6U3F
 
 | | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | | 分子名称: | Panton-Valentine Leucocidin F, SULFATE ION, fos-choline-14 | | 著者 | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | | 登録日 | 2019-08-21 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
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6U2S
 | | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | | 分子名称: | Bi-component leukocidin LukED subunit D, fos-choline-14 | | 著者 | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | | 登録日 | 2019-08-20 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
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6U33
 | | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | | 分子名称: | Bi-component leukocidin LukED subunit D, NICKEL (II) ION | | 著者 | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | | 登録日 | 2019-08-21 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
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6U3T
 | | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | | 分子名称: | Alpha-hemolysin, SULFATE ION, fos-choline-14 | | 著者 | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | | 登録日 | 2019-08-22 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
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6U4P
 | | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | | 分子名称: | Alpha-hemolysin, SULFATE ION, fos-choline-14 | | 著者 | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | | 登録日 | 2019-08-26 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
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6U3Y
 | | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | | 分子名称: | ACETATE ION, Gamma-hemolysin subunit A, Panton-Valentine Leucocidin F, ... | | 著者 | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | | 登録日 | 2019-08-22 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
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6U49
 | | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | | 分子名称: | Alpha-hemolysin, SULFATE ION, fos-choline-14 | | 著者 | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | | 登録日 | 2019-08-23 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
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8TTH
 | | NorA single mutant - D307N at pH 7.5 | | 分子名称: | Heavy Chain of FabDA1 Variable Domain, Light Chain of FabDA1 Variable Domain, Quinolone resistance protein NorA | | 著者 | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | | 登録日 | 2023-08-13 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Proton-coupled transport mechanism of the efflux pump NorA.
Nat Commun, 15, 2024
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8TTF
 | | NorA double mutant - E222QD307N at pH 7.5 | | 分子名称: | Heavy Chain of FabDA1 Variable Domain, Light Chain of FabDA1 Variable Domain, Quinolone resistance protein NorA | | 著者 | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | | 登録日 | 2023-08-13 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | | 主引用文献 | Proton-coupled transport mechanism of the efflux pump NorA.
Nat Commun, 15, 2024
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8TTE
 | | Protonated state of NorA at pH 5.0 | | 分子名称: | FabDA1 CDRH3 loop, Quinolone resistance protein NorA | | 著者 | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | | 登録日 | 2023-08-13 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Proton-coupled transport mechanism of the efflux pump NorA.
Nat Commun, 15, 2024
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8TTG
 | | NorA single mutant - E222Q at pH 7.5 | | 分子名称: | FabDA1 CDRH3 loop, Quinolone resistance protein NorA | | 著者 | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | | 登録日 | 2023-08-13 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Proton-coupled transport mechanism of the efflux pump NorA.
Nat Commun, 15, 2024
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4RBR
 | | Crystal structure of Repressor of Toxin (Rot), a central regulator of Staphylococcus aureus virulence | | 分子名称: | CHLORIDE ION, HTH-type transcriptional regulator rot | | 著者 | Killikelly, A, Jakoncic, J, Sampson, J.M, Kong, X.-P. | | 登録日 | 2014-09-12 | | 公開日 | 2014-11-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure-Based Functional Characterization of Repressor of Toxin (Rot), a Central Regulator of Staphylococcus aureus Virulence.
J.Bacteriol., 197, 2015
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7LO8
 | | NorA in complex with Fab36 | | 分子名称: | Fab36 Heavy Chain, Fab36 Light Chain, Quinolone resistance protein NorA | | 著者 | Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N. | | 登録日 | 2021-02-09 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | | 主引用文献 | Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Nat.Chem.Biol., 18, 2022
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7LO7
 | | NorA in complex with Fab25 | | 分子名称: | Fab25 Heavy Chain, Fab25 Light Chain, Quinolone resistance protein NorA | | 著者 | Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N. | | 登録日 | 2021-02-09 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | | 主引用文献 | Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Nat.Chem.Biol., 18, 2022
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7T86
 | | Crystal Structure of Fab CR5133 / Phospho-SD Peptide Complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab CR5133 Heavy Chain, Antibody Fab CR5133 Light Chain, ... | | 著者 | Luo, J, Malia, T.J, Buckley, P.T. | | 登録日 | 2021-12-15 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections.
Cell Host Microbe, 31, 2023
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7T82
 | | Crystal Structure of LEUKOCIDIN E/CENTYRIN S26/FAB B438 | | 分子名称: | Antibody Fab Heavy Chain, Antibody Fab Light Chain, Centyrin S26, ... | | 著者 | Luo, J, Malia, T.J, Buckley, P.T. | | 登録日 | 2021-12-15 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections.
Cell Host Microbe, 31, 2023
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7T87
 | | CRYSTAL STRUCTURE OF LEUKOCIDIN AB/CENTYRIN S17/FAB 214F COMPLEX | | 分子名称: | Antibody Fab B214 Heavy Chain, Antibody Fab B214 Light Chain, Centyrin S17, ... | | 著者 | Luo, J, Malia, T.J, Buckley, P.T. | | 登録日 | 2021-12-15 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections.
Cell Host Microbe, 31, 2023
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