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4I0S
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BU of 4i0s by Molmil
Crystal structure of spleen tyrosine kinase complexed with 2-(6-Chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide
Descriptor: 2-(6-chloro-1-methyl-1H-indazol-3-yl)-N-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase SYK
Authors:Kuglstatter, A, Slade, M.
Deposit date:2012-11-19
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
J.Med.Chem., 56, 2013
4HRH
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BU of 4hrh by Molmil
Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide
Descriptor: Helicase-like transcription factor, Protein S100-A10, Annexin A2, ...
Authors:Gao, P, Patel, D.J.
Deposit date:2012-10-27
Release date:2013-03-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.001 Å)
Cite:SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action.
Cell(Cambridge,Mass.), 152, 2013
4I0R
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BU of 4i0r by Molmil
Crystal structure of spleen tyrosine kinase complexed with 2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide
Descriptor: N-(propan-2-yl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase SYK
Authors:Kuglstatter, A, Villasenor, A.G.
Deposit date:2012-11-19
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
J.Med.Chem., 56, 2013
4HRG
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BU of 4hrg by Molmil
Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with AHNAK1 Peptide
Descriptor: Neuroblast differentiation-associated protein AHNAK, Protein S100-A10
Authors:Gao, P, Patel, D.J.
Deposit date:2012-10-27
Release date:2013-03-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.0001 Å)
Cite:SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action.
Cell(Cambridge,Mass.), 152, 2013
6K9R
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BU of 6k9r by Molmil
Crystal Structure Analysis of Endo-beta-1,4-xylanase II Complexed with Xylotriose
Descriptor: Endo-1,4-beta-xylanase 2, IODIDE ION, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose
Authors:Li, C, Wan, Q.
Deposit date:2019-06-17
Release date:2020-07-08
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Studying the Role of a Single Mutation of a Family 11 Glycoside Hydrolase Using High-Resolution X-ray Crystallography.
Protein J., 39, 2020
7CBQ
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BU of 7cbq by Molmil
Crystal structure of PDE4D catalytic domain in complex with Apremilast
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide, ...
Authors:Zhang, X.L, Xu, Y.C.
Deposit date:2020-06-13
Release date:2021-01-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.
Eur.J.Med.Chem., 211, 2021
6K9O
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BU of 6k9o by Molmil
Crystal Structure Analysis of Protein
Descriptor: Endo-1,4-beta-xylanase 2, GLYCEROL, IODIDE ION
Authors:Li, C, Wan, Q.
Deposit date:2019-06-17
Release date:2020-06-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Studying the Role of a Single Mutation of a Family 11 Glycoside Hydrolase Using High-Resolution X-ray Crystallography.
Protein J., 39, 2020
7CH7
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BU of 7ch7 by Molmil
Cryo-EM structure of E.coli MlaFEB
Descriptor: Lipid asymmetry maintenance ABC transporter permease subunit MlaE, Lipid asymmetry maintenance protein MlaB, Phospholipid ABC transporter ATP-binding protein MlaF
Authors:Zhou, C, Shi, H, Huang, Y.
Deposit date:2020-07-05
Release date:2021-05-19
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural Insight into Phospholipid Transport by the MlaFEBD Complex from P. aeruginosa.
J.Mol.Biol., 433, 2021
7CHA
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BU of 7cha by Molmil
Cryo-EM structure of P.aeruginosa MlaFEBD with AMPPNP
Descriptor: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, MlaD domain-containing protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Zhou, C, Shi, H, Zhang, M, Huang, Y.
Deposit date:2020-07-05
Release date:2021-05-19
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural Insight into Phospholipid Transport by the MlaFEBD Complex from P. aeruginosa.
J.Mol.Biol., 433, 2021
7CBJ
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BU of 7cbj by Molmil
Crystal structure of PDE4D catalytic domain in complex with compound 36
Descriptor: (1S)-1-[(7-chloranyl-1H-indol-3-yl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ...
Authors:Zhang, X.L, Xu, Y.C.
Deposit date:2020-06-12
Release date:2021-06-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.
Eur.J.Med.Chem., 211, 2021
4NNH
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BU of 4nnh by Molmil
Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide
Descriptor: 30S ribosomal protein S1
Authors:Yang, J, Liu, Y, Cai, Q, Lin, D.
Deposit date:2013-11-18
Release date:2014-12-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide.
Mol.Microbiol., 95, 2015
7CH6
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BU of 7ch6 by Molmil
Cryo-EM structure of E.coli MlaFEB with AMPPNP
Descriptor: Lipid asymmetry maintenance ABC transporter permease subunit MlaE, Lipid asymmetry maintenance protein MlaB, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Zhou, C, Shi, H, Zhang, M, Huang, Y.
