2HEO
| General Structure-Based Approach to the Design of Protein Ligands: Application to the Design of Kv1.2 Potassium Channel Blockers. | Descriptor: | 5'-D(*TP*CP*GP*CP*GP*CP*G)-3', Z-DNA binding protein 1 | Authors: | Magis, C, Gasparini, S, Charbonnier, J.B, Stura, E, Le Du, M.H, Menez, A, Cuniasse, P. | Deposit date: | 2006-06-21 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure-based secondary structure-independent approach to design protein ligands: Application to the design of Kv1.2 potassium channel blockers. J.Am.Chem.Soc., 128, 2006
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2XT1
| Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 231) in complex with a camelid VHH. | Descriptor: | CAMELID VHH 9, GAG POLYPROTEIN, GLYCEROL | Authors: | Igonet, S, Vaney, M.C, Bartonova, V, Helma, J, Rothbauer, U, Leonhardt, H, Stura, E, Krausslich, H.-G, Rey, F.A. | Deposit date: | 2010-10-03 | Release date: | 2011-10-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Targeting HIV-1 Virion Formation with Nanobodies -Implications for the Design of Assembly Inhibitors To be Published
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2XXC
| Crystal structure of a camelid VHH raised against the HIV-1 capsid protein C-terminal domain. | Descriptor: | CAMELID VHH 9 | Authors: | Igonet, S, Vaney, M.C, Bartonova, V, Helma, J, Rothbauer, U, Leonhardt, H, Stura, E, Krausslich, H.-G, Rey, F.A. | Deposit date: | 2010-11-10 | Release date: | 2011-10-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Targeting HIV-1 Virion Formation with Nanobodies -Implications for the Design of Assembly Inhibitors To be Published
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2XXM
| Crystal structure of the HIV-1 capsid protein C-terminal domain in complex with a camelid VHH and the CAI peptide. | Descriptor: | ACETATE ION, CAMELID VHH 9, CAPSID PROTEIN P24, ... | Authors: | Igonet, S, Vaney, M.C, Bartonova, V, Helma, J, Rothbauer, U, Leonhardt, H, Stura, E, Krausslich, H.-G, Rey, F.A. | Deposit date: | 2010-11-10 | Release date: | 2011-10-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Targeting HIV-1 Virion Formation with Nanobodies -Implications for the Design of Assembly Inhibitors To be Published
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2XV6
| Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 220) in complex with a camelid VHH. | Descriptor: | CAMELID VHH 9, CAPSID PROTEIN P24 | Authors: | Igonet, S, Vaney, M.C, Bartonova, V, Helma, J, Rothbauer, U, Leonhardt, H, Stura, E, Krausslich, H.-G, Rey, F.A. | Deposit date: | 2010-10-22 | Release date: | 2011-10-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Targeting HIV-1 Virion Formation with Nanobodies -Implications for the Design of Assembly Inhibitors To be Published
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1DT1
| THERMUS THERMOPHILUS CYTOCHROME C552 SYNTHESIZED BY ESCHERICHIA COLI | Descriptor: | CYTOCHROME C552, HEME C | Authors: | Fee, J.A, Chen, Y, Hill, M.J, Gomez-Moran, E, Loehr, T, Ai, J, Thony-Meyer, L, Williams, P.A, Stura, E, Sridhar, V, McRee, D.E. | Deposit date: | 2000-01-10 | Release date: | 2000-02-18 | Last modified: | 2021-03-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Integrity of thermus thermophilus cytochrome c552 synthesized by Escherichia coli cells expressing the host-specific cytochrome c maturation genes, ccmABCDEFGH: biochemical, spectral, and structural characterization of the recombinant protein. Protein Sci., 9, 2000
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2AS8
| Crystal structure of mature and fully active Der p 1 allergen | Descriptor: | MAGNESIUM ION, Major mite fecal allergen Der p 1 | Authors: | de Halleux, S, Stura, E, VanderElst, L, Carlier, V, Jacquemin, M, Saint-Remy, J.-M. | Deposit date: | 2005-08-23 | Release date: | 2005-12-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen J.Allergy Clin.Immunol., 117, 2006
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3LIK
