8FKM
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6KNE
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6KND
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6KW3
| The ClassA RSC-Nucleosome Complex | Descriptor: | Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... | Authors: | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | Deposit date: | 2019-09-05 | Release date: | 2019-11-13 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (7.13 Å) | Cite: | Structure of the RSC complex bound to the nucleosome. Science, 366, 2019
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6KW4
| The ClassB RSC-Nucleosome Complex | Descriptor: | Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... | Authors: | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | Deposit date: | 2019-09-06 | Release date: | 2019-11-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (7.55 Å) | Cite: | Structure of the RSC complex bound to the nucleosome. Science, 366, 2019
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6K15
| RSC substrate-recruitment module | Descriptor: | Chromatin structure-remodeling complex protein RSC3, Chromatin structure-remodeling complex protein RSC30, Chromatin structure-remodeling complex protein RSC58, ... | Authors: | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | Deposit date: | 2019-05-09 | Release date: | 2019-11-13 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the RSC complex bound to the nucleosome. Science, 366, 2019
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3L5C
| Structure of BACE Bound to SCH723871 | Descriptor: | 1-(4-cyanophenyl)-3-(4-{[(2Z,4R)-2-imino-4-methyl-4-(2-methylpropyl)-5-oxoimidazolidin-1-yl]methyl}benzyl)urea, Beta-secretase 1, D(-)-TARTARIC ACID | Authors: | Strickland, C, Zhu, Z. | Deposit date: | 2009-12-21 | Release date: | 2010-02-16 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation J.Med.Chem., 53, 2010
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3L5F
| Structure of BACE Bound to SCH736201 | Descriptor: | (2E,5R)-5-(2-cyclohexylethyl)-5-(cyclohexylmethyl)-2-imino-3-methylimidazolidin-4-one, Beta-secretase 1, D(-)-TARTARIC ACID | Authors: | Strickland, C, Zhu, Z. | Deposit date: | 2009-12-21 | Release date: | 2010-02-16 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation J.Med.Chem., 53, 2010
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6IV9
| the Cas13d binary complex | Descriptor: | Cas13d, MAGNESIUM ION, crRNA (50-MER) | Authors: | Zhang, B, Ye, Y.M, Ye, W.W, OuYang, S.Y. | Deposit date: | 2018-12-02 | Release date: | 2019-06-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d. Nat Commun, 10, 2019
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8I16
| Crystal structure of the selenomethionine (SeMet)-derived Cas12g (D513A) mutant | Descriptor: | Cas12g, ZINC ION | Authors: | Zhang, B, Chen, J, Ye, Y.M, OuYang, S.Y. | Deposit date: | 2023-01-12 | Release date: | 2023-08-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Structural transitions upon guide RNA binding and their importance in Cas12g-mediated RNA cleavage. Plos Genet., 19, 2023
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8IN4
| Eisenia hydrolysis-enhancing protein from Aplysia kurodai | Descriptor: | 25 kDa polyphenol-binding protein, ACETYL GROUP, GLYCEROL | Authors: | Sun, X.M, Ye, Y.X, Kato, K, Yu, J, Yao, M. | Deposit date: | 2023-03-08 | Release date: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect aku BGL activity. Elife, 12, 2023
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8IN1
| beta-glucosidase protein from Aplysia kurodai | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-Glucosidase, alpha-L-fucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sun, X.M, Ye, Y.X, Kato, K, Yu, J, Yao, M. | Deposit date: | 2023-03-08 | Release date: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect aku BGL activity. Elife, 12, 2023
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8IN3
| Eisenia hydrolysis-enhancing protein from Aplysia kurodai | Descriptor: | 25 kDa polyphenol-binding protein, GLYCEROL | Authors: | Sun, X.M, Ye, Y.X, Kato, K, Yu, J, Yao, M. | Deposit date: | 2023-03-08 | Release date: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect aku BGL activity. Elife, 12, 2023
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8IN6
