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Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1088
Descriptor:	1,2-ETHANEDIOL, 3-{2-[(3-{[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]methyl}oxetan-3-yl)methoxy]phenyl}propanoic acid, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1088 to be published

5SCV

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889
Descriptor:	6-ethyl-5-(4-{3-[3-(1H-tetrazol-5-yl)propyl]phenoxy}butoxy)pyrimidine-2,4-diamine, CHLORIDE ION, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889 to be published

5SD5

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1230
Descriptor:	1,2-ETHANEDIOL, 1-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}-4-methylphenyl)azetidine-3-carboxylic acid, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.2 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1230 to be published

5SD8

Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture)
Descriptor:	(2R)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, (2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture) to be published

5SDA

Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-774
Descriptor:	(2R)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-774 to be published

5SD7

Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-735
Descriptor:	(2S)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-735 to be published

5SD9

Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1096
Descriptor:	(2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3-fluoropropanoic acid, 1,2-ETHANEDIOL, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1096 to be published

5SCO

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-M7
Descriptor:	2-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-N,N-dimethylethane-1-sulfonamide, BROMIDE ION, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-M7 to be published

5SCX

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture)
Descriptor:	(2R)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, 1,2-ETHANEDIOL, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture) to be published

5SCM

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-22
Descriptor:	1,2-ETHANEDIOL, Dihydrofolate reductase, IODIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-22 to be published

5SDB

Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate
Descriptor:	1,2-ETHANEDIOL, Dihydrofolate reductase, N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate to be published

5SD1

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1235 (enantiomer)
Descriptor:	(2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, 1,2-ETHANEDIOL, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1235 (enantiomer) to be published

5SCR

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-735
Descriptor:	(2R)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-735 to be published

5SD4

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1218
Descriptor:	1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}pyridin-3-yl)prop-2-yn-1-ol, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.25 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1218 to be published

5SD6

Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892
Descriptor:	1,2-ETHANEDIOL, 6-ethyl-5-(4-{2-[2-(1H-tetrazol-5-yl)ethyl]phenoxy}butoxy)pyrimidine-2,4-diamine, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892 to be published

5SCN

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-25
Descriptor:	3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-N-(methanesulfonyl)propanamide, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-25 to be published

5SCP

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-23
Descriptor:	1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanamide, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-23 to be published

3K2H

Co-crystal structure of dihydrofolate reductase/thymidylate synthase from Babesia bovis with dUMP, Pemetrexed and NADP
Descriptor:	1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2009-09-30
Release date:	2009-10-13
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis. Acta Crystallogr.,Sect.F, 67, 2011

3MEB

Structure of cytoplasmic aspartate aminotransferase from giardia lamblia
Descriptor:	1,2-ETHANEDIOL, Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2010-03-31
Release date:	2010-04-21
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia. Acta Crystallogr F Struct Biol Commun, 71, 2015

8D1X

Crystal Structure of aminopeptidase A from Neisseria gonorrhoeae
Descriptor:	ACETATE ION, CHLORIDE ION, D(-)-TARTARIC ACID, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2022-05-27
Release date:	2022-06-08
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Crystal Structure of aminopeptidase A from Neisseria gonorrhoeae to be published

8D57

Crystal Structure of dihydrodipicolinate reductase from Acinetobacter baumannii
Descriptor:	4-hydroxy-tetrahydrodipicolinate reductase, CITRIC ACID
Authors:	Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2022-06-04
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Crystal Structure of dihydrodipicolinate reductase from Acinetobacter baumannii to be published

8D2Z

Crystal Structure of a Metallo-beta-lactamase superfamily protein from Burkholderia cenocepacia
Descriptor:	(4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2022-05-31
Release date:	2023-07-05
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Crystal Structure of a Metallo-beta-lactamase superfamily protein from Burkholderia cenocepacia to be published

8DT1

Crystal Structure of a Putative D-beta-hydroxybutyrate dehydrogenase from Burkholderia cenocepacia J2315 in complex with NAD
Descriptor:	3-hydroxybutyrate dehydrogenase, CITRIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2022-07-25
Release date:	2022-08-17
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal Structure of a Putative D-beta-hydroxybutyrate dehydrogenase from Burkholderia cenocepacia J2315 in complex with NAD To Be Published

8DP2

Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 in complex with UMA (Uridine-5'-diphosphate-N-acetylmuramoyl-L-Alanine)
Descriptor:	3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ACETATE ION, GLYCEROL, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2022-07-14
Release date:	2022-08-17
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 in complex with UMA (Uridine-5'-diphosphate-N-acetylmuramoyl-L-Alanine) to be published

8EGN

Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa in complex with ligand AZ-13643701
Descriptor:	(1R,2S)-1-({4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}amino)-2,3-dihydro-1H-inden-2-ol, SULFATE ION, UDP-N-acetylmuramate--L-alanine ligase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2022-09-12
Release date:	2022-09-28
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa in complex with ligand AZ-13643701 to be published

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