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3H6K
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BU of 3h6k by Molmil
Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Ortho-chlro-sulfonyl-piperazine Inhibitor
Descriptor: 3-chloro-4-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)benzamide, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bard, J, Svenson, K.
Deposit date:2009-04-23
Release date:2009-12-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.187 Å)
Cite:Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
J.Med.Chem., 52, 2009
3HFG
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BU of 3hfg by Molmil
Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Sulfonyl-piperazine Inhibitor
Descriptor: (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-{[3-(1H-1,2,4-triazol-1-yl)phenyl]sulfonyl}piperazine, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bard, J, Svenson, K.
Deposit date:2009-05-11
Release date:2009-09-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
J.Med.Chem., 52, 2009
7DH7
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BU of 7dh7 by Molmil
Crystal structure of apo XcZur
Descriptor: PHOSPHATE ION, Transcriptional regulator fur family, ZINC ION
Authors:Liu, F.M, Su, Z.H, Chen, P, Tian, X.L, Wu, L.J, Tang, D.J, Li, P.F, Deng, H.T, Tang, J.L, Ming, Z.H.
Deposit date:2020-11-13
Release date:2021-06-09
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for zinc-induced activation of a zinc uptake transcriptional regulator.
Nucleic Acids Res., 49, 2021
7DH8
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BU of 7dh8 by Molmil
Crystal structure of holo XcZur
Descriptor: Transcriptional regulator fur family, ZINC ION
Authors:Liu, F.M, Su, Z.H, Chen, P, Tian, X.L, Wu, L.J, Tang, D.J, Li, P.F, Deng, H.T, Tang, J.L, Ming, Z.H.
Deposit date:2020-11-13
Release date:2021-06-09
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for zinc-induced activation of a zinc uptake transcriptional regulator.
Nucleic Acids Res., 49, 2021
5WTW
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BU of 5wtw by Molmil
Hepatitis B virus core protein Y132A mutant in P 41 21 2 Space Group
Descriptor: CHLORIDE ION, Core protein
Authors:Zhou, Z, Xu, Z.H.
Deposit date:2016-12-15
Release date:2017-02-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.623 Å)
Cite:Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms.
Sci Rep, 7, 2017
5WRE
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BU of 5wre by Molmil
Hepatitis B virus core protein Y132A mutant in complex with heteroaryldihydropyrimidine (HAP_R01)
Descriptor: (2S)-1-[[(4R)-4-(2-chloranyl-4-fluoranyl-phenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-bis(fluoranyl)pyrrolidine-2-carboxylic acid, CHLORIDE ION, Core protein, ...
Authors:Zhou, Z, Xu, Z.H.
Deposit date:2016-12-01
Release date:2017-02-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.946 Å)
Cite:Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms.
Sci Rep, 7, 2017
4KZJ
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BU of 4kzj by Molmil
Crystal Structure of TR3 LBD L449W Mutant
Descriptor: GLYCEROL, Nuclear receptor subfamily 4 group A member 1
Authors:Li, F, Zhang, Q, Li, A, Tian, X, Cai, Q, Wang, W, Wang, Y, Chen, H, Xing, Y, Wu, Q, Lin, T.
Deposit date:2013-05-30
Release date:2013-12-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
Nat.Chem.Biol., 10, 2014
4KZI
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BU of 4kzi by Molmil
Crystal Structure of TR3 LBD in complex with DPDO
Descriptor: 1-(3,5-dimethoxyphenyl)decan-1-one, GLYCEROL, Nuclear receptor subfamily 4 group A member 1
Authors:Li, F, Zhang, Q, Li, A, Tian, X, Cai, Q, Wang, W, Wang, Y, Chen, H, Xing, Y, Wu, Q, Lin, T.
Deposit date:2013-05-30
Release date:2013-12-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
Nat.Chem.Biol., 10, 2014
4KZM
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BU of 4kzm by Molmil
Crystal Structure of TR3 LBD S553A Mutant
Descriptor: GLYCEROL, Nuclear receptor subfamily 4 group A member 1
Authors:Li, F, Zhang, Q, Li, A, Tian, X, Cai, Q, Wang, W, Wang, Y, Chen, H, Xing, Y, Wu, Q, Lin, T.
Deposit date:2013-05-30
Release date:2013-12-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
Nat.Chem.Biol., 10, 2014
4JHD
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BU of 4jhd by Molmil
Crystal Structure of an Actin Dimer in Complex with the Actin Nucleator Cordon-Bleu
Descriptor: Actin-5C, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Chen, X, Ni, F, Wang, Q.
Deposit date:2013-03-04
Release date:2013-06-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural basis of actin filament nucleation by tandem w domains.
Cell Rep, 3, 2013
8XVA
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BU of 8xva by Molmil
Human TOM complex with whole Tom20
Descriptor: Mitochondrial import receptor subunit TOM20 homolog, Mitochondrial import receptor subunit TOM22 homolog, Mitochondrial import receptor subunit TOM40 homolog, ...
Authors:Tian, X.Y, Su, J.Y, Sui, S.F.
Deposit date:2024-01-14
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (5.92 Å)
Cite:Structure of the intact Tom20 receptor in the human translocase of the outer membrane complex.
