4X4J
| Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Putative oxygenase, SULFATE ION | 著者 | Tsai, S.-C, Jackson, D.R, Patel, A, Barajas, J.F, Rohr, J, Yu, X, Liu, H.-W, Sasaki, E, Calveras, J, Metsa-Ketela, M. | 登録日 | 2014-12-02 | 公開日 | 2015-12-02 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis To Be Published
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3FMW
| The crystal structure of MtmOIV, a Baeyer-Villiger monooxygenase from the mithramycin biosynthetic pathway in Streptomyces argillaceus. | 分子名称: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, Oxygenase | 著者 | Noinaj, N, Beam, M.P, Wang, C, Rohr, J. | 登録日 | 2008-12-22 | 公開日 | 2009-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway . Biochemistry, 48, 2009
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3POP
| The crystal structure of GilR, an oxidoreductase that catalyzes the terminal step of gilvocarcin biosynthesis | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GilR oxidase | 著者 | Noinaj, N, Bosserman, M.A, Schickli, M.A, Kharel, M.K, Rohr, J, Buchanan, S.K. | 登録日 | 2010-11-23 | 公開日 | 2011-05-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.651 Å) | 主引用文献 | The Crystal Structure and Mechanism of an Unusual Oxidoreductase, GilR, Involved in Gilvocarcin V Biosynthesis. J.Biol.Chem., 286, 2011
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4K5R
| The 2.0 angstrom crystal structure of MTMOIV, a baeyer-villiger monooxygenase from the mithramycin biosynthetic pathway in streptomyces argillaceus. | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Oxygenase | 著者 | Noinaj, N, Bosserman, M.A, Rohr, J, Buchanan, S.K. | 登録日 | 2013-04-15 | 公開日 | 2013-10-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular Insight into Substrate Recognition and Catalysis of Baeyer-Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin. Acs Chem.Biol., 8, 2013
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3PQB
| The crystal structure of pregilvocarcin in complex with GilR, an oxidoreductase that catalyzes the terminal step of gilvocarcin biosynthesis | 分子名称: | (1R)-1,4-anhydro-6-deoxy-1-[(6R)-8-ethenyl-1,6-dihydroxy-10,12-dimethoxy-6H-dibenzo[c,h]chromen-4-yl]-D-galactitol, FLAVIN-ADENINE DINUCLEOTIDE, Putative oxidoreductase | 著者 | Noinaj, N, Bosserman, M.A, Schickli, M.A, Kharel, M.K, Rohr, J, Buchanan, S.K. | 登録日 | 2010-11-25 | 公開日 | 2011-05-11 | 最終更新日 | 2011-08-03 | 実験手法 | X-RAY DIFFRACTION (2.324 Å) | 主引用文献 | The Crystal Structure and Mechanism of an Unusual Oxidoreductase, GilR, Involved in Gilvocarcin V Biosynthesis. J.Biol.Chem., 286, 2011
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4K5S
| The crystal structure of premithramycin B in complex with MTMOIV, a baeyer-villiger monooxygenase from the mithramycin biosynthetic pathway in streptomyces argillaceus. | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Oxygenase, premithramycin B | 著者 | Noinaj, N, Bosserman, M.A, Rohr, J, Buchanan, S.K. | 登録日 | 2013-04-15 | 公開日 | 2013-10-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular Insight into Substrate Recognition and Catalysis of Baeyer-Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin. Acs Chem.Biol., 8, 2013
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6OVQ
| Crystal structure of mithramycin 3-side chain keto-reductase MtmW | 分子名称: | GLYCEROL, Putative Side chain reductase | 著者 | Hou, C, Yu, X, Rohr, J, Tsodikov, O.V. | 登録日 | 2019-05-08 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis. Angew.Chem.Int.Ed.Engl., 59, 2020
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6OW0
| Crystal structure of mithramycin 3-side chain keto-reductase MtmW in complex with NAD+ and PEG | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, MtmW, ... | 著者 | Hou, C, Yu, X, Rohr, J, Tsodikov, O.V. | 登録日 | 2019-05-08 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis. Angew.Chem.Int.Ed.Engl., 59, 2020
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6OVX
| Crystal structure of mithramycin 3-side chain keto-reductase MtmW in complex with NAD+, P422 form | 分子名称: | GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative side chain reductase | 著者 | Hou, C, Yu, X, Rohr, J, Tsodikov, O.V. | 登録日 | 2019-05-08 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis. Angew.Chem.Int.Ed.Engl., 59, 2020
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6VGG
| Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC | 分子名称: | Core-binding factor subunit beta, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... | 著者 | Hou, C, Rohr, J, Tsodikov, O.V. | 登録日 | 2020-01-08 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (4.31 Å) | 主引用文献 | Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. Structure, 29, 2021
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5JW2
| Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGATCCCT | 分子名称: | DNA (5'-D(*AP*GP*GP*GP*AP*TP*CP*CP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Phe, ... | 著者 | Hou, C, Rohr, J, Tsodikov, O.V. | 登録日 | 2016-05-11 | 公開日 | 2016-09-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res., 44, 2016
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5JVW
| Crystal structure of mithramycin analogue MTM SA-Trp in complex with a 10-mer DNA AGAGGCCTCT. | 分子名称: | DNA (5'-D(*AP*GP*AP*GP*GP*CP*CP*TP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Trp, ... | 著者 | Hou, C, Rohr, J, Tsodikov, O.V. | 登録日 | 2016-05-11 | 公開日 | 2016-09-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res., 44, 2016
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5JW0
| Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGTACCCT | 分子名称: | DNA (5'-D(P*AP*GP*GP*GP*TP*AP*CP*CP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Phe, ... | 著者 | Hou, C, Rohr, J, Tsodikov, O.V. | 登録日 | 2016-05-11 | 公開日 | 2016-09-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res., 44, 2016
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4RVH
| Crystal structure of MtmC in complex with SAH and TDP-4-keto-D-olivose | 分子名称: | D-mycarose 3-C-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... | 著者 | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | 登録日 | 2014-11-26 | 公開日 | 2015-01-28 | 最終更新日 | 2015-05-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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4RVG
| Crystal structure of MtmC in complex with SAM and TDP | 分子名称: | ACETATE ION, D-mycarose 3-C-methyltransferase, S-ADENOSYLMETHIONINE, ... | 著者 | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | 登録日 | 2014-11-26 | 公開日 | 2015-01-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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4RVD
| Crystal structure of MtmC in complex with SAM | 分子名称: | ACETATE ION, D-mycarose 3-C-methyltransferase, S-ADENOSYLMETHIONINE, ... | 著者 | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | 登録日 | 2014-11-26 | 公開日 | 2015-01-28 | 最終更新日 | 2015-05-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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4RVF
| Crystal structure of MtmC in complex with TDP | 分子名称: | D-mycarose 3-C-methyltransferase, THYMIDINE-5'-DIPHOSPHATE, ZINC ION | 著者 | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | 登録日 | 2014-11-26 | 公開日 | 2015-01-28 | 最終更新日 | 2015-05-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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4RV9
| Crystal structure of MtmC in complex with SAH | 分子名称: | ACETATE ION, CHLORIDE ION, D-mycarose 3-C-methyltransferase, ... | 著者 | Hou, C, Chen, J.-M, Rohr, J, Tsodikov, O.V. | 登録日 | 2014-11-25 | 公開日 | 2015-02-04 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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5NV8
| Structural basis for EarP-mediated arginine glycosylation of translation elongation factor EF-P | 分子名称: | 2'-DEOXY-THYMIDINE-BETA-L-RHAMNOSE, EF-P arginine 32 rhamnosyl-transferase | 著者 | Macosek, J, Krafczyk, R, Jagtap, P.K.A, Lassaka, J, Hennig, J. | 登録日 | 2017-05-03 | 公開日 | 2017-10-04 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.294 Å) | 主引用文献 | Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P. MBio, 8, 2017
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4RIE
| Landomycin Glycosyltransferase LanGT2 | 分子名称: | Glycosyl transferase homolog | 著者 | Tam, H.K, Gerhardt, S, Breit, B, Bechthold, A, Einsle, O. | 登録日 | 2014-10-06 | 公開日 | 2015-01-28 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.162 Å) | 主引用文献 | Structural Characterization of O- and C-Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2. Angew.Chem.Int.Ed.Engl., 54, 2015
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4RIF
| Landomycin Glycosyltransferase LanGT2, carbasugar substrate complex | 分子名称: | 2'-deoxy-5'-O-[(R)-{[(R)-{[(1S,3R,4R,5S)-3,4-dihydroxy-5-methylcyclohexyl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-3,4-dihydrothymidine, Glycosyl transferase homolog | 著者 | Tam, H.K, Gerhardt, S, Breit, B, Bechthold, A, Einsle, O. | 登録日 | 2014-10-06 | 公開日 | 2015-01-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural Characterization of O- and C-Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2. Angew.Chem.Int.Ed.Engl., 54, 2015
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4RIG
| Chimeric Glycosyltransferase LanGT2S8Ac | 分子名称: | Glycosyl transferase, MAGNESIUM ION | 著者 | Tam, H.K, Gerhardt, S, Breit, B, Bechthold, A, Einsle, O. | 登録日 | 2014-10-06 | 公開日 | 2015-01-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Characterization of O- and C-Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2. Angew.Chem.Int.Ed.Engl., 54, 2015
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4RIH
| Chimeric Glycosyltransferase LanGT2S8Ac, carbasugar substrate complex | 分子名称: | 2'-deoxy-5'-O-[(R)-{[(R)-{[(1S,3R,4R,5S)-3,4-dihydroxy-5-methylcyclohexyl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-3,4-dihydrothymidine, Glycosyl transferase homolog,Glycosyl transferase, MAGNESIUM ION | 著者 | Tam, H.K, Gerhardt, S, Breit, B, Bechthold, A, Einsle, O. | 登録日 | 2014-10-06 | 公開日 | 2015-01-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structural Characterization of O- and C-Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2. Angew.Chem.Int.Ed.Engl., 54, 2015
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4RII
| Chimeric Glycosyltransferase LanGT2S8Ac, TDP complex | 分子名称: | Glycosyl transferase homolog,Glycosyl transferase, MAGNESIUM ION, THYMIDINE-5'-DIPHOSPHATE | 著者 | Tam, H.K, Gerhardt, S, Breit, B, Bechthold, A, Einsle, O. | 登録日 | 2014-10-06 | 公開日 | 2015-01-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Characterization of O- and C-Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2. Angew.Chem.Int.Ed.Engl., 54, 2015
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5I34
| Adenylosuccinate synthetase from Cryptococcus neoformans complexed with GDP and IMP | 分子名称: | Adenylosuccinate synthetase, GUANOSINE-5'-DIPHOSPHATE, INOSINIC ACID | 著者 | Blundell, R.D, Williams, S.J, Ericsson, D, Fraser, J.A, Kobe, B. | 登録日 | 2016-02-09 | 公開日 | 2016-08-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans. Acs Infect Dis., 2, 2016
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