| Eisenia hydrolysis-enhancing protein from Aplysia kurodai complex with tannic acid | Descriptor: | 25 kDa polyphenol-binding protein, BETA-1,2,3,4,6-PENTA-O-GALLOYL-D-GLUCOPYRANOSE | Authors: | Sun, X.M, Ye, Y.X, Kato, K, Yu, J, Yao, M. | Deposit date: | 2023-03-08 | Release date: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect aku BGL activity. Elife, 12, 2023
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8IJK
| human KCNQ2-CaM-Ebio1 complex in the presence of PIP2 | Descriptor: | Calmodulin-1, N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | Authors: | Ma, D, Guo, J. | Deposit date: | 2023-02-27 | Release date: | 2024-01-17 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A small-molecule activation mechanism that directly opens the KCNQ2 channel. Nat.Chem.Biol., 20, 2024
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8I3Q
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3FSH
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6IV8
| the selenomethionine(SeMet)-derived Cas13d binary complex | Descriptor: | MAGNESIUM ION, RNA (51-MER), RNA (53-MER), ... | Authors: | Zhang, B, Ye, Y.M, Ye, W.W, OuYang, S.Y. | Deposit date: | 2018-12-02 | Release date: | 2019-06-19 | Last modified: | 2019-06-26 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d. Nat Commun, 10, 2019
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6VY9
| Crystal structure of NotF prenyltransferase | Descriptor: | Deoxybrevianamide E synthase notF | Authors: | Dan, Q, Smith, J.L. | Deposit date: | 2020-02-25 | Release date: | 2021-02-03 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A. J.Am.Chem.Soc., 144, 2022
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4WWR
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6PVF
| Crystal structure of PhqK in complex with malbrancheamide B | Descriptor: | (5aS,12aS,13aS)-9-chloro-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7,6-b]carbazol-14-one, FAD monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Fraley, A.E, Smith, J.L, Sherman, D.H. | Deposit date: | 2019-07-20 | Release date: | 2020-01-22 | Last modified: | 2020-02-19 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway. J.Am.Chem.Soc., 142, 2020
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6PVH
| Crystal structure of PhqK in complex with paraherquamide K | Descriptor: | (7aS,12S,12aR,13aS)-3,3,12,14,14-pentamethyl-3,7,11,12,13,13a,14,15-octahydro-8H,10H-7a,12a-(epiminomethano)indolizino[6,7-h]pyrano[3,2-a]carbazol-16-one, FAD monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Fraley, A.E, Smith, J.L, Sherman, D.H. | Deposit date: | 2019-07-20 | Release date: | 2020-01-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway. J.Am.Chem.Soc., 142, 2020
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6PVG
| Crystal structure of ligand free PhqK | Descriptor: | FAD monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Fraley, A.E, Smith, J.L, Sherman, D.H. | Deposit date: | 2019-07-20 | Release date: | 2020-01-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.709 Å) | Cite: | Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway. J.Am.Chem.Soc., 142, 2020
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6PVI
| Crystal structure of PhqK in complex with paraherquamide L | Descriptor: | (8aS,13S,13aR,14aS)-4,4,13,15,15-pentamethyl-12,13,14,14a,15,16-hexahydro-4H,8H,9H,11H-8a,13a-(epiminomethano)[1,4]dioxepino[2,3-a]indolizino[6,7-h]carbazol-17-one, FAD monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Fraley, A.E, Smith, J.L, Sherman, D.H. | Deposit date: | 2019-07-20 | Release date: | 2020-01-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.093 Å) | Cite: | Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway. J.Am.Chem.Soc., 142, 2020
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6PVJ
| Crystal structure of PhqK in complex with malbrancheamide C | Descriptor: | (5aS,12aS,13aS)-9-bromo-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7,6-b]carbazol-14-one, FAD monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Fraley, A.E, Smith, J.L, Sherman, D.H. | Deposit date: | 2019-07-20 | Release date: | 2020-01-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway. J.Am.Chem.Soc., 142, 2020
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