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6UJL
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BU of 6ujl by Molmil
Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction
Descriptor: 6-methyl-3-(propylsulfanyl)-1,2,4-triazin-5-ol, WD repeat-containing protein 5
Authors:Phan, J.
Deposit date:2019-10-03
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 63, 2020
2LNW
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BU of 2lnw by Molmil
Identification and structural basis for a novel interaction between Vav2 and Arap3
Descriptor: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, Guanine nucleotide exchange factor VAV2
Authors:Wu, B, Zhang, J, Wu, J, Shi, Y.
Deposit date:2012-01-05
Release date:2012-11-21
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Identification and structural basis for a novel interaction between Vav2 and Arap3.
J.Struct.Biol., 180, 2012
7KHY
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BU of 7khy by Molmil
Crystal structure of OXA-163 K73A in complex with meropenem
Descriptor: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-lactamase, ...
Authors:Palzkill, T, Hu, L, Sankaran, B, Prasad, B.V.V.
Deposit date:2020-10-22
Release date:2021-02-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Mechanistic Basis of OXA-48-like beta-Lactamases' Hydrolysis of Carbapenems.
Acs Infect Dis., 7, 2021
7KH9
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BU of 7kh9 by Molmil
Crystal structure of OXA-48 K73A in complex with imipenem
Descriptor: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, Beta-lactamase, CHLORIDE ION
Authors:Palzkill, T, Hu, L, Sankaran, B, Prasad, B.V.V.
Deposit date:2020-10-20
Release date:2021-02-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Mechanistic Basis of OXA-48-like beta-Lactamases' Hydrolysis of Carbapenems.
Acs Infect Dis., 7, 2021
7KHZ
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BU of 7khz by Molmil
Crystal structure of OXA-163 K73A in complex with imipenem
Descriptor: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, Beta-lactamase, CHLORIDE ION, ...
Authors:Palzkill, T, Hu, L, Sankaran, B, Prasad, B.V.V.
Deposit date:2020-10-22
Release date:2021-02-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Mechanistic Basis of OXA-48-like beta-Lactamases' Hydrolysis of Carbapenems.
Acs Infect Dis., 7, 2021
7KHQ
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BU of 7khq by Molmil
Crystal structure of OXA-48 K73A in complex with meropenem
Descriptor: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, CHLORIDE ION, ...
Authors:Palzkill, T, Hu, L, Sankaran, B, Prasad, B.V.V.
Deposit date:2020-10-21
Release date:2021-02-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanistic Basis of OXA-48-like beta-Lactamases' Hydrolysis of Carbapenems.
Acs Infect Dis., 7, 2021
7EBO
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BU of 7ebo by Molmil
Crystal structure of a feruloyl esterase LP_0796 from Lactobacillus plantarum
Descriptor: Carboxylesterase, SULFATE ION
Authors:Zhang, H.W, Wang, Y.L, Xin, F.J.
Deposit date:2021-03-10
Release date:2022-08-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A reverse catalytic triad Asp containing loop shaping a wide substrate binding pocket of a feruloyl esterase from Lactobacillus plantarum.
Int.J.Biol.Macromol., 184, 2021
6JDD
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BU of 6jdd by Molmil
Crystal structure of the cypemycin decarboxylase CypD.
Descriptor: Cypemycin cysteine dehydrogenase (decarboxylating), DI(HYDROXYETHYL)ETHER, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Zhang, Q, Yuan, H.
Deposit date:2019-02-01
Release date:2019-03-06
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Convergent evolution of the Cys decarboxylases involved in aminovinyl-cysteine (AviCys) biosynthesis.
FEBS Lett., 593, 2019
3OWT
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BU of 3owt by Molmil
Crystal structure of S. cerevisiae RAP1-Sir3 complex
Descriptor: DNA-binding protein RAP1, Regulatory protein SIR3
Authors:Chen, Y, Yang, Y, Lei, M.
Deposit date:2010-09-20
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
8J67
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BU of 8j67 by Molmil
Crystal structure of Toxoplasma gondii M2AP
Descriptor: MIC2-associated protein
Authors:Wang, F.F, Zhang, D.J, Zhang, S, Springer, T.A, Song, G.J.
Deposit date:2023-04-24
Release date:2023-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii.
Commun Biol, 6, 2023
8J64
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BU of 8j64 by Molmil
Crystal structure of Toxoplasma gondii MIC2-M2AP complex
Descriptor: MIC2-associated protein, Micronemal protein MIC2
Authors:Zhang, S, Wang, F.F, Zhang, D.J, Song, G.J, Springer, T.A.
