6ASG
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![BU of 6asg by Molmil](/molmil-images/mine/6asg) | Crystal structure of Thermus thermophilus RNA polymerase core enzyme | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Liu, Y, Lin, W, Ying, R, Ebright, R.H. | Deposit date: | 2017-08-24 | Release date: | 2018-04-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
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3G3D
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![BU of 3g3d by Molmil](/molmil-images/mine/3g3d) | Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-azido-UMP | Descriptor: | 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, GLYCEROL, SULFATE ION, ... | Authors: | Liu, Y, Tang, H.L, Bello, A, Poduch, E, Kotra, L, Pai, E. | Deposit date: | 2009-02-02 | Release date: | 2009-03-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J.Med.Chem., 52, 2009
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3G3M
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![BU of 3g3m by Molmil](/molmil-images/mine/3g3m) | Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-iodo-UMP | Descriptor: | 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, Uridine 5'-monophosphate synthase | Authors: | Liu, Y, Tang, H.L, Bello, A.M, Poduch, E, Kotra, L.P, Pai, E.F. | Deposit date: | 2009-02-02 | Release date: | 2009-03-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J.Med.Chem., 52, 2009
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5W3M
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![BU of 5w3m by Molmil](/molmil-images/mine/5w3m) | CryoEM structure of rhinovirus B14 in complex with C5 Fab (33 degrees Celsius, molar ratio 1:1, full particle) | Descriptor: | C5 antibody variable heavy domain, C5 antibody variable light domain, viral protein 1, ... | Authors: | Liu, Y, Dong, Y, Rossmann, M.G. | Deposit date: | 2017-06-08 | Release date: | 2017-07-12 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (2.26 Å) | Cite: | Antibody-induced uncoating of human rhinovirus B14. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5W3O
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![BU of 5w3o by Molmil](/molmil-images/mine/5w3o) | CryoEM structure of rhinovirus B14 in complex with C5 Fab (33 degrees Celsius, molar ratio 1:3, empty particle) | Descriptor: | C5 antibody variable heavy domain, C5 antibody variable light domain, viral protein 1, ... | Authors: | Liu, Y, Dong, Y, Rossmann, M.G. | Deposit date: | 2017-06-08 | Release date: | 2017-07-12 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Antibody-induced uncoating of human rhinovirus B14. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5W3L
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![BU of 5w3l by Molmil](/molmil-images/mine/5w3l) | CryoEM structure of rhinovirus B14 in complex with C5 Fab (4 degrees Celsius, molar ratio 1:3, full particle) | Descriptor: | C5 antibody variable heavy domain, C5 antibody variable light domain, viral protein 1, ... | Authors: | Liu, Y, Dong, Y, Rossmann, M.G. | Deposit date: | 2017-06-08 | Release date: | 2017-07-12 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Antibody-induced uncoating of human rhinovirus B14. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5W3E
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![BU of 5w3e by Molmil](/molmil-images/mine/5w3e) | CryoEM structure of rhinovirus B14 in complex with C5 Fab (33 degrees Celsius, molar ratio 1:3, full particle) | Descriptor: | C5 antibody variable heavy domain, C5 antibody variable light domain, viral protein 1, ... | Authors: | Liu, Y, Dong, Y, Rossmann, M.G. | Deposit date: | 2017-06-07 | Release date: | 2017-07-12 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | Antibody-induced uncoating of human rhinovirus B14. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4PLI
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![BU of 4pli by Molmil](/molmil-images/mine/4pli) | |
5DF6
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![BU of 5df6 by Molmil](/molmil-images/mine/5df6) | Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11, UNKNOWN ATOM OR ION, txnip | Authors: | Dong, A, Li, W, Tempel, W, Liu, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2015-08-26 | Release date: | 2015-09-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem.J., 473, 2016
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5EG8
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![BU of 5eg8 by Molmil](/molmil-images/mine/5eg8) | The cap binding site of influenza virus protein PB2 as a drug target | Descriptor: | Polymerase basic protein 2, THIOCYANATE ION | Authors: | Liu, Y, Zheng, X, Severin, C, Rocha de Moura, T, Li, K, Luo, M. | Deposit date: | 2015-10-26 | Release date: | 2016-02-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | The cap-binding site of influenza virus protein PB2 as a drug target. Acta Crystallogr D Struct Biol, 72, 2016
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5EQ0
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![BU of 5eq0 by Molmil](/molmil-images/mine/5eq0) | Crystal Structure of chromodomain of CBX8 in complex with inhibitor UNC3866 | Descriptor: | Chromobox protein homolog 8, UNKNOWN ATOM OR ION, unc3866 | Authors: | Liu, Y, Tempel, W, Walker, J.R, Stuckey, J.I, Dickson, B.M, James, L.I, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2015-11-12 | Release date: | 2015-12-23 | Last modified: | 2019-11-27 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol., 12, 2016
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5EPK
