL, 7-methylguanosine phosphate-specific 5'-nucleotidase, D-ribulose, ... | Authors: | Kubacka, D, Kozarski, M, Baranowski, M.R, Wojcik, R, Jemielity, J, Kowalska, J, Basquin, J. | Deposit date: | 2022-03-31 | Release date: | 2022-05-25 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism. Pharmaceuticals, 15, 2022
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6G0C
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![BU of 6g0c by Molmil](/molmil-images/mine/6g0c) | Crystal structure of SdeA catalytic core | Descriptor: | 1,2-ETHANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, Ubiquitinating/deubiquitinating enzyme SdeA | Authors: | Kalayil, S, Bhogaraju, S, Basquin, J, Dikic, I. | Deposit date: | 2018-03-17 | Release date: | 2018-05-30 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.802 Å) | Cite: | Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination. Nature, 557, 2018
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6FLO
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![BU of 6flo by Molmil](/molmil-images/mine/6flo) | Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei at 2.1 Angstrom resolution | Descriptor: | GLYCEROL, INOSINE, Protein kinase A regulatory subunit | Authors: | Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. | Deposit date: | 2018-01-26 | Release date: | 2019-08-14 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.13868666 Å) | Cite: | Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens. Elife, 12, 2024
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6H25
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![BU of 6h25 by Molmil](/molmil-images/mine/6h25) | Human nuclear RNA exosome EXO-10-MPP6 complex | Descriptor: | Exosome complex component CSL4, Exosome complex component MTR3, Exosome complex component RRP4, ... | Authors: | Gerlach, P, Schuller, J.M, Falk, S, Basquin, J, Conti, E. | Deposit date: | 2018-07-13 | Release date: | 2018-08-15 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Distinct and evolutionary conserved structural features of the human nuclear exosome complex. Elife, 7, 2018
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2HSN
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![BU of 2hsn by Molmil](/molmil-images/mine/2hsn) | Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes | Descriptor: | GU4 nucleic-binding protein 1, Methionyl-tRNA synthetase, cytoplasmic | Authors: | Simader, H, Koehler, C, Basquin, J, Suck, D. | Deposit date: | 2006-07-22 | Release date: | 2006-09-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes. Nucleic Acids Res., 34, 2006
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6I59
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![BU of 6i59 by Molmil](/molmil-images/mine/6i59) | Long wavelength native-SAD phasing of Sen1 helicase | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Basu, S, Olieric, V, Matsugaki, N, Kawano, Y, Takashi, T, Huang, C.Y, Leonarski, F, Yamada, Y, Vera, L, Olieric, N, Basquin, J, Wojdyla, J.A, Diederichs, K, Yamamoto, M, Bunk, O, Wang, M. | Deposit date: | 2018-11-13 | Release date: | 2019-03-13 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Long-wavelength native-SAD phasing: opportunities and challenges. Iucrj, 6, 2019
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5MZN
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![BU of 5mzn by Molmil](/molmil-images/mine/5mzn) | Helicase Sen1 | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Leonaite, B, Basquin, J, Conti, E. | Deposit date: | 2017-02-01 | Release date: | 2017-04-19 | Last modified: | 2017-06-14 | Method: | X-RAY DIFFRACTION (1.787 Å) | Cite: | Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family. EMBO J., 36, 2017
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4JA0
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![BU of 4ja0 by Molmil](/molmil-images/mine/4ja0) | Crystal structure of the invertebrate bi-functional purine biosynthesis enzyme PAICS at 2.8 A resolution | Descriptor: | Phosphoribosylaminoimidazole carboxylase, SULFATE ION | Authors: | Taschner, M, Basquin, J, Benda, C, Lorentzen, E. | Deposit date: | 2013-02-18 | Release date: | 2013-02-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the invertebrate bifunctional purine biosynthesis enzyme PAICS at 2.8 angstrom resolution. Proteins, 81, 2013
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5NNZ
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![BU of 5nnz by Molmil](/molmil-images/mine/5nnz) | Crystal structure of human ODA16 | Descriptor: | Dynein assembly factor with WDR repeat domains 1 | Authors: | Lorentzen, E, Taschner, T, Basquin, J. | Deposit date: | 2017-04-10 | Release date: | 2017-06-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.651 Å) | Cite: | Purification and crystal structure of human ODA16: Implications for ciliary import of outer dynein arms by the intraflagellar transport machinery. Protein Sci., 29, 2020
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5MZH
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![BU of 5mzh by Molmil](/molmil-images/mine/5mzh) | Crystal structure of ODA16 from Chlamydomonas reinhardtii | Descriptor: | Dynein assembly factor with WDR repeat domains 1, SULFATE ION | Authors: | Lorentzen, E, Taschner, M, Basquin, J, Mourao, A. | Deposit date: | 2017-01-31 | Release date: | 2017-03-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.398 Å) | Cite: | Structural basis of outer dynein arm intraflagellar transport by the transport adaptor protein ODA16 and the intraflagellar transport protein IFT46. J. Biol. Chem., 292, 2017