Deposit date:2023-04-24
Release date:2023-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii.
Commun Biol, 6, 2023
7YFG
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BU of 7yfg by Molmil
Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate (major class in asymmetry)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
Authors:Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S.
Deposit date:2022-07-08
Release date:2023-03-29
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
7YFH
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BU of 7yfh by Molmil
Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine, glutamate and (R)-PYD-106
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
Authors:Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S.
Deposit date:2022-07-08
Release date:2023-03-29
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
7YFI
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BU of 7yfi by Molmil
Structure of the Rat tri-heteromeric GluN1-GluN2A-GluN2C NMDA receptor in complex with glycine and glutamate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
Authors:Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S.
Deposit date:2022-07-08
Release date:2023-03-29
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
6KRE
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BU of 6kre by Molmil
TRiC at 0.05 mM ADP-AlFx, Conformation 2, 0.05-C2
Descriptor: T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M, Cong, Y.
Deposit date:2019-08-21
Release date:2019-09-18
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.45 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KRD
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BU of 6krd by Molmil
TRiC at 0.05 mM ADP-AlFx, Conformation 4, 0.05-C4
Descriptor: T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M, Cong, Y.
Deposit date:2019-08-21
Release date:2019-09-18
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.38 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KS8
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BU of 6ks8 by Molmil
TRiC at 0.1 mM ADP-AlFx, Conformation 4, 0.1-C4
Descriptor: T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M, Cong, Y.
Deposit date:2019-08-23
Release date:2019-09-18
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.69 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KS7
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BU of 6ks7 by Molmil
TRiC at 0.1 mM ADP-AlFx, Conformation 1, 0.1-C1
Descriptor: T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M, Cong, Y.
Deposit date:2019-08-23
Release date:2019-09-18
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.62 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
3S2X
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BU of 3s2x by Molmil
Structure of acetyl-Coenzyme A synthase Alpha subunit C-terminal domain
Descriptor: NICKEL (II) ION, acetyl-CoA synthase subunit alpha
Authors:Li, P.
Deposit date:2011-05-17
Release date:2011-07-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Insights into the Mechanistic Role of the [Fe(4) S(4) ] Cubane in the A-Cluster {[Fe(4) S(4) ]-(SR)-[Ni(p) Ni(d) ]} of Acetyl-Coenzyme A Synthase.
Chembiochem, 12, 2011
7VWZ
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BU of 7vwz by Molmil
Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W, Feng, Y, Shi, J.
Deposit date:2021-11-12
Release date:2022-06-08
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator.
Nucleic Acids Res., 50, 2022
7VWY
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BU of 7vwy by Molmil
Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W, Feng, Y.
Deposit date:2021-11-12
Release date:2022-06-08
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (4.57 Å)
Cite:Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator.
Nucleic Acids Res., 50, 2022
7W5W
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BU of 7w5w by Molmil
Cryo-EM structure of SoxS-dependent transcription activation complex with micF promoter DNA
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W, Feng, Y.
Deposit date:2021-11-30
Release date:2022-10-26
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (4.55 Å)
Cite:Structural basis of three different transcription activation strategies adopted by a single regulator SoxS.
Nucleic Acids Res., 50, 2022
7W5X
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BU of 7w5x by Molmil
Cryo-EM structure of SoxS-dependent transcription activation complex with zwf promoter DNA
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W, Feng, Y, Shi, J.
Deposit date:2021-11-30
Release date:2022-10-26
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of three different transcription activation strategies adopted by a single regulator SoxS.
Nucleic Acids Res., 50, 2022
6VOY
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BU of 6voy by Molmil
Cryo-EM structure of HTLV-1 instasome
Descriptor: DNA (25-MER), DNA (5'-D(P*AP*CP*AP*CP*AP*CP*TP*TP*GP*AP*CP*TP*AP*GP*GP*GP*TP*G)-3'), DNA-binding protein 7d, ...
Authors:Bhatt, V, Shi, K, Sundborger, A, Aihara, H.
Deposit date:2020-02-01
Release date:2020-07-01
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of host protein hijacking in human T-cell leukemia virus integration.
Nat Commun, 11, 2020
7W5Y
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BU of 7w5y by Molmil
Cryo-EM structure of SoxS-dependent transcription activation complex with fpr promoter DNA
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W, Feng, Y.
Deposit date:2021-11-30
Release date:2022-10-26
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural basis of three different transcription activation strategies adopted by a single regulator SoxS.
Nucleic Acids Res., 50, 2022

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