| Human MMP12 in complex with non-zinc chelating inhibitor | Descriptor: | ACETOHYDROXAMIC ACID, CALCIUM ION, HEXAETHYLENE GLYCOL, ... | Authors: | Stura, E.A, Dive, V, Devel, L, Czarny, B, Vera, L, Beau, F. | Deposit date: | 2010-01-25 | Release date: | 2010-09-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation. J.Biol.Chem., 285, 2010
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8AJ7
| Kunitz domain of Amblyomin-X | Descriptor: | 1,2-ETHANEDIOL, Kunitz domain of Amblyomin-X | Authors: | Ciccone, L, Servent, D, Stura, E.A. | Deposit date: | 2022-07-27 | Release date: | 2023-02-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity. Front Mol Biosci, 10, 2023
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6R5M
| Crystal structure of toxin MT9 from mamba venom | Descriptor: | ACETYL GROUP, Dendroaspis polylepis MT9, GLYCEROL, ... | Authors: | Stura, E.A, Tepshi, L, Ciolek, J, Triquigneaux, M, Zoukimian, C, De Waard, M, Beroud, R, Servent, D, Gilles, N, Legrand, P, Ciccone, L. | Deposit date: | 2019-03-25 | Release date: | 2020-02-12 | Last modified: | 2022-05-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries Biomed Pharmacother, 150, 2022
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3V95
| Crystal structure of monoclonal human anti-rhesus D Fc and IgG1 t125(yb2/0) in the presence of EDTA | Descriptor: | GLYCEROL, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Menez, R, A Stura, E, Bourel, D, Siberil, S, Jorieux, S, De Romeuf, C, Ducancel, F, Fridman, W.H, Teillaud, J.L. | Deposit date: | 2011-12-23 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Effect of zinc on human IgG1 and its Fc gamma R interactions. Immunol.Lett., 143, 2012
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3F58
| IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 12-RESIDUE CYCLIC PEPTIDE (INCLUDING RESIDUES 315-324 OF HIV-1 GP120 (MN ISOLATE); H315S MUTATION | Descriptor: | PROTEIN (CYCLIC PEPTIDE (GP120)), PROTEIN (IMMUNOGLOBULIN GAMMA I (58.2)) | Authors: | Stanfield, R.L, Cabezas, E, Satterthwait, A.C, Stura, E.A, Profy, A.T, Wilson, I.A. | Deposit date: | 1998-10-23 | Release date: | 1999-02-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs. Structure Fold.Des., 7, 1999
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3LJG
| Human MMP12 in complex with non-zinc chelating inhibitor | Descriptor: | ACETOHYDROXAMIC ACID, CALCIUM ION, HEXAETHYLENE GLYCOL, ... | Authors: | Stura, E.A, Dive, V, Devel, L, Vera, L, Beau, F. | Deposit date: | 2010-01-26 | Release date: | 2010-09-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.313 Å) | Cite: | Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation. J.Biol.Chem., 285, 2010
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3LIR
| Human MMP12 in complex with non-zinc chelating inhibitor | Descriptor: | CALCIUM ION, GLYCINE, Macrophage metalloelastase, ... | Authors: | Stura, E.A, Dive, V, Devel, L, Czarny, B, Vera, L, Beau, F. | Deposit date: | 2010-01-25 | Release date: | 2010-09-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation. J.Biol.Chem., 285, 2010
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3LIL
| Human MMP12 in complex with non-zinc chelating inhibitor | Descriptor: | ACETOHYDROXAMIC ACID, CALCIUM ION, Macrophage metalloelastase, ... | Authors: | Stura, E.A, Dive, V, Devel, L, Czarny, B, Vera, L, Beau, F. | Deposit date: | 2010-01-25 | Release date: | 2010-09-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation. J.Biol.Chem., 285, 2010
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2VLW
| Crystal structure of the muscarinic toxin MT7 diiodoTYR51 derivative. | Descriptor: | ACETATE ION, MUSCARINIC M1-TOXIN1, SULFATE ION | Authors: | Menez, R, Granata, V, Mourier, G, Fruchart-Gaillard, C, Menez, A, Servant, D, Stura, E.A. | Deposit date: | 2008-01-17 | Release date: | 2008-10-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Different Interactions between Mt7 Toxin and the Human Muscarinic M1 Receptor in its Free and N-Methylscopolamine-Occupied States. Mol.Pharmacol., 74, 2008
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3NDS
