4CI8
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4CGC
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4CGB
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2WQM
| Structure of apo human Nek7 | 分子名称: | NICKEL (II) ION, SERINE/THREONINE-PROTEIN KINASE NEK7, SULFATE ION | 著者 | Richards, M.W, Bayliss, R. | 登録日 | 2009-08-24 | 公開日 | 2009-12-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | An Auto-Inhibitory Tyrosine Motif in the Cell-Cycle Regulated Nek7 Kinase is Released Through Binding of Nek9 Mol.Cell, 36, 2009
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2WT8
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2WQN
| Structure of ADP-bound human Nek7 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NICKEL (II) ION, ... | 著者 | Richards, M.W, Bayliss, R. | 登録日 | 2009-08-24 | 公開日 | 2009-12-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | An Autoinhibitory Tyrosine Motif in the Cell-Cycle- Regulated Nek7 Kinase is Released Through Binding of Nek9. Mol.Cell, 36, 2009
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6SGK
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6SGI
| Nek2 kinase bound to inhibitor 96 | 分子名称: | 4-[(6-ethyl-7~{H}-purin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, Serine/threonine-protein kinase Nek2 | 著者 | Richards, M.W, Mas-Droux, C.P, Bayliss, R. | 登録日 | 2019-08-05 | 公開日 | 2020-06-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase. Rsc Med Chem, 11, 2020
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6SGH
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6SGD
| Nek2 kinase covalently bound to 2-arylamino-6-ethynylpurine inhibitor 24 | 分子名称: | 4-[(6-ethenyl-7~{H}-purin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, SODIUM ION, ... | 著者 | Richards, M.W, Mas-Droux, C.P, Bayliss, R. | 登録日 | 2019-08-04 | 公開日 | 2020-06-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase. Rsc Med Chem, 11, 2020
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5ORL
| Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ... | 著者 | McIntyre, P.J, Collins, P.M, Vrzal, L, Birchall, K, Arnold, L.H, Mpamhanga, C, Coombs, P.J, Burgess, S.G, Richards, M.W, Winter, A, Veverka, V, von Delft, F, Merritt, A, Bayliss, R. | 登録日 | 2017-08-16 | 公開日 | 2017-11-01 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. ACS Chem. Biol., 12, 2017
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5G1X
| Crystal structure of Aurora-A kinase in complex with N-Myc | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AURORA KINASE A, MAGNESIUM ION, ... | 著者 | Richards, M.W, Burgess, S.G, Bayliss, R. | 登録日 | 2016-03-31 | 公開日 | 2016-11-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structural Basis of N-Myc Binding by Aurora-A and its Destabilization by Kinase Inhibitors Proc.Natl.Acad.Sci.USA, 113, 2016
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2WQO
| STRUCTURE OF NEK2 BOUND TO THE AMINOPYRIDINE CCT241950 | 分子名称: | 4-[2-AMINO-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL]BENZOIC ACID, CHLORIDE ION, SERINE/THREONINE-PROTEIN KINASE NEK2 | 著者 | Mas-Droux, C, Bayliss, R. | 登録日 | 2009-08-24 | 公開日 | 2009-12-08 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.167 Å) | 主引用文献 | An Autoinhibitory Tyrosine Motif in the Cell-Cycle- Regulated Nek7 Kinase is Released Through Binding of Nek9. Mol.Cell, 36, 2009
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6FHK
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5ODT
| Aurora-A in complex with TACC3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, GLYCEROL, ... | 著者 | Burgess, S.G, Bayliss, R. | 登録日 | 2017-07-06 | 公開日 | 2018-03-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.021 Å) | 主引用文献 | Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic alpha-helix. EMBO J., 37, 2018
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7ZAU
| Fascin-1 in complex with Nb 3E11 | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Fascin, ... | 著者 | Burgess, S.G, Bayliss, R. | 登録日 | 2022-03-22 | 公開日 | 2023-09-27 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation. Open Biology, 14, 2024
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5L8K
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5L8J
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5L8L
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6I2I
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5ORV
| Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ... | 著者 | McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R. | 登録日 | 2017-08-16 | 公開日 | 2017-11-01 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. ACS Chem. Biol., 12, 2017
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5OS3
| Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment | 分子名称: | (1~{R})-1-(4-ethoxyphenyl)ethanamine, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ... | 著者 | McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R. | 登録日 | 2017-08-16 | 公開日 | 2017-11-01 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. ACS Chem. Biol., 12, 2017
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5OS4
| Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment | 分子名称: | (3~{a}~{R},5~{S},7~{a}~{S})-5-phenyl-3~{a},4,5,6,7,7~{a}-hexahydroisoindole-1,3-dione, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ... | 著者 | McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R. | 登録日 | 2017-08-16 | 公開日 | 2017-11-01 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. ACS Chem. Biol., 12, 2017
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5ORS
| Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, MAGNESIUM ION, ... | 著者 | McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R. | 登録日 | 2017-08-16 | 公開日 | 2017-11-01 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. ACS Chem. Biol., 12, 2017
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5ORW
| Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment | 分子名称: | 3-(4-fluoranylphenoxy)-1-thiomorpholin-4-yl-propan-1-one, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ... | 著者 | McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R. | 登録日 | 2017-08-16 | 公開日 | 2017-11-01 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. ACS Chem. Biol., 12, 2017
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