8U27
 
 | | Bcl-2-xL complexed with compound 35 | | 分子名称: | Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, propan-2-yl {4-[(5S)-1-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]phenyl}carbamate | | 著者 | Rizo, J, Pan, Y.-Z. | | 登録日 | 2023-09-05 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural insights for selective disruption of Beclin 1 binding to Bcl-2.
Commun Biol, 6, 2023
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7UDB
 | | Cryo-EM structure of a synaptobrevin-Munc18-1-syntaxin-1 complex class 2 | | 分子名称: | Synaptobrevin-2, Syntaxin-1A, Syntaxin-binding protein 1 | | 著者 | Rizo, J, Bai, X, Stepien, K.P, Xu, J, Zhang, X. | | 登録日 | 2022-03-18 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-07-06 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex.
Sci Adv, 8, 2022
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7UDC
 | | cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex class1 | | 分子名称: | Synaptobrevin-2, Syntaxin-1A, Syntaxin-binding protein 1 | | 著者 | Rizo, J, Bai, X, Stepien, K.P, Xu, J, Zhang, X. | | 登録日 | 2022-03-18 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-07-06 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex.
Sci Adv, 8, 2022
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4OMO
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4OMN
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4OMP
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4OML
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4QT7
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1KMD
 | | SOLUTION STRUCTURE OF THE VAM7P PX DOMAIN | | 分子名称: | Vacuolar morphogenesis protein VAM7 | | 著者 | Lu, J, Garcia, J, Dulubova, I, Sudhof, T.C, Rizo, J. | | 登録日 | 2001-12-14 | | 公開日 | 2002-06-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the Vam7p PX domain.
Biochemistry, 41, 2002
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6ANJ
 | | Synaptotagmin-7, C2A domain | | 分子名称: | ACETATE ION, CALCIUM ION, Synaptotagmin-7, ... | | 著者 | Tomchick, D.R, Rizo, J, Voleti, R. | | 登録日 | 2017-08-13 | | 公開日 | 2017-09-20 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.698 Å) | | 主引用文献 | Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1KIL
 | | Three-dimensional structure of the complexin/SNARE complex | | 分子名称: | Complexin I SNARE-complex binding region, MAGNESIUM ION, SNAP-25 C-terminal SNARE motif, ... | | 著者 | Chen, X, Tomchick, D, Kovrigin, E, Arac, D, Machius, M, Sudhof, T.C, Rizo, J. | | 登録日 | 2001-12-03 | | 公開日 | 2002-03-13 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Three-dimensional structure of the complexin/SNARE complex.
Neuron, 33, 2002
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5UF7
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6ANK
 | | Synaptotagmin-7, C2A- and C2B-domains | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Synaptotagmin-7 | | 著者 | Tomchick, D.R, Rizo, J, Voleti, R. | | 登録日 | 2017-08-13 | | 公開日 | 2017-09-20 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.254 Å) | | 主引用文献 | Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5UE8
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3SWH
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4Y21
 | | Crystal Structure of Munc13-1 MUN domain | | 分子名称: | Protein unc-13 homolog A | | 著者 | Yang, X.Y, Wang, S, Sheng, Y, Zhang, M, Zou, W.J, Wu, L.J, Kang, L.J, Rizo, J, Zhang, R.G, Xu, T, Ma, C. | | 登録日 | 2015-02-09 | | 公開日 | 2015-06-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.
Nat.Struct.Mol.Biol., 22, 2015
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2Q3X
 | | The RIM1alpha C2B domain | | 分子名称: | CHLORIDE ION, Regulating synaptic membrane exocytosis protein 1, SODIUM ION, ... | | 著者 | Guan, R, Dai, H, Tomchick, D.R, Machius, M, Sudhof, T.C, Rizo, J. | | 登録日 | 2007-05-30 | | 公開日 | 2007-08-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Crystal Structure of the RIM1alpha C(2)B Domain at 1.7 A Resolution.
Biochemistry, 46, 2007
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2CJS
 | | Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2, ... | | 著者 | Lu, J, Machius, M, Dulubova, I, Dai, H, Sudhof, T.C, Tomchick, D.R, Rizo, J. | | 登録日 | 2006-04-06 | | 公開日 | 2006-06-07 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Structural Basis for a Munc13-1 Homodimer to Munc13-1/Rim Heterodimer Switch.
Plos Biol., 4, 2006
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2CJT
 | | Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules | | 分子名称: | 1,2-ETHANEDIOL, FORMIC ACID, UNC-13 HOMOLOG A | | 著者 | Lu, J, Machius, M, Dulubova, I, Dai, H, Sudhof, T.C, Tomchick, D.R, Rizo, J. | | 登録日 | 2006-04-06 | | 公開日 | 2006-06-07 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Structural Basis for a Munc13-1 Dimeric to Munc13-1/Rim Heterodimer Switch
Plos Biol., 4, 2006
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1S2H
 | | The Mad2 spindle checkpoint protein possesses two distinct natively folded states | | 分子名称: | Mitotic spindle assembly checkpoint protein MAD2A | | 著者 | Luo, X, Tang, Z, Xia, G, Wassmann, K, Matsumoto, T, Rizo, J, Yu, H. | | 登録日 | 2004-01-08 | | 公開日 | 2004-03-30 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Mad2 spindle checkpoint protein has two distinct natively folded states.
Nat.Struct.Mol.Biol., 11, 2004
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3N5A
 | | Synaptotagmin-7, C2B-domain, calcium bound | | 分子名称: | CALCIUM ION, Synaptotagmin-7 | | 著者 | Tomchick, D.R, Rizo, J, Craig, T.K. | | 登録日 | 2010-05-24 | | 公開日 | 2010-09-29 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.441 Å) | | 主引用文献 | Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Plos One, 5, 2010
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6NYT
 | | Munc13-1 C2B-domain, calcium bound | | 分子名称: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Tomchick, D.R, Rizo, J, Machius, M, Lu, J. | | 登録日 | 2019-02-12 | | 公開日 | 2019-02-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.369 Å) | | 主引用文献 | Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Nat. Struct. Mol. Biol., 17, 2010
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6NYC
 | | Munc13-1 C2B-domain, calcium free | | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Munc13-1 | | 著者 | Tomchick, D.R, Rizo, J, Machius, M, Lu, J. | | 登録日 | 2019-02-11 | | 公開日 | 2019-02-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.893 Å) | | 主引用文献 | Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Nat. Struct. Mol. Biol., 17, 2010
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1Y9J
 | | Solution structure of the rat Sly1 N-terminal domain | | 分子名称: | Sec1 family domain containing protein 1 | | 著者 | Arac, D, Dulubova, I, Pei, J, Huryeva, I, Grishin, N.V, Rizo, J. | | 登録日 | 2004-12-15 | | 公開日 | 2005-02-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Three-dimensional Structure of the rSly1 N-terminal Domain Reveals a Conformational Change Induced by Binding to Syntaxin 5.
J.Mol.Biol., 346, 2005
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1BR0
 | | THREE DIMENSIONAL STRUCTURE OF THE N-TERMINAL DOMAIN OF SYNTAXIN 1A | | 分子名称: | PROTEIN (SYNTAXIN 1-A) | | 著者 | Fernandez, I, Ubach, J, Dubulova, I, Zhang, X, Sudhof, T.C, Rizo, J. | | 登録日 | 1998-08-25 | | 公開日 | 1998-09-02 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A.
Cell(Cambridge,Mass.), 94, 1998
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