| Crystal structure of engineered Naja Nigricollis toxin alpha | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, SULFATE ION, Short neurotoxin 1 | Authors: | Stura, E.A, Drevet, P, Gregory, G, Gallopin, M, Vandame, M. | Deposit date: | 2010-06-08 | Release date: | 2010-08-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Conformational exchange is critical for the productivity of an oxidative folding intermediate with buried free cysteines. J.Mol.Biol., 403, 2010
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2ZCH
| Crystal structure of human prostate specific antigen complexed with an activating antibody | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, CHLORIDE ION, PHOSPHATE ION, ... | Authors: | Menez, R, Stura, E, Jolivet-Reynaud, C. | Deposit date: | 2007-11-08 | Release date: | 2008-01-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody J.Mol.Biol., 376, 2008
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2ZCL
| Crystal structure of human prostate specific antigen complexed with an activating antibody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prostate-specific antigen, monoclonal antibody 8G8F5 Fab | Authors: | Menez, R, Stura, E, Jolivet-Reynaud, C. | Deposit date: | 2007-11-09 | Release date: | 2008-01-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody J.Mol.Biol., 376, 2008
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2ZCK
| Crystal structure of a ternary complex between PSA, a substrat-acyl intermediate and an activating antibody | Descriptor: | KGISSQY, Prostate-specific antigen, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Menez, R, Stura, E, Jolivet-Reynaud, C. | Deposit date: | 2007-11-09 | Release date: | 2008-01-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody J.Mol.Biol., 376, 2008
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2F58
| IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 12-RESIDUE CYCLIC PEPTIDE (INCLUDING RESIDUES 315-324 OF HIV-1 GP120) (MN ISOLATE) | Descriptor: | 1-IMINO-5-PENTANONE, PROTEIN (HIV-1 GP120), PROTEIN (IGG1 FAB 58.2 ANTIBODY (HEAVY CHAIN)), ... | Authors: | Stanfield, R.L, Cabezas, E, Satterthwait, A.C, Stura, E.A, Profy, A.T, Wilson, I.A. | Deposit date: | 1998-10-23 | Release date: | 1999-02-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs. Structure Fold.Des., 7, 1999
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2H7Z
| Crystal structure of irditoxin | Descriptor: | Irditoxin subunit A, Irditoxin subunit B | Authors: | Pawlak, J, Kini, R.M, Stura, E.A, Le Du, M.H. | Deposit date: | 2006-06-06 | Release date: | 2006-08-29 | Last modified: | 2011-10-05 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity. Faseb J., 23, 2009
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1F58
| IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 24-RESIDUE PEPTIDE (RESIDUES 308-333 OF HIV-1 GP120 (MN ISOLATE) WITH ALA TO AIB SUBSTITUTION AT POSITION 323 | Descriptor: | Envelope glycoprotein gp120, PROTEIN (IGG1 ANTIBODY 58.2 (HEAVY CHAIN)), PROTEIN (IGG1 ANTIBODY 58.2 (LIGHT CHAIN)) | Authors: | Stanfield, R.L, Cabezas, E, Satterthwait, A.C, Stura, E.A, Profy, A.T, Wilson, I.A. | Deposit date: | 1998-10-21 | Release date: | 1999-02-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs. Structure Fold.Des., 7, 1999
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2H5F
| Denmotoxin: A the three-finger toxin from colubrid snake Boiga dendrophila with bird-specific activity | Descriptor: | PHOSPHATE ION, POTASSIUM ION, SODIUM ION, ... | Authors: | Pawlak, J, Kini, R.M, Stura, E.A. | Deposit date: | 2006-05-26 | Release date: | 2006-08-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity. J.Biol.Chem., 281, 2006
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6EXF
| Crystal structure of the complex Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO5 with Fe(II)/Lysine | Descriptor: | FE (III) ION, GLYCEROL, L-lysine 4-hydroxylase, ... | Authors: | Isabet, T, Stura, E, Legrand, P, Zaparucha, A, Bastard, K. | Deposit date: | 2017-11-08 | Release date: | 2018-11-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family. Sci Rep, 8, 2018
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