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![BU of 5epk by Molmil](/molmil-images/mine/5epk) | Crystal Structure of chromodomain of CBX2 in complex with inhibitor UNC3866 | Descriptor: | Chromobox protein homolog 2, UNKNOWN ATOM OR ION, unc3866 | Authors: | Liu, Y, Tempel, W, Walker, J.R, Stuckey, J.I, Dickson, B.M, James, L.I, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2015-11-11 | Release date: | 2015-12-23 | Last modified: | 2019-11-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol., 12, 2016
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4PLL
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![BU of 4pll by Molmil](/molmil-images/mine/4pll) | |
8CVZ
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![BU of 8cvz by Molmil](/molmil-images/mine/8cvz) | |
8CVY
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![BU of 8cvy by Molmil](/molmil-images/mine/8cvy) | |
8CVX
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![BU of 8cvx by Molmil](/molmil-images/mine/8cvx) | Human glycogenin-1 and glycogen synthase-1 complex in the presence of glucose-6-phosphate | Descriptor: | 6-O-phosphono-alpha-D-glucopyranose, Glycogen [starch] synthase, muscle, ... | Authors: | Liu, Y, Fastman, N.M, Tzitzilonis, C. | Deposit date: | 2022-05-18 | Release date: | 2022-07-13 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex. Cell Rep, 40, 2022
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3BAR
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![BU of 3bar by Molmil](/molmil-images/mine/3bar) | Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase covalently modified by 6-azido-UMP | Descriptor: | Orotidine 5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE | Authors: | Liu, Y, Bello, A.M, Poduch, E, Lau, W, Kotra, L.P, Pai, E.F. | Deposit date: | 2007-11-08 | Release date: | 2008-01-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-Activity Relationships of C6-Uridine Derivatives Targeting Plasmodia Orotidine Monophosphate Decarboxylase. J.Med.Chem., 51, 2008
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5IN1
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![BU of 5in1 by Molmil](/molmil-images/mine/5in1) | Crystal Structure of the MRG701 chromodomain | Descriptor: | 1,2-ETHANEDIOL, MRG701, SULFATE ION | Authors: | Huang, Y, Liu, Y. | Deposit date: | 2016-03-07 | Release date: | 2017-03-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural studies on MRG701 chromodomain reveal a novel dimerization interface of MRG proteins in green plants Protein Cell, 7, 2016
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4XNR
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![BU of 4xnr by Molmil](/molmil-images/mine/4xnr) | Vibrio Vulnificus Adenine Riboswitch Aptamer Domain, Synthesized by Position-selective Labeling of RNA (PLOR), in Complex with Adenine | Descriptor: | ADENINE, MAGNESIUM ION, Vibrio Vulnificus Adenine Riboswitch | Authors: | Zhang, J, Liu, Y, Wang, Y.-X, Ferre-D'Amare, A.R. | Deposit date: | 2015-01-16 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Synthesis and applications of RNAs with position-selective labelling and mosaic composition. Nature, 522, 2015
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4ZK7
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![BU of 4zk7 by Molmil](/molmil-images/mine/4zk7) | Crystal structure of rescued two-component self-assembling tetrahedral cage T33-31 | Descriptor: | Chorismate mutase, Divalent-cation tolerance protein CutA | Authors: | Liu, Y, Cascio, D, Sawaya, M.R, Bale, J, Collazo, M.J, Park, R, King, N, Baker, D, Yeates, T. | Deposit date: | 2015-04-30 | Release date: | 2015-07-29 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression. Protein Sci., 24, 2015
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4PEK
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![BU of 4pek by Molmil](/molmil-images/mine/4pek) | Crystal structure of a computationally designed retro-aldolase, RA114.3 | Descriptor: | Retro-aldolase | Authors: | Bhabha, G, Zhang, X, Liu, Y, Ekiert, D.C. | Deposit date: | 2014-04-23 | Release date: | 2015-04-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters. J.Am.Chem.Soc., 136, 2014
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4PEJ
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![BU of 4pej by Molmil](/molmil-images/mine/4pej) | Crystal structure of a computationally designed retro-aldolase, RA110.4 (Cys free) | Descriptor: | Retro-aldolase | Authors: | Bhabha, G, Zhang, X, Liu, Y, Ekiert, D.C. | Deposit date: | 2014-04-23 | Release date: | 2015-04-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters. J.Am.Chem.Soc., 136, 2014
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7S15
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![BU of 7s15 by Molmil](/molmil-images/mine/7s15) | GLP-1 receptor bound with Pfizer small molecule agonist | Descriptor: | 2-[(4-{6-[(2,4-difluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5-yl)methyl]-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor | Authors: | Liu, Y, Dias, J.M, Han, S. | Deposit date: | 2021-09-01 | Release date: | 2022-06-08 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor. J.Med.Chem., 65, 2022
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5H05
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![BU of 5h05 by Molmil](/molmil-images/mine/5h05) | Crystal structure of AmyP E221Q in complex with MALTOTRIOSE | Descriptor: | AmyP, CALCIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | He, C, Liu, Y. | Deposit date: | 2016-10-03 | Release date: | 2017-08-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal structure of a raw-starch-degrading bacterial alpha-amylase belonging to subfamily 37 of the glycoside hydrolase family GH13 Sci Rep, 7, 2017
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6CV5
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![BU of 6cv5 by Molmil](/molmil-images/mine/6cv5) | |