3F6X
| c-Src kinase domain in complex with small molecule inhibitor | Descriptor: | Proto-oncogene tyrosine-protein kinase Src, [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile | Authors: | Seeliger, M.A, Statsuk, A.V, Maly, D.J, Patrick, P.Z, Kuriyan, J, Shokat, K.M. | Deposit date: | 2008-11-06 | Release date: | 2008-12-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Tuning a three-component reaction for trapping kinase substrate complexes. J.Am.Chem.Soc., 130, 2008
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3DQW
| c-Src kinase domain Thr338Ile mutant in complex with ATPgS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Proto-oncogene tyrosine-protein kinase Src | Authors: | Azam, M, Seeliger, M.A, Gray, N, Kuriyan, J, Daley, G.Q. | Deposit date: | 2008-07-09 | Release date: | 2008-09-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.017 Å) | Cite: | Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat.Struct.Mol.Biol., 15, 2008
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3G6H
| Src Thr338Ile inhibited in the DFG-Asp-Out conformation | Descriptor: | N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide, Proto-oncogene tyrosine-protein kinase Src | Authors: | Seeliger, M.A, Ranjitkar, P, Kasap, C, Shan, Y, Shaw, D.E, Shah, N.P, Kuriyan, J, Maly, D.J. | Deposit date: | 2009-02-06 | Release date: | 2009-03-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations Cancer Res., 69, 2009
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3G6G
| Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations | Descriptor: | GLYCEROL, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide, Proto-oncogene tyrosine-protein kinase Src | Authors: | Seeliger, M.A, Ranjitkar, P, Kasap, C, Shan, Y, Shaw, D.E, Shah, N.P, Kuriyan, J, Maly, D.J. | Deposit date: | 2009-02-06 | Release date: | 2009-03-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations Cancer Res., 69, 2009
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3GLG
| Crystal Structure of a Mutant (gammaT157A) E. coli Clamp Loader Bound to Primer-Template DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*AP*TP*A)-3'), ... | Authors: | Simonetta, K.R, Seyedin, S.N, Kuriyan, J. | Deposit date: | 2009-03-12 | Release date: | 2009-05-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell(Cambridge,Mass.), 137, 2009
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3GLF
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3GT8
| Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP | Descriptor: | Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Jura, N, Endres, N.F, Engel, K, Deindl, S, Das, R, Lamers, M.H, Wemmer, D.E, Zhang, X, Kuriyan, J. | Deposit date: | 2009-03-27 | Release date: | 2009-07-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell(Cambridge,Mass.), 137, 2009
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3DQX
| chicken c-Src kinase domain in complex with ATPgS | Descriptor: | ADENOSINE MONOPHOSPHATE, Proto-oncogene tyrosine-protein kinase Src | Authors: | Azam, M, Seeliger, M.A, Gray, N, Kuriyan, J, Daley, G.Q. | Deposit date: | 2008-07-09 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat.Struct.Mol.Biol., 15, 2008
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3GLI
| Crystal Structure of the E. coli clamp loader bound to Primer-Template DNA and Psi Peptide | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*AP*TP*A)-3'), ... | Authors: | Simonetta, K.R, Cantor, A.J, Kuriyan, J. | Deposit date: | 2009-03-12 | Release date: | 2009-05-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell(Cambridge,Mass.), 137, 2009
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3GLH
| Crystal Structure of the E. coli clamp loader bound to Psi Peptide | Descriptor: | DNA polymerase III subunit delta, DNA polymerase III subunit delta', DNA polymerase III subunit tau | Authors: | Kazmirski, S.L, Simonetta, K.R, Kuriyan, J. | Deposit date: | 2009-03-12 | Release date: | 2009-05-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.891 Å) | Cite: | The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell(Cambridge,Mass.), 137, 2009
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3TF0
| Crystal structure of an H-NOX protein from T. tengcongensis | Descriptor: | ACETATE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.743 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFE
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant under 6 atm of xenon | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.991 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFG
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W/L67W double mutant | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9003 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFA
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 under 6 atm of xenon | Descriptor: | Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, XENON | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2711 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFD
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3U5Z
| Structure of T4 Bacteriophage clamp loader bound to the T4 clamp, primer-template DNA, and ATP analog | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase accessory protein 44, DNA polymerase accessory protein 62, ... | Authors: | Kelch, B.A, Makino, D.L, O'Donnell, M, Kuriyan, J. | Deposit date: | 2011-10-11 | Release date: | 2012-01-04 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | How a DNA polymerase clamp loader opens a sliding clamp. Science, 334, 2011
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3U60
| Structure of T4 Bacteriophage Clamp Loader Bound To Open Clamp, DNA and ATP Analog | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase accessory protein 44, DNA polymerase accessory protein 62, ... | Authors: | Kelch, B.A, Makino, D.L, O'Donnell, M, Kuriyan, J. | Deposit date: | 2011-10-11 | Release date: | 2012-01-04 | Method: | X-RAY DIFFRACTION (3.34 Å) | Cite: | How a DNA polymerase clamp loader opens a sliding clamp. Science, 334, 2011
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3U61
| Structure of T4 Bacteriophage Clamp Loader Bound To Closed Clamp, DNA and ATP Analog and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase accessory protein 44, DNA polymerase accessory protein 62, ... | Authors: | Kelch, B.A, Makino, D.L, O'Donnell, M, Kuriyan, J. | Deposit date: | 2011-10-11 | Release date: | 2012-01-04 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | How a DNA polymerase clamp loader opens a sliding clamp. Science, 334, 2011
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3TF8
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 | Descriptor: | Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1302 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TF9
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 under 1 atm of xenon | Descriptor: | Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION, ... | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5901 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TF1
| Crystal structure of an H-NOX protein from T. tengcongensis under 6 atm of xenon | Descriptor: | ACETATE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.0369 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFF
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L67W mutant | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9401 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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1FJM
| Protein serine/threonine phosphatase-1 (alpha isoform, type 1) complexed with microcystin-LR toxin | Descriptor: | BETA-MERCAPTOETHANOL, MANGANESE (II) ION, PROTEIN SERINE/THREONINE PHOSPHATASE-1 (ALPHA ISOFORM, ... | Authors: | Goldberg, J, Nairn, A.C, Kuriyan, J. | Deposit date: | 1995-12-17 | Release date: | 1996-06-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature, 376, 1995
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1QCF
| CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR | Descriptor: | 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Tyrosine-protein kinase HCK | Authors: | Schindler, T, Sicheri, F, Pico, A, Gazit, A, Levitzki, A, Kuriyan, J. | Deposit date: | 1999-05-04 | Release date: | 1999-06-08 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol.Cell, 3, 1999
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1Q9C
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