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6IAN
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![BU of 6ian by Molmil](/molmil-images/mine/6ian) | T. brucei IFT22/74/81 GTP-bound crystal structure | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Intraflagellar transport protein 74, Intraflagellar transport protein 81, ... | Authors: | Wachter, S, Basquin, J, Lorentzen, E. | Deposit date: | 2018-11-27 | Release date: | 2019-05-01 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly. Embo J., 38, 2019
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6IA7
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![BU of 6ia7 by Molmil](/molmil-images/mine/6ia7) | T. brucei IFT22 GTP-bound crystal structure | Descriptor: | CALCIUM ION, GUANOSINE-5'-TRIPHOSPHATE, Intraflagellar transport protein 22, ... | Authors: | Wachter, S, Basquin, J, Lorentzen, E. | Deposit date: | 2018-11-26 | Release date: | 2019-04-10 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly. Embo J., 38, 2019
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6IAE
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![BU of 6iae by Molmil](/molmil-images/mine/6iae) | T. brucei IFT22 GDP-bound crystal structure | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Intraflagellar transport protein 22, MAGNESIUM ION | Authors: | Wachter, S, Basquin, J, Lorentzen, E. | Deposit date: | 2018-11-26 | Release date: | 2019-04-10 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly. Embo J., 38, 2019
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6I5C
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![BU of 6i5c by Molmil](/molmil-images/mine/6i5c) | Long wavelength native-SAD phasing of Tubulin-Stathmin-TTL complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | Authors: | Basu, S, Olieric, V, Matsugaki, N, Kawano, Y, Takashi, T, Huang, C.Y, Leonarski, F, Yamada, Y, Vera, L, Olieric, N, Basquin, J, Wojdyla, J.A, Diederichs, K, Yamamoto, M, Bunk, O, Wang, M. | Deposit date: | 2018-11-13 | Release date: | 2019-03-13 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Long-wavelength native-SAD phasing: opportunities and challenges. Iucrj, 6, 2019
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8A3N
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![BU of 8a3n by Molmil](/molmil-images/mine/8a3n) | Geissoschizine synthase from Catharanthus roseus - binary complex with NADP+ | Descriptor: | Geissoschizine synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ZINC ION | Authors: | Langley, C, Tatsis, E, Hong, B, Nakamura, Y, Kamileen, M.O, Paetz, C, Stevenson, C.E.M, Basquin, J, Lawson, D.M, Caputi, L, O'Connor, S.E. | Deposit date: | 2022-06-08 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism. Angew.Chem.Int.Ed.Engl., 61, 2022
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8B1V
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![BU of 8b1v by Molmil](/molmil-images/mine/8b1v) | Dihydroprecondylocarpine acetate synthase 2 from Tabernanthe iboga | Descriptor: | Dihydroprecondylocarpine acetate synthase 2, ZINC ION, precondylocarpine acetate | Authors: | Langley, C, Basquin, J, Caputi, L, O'Connor, S.E. | Deposit date: | 2022-09-12 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.882 Å) | Cite: | Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism. Angew.Chem.Int.Ed.Engl., 61, 2022
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8B25
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![BU of 8b25 by Molmil](/molmil-images/mine/8b25) | Dihydroprecondylocarpine acetate synthase 2 from Tabernanthe iboga - stemmadenine acetate bound structure | Descriptor: | 1,2-ETHANEDIOL, Dihydroprecondylocarpine acetate synthase 2, SULFATE ION, ... | Authors: | Langley, C, Basquin, J, Caputi, L, O'Connor, S.E. | Deposit date: | 2022-09-13 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism. Angew.Chem.Int.Ed.Engl., 61, 2022
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8B26
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![BU of 8b26 by Molmil](/molmil-images/mine/8b26) | Dihydroprecondylocarpine acetate synthase 2 from Tabernanthe iboga | Descriptor: | Dihydroprecondylocarpine acetate synthase 2, ZINC ION | Authors: | Langley, C, Basquin, J, Caputi, L, O'Connor, S.E. | Deposit date: | 2022-09-13 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism. Angew.Chem.Int.Ed.Engl., 61, 2022
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8B27
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![BU of 8b27 by Molmil](/molmil-images/mine/8b27) | Dihydroprecondylocarpine acetate synthase from Catharanthus roseus | Descriptor: | Dehydroprecondylocarpine acetate synthase, SULFATE ION | Authors: | Langley, C, Basquin, J, Caputi, L, O'Connor, S.E. | Deposit date: | 2022-09-13 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism. Angew.Chem.Int.Ed.Engl., 61, 2022
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8AP3
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![BU of 8ap3 by Molmil](/molmil-images/mine/8ap3) | |
7Z52
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![BU of 7z52 by Molmil](/molmil-images/mine/7z52) | Human NEXT dimer - focused reconstruction of the single MTR4 | Descriptor: | Exosome RNA helicase MTR4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*UP*UP*UP*UP*U)-3'), ... | Authors: | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | Deposit date: | 2022-03-07 | Release date: | 2022-06-22 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
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