7ZSS
| cryo-EM structure of D614 spike in complex with de novo designed binder | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Pablo, G, Sarah, W, Alexandra, V.H, Anthony, M, Andreas, S, Zander, H, Dongchun, N, Shuguang, T, Freyr, S, Casper, G, Priscilla, T, Alexandra, T, Stephane, R, Sandrine, G, Jane, M, Aaron, P, Zepeng, X, Yan, C, Pu, H, George, G, Elisa, O, Beat, F, Didier, T, Henning, S, Michael, B, Bruno, E.C. | Deposit date: | 2022-05-08 | Release date: | 2023-03-01 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
|
|
7ZRV
| cryo-EM structure of omicron spike in complex with de novo designed binder, full map | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, ... | Authors: | Pablo, G, Sarah, W, Alexandra, V.H, Anthony, M, Andreas, S, Zander, H, Dongchun, N, Shuguang, T, Freyr, S, Casper, G, Priscilla, T, Alexandra, T, Stephane, R, Sandrine, G, Jane, M, Aaron, P, Zepeng, X, Yan, C, Pu, H, George, G, Elisa, O, Beat, F, Didier, T, Henning, S, Michael, B, Bruno, E.C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-08 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
|
|
8IBX
| Structure of R2 with 3'UTR and DNA in unwinding state | Descriptor: | 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ... | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
|
|
8IBW
| Structure of R2 with 3'UTR and DNA in binding state | Descriptor: | 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ... | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
|
|
8IBZ
| Structure of R2 with 5'ORF and 3'UTR | Descriptor: | 5ORF-linker-3UTR, Reverse transcriptase-like protein, ZINC ION | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
|
|
8IBY
| Structure of R2 with 5'ORF | Descriptor: | 5'ORF RNA, Reverse transcriptase-like protein, ZINC ION | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
|
|
4PF3
| Mineralocorticoid receptor ligand-binding domain with compuond 37a | Descriptor: | 1,2-ETHANEDIOL, 6-[1-(2,2-difluoro-3-hydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one, Mineralocorticoid receptor | Authors: | Sogabe, S, Habuka, N. | Deposit date: | 2014-04-28 | Release date: | 2014-11-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists Bioorg.Med.Chem., 22, 2014
|
|
6VJ9
| |
3VS2
| Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | Descriptor: | 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kuratani, M, Tomabechi, Y, Niwa, H, Parker, J.L, Handa, N, Yokoyama, S. | Deposit date: | 2012-04-21 | Release date: | 2013-05-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.609 Å) | Cite: | A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
|
|
3VRY
| Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Descriptor: | 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kuratani, M, Tomabechi, Y, Niwa, H, Handa, N, Yokoyama, S. | Deposit date: | 2012-04-21 | Release date: | 2013-05-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.481 Å) | Cite: | A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
|
|
3VRZ
| Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea | Descriptor: | 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. | Deposit date: | 2012-04-21 | Release date: | 2013-05-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.218 Å) | Cite: | A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
|
|
3VS7
| Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Descriptor: | 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kuratani, M, Honda, K, Niwa, H, Toyama, M, Handa, N, Yokoyama, S. | Deposit date: | 2012-04-21 | Release date: | 2013-05-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.001 Å) | Cite: | A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
|
|
3MBC
| Crystal structure of monomeric isocitrate dehydrogenase from Corynebacterium glutamicum in complex with NADP | Descriptor: | Isocitrate dehydrogenase [NADP], MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Sidhu, N.S, Aich, S, Sheldrick, G.M, Delbaere, L.T.J. | Deposit date: | 2010-03-25 | Release date: | 2011-04-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of a highly NADP+-specific isocitrate dehydrogenase. Acta Crystallogr.,Sect.D, 67, 2011
|
|
5HMX
| Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 10 | Descriptor: | 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION | Authors: | Noble, C.G. | Deposit date: | 2016-01-17 | Release date: | 2016-03-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
|
|
5HMY
| Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 15 | Descriptor: | 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION | Authors: | Noble, C.G. | Deposit date: | 2016-01-17 | Release date: | 2016-03-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design. J.Med.Chem., 59, 2016
|
|
5HMW
| Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 5 | Descriptor: | 2,2'-biphenyl-3,5-diyldiacetic acid, RNA-directed RNA polymerase NS5, ZINC ION | Authors: | Noble, C.G. | Deposit date: | 2016-01-17 | Release date: | 2016-03-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
|
|
6ZHX
| Cryo-EM structure of the regulatory linker of ALC1 bound to the nucleosome's acidic patch: nucleosome class. | Descriptor: | Chromodomain-helicase-DNA-binding protein 1-like, DNA (145-MER) Widom 601 sequence, Histone H2A type 1, ... | Authors: | Bacic, L, Gaullier, G, Croll, T.I, Deindl, S. | Deposit date: | 2020-06-24 | Release date: | 2020-12-23 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch. Cell Rep, 33, 2020
|
|
6ZHY
| Cryo-EM structure of the regulatory linker of ALC1 bound to the nucleosome's acidic patch: hexasome class. | Descriptor: | Chromodomain-helicase-DNA-binding protein 1-like, DNA (110-MER) Widom 601 sequence, Histone H2A type 1, ... | Authors: | Bacic, L, Gaullier, G, Deindl, S. | Deposit date: | 2020-06-24 | Release date: | 2020-12-23 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch. Cell Rep, 33, 2020
|
|
2RRA
| Solution structure of RNA binding domain in human Tra2 beta protein in complex with RNA (GAAGAA) | Descriptor: | 5'-R(*GP*AP*AP*GP*AP*A)-3', cDNA FLJ40872 fis, clone TUTER2000283, ... | Authors: | Tsuda, K, Kuwasako, K, Takahashi, M, Someya, T, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Sugano, S, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2010-06-17 | Release date: | 2011-04-27 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for the dual RNA-recognition modes of human Tra2-beta RRM. Nucleic Acids Res., 39, 2011
|
|
2RRB
| Refinement of RNA binding domain in human Tra2 beta protein | Descriptor: | cDNA FLJ40872 fis, clone TUTER2000283, highly similar to Homo sapiens transformer-2-beta (SFRS10) gene | Authors: | Tsuda, K, Kuwasako, K, Takahashi, M, Someya, T, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Sugano, S, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2010-06-17 | Release date: | 2011-04-27 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for the dual RNA-recognition modes of human Tra2-beta RRM. Nucleic Acids Res., 39, 2011
|
|
2RR6
| Solution structure of the leucine rich repeat of human acidic leucine-rich nuclear phosphoprotein 32 family member B | Descriptor: | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Authors: | Tochio, N, Umehara, T, Tsuda, K, Koshiba, S, Harada, T, Watanabe, S, Tanaka, A, Kigawa, T, Yokoyama, S. | Deposit date: | 2010-05-25 | Release date: | 2010-06-09 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of histone chaperone ANP32B: interaction with core histones H3-H4 through its acidic concave domain. J.Mol.Biol., 401, 2010
|
|
2RPP
| Solution structure of Tandem zinc finger domain 12 in Muscleblind-like protein 2 | Descriptor: | Muscleblind-like protein 2, ZINC ION | Authors: | Abe, C, Dang, W, Tsuda, K, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2008-06-24 | Release date: | 2009-05-12 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the RNA binding domain in the human muscleblind-like protein 2 Protein Sci., 18, 2009
|
|
2RPJ
| Solution structure of Fn14 CRD domain | Descriptor: | Tumor necrosis factor receptor superfamily member 12A | Authors: | He, F, Dang, W, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2008-05-19 | Release date: | 2009-03-24 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily Protein Sci., 18, 2009
|
|
5YS2
| |
5YSL
| Crystal structure of antibody 1H1 Fab | Descriptor: | 1H1 heavy chain, 1H1 light chain | Authors: | Hu, X.L, Yang, F.L. | Deposit date: | 2017-11-14 | Release date: | 2017-12-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design. PLoS Pathog., 13, 2017
|
|