8K9X
| Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 5 (ADKI5) | Descriptor: | (2~{S})-2,6-bis(azanyl)-~{N}-[3-[2-[[4-[(2,5-dimethoxyphenyl)amino]-1,3,5-triazin-2-yl]amino]phenyl]sulfonylpropyl]hexanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Lysine--tRNA ligase | Authors: | Zhou, J, Xia, M, Yang, G, Li, P, Fang, P. | Deposit date: | 2023-08-01 | Release date: | 2024-06-26 | Last modified: | 2024-07-03 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors. Commun Biol, 7, 2024
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7VM5
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7VM6
| Crystal structure of uPA in complex with 6-amidino-2-naphthol | Descriptor: | 6-oxidanylnaphthalene-2-carboximidamide, SULFATE ION, TRIETHYLENE GLYCOL, ... | Authors: | Jiang, L.G, Huang, M.D. | Deposit date: | 2021-10-07 | Release date: | 2022-10-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat. Biophys.J., 121, 2022
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7VM7
| Crystal structure of inactive uPA in complex with nafamostat | Descriptor: | (6-carbamimidoylnaphthalen-2-yl) 4-carbamimidamidobenzoate, Urokinase-type plasminogen activator chain B | Authors: | Jiang, L.G, Huang, M.D. | Deposit date: | 2021-10-07 | Release date: | 2022-11-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat. Biophys.J., 121, 2022
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7XUZ
| Crystal structure of a HDAC4-MEF2A-DNA ternary complex | Descriptor: | DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ... | Authors: | Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H. | Deposit date: | 2022-05-20 | Release date: | 2023-11-29 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (3.591 Å) | Cite: | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation. Nucleic Acids Res., 52, 2024
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7XP6
| Cryo-EM structure of a class T GPCR in active state | Descriptor: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | Deposit date: | 2022-05-03 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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7XP4
| Cryo-EM structure of a class T GPCR in apo state | Descriptor: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | Deposit date: | 2022-05-03 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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7XP5
| Cryo-EM structure of a class T GPCR in ligand-free state | Descriptor: | Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | Deposit date: | 2022-05-03 | Release date: | 2022-10-12 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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7XV9
| Crystal structure of the Human TR4 DNA-Binding Domain | Descriptor: | Nuclear receptor subfamily 2 group C member 2, ZINC ION | Authors: | Liu, Y, Chen, Z. | Deposit date: | 2022-05-21 | Release date: | 2022-12-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.599 Å) | Cite: | Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation. Nucleic Acids Res., 51, 2023
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7XV8
| Crystal structure of the Human TR4 DNA-Binding Domain Homodimer Bound to DR1 Response Element | Descriptor: | DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*AP*GP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*A)-3'), Nuclear receptor subfamily 2 group C member 2, ... | Authors: | Liu, Y, Chen, Z. | Deposit date: | 2022-05-21 | Release date: | 2022-12-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.199 Å) | Cite: | Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation. Nucleic Acids Res., 51, 2023
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7XV6
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7XVA
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7F2D
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7F2I
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7V63
| Structure of dimeric uPAR at low pH | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor | Authors: | Yuan, C, Huang, M. | Deposit date: | 2021-08-19 | Release date: | 2021-12-22 | Last modified: | 2022-04-06 | Method: | X-RAY DIFFRACTION (2.906 Å) | Cite: | Crystal structure and cellular functions of uPAR dimer Nat Commun, 13, 2022
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7WZ6
| Crystal structure of MyoD-E47 | Descriptor: | Isoform E47 of Transcription factor E2-alpha, Myoblast determination protein 1 | Authors: | Zhong, J, Huang, Y, Ma, J. | Deposit date: | 2022-02-17 | Release date: | 2022-06-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis of the bHLH domains of MyoD-E47 heterodimer. Biochem.Biophys.Res.Commun., 621, 2022
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7X4X
| BTB domain of KEAP1 in complex with MEF | Descriptor: | 4-ethoxy-4-oxobutanoic acid, Kelch-like ECH-associated protein 1 | Authors: | Qu, L.Z. | Deposit date: | 2022-03-03 | Release date: | 2023-03-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates. Biochem.Biophys.Res.Commun., 605, 2022
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7X4W
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7XDV
| Crystal structure of a receptor like kinase from Arabidopsis | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Receptor-like protein kinase FERONIA | Authors: | Kong, Y.Q, Ming, Z.H. | Deposit date: | 2022-03-29 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structural and biochemical basis of Arabidopsis FERONIA receptor kinase-mediated early signaling initiation. Plant Commun., 4, 2023
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7XDW
| Crystal structure of a receptor like kinase from Arabidopsis | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Receptor-like protein kinase FERONIA | Authors: | Kong, Y.Q, Ming, Z.H. | Deposit date: | 2022-03-29 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.926 Å) | Cite: | Structural and biochemical basis of Arabidopsis FERONIA receptor kinase-mediated early signaling initiation. Plant Commun., 4, 2023
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7XDX
| Crystal structure of a receptor like kinase from Arabidopsis | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Receptor-like protein kinase FERONIA | Authors: | Kong, Y.Q, Ming, Z.H. | Deposit date: | 2022-03-29 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Structural and biochemical basis of Arabidopsis FERONIA receptor kinase-mediated early signaling initiation. Plant Commun., 4, 2023
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7XDY
| Crystal structure of a receptor like kinase from Arabidopsis | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Receptor-like protein kinase FERONIA | Authors: | Kong, Y.Q, Ming, Z.H. | Deposit date: | 2022-03-29 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural and biochemical basis of Arabidopsis FERONIA receptor kinase-mediated early signaling initiation. Plant Commun., 4, 2023
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7VNI
| AHR-ARNT PAS-B heterodimer | Descriptor: | Ahr homolog spineless, Aryl hydrocarbon receptor nuclear translocator, SULFATE ION | Authors: | Dai, S.Y. | Deposit date: | 2021-10-11 | Release date: | 2022-04-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
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7VNA
| drosophlia AHR PAS-B domain | Descriptor: | Ahr homolog spineless | Authors: | Dai, S.Y. | Deposit date: | 2021-10-10 | Release date: | 2022-04-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.597 Å) | Cite: | Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
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7VNH
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