7K3G
| SARS-CoV-2 Envelope Protein Transmembrane Domain: Pentameric Structure Determined by Solid-State NMR | Descriptor: | Envelope small membrane protein | Authors: | Mandala, V.S, Hong, M, McKay, M.J, Shcherbakov, A.S, Dregni, A.J. | Deposit date: | 2020-09-11 | Release date: | 2020-09-30 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers. Nat.Struct.Mol.Biol., 27, 2020
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3IF5
| Crystal Structure Analysis of Mglu | Descriptor: | Salt-tolerant glutaminase | Authors: | Yoshimune, K, Shirakihara, Y. | Deposit date: | 2009-07-24 | Release date: | 2009-08-04 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris. Febs J., 277, 2010
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6OVA
| Crystal Structure of TYK2 with novel pyrrolidinone inhibitor | Descriptor: | 6-({4-[(3S)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-N,N-dimethylpyridine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2 | Authors: | Skene, R.J, Hoffman, I.D. | Deposit date: | 2019-05-07 | Release date: | 2020-02-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors. Bioorg.Med.Chem.Lett., 30, 2020
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7X92
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7X91
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7X8W
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7X8Z
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7X8Y
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7X90
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5T8J
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5T8E
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5V8Q
| Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs): Part III | Descriptor: | 4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, Androgen receptor, GLYCEROL | Authors: | Wilson, K.P. | Deposit date: | 2017-03-22 | Release date: | 2017-05-24 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate. Bioorg. Med. Chem., 25, 2017
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6B30
| Structure of RORgt in complex with a novel inverse agonist 1 | Descriptor: | N-[(1R)-1-(4-methoxyphenyl)-2-oxo-2-{[4-(trimethylsilyl)phenyl]amino}ethyl]-N-methyl-3-oxo-2,3-dihydro-1,2-oxazole-5-carboxamide, Nuclear receptor ROR-gamma | Authors: | Skene, R.J, Hoffman, I. | Deposit date: | 2017-09-20 | Release date: | 2018-01-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Discovery of orally efficacious ROR gamma t inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds. Bioorg. Med. Chem., 26, 2018
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7POJ
| Prodomain bound BMP10 crystal form 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bone morphogenetic protein 10, TETRAETHYLENE GLYCOL | Authors: | Guo, J, Yu, M, Li, W. | Deposit date: | 2021-09-09 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022
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7POI
| Prodomain bound BMP10 crystal form 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bone morphogenetic protein 10, D(-)-TARTARIC ACID | Authors: | Guo, J, Yu, M, Li, W. | Deposit date: | 2021-09-09 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022
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7PPB
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7PPC
| Ternary signalling complex of BMP10 bound to ALK1 and BMPRII | Descriptor: | Bone morphogenetic protein 10, Bone morphogenetic protein receptor type-2, Serine/threonine-protein kinase receptor R3 | Authors: | Guo, J, Yu, M, Read, R.J, Li, W. | Deposit date: | 2021-09-13 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022
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7PPA
| High resolution structure of bone morphogenetic protein receptor type II (BMPRII) extracellular domain in complex with BMP10 | Descriptor: | Bone morphogenetic protein 10, Bone morphogenetic protein receptor type-2, GLYCEROL | Authors: | Guo, J, Yu, M, Read, R.J, Li, W. | Deposit date: | 2021-09-13 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022
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6B31
| Structure of RORgt in complex with a novel inverse agonist 2 | Descriptor: | (3S)-N~1~-(3-chloro-4-cyanophenyl)-N~5~-(1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)-3-methylpentanediamide, Nuclear receptor ROR-gamma | Authors: | Skene, R.J, Hoffman, I. | Deposit date: | 2017-09-20 | Release date: | 2018-08-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Identification of novel quinazolinedione derivatives as ROR gamma t inverse agonist. Bioorg. Med. Chem., 26, 2018
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8DOY
| Crystal structure of SARS-CoV-2 main protease in complex with an inhibitor TKB-198 | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3C-like proteinase nsp5, ... | Authors: | Bulut, H, Hayashi, H, Tsuji, K, Kuwata, N, Das, D, Tamamura, H, Mitsuya, H. | Deposit date: | 2022-07-14 | Release date: | 2022-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Potent and biostable inhibitors of the main protease of SARS-CoV-2. Iscience, 25, 2022
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1IXD
| Solution structure of the CAP-GLY domain from human cylindromatosis tomour-suppressor CYLD | Descriptor: | Cylindromatosis tumour-suppressor CYLD | Authors: | Saito, K, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2002-06-19 | Release date: | 2002-12-19 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma STRUCTURE, 12, 2004
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7ESM
| Crystal structure of a L-rhamnose-alpha-1,4-D-glucuronate lyase from Fusarium oxysporum 12S, L-Rha complex | Descriptor: | ACETATE ION, L-rhamnose-alpha-1,4-D-glucuronate lyase, SODIUM ION, ... | Authors: | Kondo, T, Arakawa, T, Fushinobu, S, Sakamoto, T. | Deposit date: | 2021-05-11 | Release date: | 2021-08-04 | Last modified: | 2021-09-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural and functional analysis of gum arabic l-rhamnose-alpha-1,4-d-glucuronate lyase establishes a novel polysaccharide lyase family. J.Biol.Chem., 297, 2021
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7ESN
| Crystal structure of a L-rhamnose-alpha-1,4-D-glucuronate lyase from Fusarium oxysporum 12S, H105F Rha-GlcA complex | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, L-Rhamnose-alpha-1,4-D-glucuronate lyase, ... | Authors: | Kondo, T, Arakawa, T, Fushinobu, S, Sakamoto, T. | Deposit date: | 2021-05-11 | Release date: | 2021-08-04 | Last modified: | 2021-09-01 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Structural and functional analysis of gum arabic l-rhamnose-alpha-1,4-d-glucuronate lyase establishes a novel polysaccharide lyase family. J.Biol.Chem., 297, 2021
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7ESK
| Crystal structure of a L-rhamnose-alpha-1,4-D-glucuronate lyase from Fusarium oxysporum 12S, Ligand free form | Descriptor: | CALCIUM ION, L-Rhamnose-alpha-1,4-D-glucuronate lyase, SODIUM ION, ... | Authors: | Kondo, T, Arakawa, T, Fushinobu, S, Sakamoto, T. | Deposit date: | 2021-05-11 | Release date: | 2021-08-04 | Last modified: | 2021-09-01 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Structural and functional analysis of gum arabic l-rhamnose-alpha-1,4-d-glucuronate lyase establishes a novel polysaccharide lyase family. J.Biol.Chem., 297, 2021
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7ESL
| Crystal structure of a L-rhamnose-alpha-1,4-D-glucuronate lyase from Fusarium oxysporum 12S, N247A N-glycan free form | Descriptor: | L-rhamnose-alpha-1,4-D-glucuronate lyase, SODIUM ION | Authors: | Kondo, T, Arakawa, T, Fushinobu, S, Sakamoto, T. | Deposit date: | 2021-05-11 | Release date: | 2021-08-04 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural and functional analysis of gum arabic l-rhamnose-alpha-1,4-d-glucuronate lyase establishes a novel polysaccharide lyase family. J.Biol.Chem., 297, 2021
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