6H0A
| Serum paraoxonase-1 by directed evolution with the L69G/H115W/H134R/F222S/T332S mutations | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, CALCIUM ION, ... | Authors: | Ben-David, M, Sussman, J.L, Tawfik, D.S. | Deposit date: | 2018-07-07 | Release date: | 2019-07-17 | Last modified: | 2020-04-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition. Mol.Biol.Evol., 37, 2020
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6C2C
| The molecular basis for the functional evolution of an organophosphate hydrolysing enzyme | Descriptor: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ZINC ION, ... | Authors: | Hong, N.-S, Jackson, C.J, Carr, P.D, Tokuriki, N, Baier, F, Yang, G. | Deposit date: | 2018-01-08 | Release date: | 2019-01-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.597 Å) | Cite: | Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme. Nat.Chem.Biol., 15, 2019
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6G82
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6G0A
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6I8A
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5WL6
| Crystal structure of chalcone isomerase engineered from ancestral inference (AncR7) | Descriptor: | CHLORIDE ION, Engineered Chalcone Isomerase AncR7 | Authors: | Burke, J.R, Kaltenbach, M, Tawfik, D.S, Noel, J.P. | Deposit date: | 2017-07-25 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Evolution of chalcone isomerase from a noncatalytic ancestor. Nat. Chem. Biol., 14, 2018
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5WL3
| Crystal structure of chalcone isomerase engineered from ancestral inference (ancR2) | Descriptor: | CHLORIDE ION, Engineered Chalcone Isomerase ancR2 | Authors: | Burke, J.R, Kaltenbach, M, Tawfik, D.S, Noel, J.P. | Deposit date: | 2017-07-25 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Evolution of chalcone isomerase from a noncatalytic ancestor. Nat. Chem. Biol., 14, 2018
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5WKS
| Crystal structure of chalcone isomerase engineered from ancestral inference complexed with naringenin (ancR1) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Engineered Chalcone Isomerase ancR1, FORMIC ACID, ... | Authors: | Burke, J.R, Kaltenbach, M, Tawfik, D.S, Noel, J.P. | Deposit date: | 2017-07-25 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Evolution of chalcone isomerase from a noncatalytic ancestor. Nat. Chem. Biol., 14, 2018
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5WL5
| Crystal structure of chalcone isomerase engineered from ancestral inference (ancR5) | Descriptor: | CHLORIDE ION, Engineered Chalcone Isomerase ancR5, SULFATE ION | Authors: | Burke, J.R, Kaltenbach, M, Tawfik, D.S, Noel, J.P. | Deposit date: | 2017-07-25 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.513 Å) | Cite: | Evolution of chalcone isomerase from a noncatalytic ancestor. Nat. Chem. Biol., 14, 2018
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5WL7
| Crystal structure of chalcone isomerase engineered from ancestral inference (ancCHI*) | Descriptor: | CHLORIDE ION, Engineered Chalcone Isomerase ancCHI* | Authors: | Burke, J.R, Kaltenbach, M, Tawfik, D.S, Noel, J.P. | Deposit date: | 2017-07-25 | Release date: | 2018-05-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Evolution of chalcone isomerase from a noncatalytic ancestor. Nat. Chem. Biol., 14, 2018
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6XEA
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to vanadate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.549 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEE
| Crystal Structure of the PTP1B YopH WPD loop Chimera 4 apo form | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XE8
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 apo form | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.952 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XED
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to tungstate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.795 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEF
| Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to vanadate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.048 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEG
| Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to tungstate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.549 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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8B67
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8B7E
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8B77
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8B6K
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8B79
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8B76
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6E8Y
| Unliganded Human Glycerol 3-Phosphate Dehydrogenase | Descriptor: | 2,2-bis(hydroxymethyl)propane-1,3-diol, Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic, ... | Authors: | Mydy, L.S, Gulick, A.M. | Deposit date: | 2018-07-31 | Release date: | 2019-01-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Human Glycerol 3-Phosphate Dehydrogenase: X-ray Crystal Structures That Guide the Interpretation of Mutagenesis Studies. Biochemistry, 58, 2019
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6E90
| Ternary complex of human glycerol 3-phosphate dehydrogenase | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,3-DIHYDROXYACETONEPHOSPHATE, CALCIUM ION, ... | Authors: | Mydy, L.S, Gulick, A.M. | Deposit date: | 2018-07-31 | Release date: | 2019-01-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Human Glycerol 3-Phosphate Dehydrogenase: X-ray Crystal Structures That Guide the Interpretation of Mutagenesis Studies. Biochemistry, 58, 2019
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6E8Z
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