Pnas Nexus, 3, 2024
7CKM
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BU of 7ckm by Molmil
Structure of Machupo virus polymerase bound to Z matrix protein (monomeric complex)
Descriptor: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ...
Authors:Xu, X, Peng, R, Peng, Q, Shi, Y.
Deposit date:2020-07-17
Release date:2021-05-05
Last modified:2021-11-17
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals
Nat Microbiol, 6, 2021
7CKL
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BU of 7ckl by Molmil
Structure of Lassa virus polymerase bound to Z matrix protein
Descriptor: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ...
Authors:Xu, X, Peng, R, Peng, Q, Shi, Y.
Deposit date:2020-07-17
Release date:2021-05-05
Last modified:2021-11-17
Method:ELECTRON MICROSCOPY (3.88 Å)
Cite:Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals
Nat Microbiol, 6, 2021
6GF6
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BU of 6gf6 by Molmil
Molecular basis of egg coat filament cross-linking: high-resolution structure of the partially deglycosylated ZP1 ZP-N1 domain homodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Zona pellucida sperm-binding protein 1,Zona pellucida sperm-binding protein 1
Authors:Nishimura, K, Jovine, L.
Deposit date:2018-04-29
Release date:2019-06-19
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility.
Nat Commun, 10, 2019
6GF7
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BU of 6gf7 by Molmil
Molecular basis of egg coat filament cross-linking: Zn-SAD structure of the partially deglycosylated ZP1 ZP-N1 domain homodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, Zona pellucida sperm-binding protein 1,Zona pellucida sperm-binding protein 1
Authors:Nishimura, K, Jovine, L.
Deposit date:2018-04-29
Release date:2019-06-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility.
Nat Commun, 10, 2019
6GF8
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BU of 6gf8 by Molmil
Molecular basis of egg coat filament cross-linking: structure of the glycosylated ZP1 ZP-N1 domain homodimer
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Nishimura, K, Jovine, L.
Deposit date:2018-04-29
Release date:2019-06-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility.
Nat Commun, 10, 2019
8HGC
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BU of 8hgc by Molmil
Crystal structure of the CYP199A4 mutant F182T in complex with 4-methoxybenzoic acid
Descriptor: 4-METHOXYBENZOIC ACID, ACETATE ION, Cytochrome P450, ...
Authors:Jiang, Y, Cong, Z.
Deposit date:2022-11-14
Release date:2023-08-16
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Enabling Peroxygenase Activity in Cytochrome P450 Monooxygenases by Engineering Hydrogen Peroxide Tunnels.
J.Am.Chem.Soc., 145, 2023
6JIV
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BU of 6jiv by Molmil
SspE crystal structure
Descriptor: SspE protein
Authors:Bing, Y.Z, Yang, H.G.
Deposit date:2019-02-23
Release date:2020-03-25
Last modified:2020-07-08
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities.
Nat Microbiol, 5, 2020
6JUF
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BU of 6juf by Molmil
SspB crystal structure
Descriptor: SspB protein
Authors:Liqiong, L, Yubing, Z.
Deposit date:2019-04-13
Release date:2020-03-25
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.587 Å)
Cite:SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities.
Nat Microbiol, 5, 2020
7EL9
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BU of 7el9 by Molmil
Structure of Machupo virus L polymerase in complex with Z protein and 3'-vRNA (dimeric complex)
Descriptor: MANGANESE (II) ION, Machupo virus 3'-vRNA promoter, RING finger protein Z, ...
Authors:Peng, R, Xu, X, Peng, Q, Shi, Y.
Deposit date:2021-04-09
Release date:2021-05-05
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
Nat Microbiol, 6, 2021
7ELB
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BU of 7elb by Molmil
Structure of Machupo virus L polymerase in complex with Z protein (dimeric form)
Descriptor: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ...
Authors:Peng, R, Xu, X, Peng, Q, Shi, Y.
Deposit date:2021-04-09
Release date:2021-05-05
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
Nat Microbiol, 6, 2021
7DWB
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BU of 7dwb by Molmil
Human Pannexin1 model
Descriptor: Pannexin-1
Authors:Zhang, S.S, Yang, M.J.
Deposit date:2021-01-17
Release date:2021-05-26
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis.
Cell Discov, 7, 2021
7ELC
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BU of 7elc by Molmil
Structure of monomeric complex of MACV L bound to Z and 3'-vRNA
Descriptor: 3'-vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ...
Authors:Xu, X, Peng, R, Peng, Q, Shi, Y.
Deposit date:2021-04-09
Release date:2021-05-05
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
Nat Microbiol, 6, 2021
7ELA
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BU of 7ela by Molmil
Structure of Lassa virus polymerase in complex with 3'-vRNA and Z mutant (F36A)
Descriptor: 3-'vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ...
Authors:Xu, X, Peng, R, Peng, Q, Shi, Y.
Deposit date:2021-04-09
Release date:2021-05-05
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
Nat Microbiol, 6, 2021
7BRE
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BU of 7bre by Molmil
The crystal structure of MLL2 in complex with ASH2L and RBBP5
Descriptor: Histone-lysine N-methyltransferase 2B, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Li, Y, Zhao, L, Chen, Y.
Deposit date:2020-03-28
Release date:2020-07-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.
Structure, 28, 2020

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