7X0G
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7X0O
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7X0Q
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7X0R
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7X0I
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7X0N
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7X0M
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7X0J
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7EXD
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![BU of 7exd by Molmil](/molmil-images/mine/7exd) | Lasmiditan-bound serotonin 1F (5-HT1F) receptor-Gi protein complex | Descriptor: | 2,4,6-tris(fluoranyl)-N-[6-(1-methylpiperidin-4-yl)carbonylpyridin-2-yl]benzamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Huang, S, Xu, P, Jiang, Y, Xu, H.E. | Deposit date: | 2021-05-27 | Release date: | 2021-08-04 | Last modified: | 2021-10-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT 1F -G protein complex. Cell Res., 31, 2021
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4HN6
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![BU of 4hn6 by Molmil](/molmil-images/mine/4hn6) | GR DNA Binding Domain R460D/D462R - TSLP nGRE Complex | Descriptor: | DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ... | Authors: | Hudson, W.H, Youn, C.E, Ortlund, E.A. | Deposit date: | 2012-10-18 | Release date: | 2012-12-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.549 Å) | Cite: | The structural basis of direct glucocorticoid-mediated transrepression. Nat.Struct.Mol.Biol., 20, 2013
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4HN5
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![BU of 4hn5 by Molmil](/molmil-images/mine/4hn5) | GR DNA Binding Domain - TSLP nGRE Complex | Descriptor: | DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ... | Authors: | Hudson, W.H, Youn, C.E, Ortlund, E.A. | Deposit date: | 2012-10-18 | Release date: | 2012-12-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | The structural basis of direct glucocorticoid-mediated transrepression. Nat.Struct.Mol.Biol., 20, 2013
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5EK0
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![BU of 5ek0 by Molmil](/molmil-images/mine/5ek0) | Human Nav1.7-VSD4-NavAb in complex with GX-936. | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide, Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha | Authors: | Ahuja, S, Mukund, S, Starovasnik, M.A, Koth, C.M, Payandeh, J. | Deposit date: | 2015-11-03 | Release date: | 2015-12-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.53 Å) | Cite: | Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science, 350, 2015
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4TNT
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![BU of 4tnt by Molmil](/molmil-images/mine/4tnt) | Structure of the human mineralocorticoid receptor in complex with DNA | Descriptor: | DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), Mineralocorticoid receptor, ... | Authors: | Hudson, W.H, Ortlund, E.A. | Deposit date: | 2014-06-04 | Release date: | 2014-09-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3938 Å) | Cite: | Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. Plos One, 9, 2014
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6S41
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![BU of 6s41 by Molmil](/molmil-images/mine/6s41) | CRYSTAL STRUCTURE OF PXR IN COMPLEX WITH XPC-7455 | Descriptor: | 4-[[(1~{S})-1-[2,5-bis(fluoranyl)phenyl]ethyl]amino]-5-chloranyl-2-fluoranyl-~{N}-(1,3-thiazol-4-yl)benzenesulfonamide, Nuclear receptor subfamily 1 group I member 2 | Authors: | Focken, T, Maskos, K, Griessner, A, Krapp, S. | Deposit date: | 2019-06-26 | Release date: | 2019-10-02 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J.Med.Chem., 62, 2019
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