Deposit date:2020-07-05
Release date:2021-08-04
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural Insight into Phospholipid Transport by the MlaFEBD Complex from P. aeruginosa.
J.Mol.Biol., 433, 2021
4JIK
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BU of 4jik by Molmil
X-RAY Crystal structure of compound 22a (R)-2-(4-chlorophenyl)-8-(piperidin-3-ylamino)imidazo[1,2-c]pyrimidine-5-carboxamide bound to human chk1 kinase domain
Descriptor: 2-(4-chlorophenyl)-8-[(3S)-piperidin-3-ylamino]imidazo[1,2-c]pyrimidine-5-carboxamide, Serine/threonine-protein kinase Chk1
Authors:Fischmann, T.O.
Deposit date:2013-03-06
Release date:2013-04-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
7CH9
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BU of 7ch9 by Molmil
Cryo-EM structure of P.aeruginosa MlaFEBD
Descriptor: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, MlaD domain-containing protein, Probable ATP-binding component of ABC transporter, ...
Authors:Zhou, C, Shi, H, Zhang, M, Huang, Y.
Deposit date:2020-07-05
Release date:2021-10-06
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural Insight into Phospholipid Transport by the MlaFEBD Complex from P. aeruginosa.
J.Mol.Biol., 433, 2021
7CH8
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BU of 7ch8 by Molmil
Cryo-EM structure of P.aeruginosa MlaFEBD with ADP-V
Descriptor: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, ADP METAVANADATE, MAGNESIUM ION, ...
Authors:Zhou, C, Shi, H, Zhang, M, Huang, Y.
Deposit date:2020-07-05
Release date:2021-10-06
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural Insight into Phospholipid Transport by the MlaFEBD Complex from P. aeruginosa.
J.Mol.Biol., 433, 2021
7Y61
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BU of 7y61 by Molmil
Cryo-EM structure of the two CAF1LCs bound right-handed Di-tetrasome
Descriptor: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ...
Authors:Liu, C.P, Yu, Z.Y, Yu, C, Xu, R.M.
Deposit date:2022-06-18
Release date:2023-08-16
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
7Y5K
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BU of 7y5k by Molmil
Crystal structure of human CAF-1 core complex in spacegroup C2221
Descriptor: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ...
Authors:Liu, C.P, Wang, M.Z, Xu, R.M.
Deposit date:2022-06-17
Release date:2023-08-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
7Y5O
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BU of 7y5o by Molmil
Crystal structure of human CAF-1 core complex in spacegroup P21
Descriptor: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ...
Authors:Liu, C.P, Wang, M.Z, Xu, R.M.
Deposit date:2022-06-17
Release date:2023-08-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.57 Å)
Cite:Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
7Y5W
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BU of 7y5w by Molmil
Cryo-EM structure of the left-handed Di-tetrasome
Descriptor: Histone H3.1, Histone H4, Widom 601 DNA (147-MER)
Authors:Liu, C.P, Yu, Z.Y, Yu, C, Xu, R.M.
Deposit date:2022-06-17
Release date:2023-08-16
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
7Y5V
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BU of 7y5v by Molmil
Cryo-EM structure of the dimeric human CAF1LC-H3-H4 complex
Descriptor: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ...
Authors:Liu, C.P, Yu, C, Yu, Z.Y, Xu, R.M.
Deposit date:2022-06-17
Release date:2023-08-16
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
7Y5U
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BU of 7y5u by Molmil
Cryo-EM structure of the monomeric human CAF1LC-H3-H4 complex
Descriptor: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ...
Authors:Liu, C.P, Yu, Z.Y, Yu, C, Xu, R.M.
Deposit date:2022-06-17
Release date:2023-08-16
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
7Y60
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BU of 7y60 by Molmil
Cryo-EM structure of human CAF1LC bound right-handed Di-tetrasome
Descriptor: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ...
Authors:Liu, C.P, Yu, C, Yu, Z.Y, Xu, R.M.
Deposit date:2022-06-18
Release date:2023-08-16
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
7Y5L
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BU of 7y5l by Molmil
Crystal structure of human CAF-1 core complex in spacegroup C2
Descriptor: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ...
Authors:Liu, C.P, Wang, M.Z, Xu, R.M.
Deposit date:2022-06-17
Release date:2023-08-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
7XJA
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BU of 7xja by Molmil
TMD masked refine map of human ClC-2
Descriptor: Chloride channel protein 2
Authors:Wang, L.
Deposit date:2022-04-15
Release date:2023-05-17
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
7XF5
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BU of 7xf5 by Molmil
Full length human CLC-2 channel in apo state
Descriptor: Chloride channel protein 2
Authors:Wang, L.
Deposit date:2022-04-01
Release date:2023-05-03
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023

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PDB entries from 2024-09-25

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